Blunted increase of digital skin vasomotion following acetylcholine and sodium nitroprusside iontophoresis in systemic sclerosis patients

Rheumatology

Volumn 47, Issue 7, 2008, Pages 1012-1017

  Rossi, M ^a   Bazzichi, L ^a   Di Maria, C ^a   Franzoni, F ^a   Raimo, K ^a   Della Rossa, A ^a   Santoro, G ^a   Bombardieri, S ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

Acetylcholine; Finger skin vasomotion; Flow motion; Laser Doppler flowmetry; Lontophoresis; Sodium nitroprusside; Spectral Fourier analysis; Systemic sclerosis

Indexed keywords

ACETYLCHOLINE; ILOPROST; METHOTREXATE; METHYLPREDNISOLONE; NIFEDIPINE; NITROPRUSSIDE SODIUM;

ADULT; AGED; ARTICLE; BLOOD VESSEL REACTIVITY; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE COURSE; DISEASE SEVERITY; DOPPLER FLOWMETRY; ENDOTHELIAL DYSFUNCTION; FEMALE; FINGER BLOOD FLOW; FOURIER ANALYSIS; HUMAN; HYPOTHESIS; IONTOPHORESIS; MALE; MICROCIRCULATION; MICROVASCULATURE; MUSCLE CONTRACTION; OSCILLATION; PRIORITY JOURNAL; SKIN BLOOD VESSEL; SPECTROMETRY; SYMPATHETIC TONE; SYSTEMIC SCLEROSIS; VASCULAR DISEASE; VASCULAR ENDOTHELIUM;

ACETYLCHOLINE; ADULT; AGED; ENDOTHELIUM, VASCULAR; FEMALE; FINGERS; HUMANS; IONTOPHORESIS; LASER-DOPPLER FLOWMETRY; MALE; MICROCIRCULATION; MIDDLE AGED; NITROPRUSSIDE; REGIONAL BLOOD FLOW; SCLERODERMA, SYSTEMIC; SEVERITY OF ILLNESS INDEX; SKIN; VASODILATION; VASODILATOR AGENTS;

EID: 45749118748     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/ken117     Document Type: Article

References (35)

