Effect of neuronal nicotinic acetylcholine receptor genes (CHRN) on longitudinal cigarettes per day in adolescents and young adults

Nicotine and Tobacco Research

Volumn 16, Issue 2, 2014, Pages 137-144

  Cannon, Dale S ^a   Mermelstein, Robin J ^b   Hedeker, Donald ^b   Coon, Hilary ^a   Cook, Edwin H ^b   McMahon, William M ^a   Hamil, Cindy ^a   Dunn, Diane ^a   Weiss, Robert B ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; NICOTINIC RECEPTOR; GENETIC MARKER;

ADOLESCENT; ADOLESCENT SMOKING; ADULT; ARTICLE; CAUCASIAN; DNA EXTRACTION; FEMALE; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; HUMAN GENETICS; MALE; PRIORITY JOURNAL; SELF CONCEPT; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; YOUNG ADULT; CHEMISTRY; COHORT ANALYSIS; EPIDEMIOLOGY; GENE FREQUENCY; GENETIC MARKER; GENETICS; HUMAN GENOME PROJECT; ISOLATION AND PURIFICATION; LONGITUDINAL STUDY; PSYCHOLOGY; QUESTIONNAIRE; SALIVA; TOBACCO USE DISORDER; UNITED STATES; URBAN POPULATION;

ADOLESCENT; CHICAGO; COHORT STUDIES; DNA; FEMALE; GENE FREQUENCY; GENETIC MARKERS; GENOTYPE; HAPLOTYPES; HUMAN GENOME PROJECT; HUMANS; LONGITUDINAL STUDIES; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; QUESTIONNAIRES; RECEPTORS, NICOTINIC; SALIVA; SMOKING; TOBACCO USE DISORDER; URBAN POPULATION; YOUNG ADULT;

EID: 84891718500     PISSN: 14622203     EISSN: 1469994X     Source Type: Journal    
DOI: 10.1093/ntr/ntt125     Document Type: Article

References (46)

