Decreased microvascular myogenic response to insulin in severely obese adolescents

Clinical Hemorheology and Microcirculation

Volumn 57, Issue 1, 2014, Pages 23-32

  Montero, David ^a,c   Walther, Guillaume ^a   Perez Martin, Antonia ^b   Santamaria, Cristina ^c   Roche, Enrique ^c   Mercier, Charles ^d   Vinet, Agnès ^a  

^a UNIVERSITY OF AVIGNON   (France)

^b NÎMES UNIVERSITY HOSPITAL   (France)

^c MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

^d Le Noble Age Group   (France)

Author keywords

adolescents; Flowmotion; insulin action; microcirculation; severe obesity

Indexed keywords

INSULIN;

ADOLESCENT; ANTHROPOMETRY; ARTICLE; BLOOD SAMPLING; BODY MASS; BODY WEIGHT; CHILD; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; DIET RESTRICTION; DISEASE SEVERITY; FEMALE; FLOW RATE; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; IONTOPHORESIS; LASER DOPPLER FLOWMETRY; MALE; MICROCIRCULATION; MICROVASCULARIZATION; OBESITY; PUBERTY; SKIN BLOOD FLOW; DRUG EFFECTS; INTRADERMAL DRUG ADMINISTRATION; METABOLISM; MICROVASCULATURE; PATHOPHYSIOLOGY; VASCULAR SMOOTH MUSCLE; VASODILATATION;

ADMINISTRATION, CUTANEOUS; ADOLESCENT; CHILD; FEMALE; HUMANS; INSULIN; INSULIN RESISTANCE; LASER-DOPPLER FLOWMETRY; MALE; MICROCIRCULATION; MICROVESSELS; MUSCLE, SMOOTH, VASCULAR; OBESITY; VASODILATION;

EID: 84891713495     PISSN: 13860291     EISSN: 18758622     Source Type: Journal    
DOI: 10.3233/CH-131769     Document Type: Article

References (50)

