Microorganism lipid droplets and biofuel development

BMB Reports

Volumn 46, Issue 12, 2013, Pages 575-581

  Liu, Yingmei ^a,b   Zhang, Congyan ^b,c   Shen, Xipeng ^b   Zhang, Xuelin ^d   Cichello, Simon ^e   Guan, Hongbin ^a   Liu, Pingsheng ^b  

^a SHANDONG UNIVERSITY   (China)

^b INSTITUTE OF BIOPHYSICS   (China)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^d CAPITAL UNIVERSITY OF PHYSICAL EDUCATION AND SPORTS   (China)

^e LA TROBE UNIVERSITY   (Australia)

Author keywords

Biofuel; Lipid droplets; Microorganism; Proteomics

Indexed keywords

BIOFUEL; TRIACYLGLYCEROL;

BACTERIUM; BIOMASS; CYTOPLASM VESICLE; GREEN ALGA; LIPID METABOLISM; METABOLISM; PHYSIOLOGY; PROTEOMICS; SACCHAROMYCES CEREVISIAE; SHORT SURVEY;

BACTERIA; BIOFUELS; BIOMASS; CHLOROPHYTA; CYTOPLASMIC VESICLES; LIPID METABOLISM; PROTEOMICS; SACCHAROMYCES CEREVISIAE; TRIGLYCERIDES;

EID: 84891655475     PISSN: 19766696     EISSN: 1976670X     Source Type: Journal    
DOI: 10.5483/BMBRep.2013.46.12.271     Document Type: Short Survey

References (75)