1. Audrain-McGovern, J., Rodriguez, D., Leventhal, A. M., Cuevas, J., Rodgers, K., & Sass, J. (2012). Where is the pleasure in that? Low hedonic capacity predicts smoking onset and escalation. Nicotine & Tobacco Research,14(10), 1187-1196. doi:10.1093/ntr/nts017
2. Baker, T. B., Weiss, R. B., Bolt, D., Von Niederhausern, A., Fiore, M. C., Dunn, D. M., Cannon, D. S. (2009). Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypes. Nicotine & Tobacco Research, 11(7), 785-796. doi:10.1093/ntr/ntp064
3. Benowitz, N. L. (2009). Pharmacology of nicotine: addiction, smoking-induced disease, and therapeutics. Annual Review of Pharmacology and Toxicology, 49, 57-71. doi:10.1146/annurev.pharmtox.48.113006.094742
4. Berrettini, W., Yuan, X., Tozzi, F., Song, K., Francks, C., Chilcoat, H., Mooser, V. (2008). Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking.Molecular Psychiatry, 13(4), 368-373. doi:10.1038/sj.mp.4002154
5. Bierut, L. J., Stitzel, J. A., Wang, J. C., Hinrichs, A. L., Grucza, R. A., Xuei, X., Goate, A. M. (2008). Variants in nicotinic receptors and risk for nicotine dependence. American Journal of Psychiatry, 165(9), 1163-1171. doi:10.1176/appi.ajp.2008.07111711
6. Brunzell, D. H. (2012). Preclinical evidence that activation of mesolimbic alpha 6 subunit containing nicotinic acetylcholine receptors supports nicotine addiction phenotype. Nicotine & Tobacco Research, 14(11), 1258-1269. doi:10.1093/ntr/nts089
7. Brunzell, D. H., Boschen, K. E., Hendrick, E. S., Beardsley, P. M., & McIntosh, J. M. (2010). Alpha-conotoxin MIIsensitive nicotinic acetylcholine receptors in the nucleus accumbens shell regulate progressive ratio responding maintained by nicotine. Neuropsychopharmacology, 35(3), 665-673. doi:10.1038/npp.2009.171
8. Caporaso, N., Gu, F., Chatterjee, N., Sheng-Chih, J., Yu, K., Yeager, M., Bergen, A. W. (2009). Genome-wide and candidate gene association study of cigarette smoking behaviors. PloS One, 4(2), e4653. doi:10.1371/journal.pone.0004653
9. Carlson, C. S., Eberle, M. A., Rieder, M. J., Yi, Q., Kruglyak, L., & Nickerson, D. A. (2004). Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. American Journal of Human Genetics, 74(1), 106-120. doi:10.1086/381000
10. Chassin, L., Presson, C. C., Rose, J. S., & Sherman, S.J.(1996). The natural history of cigarette smoking from adolescence to adulthood: demographic predictors of continuity and change. Health Psychology, 15(6), 478-484. doi:10.1037/0278-6133.15.6.478
11. Conti, D. V., Lee, W., Li, D., Liu, J., Van Den Berg, D., Thomas, P. D., Lerman, C.; Pharmacogenetics of Nicotine Addiction and Treatment Consortium. (2008). Nicotinic acetylcholine receptor beta2 subunit gene implicated in a systems-based candidate gene study of smoking cessation. Human Molecular Genetics, 17(18), 2834-2848. doi:10.1093/hmg/ddn181
12. Culverhouse, R. C., Saccone, N. L., Stitzel, J. A., Wang, J.C., Steinbach, J. H., Goate, A. M., Bierut, L. J. (2011). Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependence. Human Genetics, 129(2), 177-188. doi:10.1007/s00439-010-0911-7
13. Dierker, L., & Mermelstein, R. (2010). Early emerging nicotinedependence symptoms: a signal of propensity for chronic smoking behavior in adolescents. Journal of Pediatrics, 156(5), 818-822. doi:10.1016/j.jpeds.2009.11.044
14. Ducci, F., Kaakinen, M., Pouta, A., Hartikainen, A. L., Veijola, J., Isohanni, M., Jarvelin, M. R. (2011). TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 influence different pathways leading to smoking behavior from adolescence to mid-adulthood. Biological Psychiatry, 69(7), 650-660. doi:10.1016/j.biopsych.2010.09.055
15. Eaton, D. K., Kann, L., Kinchen, S., Shanklin, S., Flint, K. H., Hawkins, J., Wechsler, H.; Centers for Disease Control and Prevention (CDC). (2012). Youth risk behavior surveillance-United States, 2011. Morbidity and Mortality Weekly Report, 61(4), 1-162.