1. La Civita L, Rossi M, Vagheggini G et al. Microvascular involvement in systemic sclerosis: Laser Doppler evaluation of reactivity to acetylcholine and sodium nitroprusside by iontophoresis. Ann Rheum Dis 1998;57:52-5.
2. Anderson ME, Campbell F, Hollis S, Moore T, Jayson MIV, Herrick AL. Non-invasive assessment of digital vascular reactivity in patients with primary Raynaud's phenomenon and systemic sclerosis. Clin Exp Rheumatol 1999;17:49-54.
3. Anderson ME, Moore TL, Hollis S, Clark S, Jayson MI, Herrick AL. Endothelial dependent vasodilation is impaired in patients with systemic sclerosis, as assessed by low dose iontophoresis. Clin Exp Rheumatol 2003;21:403.
4. Anderson ME, Moore TL, Lunt M, Errick AL. Digital iontophoresis of vasoactive substances as measured by laser Doppler imaging - a non-invasive technique by which to measure microvascular dysfunction in Raynaud's phenomenon. Rheumatology 2004;43:986-91.
5. Gunawardena H, Harris ND, Carmichael C, McHugh NJ. Maximum blood flow and microvascular regulatory responses in systemic sclerosis. Rheumatology 2007; 46:1079-82.
6. Khan F, Belch JJF. Skin blood flow in patents with systemic sclerosis and Raynaud's phenomenon: Effects of oral L-arginine supplementation. J Rheumatol 1999;26:2389-94.
7. Campbell PM, LeRoy EC. Pathogenesis of systemic sclerosis: A vascular hypothesis. Semin Arthritis Rheum 1975;4:351-68.
8. Herrick AL. Vascular function in systemic sclerosis. Curr Opin Rheumatol 2000;12:527-33.
9. Stefanovska A, Kroselj P. Correlation integral and frequency analysis of cardiovascular functions. Open Syst Inf Dyn 1997;4:457-78.
10. Stefanovska A, Bracic M, Kvemmo K. Wavelet analysis of oscillations in the peripheral blood circulation measured by laser Doppler technique. IEEE Trans Biomed Eng 1999;46:1230-9.
11. Kvandal P, Stefanovska A, Veber M, Kvermmo HD, Kirkeboen KA. Regulation of human cutaneous circulation evaluated by laser Doppler flowmetry, iontophoresis, and spectral analysis: Importance of nitric oxide and prostaglandines. Microvasc Res 2003;65:160-71.
12. Rossi M, Rioco R, Carpi A. Spectral analysis of skin laser Doppler blood perfusion signal during cutaneous hyperemia in response to acetylcholine iontophoresis and ischemia in normal subjects. Clin Hemorheol Microcirc 2004;31:303-10.
13. Colantuoni A, Bertuglia S, Intaglietta M. Microvascular vasomotion: origin of laser Doppler fluxmotion. Int J Microcirc Clin Exp 1994;14:151-8.
14. Bertuglia S, Colantuoni A, Coppini G, Intaglietta M. Hypoxia- or hyperoxia-induced changes in arteriolar vasomotion in skeletal muscle microcirculation. Am J Physiol 1991;260:H362-72.
15. Bertuglia S, Colantuoni A, Intaglietta M. Effects of L-NMMA and indomethacin on arterial vasomotion in skeletal muscle microcirculation of conscious and anesthetized animals. Microcirc Res 1994;48:68-84.
16. Ursino M, Fabbri G. Role of the myogenic mechanism in the genesis of microvascular oscillation (vasomotion): Analysis with a mathematical model. Microvasc Res 1992;43:156-77.
17. Ursino M, Cavalcanti S, Bertuglia S, Colantuoni A. Theoretical analysis of complex oscillations in multibranched microvascular networks. Microvasc Res 1996;23:229-49.
18. Parthimos D, Edwards DH, Griffith TM. Comparison of chaotic and sinusoidal vasomotion in the regulation of microvascular flow. Cardiovasc Res 1996;31:388-99.
19. Soderstrom T, Stefanovska A, Veber M, Svensson H. Involvement of sympathetic nerve activity in skin blood flow oscillation in humans. Am J Physiol Heart Circ Physiol 2003;284:H1638-46.
20. Stauss HM, Anderson EA, Haynes WG, Kragel KC. Frequency response characteristics of sympathetically mediated vasomotor waves in humans. Am J Physiol 1998;274:H1277-83.
21. Rossi M, Carpi A, Di Maria C, Galatia F, Santoro G. Spectral analysis of laser Doppler skin blood flow oscillations in human essential arterial hypertension. Microvasc Res 2006;72:34-41.
22. Stewart J, Kohen A, Brouder D et al. Non-invasive interrogation of microvasculature for signs of andothelial dysfunction in patients with chronic renal failure. Am J Physiol Heart Circ Physiol 2004;287:H2687-96.
23. Bernardi L, Rossi M, Leuzzi S et al. Reduction of 0.1 Hz microcirculatory fluctuations as evidence of sympathetic dysfunction in insulin-dependent diabetes. Cardiovasc Res 1997;34:185-91.
24. Lefrandt JD, Bosma E, Oomen PH et al. Sympathetic mediated vasomotion and skin capillary permeability in diabetic patients with peripheral neuropathy. Diabetologia 2003;46:40-7.
25. Salvat-Melis M, Carpentier PH, Moreau-Gaudry A, Boignard A, Paris A, Cracowski JL. Fourier transform spectral analysis of cutaneus blood flux in systemic sclerosis. J Mal Vasc 2007;32:83-9.
26. Subcommittee for scleroderma criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee. Preliminary criteria for the classification of systemic sclerosis (sclarodenma). Arthritis Rheum 1980;23:581-90.
27. Medsger TA Jr, Silman AJ, Steen VD et al. A disease severity scale for systemic sclerosis: Development and testing. J Rheumatol 1999;26:2159-67.
28. Della Rossa A, Valentini G, Bombardieri S et al. European multicentre study to define disease activity criteria for systemic sclerosis: I. Clinical and epidemiological features of 290 patients from 19 centres. Ann Rheum Dis 2001;60:585-91.
29. Boignard A, Salvat-Melis M, Carpenter PH et al. Local hyperemia to heating is impaired in secondary Raynaud's phenomenon. Arthritis Res Ther 2005; 7:R1103-12.
30. Volpe A, Blasi D, Caramaschi P et al Levels of F2-isoprostanes in systemic sclerosis: Correlation with clinical features. Rheumatology 2006;45:314-20.
31. Di Franco M, Paradiso M, Riccieri V, Basili S, Mammarella A, Valesini G. Autonomic dysfunction and microvascular damage in systemic sclerosis. Clin Rheumatol 2007;26:1278-83.
32. Shamim-Uizzaman O, Pfenninger D, Kehrer C. Altered cutaneous microvascular responses to reactive hyperemia in coronary artery disease: A comparative study with conduit vessel responses. Clin Sci 2002;103:267-73.
33. Jung F, Mrowietz C, Labarrere C. Primary cutaneous microangiopethy in heart recipients. Microvasc Res 2001;62:154-63.
34. Anderson ME, Moore TL, Hollis S, Jayson MI, King TA, Herrick AL. Digital vascular response to topical glyceryl trinitrate, as measurement by laser Doppler imaging, in primary Raynaud's phenomenon and systemic sclerosis. Rheumatology 2002; 41:324-8.
35. Andersen GIN, Mincheva-Nilsson L, Kazzarn E et al. Assessment of vascular function in systemic sclerosis: Indications of the development of nitrate tolerance as a result of enhanced endothelial nitric oxide production. Arthritis Rheum 2002;46:1324-32.