1. Murphy, D. J. (2001) The biogenesis and functions of lipid bodies in animals, plants and microorganisms. Prog. Lipid. Res. 40, 325-438.
2. Martin, S. and Parton, R. G. (2006) Lipid droplets: a unified view of a dynamic organelle. Nat. Rev. Mol. Cell. Biol. 7, 373-378.
3. Thiam, A. R., Farese, R. V., Jr. and Walther, T. C. (2013) The biophysics and cell biology of lipid droplets. Nat. Rev. Mol. Cell. Biol. 14, 775-786.
4. Farese, R. V., Jr. and Walther, T. C. (2009) Lipid droplets finally get a little R-E-S-P-E-C-T. Cell 139, 855-860.
5. Yang, L., Ding, Y., Chen, Y., Zhang, S., Huo, C., Wang, Y., Yu, J., Zhang, P., Na, H., Zhang, H., Ma, Y. and Liu, P. (2012) The proteomics of lipid droplets: structure, dynamics, and functions of the organelle conserved from bacteria to humans. J. Lipid. Res. 53, 1245-1253.
6. Greenberg, A. S., Egan, J. J., Wek, S. A., Garty, N. B., Blanchette-Mackie, E. J. and Londos, C. (1991) Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets. J. Biol. Chem. 266, 11341-11346.
7. Jiang, H. P. and Serrero, G. (1992) Isolation and characterization of a full-length cDNA coding for an adipose differentiation- related protein. Proc. Natl. Acad. Sci. U. S. A. 89, 7856-7860.
8. Brasaemle, D. L., Barber, T., Wolins, N. E., Serrero, G., Blanchette-Mackie, E. J. and Londos, C. (1997) Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein. J. Lipid. Res. 38, 2249-2263.
9. Wolins, N. E., Rubin, B. and Brasaemle, D. L. (2001) TIP47 associates with lipid droplets. J. Biol. Chem. 276, 5101-5108.
10. Wolins, N. E., Skinner, J. R., Schoenfish, M. J., Tzekov, A., Bensch, K. G. and Bickel, P. E. (2003) Adipocyte protein S3-12 coats nascent lipid droplets. J. Biol. Chem. 278, 37713-37721.
11. Wolins, N. E., Quaynor, B. K., Skinner, J. R., Tzekov, A., Croce, M. A., Gropler, M. C., Varma, V., Yao-Borengasser, A., Rasouli, N., Kern, P. A., Finck, B. N. and Bickel, P. E. (2006) OXPAT/PAT-1 is a PPAR-induced lipid droplet protein that promotes fatty acid utilization. Diabetes 55, 3418-3428.
12. Miura, S., Gan, J. W., Brzostowski, J., Parisi, M. J., Schultz, C. J., Londos, C., Oliver, B. and Kimmel, A. R. (2002) Functional conservation for lipid storage droplet association among Perilipin, ADRP, and TIP47 (PAT)-related proteins in mammals, Drosophila, and Dictyostelium. J. Biol. Chem. 277, 32253-32257.
13. Kimmel, A. R., Brasaemle, D. L., McAndrews-Hill, M., Sztalryd, C. and Londos, C. (2010) Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins. J. Lipid. Res. 51, 468-471.
14. Welte, M. A., Gross, S. P., Postner, M., Block, S. M. and Wieschaus, E. F. (1998) Developmental regulation of vesicle transport in Drosophila embryos: forces and kinetics. Cell 92, 547-557.
15. Liu, P., Ying, Y., Zhao, Y., Mundy, D. I., Zhu, M. and Anderson, R. G. (2004) Chinese hamster ovary K2 cell lipid droplets appear to be metabolic organelles involved in membrane traffic. J. Biol. Chem. 279, 3787-3792.
16. Liu, P., Bartz, R., Zehmer, J. K., Ying, Y. S., Zhu, M., Serrero, G. and Anderson, R. G. (2007) Rab-regulated interaction of early endosomes with lipid droplets. Bba-Mol. Cell. Res. 1773, 784-793.
17. Martin, S., Driessen, K., Nixon, S. J., Zerial, M. and Parton, R. G. (2005) Regulated localization of Rab18 to lipid droplets: effects of lipolytic stimulation and inhibition of lipid droplet catabolism. J. Biol. Chem. 280, 42325-42335.
18. Ozeki, S., Cheng, J., Tauchi-Sato, K., Hatano, N., Taniguchi, H. and Fujimoto, T. (2005) Rab18 localizes to lipid droplets and induces their close apposition to the endoplasmic reticulum-derived membrane. J. Cell. Sci. 118, 2601-2611.
19. Boström, P., Andersson, L., Rutberg, M., Perman, J., Lidberg, U., Johansson, B. R., Fernandez-Rodriguez, J., Ericson, J., Nilsson, T., Borén, J. and Olofsson, S. O. (2007) SNARE proteins mediate fusion between cytosolic lipid droplets and are implicated in insulin sensitivity. Nat. Cell. Biol. 9, 1286-1293.
20. Gong, J., Sun, Z., Wu, L., Xu, W., Schieber, N., Xu, D., Shui, G., Yang, H., Parton, R. G. and Li, P. (2011) Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites. J. Cell. Biol. 195, 953-963.