16. Ehringer, M. A., Clegg, H. V., Collins, A. C., Corley, R.P., Crowley, T., Hewitt, J. K., Zeiger, J. S. (2007). Association of the neuronal nicotinic receptor beta2 subunitgene (CHRNB2) with subjective responses to alcohol and nicotine. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 144B(5), 596-604. doi:10.1002/ajmg.b.30464
17. Ehringer, M. A., McQueen, M. B., Hoft, N. R., Saccone, N. L., Stitzel, J. A., Wang, J. C., & Bierut, L. J. (2010). Association of CHRN genes with "dizziness" to tobacco. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 153B, 600-609. doi:10.1002/ajmg.b.31027
18. Exley, R., Clements, M. A., Hartung, H., McIntosh, J. M., & Cragg, S. J. (2008). Alpha6-containing nicotinic acetylcholine receptors dominate the nicotine control of dopamine neurotransmission in nucleus accumbens. Neuropsychopharmacology, 33(9), 2158-2166. doi:10.1038/sj.npp.1301617
19. Fowler, C. D., & Kenny, P. J. (2012). Habenular signaling in nicotine reinforcement. Neuropsychopharmacology, 37(1), 306-307. doi:10.1038/npp.2011.197
20. Fowler, C. D., Lu, Q., Johnson, P. M., Marks, M. J., & Kenny, P. J. (2011). Habenular a5 nicotinic receptor subunit signalling controls nicotine intake. Nature, 471(7340), 597-601. doi:10.1038/nature09797
21. Frahm, S., Slimak, M. A., Ferrarese, L., Santos-Torres, J., Antolin-Fontes, B., Auer, S., Ibanez-Tallon, I. (2011). Aversion to nicotine is regulated by the balanced activity of ß4 and a5 nicotinic receptor subunits in the medial habenula. Neuron, 70(3), 522-535. doi:S0896-6273 (11)00339-4
22. Galwey, N. W. (2009). A new measure of the effective number of tests, a practical tool for comparing families of nonindependent significance tests. Genetic Epidemiology, 33(7), 559-568. doi:10.1002/gepi.20408
23. Greenbaum, L., & Lerer, B. (2009). Differential contribution of genetic variation in multiple brain nicotinic cholinergic receptors to nicotine dependence: recent progress and emerging open questions. Molecular Psychiatry, 14(10), 912-945. doi:10.1038/mp.2009.59
24. Hartz, S. M., Short, S. E., Saccone, N. L., Culverhouse, R., Chen, L., Schwantes-An, T. H., Bierut, L. J. (2012). Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers. Archives of General Psychiatry, 69(8), 854-860. doi:10.1001/archgenpsychiatry.2012.124
25. Hedeker, D., & Gibbons, R. D. (2006). Longitudinal data analysis. Wiley-Interscience. John Wiley & Sons, Inc., Hoboken, N.J.
26. Hedeker, D., Gibbons, R. D., & Waternaux, C. (1999). Sample size estimation for longitudinal designs with attrition. Journal of Educational and Behavioral Statistics, 24(1), 70-93. doi:10.3102/10769986024001070
27. Hoft, N. R., Corley, R. P., McQueen, M. B., Schlaepfer, I. R., Huizinga, D., & Ehringer, M. A. (2009). Genetic association of the CHRNA6 and CHRNB3 genes with tobacco dependence in a nationally representative sample. Neuropsychopharmacology, 34, 698-706. doi:10.1038/npp.2008.122
28. Liu, J. Z., Tozzi, F., Waterworth, D. M., Pillai, S. G., Muglia, P., Middleton, L., Marchini, J.; Wellcome Trust Case Control Consortium. (2010). Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nature Genetics, 42(5), 436-440. doi:10.1038/ng.572
29. Mermelstein, R., Colby, S. M., Patten, C., Prokhorov, A., Brown, R., Myers, M., McDonald, P. (2002). Methodological issues in measuring treatment outcome in adolescent smoking cessation studies. Nicotine & Tobacco Research, 4(4), 395-403. doi:10.1080/1462220021000018470
30. Mermelstein, R., Hedeker, D., & Weinstein, S. (2009). Ecological momentary assessment of mood/smoking relationships in adolescent smokers. In J. D. Kassel (Ed.), Substance abuse and emotion (pp. 217-236). Washington, DC: American Psychological Association.
