Toll-like receptor 7 gene deficiency and early-life Pneumovirus infection interact to predispose toward the development of asthma-like pathology in mice

Journal of Allergy and Clinical Immunology

Volumn 131, Issue 5, 2013, Pages

  Kaiko, Gerard E ^a,b   Loh, Zhixuan ^c   Spann, Kirsten ^c   Lynch, Jason P ^c   Lalwani, Amit ^c   Zheng, Zhenglong ^c   Davidson, Sophia ^a   Uematsu, Satoshi ^d   Akira, Shizuo ^d   Hayball, John ^e   Diener, Kerrilyn R ^e,f   Baines, Katherine J ^a,g   Simpson, Jodie L ^a,g   Foster, Paul S ^a,b   Phipps, Simon ^c  

^a UNIVERSITY OF NEWCASTLE   (Australia)

^b Cooperative Research Centre ^*  (Australia)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d OSAKA UNIVERSITY   (Japan)

^e UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

^f UNIVERSITY OF ADELAIDE   (Australia)

^g JOHN HUNTER HOSPITAL   (Australia)

Author keywords

asthma; bronchiolitis; exacerbation; IL 13; infection; nuocyte; Pneumovirus; respiratory syncytial virus; Toll like receptor 7; type 2 innate lymphoid cell

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; IMMUNOGLOBULIN E; INTERLEUKIN 12P70; INTERLEUKIN 1BETA; INTERLEUKIN 25; INTERLEUKIN 33; TOLL LIKE RECEPTOR 7;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; BRONCHIOLITIS; CD4+ T LYMPHOCYTE; COCKROACH; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE PREDISPOSITION; EOSINOPHILIA; EXPOSURE; GENETIC DISORDER; HYPERPLASIA; IMMUNITY; LYMPHOID CELL; MAST CELL; MICROENVIRONMENT; MOUSE; NONHUMAN; PATHOGENESIS; PNEUMOVIRUS INFECTION; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; RISK ASSESSMENT; TH2 CELL; VIRUS LOAD;

EID: 84876950083     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2013.02.041     Document Type: Article

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