1. G.E. Alvarez, S.D. Beske, T.P. Ballard and K.P. Davy, Sympathetic neural activation in visceral obesity, Circulation 106 (2002), 2533-2536
2. A.D. Baron, Hemodynamic actions of insulin, Am J Physiol 267 (1994), E187-E202
3. L.M. Biasucci, F. Graziani and V. Rizzello, et al., Paradoxical preservation of vascular function in severe obesity, Am J Med 123 (2010), 727-734
4. M. Bracic and A. Stefanovska,Wavelet-based analysis of human blood-flow dynamics, Bull Math Biol 60 (1998), 919-935
5. F. Brandou, J.F. Brun and J. Mercier, Limited accuracy of surrogates of insulin resistance during puberty in obese and lean children at risk for altered glucoregulation, J Clin Endocrinol Metab 90 (2005), 761-767
6. J.F. Brun, I. Aloulou and E. Varlet-Marie, Hemorheological aspects of the metabolic syndrome: Markers of insulin resistance, obesity or hyperinsulinemia? Clin Hemorheol Microcirc 30 (2004), 203-209
7. J.F. Brun, E. Varlet-Marie and E. Raynaud De Mauverger, Relationships between insulin sensitivity measured with the oral minimal model and blood rheology, Clin Hemorheol Microcirc 51 (2012), 29-34
8. J.F. Brun, E. Varlet-Marie, E. Raynaud De Mauverger and J. Mercier, Minimal model-derived insulin sensitivity, insulin secretion and glucose tolerance: Relationships with blood rheology, Clin Hemorheol Microcirc 51 (2012), 21-27
9. M. Bryszewska andW. Leyko, Effect of insulin on human erythrocyte membrane fluidity in Diabetes mellitus, Diabetologia 24 (1983), 311-313
10. M.G. Clark, Impaired microvascular perfusion: A consequence of vascular dysfunction and a potential cause of insulin resistance in muscle, Am J Physiol Endocrinol Metab 295 (2008), E732-E750
11. L.H. Clerk, M.A. Vincent, L.A. Jahn, Z. Liu, J.R. Lindner and E.J. Barrett, Obesity blunts insulin-mediated microvascular recruitment in human forearm muscle, Diabetes 55 (2006), 1436-1442
12. A. Colantuoni, S. Bertuglia, G. Coppini and L. Donato, Superposition of arteriolar vasomotion waves and regulation of blood flow in skeletal muscle microcirculation, Adv Exp Med Biol 277 (1990), 549-558
13. T.J. Cole, M.C. Bellizzi, K.M. Flegal and W.H. Dietz, Establishing a standard definition for child overweight and obesity worldwide: International survey, BMJ 320 (2000), 1240-1243
14. C. Contreras, A. Sanchez, A. Garcia-Sacristan, M.C. Martinez, R. Andriantsitohaina and D. Prieto, Preserved insulin vasorelaxation and up-regulation of the Akt/eNOS pathway in coronary arteries from insulin resistant obese Zucker rats, Atherosclerosis 217 (2011), 331-339
15. R.T.De Jongh, A.D. Clark, I.J. Rg, E.H. Serne, G. De Vries and C.D. Stehouwer, Physiological hyperinsulinaemia increases intramuscular microvascular reactive hyperaemia and vasomotion in healthy volunteers, Diabetologia 47 (2004), 978-986
16. R.T. De Jongh, E.H. Serne, I.J. Rg, G. De Vries and C.D. Stehouwer, Impaired microvascular function in obesity: Implications for obesity-Associated microangiopathy, hypertension, and insulin resistance, Circulation 109 (2004), 2529-2535
17. R.T. De Jongh, E.H. Serne, I.J. Rg, H.T. Jorstad and C.D. Stehouwer, Impaired local microvascular vasodilatory effects of insulin and reduced skin microvascular vasomotion in obese women, Microvasc Res 75 (2008), 256-262
18. E.R. Duncan, P.A. Crossey and S. Walker, et al., Effect of endothelium-specific insulin resistance on endothelial function in vivo, Diabetes 57 (2008), 3307-3314
19. S. Durand, B. Fromy, P. Bouye, J.L. Saumet and P. Abraham, Current-induced vasodilation During water iontophoresis (5min, 0.10mA) is delayed from current onset and involves aspirin sensitive mechanisms, J Vasc Res 39 (2002), 59-71
20. T. Forst, M.M.Weber and M. Mitry, et al., Pilot study for the evaluation of morphological and functional changes in retinal blood flow in patients with insulin resistance and/or type 2 diabetes mellitus, J Diabetes Sci Technol 6 (2012), 163-168
21. A.K. Gupta and S.K. Jain, A study to evaluate surrogate markers of insulin resistance in forty euglycemic healthy subjects, J Assoc Physicians India 52 (2004), 549-553
22. G. Guzzaloni, G. Grugni, G. Mazzilli, D. Moro and F. Morabito, Comparison between beta-cell function and insulin resistance indexes in prepubertal and pubertal obese children, Metabolism 51 (2002), 1011-1016
23. L.A. Holowatz, C.S. Thompson-Torgerson and W.L. Kenney, The human cutaneous circulation as a model of generalized microvascular function, J Appl Physiol 105 (2008), 370-372
24. A.M. Jonk, A.J. Houben, N.C. Schaper, et al., Meal-related increases in microvascular vasomotion are impaired in obese individuals: A potential mechanism in the pathogenesis of obesity-related insulin resistance, Diabetes Care 34 Suppl 2 (2011), S342-348
