Combined intrathymic and intravenous injection of mesenchymal stem cells can prolong the survival of rat cardiac allograft associated with decrease in miR-155 expression

Journal of Surgical Research

Volumn 185, Issue 2, 2013, Pages 896-903

  Huang, Haoyue ^a   He, Jigang ^a   Teng, Xiaomei ^a   Yu, Yunsheng ^a   Ye, Wenxue ^a   Hu, Yanqiu ^a   Shen, Zhenya ^a  

^a THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

Author keywords

Cytokine; IT IV injection; miR 155; MSCs; Rat cardiac allograft

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; MICRORNA 155; TRANSCRIPTION FACTOR FOXP3; CYTOKINE; MICRORNA; MIRN155 MICRORNA, RAT;

ANIMAL EXPERIMENT; ARTICLE; CD25+ T LYMPHOCYTE; CELL CULTURE; CELL DIFFERENTIATION; CELL INFILTRATION; CELL ISOLATION; CELL POPULATION; CELL STRUCTURE; COCULTURE; CONTROLLED STUDY; FLOW CYTOMETRY; GENE EXPRESSION; GRAFT RECIPIENT; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNOMODULATION; IN VITRO STUDY; INTRATHYMIC MESENCHYMAL STEM CELL TRANSPLANTATION; INTRAVENOUS MESENCHYMAL STEM CELL TRANSPLANTATION; LIMIT OF QUANTITATION; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; MIXED LYMPHOCYTE REACTION; NERVE CELL; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY T LYMPHOCYTE; SPRAGUE DAWLEY RAT; SURFACE PROPERTY; WISTAR RAT; ALLOTRANSPLANTATION; ANIMAL; CYTOLOGY; GENETICS; HEART MUSCLE; IMMUNOLOGY; INTRAVENOUS DRUG ADMINISTRATION; IT/IV INJECTION; MALE; MESENCHYMAL STROMA CELL; METHODOLOGY; MIR-155; MIXED LYMPHOCYTE CULTURE; MSCS; RAT CARDIAC ALLOGRAFT; TH1 CELL; TH2 CELL; THYMUS; PROCEDURES;

CYTOKINE; IT/IV INJECTION; MIR-155; MSCS; RAT CARDIAC ALLOGRAFT;

ANIMALS; CELLS, CULTURED; COCULTURE TECHNIQUES; GRAFT SURVIVAL; INJECTIONS, INTRAVENOUS; LYMPHOCYTE CULTURE TEST, MIXED; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MICRORNAS; MYOCARDIUM; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; T-LYMPHOCYTES, REGULATORY; TH1 CELLS; TH2 CELLS; THYMUS GLAND; TRANSPLANTATION, HOMOLOGOUS;

EID: 84891721275     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2013.06.015     Document Type: Article

References (32)

