Combined analysis of CHRNA5, CHRNA3 and CYP2A6 in relation to adolescent smoking behaviour

Journal of Psychopharmacology

Volumn 25, Issue 7, 2011, Pages 915-923

  Rodriguez, Santiago ^a   Cook, Derek G ^b   Gaunt, Tom R ^a   Nightingale, Claire M ^b   Whincup, Peter H ^b   Day, Ian N M ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Adolescents; CHRNA3; CHRNA5; CYP2A6; smoking behaviour; Ten Towns Heart Health Study (TTHHS)

Indexed keywords

CYTOCHROME P450 2A6; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA3; NICOTINIC RECEPTOR ALPHA5; UNCLASSIFIED DRUG;

ADOLESCENT; ADOLESCENT SMOKING; ADULT; ARTICLE; CHRNA3 GENE; CHRNA5 GENE; CONTROLLED STUDY; CYP2A6 GENE; FEMALE; GENE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; MALE; NORMAL HUMAN; PHENOTYPE; PRIORITY JOURNAL; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING CESSATION; SMOKING HABIT;

ADOLESCENT; ADOLESCENT BEHAVIOR; AGE FACTORS; ARYL HYDROCARBON HYDROXYLASES; ENGLAND; GENOTYPE; HUMANS; LOGISTIC MODELS; LONGITUDINAL STUDIES; NERVE TISSUE PROTEINS; ODDS RATIO; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSPECTIVE STUDIES; RECEPTORS, NICOTINIC; RISK ASSESSMENT; RISK FACTORS; SMOKING; WALES;

EID: 80052009517     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881111405352     Document Type: Article

References (41)