25. P. Kvandal, S.A. Landsverk, A. Bernjak, A. Stefanovska, H.D. Kvernmo and K.A. Kirkeboen, Low-frequency oscillations of the laser Doppler perfusion signal in human skin, Microvasc Res 72 (2006), 120-127
26. M. Laakso, How good a marker is insulin level for insulin resistance?, Am J Epidemiol 137 (1993), 959-965
27. C.H. Lang, Rates and tissue sites of noninsulin- And insulin-mediated glucose uptake in Diabetic rats, Proc Soc Exp Biol Med 199 (1992), 81-87
28. M.J. Leahy, F.F. De Mul, G.E. Nilsson and R. Maniewski, Principles and practice of the laser-Doppler perfusion technique, Technol Health Care 7 (1999), 143-162
29. J.C. Levy, D.R. Matthews and M.P. Hermans, Correct homeostasis model assessment(HOMA)evaluation uses the computer program, Diabetes Care 21 (1998), 2191-2192
30. D.R. Matthews, J.P. Hosker, A.S. Rudenski, B.A. Naylor, D.F. Treacher and R.C. Turner, Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man, Diabetologia 28 (1985), 412-419
31. R.I. Meijer, M.P. De Boer and M.R. Groen, et al., Insulin-induced microvascular recruitment in skin and muscle are related and both are associated with whole-body glucose uptake, Microcirculation 19 (2012), 494-500
32. S.J. Morris, A.C. Shore and J.E. Tooke, Responses of the skin microcirculation to acetylcholine and sodium nitroprusside in patients with NIDDM, Diabetologia 38 (1995), 1337-1344
33. J.M. Newman, R.M. Dwyer, P. St-Pierre, S.M. Richards, M.G. Clark and S. Rattigan, Decreased microvascular vasomotion and myogenic response in rat skeletal muscle in association with acute insulin resistance, J Physiol 587 (2009), 2579-2588
34. S. Pilia, M.R. Casini and M.L. Foschini, et al., The effect of puberty on insulin resistance in obese children, J Endocrinol Invest 32 (2009), 401-405
35. S. Rattigan, M.G. Clark and E.J. Barrett, Acute vasoconstriction-induced insulin resistance in rat muscle in vivo, Diabetes 48 (1999), 564-569
36. S. Rattigan, M.G. Clark and E.J. Barrett, Hemodynamic actions of insulin in rat skeletal muscle: Evidence for capillary recruitment, Diabetes 46 (1997), 1381-1388
37. M.F. Rolland-Cachera, T.J. Cole, M. Sempe, J. Tichet, C. Rossignol, A. Charraud and Mass Body, Index variations: Centiles from birth to 87 years, Eur J Clin Nutr 45 (1991), 13-21
38. M. Rossi, L. Bazzichi and C. Di Maria, et al., Blunted increase of digital skin vasomotion following acetylcholine and sodium nitroprusside iontophoresis in systemic sclerosis patients, Rheumatology (Oxford) 47 (2008), 1012-1017
39. M. Rossi, A. Bradbury, A. Magagna, M. Pesce, S. Taddei and A. Stefanovska, Investigation of skin vasoreactivity and blood flow oscillations in hypertensive patients: Effect of short-Term antihypertensive treatment, J Hypertens 29 (2011), 1569-1576
40. M. Rossi, A. Cupisti, R. Ricco, G. Santoro, F. Pentimone and A. Carpi, Skin vasoreactivity to insulin iontophoresis is reduced in elderly subjects and is absent in treated non-insulin-dependent diabetes patients, Biomed Pharmacother 58 (2004), 560-565
41. M. Rossi, S. Maurizio and A. Carpi, Skin blood flowmotion response to insulin iontophoresis in normal subjects, Microvasc Res 70 (2005), 17-22
42. M. Rossi, M. Nannipieri, M. Anselmino, et al., Skin vasodilator function and vasomotion in patients with morbid obesity: Effects of gastric bypass surgery, Obes Surg 21 (2011), 87-94
43. E.H. Serne, I.J. Rg and R.O. Gans, et al., Direct evidence for insulin-induced capillary recruitment in skin of healthy subjects during physiological hyperinsulinemia, Diabetes 51 (2002), 1515-1522
44. A. Stefanovska, M. Bracic and H.D. Kvernmo,Wavelet analysis of oscillations in the peripheral blood circulation measured by laser Doppler technique, IEEE Trans Biomed Eng 46 (1999), 1230-1239
45. H.O. Steinberg, H. Chaker, R. Leaming, A. Johnson, G. Brechtel and A.D. Baron, Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance, J Clin Invest 97 (1996), 2601-2610
46. M. Trovati, P. Massucco and L. Mattiello, et al., Human vascular smooth muscle cells express a constitutive nitric oxide synthase that insulin rapidly activates, thus increasing guanosine 3':5'-cyclic monophosphate and adenosine 3-:5-cyclic monophosphate concentrations, Diabetologia 42 (1999), 831-839
47. S. Van Veen and P.C. Chang, Prostaglandins and nitric oxide mediate insulin-induced vasodilation in the human forearm, Cardiovasc Res 34 (1997), 223-229
48. A. Vaya, A. Hernandez-Mijares and M. Suescun, et al., Metabolic alterations in morbid obesity. Influence on the haemorheological profile, Clin Hemorheol Microcirc 48 (2011), 247-255
49. D. Vicent, J. Ilany and T. Kondo, et al., The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance, J Clin Invest 111 (2003), 1373-1380
50. G. Zeng, F.H. Nystrom and L.V. Ravichandran, et al., Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells, Circulation 101 (2000), 1539-1545