1. English K, French A, Wood KJ. Mesenchymal stromal cells: facilitators of successful transplantation? Cell Stem Cell 2010;7:431.
2. Bartholomew A, Sturgeon C, Siatskas M, et al. Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol 2002;30:42.
3. Dai W, Hale SL, Martin BJ, et al. Allogeneic mesenchymal stem cell transplantation in postinfarcted rat myocardium: short-and long-term effects. Circulation 2005;112:214.
4. Kuo YR, Goto S, Shih HS, et al. Mesenchymal stem cells prolong composite tissue allotransplant survival in a swine model. Transplantation 2009;87:1769.
5. Friedenstein AJ, Piatetzky-Shapiro II, Petrakova KV. Osteogenesis in transplants of bone marrow cells. J Embryol Exp Morphol 1966;16:381.
6. Zuk PA, Zhu M, Ashjian P, et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 2002;13:4279.
7. Huss R, Lange C, Weissinger EM, et al. Evidence of peripheral blood-derived, plastic-adherent CD34(-/low) hematopoietic stem cell clones with mesenchymal stem cell characteristics. Stem Cells 2000;18:252.
8. Le Blanc K, Ringdén O. Mesenchymal stem cells: properties and role in clinical bone marrow transplantation. Curr Opin Immunol 2006;18:586.
9. Csaki C, Schneider PR, Shakibaei M. Mesenchymal stem cells as a potential pool for cartilage tissue engineering. Ann Anat 2008;190:395.
10. Zhou HP, Yi DH, Yu SQ, et al. Administration of donor-derived mesenchymal stem cells can prolong the survival of at cardiac allograft. Transpl Proc 2006;38:3046.
11. Casiraghi F, Azzollini N, Cassis P, et al. Pretransplant infusion of mesenchymal stem cells prolongs the survival of a semiallogeneic heart transplant through the generation of regulatory T cells. J Immunol 2008;181:3933.
12. Ge W, Jiang J, Baroja ML, et al. Infusion of mesenchymal stem cells and rapamycin synergize to attenuate alloimmune responses and promote cardiac allograft tolerance. Am J Transpl 2009;9:1760.
13. Takayashiki T, Asakura H, Ku G, et al. Infectious tolerance develops after intrathymic alloantigen-induced acceptance of rat heart allografts can be adoptively transferred. Surgery 2005;138:254.
14. Sawai T, Ito T, Nakata S, et al. A successful induction of tolerance by perioperative intrathymic injection in rat "high-responder" heart transplantation. Transpl Proc 1999;31:2747.
15. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004;116:281.
16. Harris A, Krams SM, Martinez OM. MicroRNAs as immune regulators: implications for transplantation. Am J Transpl 2010;10:713.
17. Wei L, Wang M, Qu X, et al. Differential expression of microRNAs during allograft rejection. Am J Transpl 2012;12: 1113.
18. Leng RX, Pan HF, Qin WZ, et al. Role of microRNA-155 in autoimmunity. Cytokine Growth Factor Rev 2011;22:141.
19. Banerjee A, Schambach F, DeJong CS, et al. Micro-RNA-155 inhibits IFN-gamma signaling in CD4+ T cells. Eur J Immunol 2010;40:225.
20. Kohlhaas S, Garden OA, Scudamore C, et al. Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells. J Immunol 2009;182:2578.
21. Nagaya N, Kangawa K, Itoh T, et al. Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy. Circulation 2005;112:1128.
22. Duffy GP, D'Arcy S, Ahsan T, et al. Mesenchymal stem cells overexpressing ephrin-b2 rapidly adopt an early endothelial phenotype with simultaneous reduction of osteogenic potential. Tissue Eng Part A 2010;16:2755.
23. Stinn JL, Taylor MK, Becker G, et al. Interferon-gamma-secreting T-cell populations in rejecting murine cardiac allografts: assessment by flow cytometry. Am J Pathol 1998; 153:1383.
24. Ono K, Lindsey ES. Improved technique of heart transplantation in rats. J Thorac Cardiovasc Surg 1969;57:225.
25. Jia Z, Jiao C, Zhao S, et al. Immunomodulatory effect of mesenchymal stem cells in a rat corneal allograft rejection model. Exp Eye Res 2012;102:44.
26. Inoue S, Popp FC, Koehl GE, et al. Immunomodulatory effects of mesenchymal stem cells in a rat organ transplant model. Transplantation 2006;81:1589.
27. Nauta AJ, Westerhuis G, Kruisselbrink AB, et al. Donor-derived mesenchymal stem cells are immunogenic in an allogeneic host and stimulate donor graft rejection in a nonmyeloablative setting. Blood 2006;108:2114.
28. François M, Romieu-Mourez R, Stock-Martineau S, et al. Mesenchymal stromal cells cross-present soluble exogenous antigens as part of their antigen-presenting cell properties. Blood 2009;114:2632.
29. Chen L, Tredget EE, Liu C, et al. Analysis of allogenicity of mesenchymal stem cells in engraftment and wound healing in mice. PloS One 2009;4:e7119.
30. Jones ND, Fluck NC, Roelen DL, et al. Deletion of alloantigen-reactive thymocytes as a mechanism of adult tolerance induction following intrathymic antigen administration. Eur J Immunol 1997;27:1591.
31. Chen W, Sayegh MH, Khoury SJ. Mechanisms of acquired thymic tolerance in vivo: intrathymic injection of antigen induce apoptosis of thymocytes and peripheral T cell anergy. J Immunol 1998;160:1504.
32. Liang H, Liao C, Qi Z, et al. Rapamycin or tacrolimus alone fails to resist cardiac allograft accelerated rejection mediated by alloreactive CD4(+) memory T cells in mice. Transpl Immunol 2010;22:128.