1. Amos CI, Wu X, Broderick P, Gorlov IP, Gu J, Eisen T, et al. Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat Genet. 2008 ; 40: 616-622 (Pubitemid 351601203)
2. Audrain-McGovern J, Al KN, Rodriguez D, Wileyto EP, Shields PG, Tyndale RF. The role of CYP2A6 in the emergence of nicotine dependence in adolescents. Pediatrics. 2007 ; 119: e264 - e274
3. Berrettini W, Yuan X, Tozzi F, Song K, Francks C, Chilcoat H, et al. Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking. Mol Psychiatry. 2008 ; 13: 368-373 (Pubitemid 351399826)
4. Bierut LJ, Stitzel JA, Wang JC, Hinrichs AL, Grucza RA, Xuei X, et al. Variants in nicotinic receptors and risk for nicotine dependence. Am J Psychiatry. 2008 ; 165: 1163-1171
5. Breitling LP, Dahmen N, Mittelstrass K, Illig T, Rujescu D, Raum E, et al. Smoking cessation and variations in nicotinic acetylcholine receptor subunits alpha-5, alpha-3, and beta-4 genes. Biol Psychiatry. 2009 ; 65: 691-695
6. Fagerstrom K. The epidemiology of smoking: health consequences and benefits of cessation. Drugs. 2002 ; 62 (Suppl 2). 1-9 (Pubitemid 34809710)
7. Feyerabend C, Russell MA. A rapid gas-liquid chromatographic method for the determination of cotinine and nicotine in biological fluids. J Pharm Pharmacol. 1990 ; 42: 450-452 (Pubitemid 20313701)
8. Fuller E Smoking, drinking and drug use among young people in England in 2006. The Information Centre for health and social care ; 2007 :
9. Greenbaum L, Kanyas K, Karni O, Merbl Y, Olender T, Horowitz A, et al. Why do young women smoke? I. Direct and interactive effects of environment, psychological characteristics and nicotinic cholinergic receptor genes. Mol Psychiatry. 2006 ; 11: 312-323
10. Gu DF, Hinks LJ, Morton NE, Day IN. The use of long PCR to confirm three common alleles at the CYP2A6 locus and the relationship between genotype and smoking habit. Ann Hum Genet. 2000 ; 64: 383-390 (Pubitemid 32055729)
11. Hall W, Madden P, Lynskey M. The genetics of tobacco use: methods, findings and policy implications. Tob Control. 2002 ; 11: 119-124
12. Huang S, Cook DG, Hinks LJ, Chen XH, Ye S, Gilg JA, et al. CYP2A6, MAOA, DBH, DRD4, and 5HT2A genotypes, smoking behaviour and cotinine levels in 1518 UK adolescents. Pharmacogenet Genomics. 2005 ; 15: 839-850 (Pubitemid 41666766)
13. Hung RJ, McKay JD, Gaborieau V, Boffetta P, Hashibe M, Zaridze D, et al. A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature. 2008 ; 452: 633-637 (Pubitemid 351483367)
14. Johnstone E, Benowitz N, Cargill A, Jacob R, Hinks L, Day I, et al. Determinants of the rate of nicotine metabolism and effects on smoking behavior. Clin Pharmacol Ther. 2006 ; 80: 319-330 (Pubitemid 44479751)
15. KBioscience (2009) KBioscience: Genotyping Chemistry. http://www.kbioscience.co.uk/reagents/KASP.html (accessed 02 June 2011).
16. Keskitalo K, Broms U, Heliovaara M, Ripatti S, Surakka I, Perola M, et al. Association of serum cotinine level with a cluster of three nicotinic acetylcholine receptor genes (CHRNA3/CHRNA5/CHRNB4) on chromosome 15. Hum Mol Genet. 2009 ; 18: 4007-4012
17. Le ML, Derby KS, Murphy SE, Hecht SS, Hatsukami D, Carmella SG, et al. Smokers with the CHRNA lung cancer-associated variants are exposed to higher levels of nicotine equivalents and a carcinogenic tobacco-specific nitrosamine. Cancer Res. 2008 ; 68: 9137-9140
18. Li MD, Burmeister M. New insights into the genetics of addiction. Nat Rev Genet. 2009 ; 10: 225-231
19. Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, et al. Finding the missing heritability of complex diseases. Nature. 2009 ; 461: 747-753
20. Mwenifumbo JC, Tyndale RF. Genetic variability in CYP2A6 and the pharmacokinetics of nicotine. Pharmacogenomics. 2007 ; 8: 1385-1402 (Pubitemid 350162852)
21. Nakajima M. Smoking behavior and related cancers: the role of CYP2A6 polymorphisms. Curr Opin Mol Ther. 2007 ; 9: 538-544 (Pubitemid 350182382)
22. O'Loughlin J, Paradis G, Kim W, DiFranza J, Meshefedjian G, McMillan-Davey E, et al. Genetically decreased CYP2A6 and the risk of tobacco dependence: a prospective study of novice smokers. Tob Control. 2004 ; 13: 422-428 (Pubitemid 39635932)
23. Owen CG, Whincup PH, Odoki K, Gilg JA, Cook DG. Birth weight and blood cholesterol level: a study in adolescents and systematic review. Pediatrics. 2003 ; 111: 1081-1089 (Pubitemid 36542625)
24. Rodríguez S, Huang S, Chen XH, Gaunt TR, Syddall HE, Gilg JA, et al. A study of TH01 and IGF2-INS-TH haplotypes in relation to smoking initiation in three independent surveys. Pharmacogenet Genomics. 2006 ; 16: 15-23 (Pubitemid 41803873)
25. Saccone NL, Saccone SF, Hinrichs AL, Stitzel JA, Duan W, Pergadia ML, et al. Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes. Am J Med Genet B Neuropsychiatr Genet. 2009a ; 150B: 453-466
26. Saccone NL, Wang JC, Breslau N, Johnson EO, Hatsukami D, Saccone SF, et al. The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans. Cancer Res. 2009b ; 69: 6848-6856
27. Saccone SF, Hinrichs AL, Saccone NL, Chase GA, Konvicka K, Madden PA, et al. Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. Hum Mol Genet. 2007 ; 16: 36-49 (Pubitemid 46152543)
28. Schlaepfer IR, Hoft NR, Collins AC, Corley RP, Hewitt JK, Hopfer CJ, et al. The CHRNA5/A3/B4 gene cluster variability as an important determinant of early alcohol and tobacco initiation in young adults. Biol Psychiatry. 2008 ; 63: 1039-1046
29. Sherva R, Wilhelmsen K, Pomerleau CS, Chasse SA, Rice JP, Snedecor SM, et al. Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with 'pleasurable buzz' during early experimentation with smoking. Addiction. 2008 ; 103: 1544-1552
30. Spitz MR, Amos CI, Dong Q, Lin J, Wu X. The CHRNA5-A3 region on chromosome 15q24-25.1 is a risk factor both for nicotine dependence and for lung cancer. J Natl Cancer Inst. 2008 ; 100: 1552-1556
31. Stevens VL, Bierut LJ, Talbot JT, Wang JC, Sun J, Hinrichs AL, et al. Nicotinic receptor gene variants influence susceptibility to heavy smoking. Cancer Epidemiol Biomarkers Prev. 2008 ; 17: 3517-3525
32. Tabakoff B, Saba L, Printz M, Flodman P, Hodgkinson C, Goldman D, et al. Genetical genomic determinants of alcohol consumption in rats and humans. BMC Biol. 2009 ; 7: 70-70
33. Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Nat Genet. 2010 ; 42: 441-447
34. Thorgeirsson TE, Geller F, Sulem P, Rafnar T, Wiste A, Magnusson KP, et al. A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature. 2008 ; 452: 638-642 (Pubitemid 351483366)
35. Thorgeirsson TE, Gudbjartsson DF, Surakka I, Vink JM, Amin N, Geller F, et al. Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat Genet. 2010 ; 42: 448-453
36. Wang JC, Cruchaga C, Saccone NL, Bertelsen S, Liu P, Budde JP, et al. Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5. Hum Mol Genet. 2009a ; 18: 3125-3135
37. Wang JC, Grucza R, Cruchaga C, Hinrichs AL, Bertelsen S, Budde JP, et al. Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence. Mol Psychiatry. 2009b ; 14: 501-510
38. Weiss RB, Baker TB, Cannon DS, von Niderhausern A, Dunn DM, Matsunami N, et al. A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction. PLoS Genet. 2008 ; 4: e1000125 - e1000125
39. Whincup PH, Cook DG, Papacosta O, Walker M. Childhood blood pressure, body build, and birthweight: geographical associations with cardiovascular mortality. J Epidemiol Community Health. 1992 ; 46: 396-402 (Pubitemid 23364601)
40. Whincup PH, Gilg JA, Owen CG, Odoki K, Alberti KG, Cook DG. British South Asians aged 13-16 years have higher fasting glucose and insulin levels than Europeans. Diabet Med. 2005 ; 22: 1275-1277 (Pubitemid 41224193)
41. Zienolddiny S, Skaug V, Landvik NE, Ryberg D, Phillips DH, Houlston R, et al. The TERT-CLPTM1L lung cancer susceptibility variant associates with higher DNA adduct formation in the lung. Carcinogenesis. 2009 ; 30: 1368-1371