Efficient siRNA transfection to the inner ear through the intact round window by a novel proteidic delivery technology in the chinchilla

Gene Therapy

Volumn 21, Issue 1, 2014, Pages 10-18

  Qi, W ^a   Ding, D ^b   Zhu, H ^c   Lu, D ^d   Wang, Y ^c   Ding, J ^c   Yan, W ^a   Jia, M ^a   Guo, Y ^a  

^a FUDAN UNIVERSITY   (China)

^b UNIVERSITY AT BUFFALO   (United States)

^c Novoprotein Scientific Inc   (China)

^d FUDAN UNIVERSITY   (China)

Author keywords

chinchilla; inner ear; small interfering RNA; TAT double stranded RNA binding domains; transfection

Indexed keywords

DOUBLE STRANDED RNA; HYBRID PROTEIN; SMALL INTERFERING RNA; TAT DOUBLESTRANDED RNA BINDING DOMAIN PROTEIN; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHINCHILLA; COCHLEA FENESTRA; CONTROLLED STUDY; EPITHELIUM; FEMALE; GENE VECTOR; GENETIC TRANSFECTION; HAIR CELL; IN VIVO STUDY; INNER EAR; MALE; MEMBRANE PERMEABILITY; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN RNA BINDING; SPIRAL GANGLION; STRIA VASCULARIS;

ANIMALS; CARBOCYANINES; CHINCHILLA; GENETIC VECTORS; RECOMBINANT PROTEINS; RNA, DOUBLE-STRANDED; RNA, SMALL INTERFERING; ROUND WINDOW, EAR; SPIRAL GANGLION; STRIA VASCULARIS; TRANSFECTION;

EID: 84891739644     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2013.49     Document Type: Article

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