31. Mineur, Y. S., & Picciotto, M. R. (2008). Genetics of nicotinic acetylcholine receptors: relevance to nicotine addiction. Biochemical Pharmacology, 75(1), 323-333. doi:10.1016/j.bcp.2007.06.010
32. Pritchard, J. K., & Rosenberg, N. A. (1999). Use of unlinked genetic markers to detect population stratification in association studies. American Journal of Human Genetics, 65, 220-228. doi:10.1086/302449
33. Rice, J. P., Hartz, S. M., Agrawal, A., Almasy, L., Bennett, S., Breslau, N., Bierut, L. J.; GENEVA Consortium. (2012). CHRNB3 is more strongly associated with Fagerström test for cigarette dependence-based nicotine dependence than cigarettes per day: phenotype definition changes genomewide association studies results. Addiction, 107, 2019-2028. doi:10.1111/j.1360-0443.2012.03922.x
34. Rodriguez, S., Cook, D. G., Gaunt, T. R., Nightingale, C. M., Whincup, P. H., & Day, I. N. (2011). Combined analysis of CHRNA5, CHRNA3 and CYP2A6 in relation to adolescent smoking behaviour. Journal of Psychopharmacology, 25(7), 915-923. doi:10.1177/0269881111405352
35. Saccone, N. L., Culverhouse, R. C., Schwantes-An, T. H., Cannon, D. S., Chen, X., Cichon, S., Bierut, L. J. (2010). Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD. PLoS Genetics, 6(8). doi:10.1371/journal.pgen.1001053
36. Saccone, N. L., Saccone, S. F., Hinrichs, A. L., Stitzel, J. A., Duan, W., Pergadia, M. L., Bierut, L. J. (2009). Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 150B(4), 453-466. doi:10.1002/ajmg.b.30828
37. Saccone, S. F., Hinrichs, A. L., Saccone, N. L., Chase, G.A., Konvicka, K., Madden, P. A., Bierut, L. J. (2007). Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. Human Molecular Genetics, 16(1), 36-49. doi:10.1093/hmg/ddl438
38. Schlaepfer, I. R., Hoft, N. R., Collins, A. C., Corley, R. P., Hewitt, J. K., Hopfer, C. J., Ehringer, M. A. (2008). The CHRNA5/A3/B4 gene cluster variability as an important determinant of early alcohol and tobacco initiation in young adults. Biological Psychiatry, 63(11), 1039-1046. doi:10.1016/j.biopsych.2007.10.024
39. Selya, A. S., Dierker, L. C., Rose, J. S., Hedeker, D., Tan, X., Li, R., & Mermelstein, R. J. (2013). Time-varying effects of smoking quantity and nicotine dependence on adolescent smoking regularity. Drug and Alcohol Dependence, 128, 230-237. doi:10.1016/j.drugalcdep.2012.08.026
40. TAG Consortium. (2010). Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Nature Genetics, 42(5), 441-447. doi:10.1038/ng.571
41. Thorgeirsson, T. E., Gudbjartsson, D. F., Surakka, I., Vink, J. M., Amin, N., Geller, F., Stefansson, K.; ENGAGE Consortium. (2010). Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nature Genetics, 42(5), 448-453. doi:10.1038/ng.573
42. U.S. Department of Health and Human Services. (2012). Preventing tobacco use among youth and young adults: a report of the Surgeon General. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health. Retrieved from http://www.cdc.gov/tobacco
43. Weiss, R. B., Baker, T. B., Cannon, D. S., Von Niederhausern, A., Dunn, D. M., Matsunami, N., Leppert, M. F. (2008). A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction. PLoS Genetics, 4(7), e1000125. doi:10.1371/journal.pgen.1000125
44. Yuan, K. H., & Maxwell, S. (2005). On the post hoc power in testing mean differences. Journal of Educational and Behavioral Statistics, 30(2), 141-167. doi:10.3102/10769986030002141
45. Zeiger, J. S., Haberstick, B. C., Schlaepfer, I., Collins, A. C., Corley, R. P., Crowley, T. J., Ehringer, M. A. (2008). The neuronal nicotinic receptor subunit genes (CHRNA6 and CHRNB3) are associated with subjective responses to tobacco. Human Molecular Genetics, 17(5), 724-734.
46. Zhan, W., Dierker, L. C., Rose, J. S., Selya, A., & Mermelstein, R. J. (2012). The natural course of nicotine dependence symptoms among adolescent smokers. Nicotine & Tobacco Research, 14(12), 1445-1452. doi:10.1093/ntr/nts031