21. Bartz, R., Li, W. H., Venables, B., Zehmer, J. K., Roth, M. R., Welti, R., Anderson, R. G., Liu, P. and Chapman, K. D. (2007) Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic. J. Lipid. Res. 48, 837-847.
22. Yatsu, L. Y., Jacks, T. J. and Hensarling, T. P. (1971) Isolation of spherosomes (oleosomes) from onion, cabbage, and cottonseed tissues. Plant. Physiol. 48, 675-682.
23. Jacks, T. J., Yatsu, L. Y. and Altschul, A. M. (1967) Isolation and characterization of peanut spherosomes. Plant. Physiol. 42, 585-597.
24. Jolivet, P., Boulard, C., Bellamy, A., Larre, C., Barre, M., Rogniaux, H., d'Andrea, S., Chardot, T. and Nesi, N. (2009) Protein composition of oil bodies from mature Brassica napus seeds. Proteomics 9, 3268-3284.
25. Katavic, V., Agrawal, G. K., Hajduch, M., Harris, S. L. and Thelen, J. J. (2006) Protein and lipid composition analysis of oil bodies from two Brassica napus cultivars. Proteomics 6, 4586-4598.
26. Qu, R. D. and Huang, A. H. (1990) Oleosin KD 18 on the surface of oil bodies in maize. Genomic and cDNA sequences and the deduced protein structure. J. Biol. Chem. 265, 2238-2243.
27. Chen, J. C., Tsai, C. C. and Tzen, J. T. (1999) Cloning and secondary structure analysis of caleosin, a unique calcium- binding protein in oil bodies of plant seeds. Plant. Cell. Physiol. 40, 1079-1086.
28. Au, D. M., Kang, A. S. and Murphy, D. J. (1989) An immunologically related family of apolipoproteins associated with triacylglycerol storage in the Cruciferae. Arch. Biochem. Biophys. 273, 516-526.
29. Murphy, D. J. (2012) The dynamic roles of intracellular lipid droplets: from archaea to mammals. Protoplasma 249, 541-585.
30. Binns, D., Januszewski, T., Chen, Y., Hill, J., Markin, V. S., Zhao, Y., Gilpin, C., Chapman, K. D., Anderson, R. G. and Goodman, J. M. (2006) An intimate collaboration between peroxisomes and lipid bodies. J. Cell. Biol. 173, 719-731.
31. Fei, W., Shui, G., Gaeta, B., Du, X., Kuerschner, L., Li, P., Brown, A. J., Wenk, M. R., Parton, R. G. and Yang, H. (2008) Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast. J. Cell. Biol. 180, 473-482.
32. Grillitsch, K., Connerth, M., Kofeler, H., Arrey, T. N., Rietschel, B., Wagner, B., Karas, M. and Daum, G. (2011) Lipid particles/droplets of the yeast Saccharomyces cerevisiae revisited: lipidome meets proteome. Biochim. Biophys. Acta. 12, 26.
33. Nguyen, H. M., Baudet, M., Cuiné, S., Adriano, J. M., Barthe, D., Billon, E., Bruley, C., Beisson, F., Peltier, G., Ferro, M. and Li-Beisson, Y. (2011) Proteomic profiling of oil bodies isolated from the unicellular green microalga Chlamydomonas reinhardtii: with focus on proteins involved in lipid metabolism. Proteomics 11, 4266-4273.
34. Peled, E., Leu, S., Zarka, A., Weiss, M., Pick, U., Khozin-Goldberg, I. and Boussiba, S. (2011) Isolation of a novel oil globule protein from the green alga Haematococcus pluvialis (Chlorophyceae). Lipids 46, 851-861.
35. Low, K. L., Shui, G., Natter, K., Yeo, W. K., Kohlwein, S. D., Dick, T., Rao, S. P. and Wenk, M. R. (2010) Lipid droplet-associated proteins are involved in the biosynthesis and hydrolysis of triacylglycerol in Mycobacterium bovis bacillus Calmette-Guerin. J. Biol. Chem. 285, 21662-21670.
36. Kalscheuer, R., Waltermann, M., Alvarez, M. and Steinbuchel, A. (2001) Preparative isolation of lipid inclusions from Rhodococcus opacus and Rhodococcus ruber and identification of granule-associated proteins. Arch. Microbiol. 177, 20-28.
37. Ding, Y., Yang, L., Zhang, S., Wang, Y., Du, Y., Pu, J., Peng, G., Chen, Y., Zhang, H., Yu, J., Hang, H., Wu, P., Yang, F., Yang, H., Steinbüchel, A. and Liu, P. (2012) Identification of the major functional proteins of prokaryotic lipid droplets. J. Lipid. Res. 53, 399-411.
38. Miao, X. and Wu, Q. (2004) High yield bio-oil production from fast pyrolysis by metabolic controlling of Chlorella protothecoides. J. Biotechnol. 110, 85-93.
39. McLaughlin, S. B. and Adams Kszos, L. (2005) Development of switchgrass (Panicum virgatum) as a bioenergy feedstock in the United States. Biomass and Bioenergy 28, 515-535.
40. McKendry, P. (2002) Energy production from biomass (part 1): overview of biomass. Bioresour. Technol. 83, 37-46.
41. Fargione, J., Hill, J., Tilman, D., Polasky, S. and Hawthorne, P. (2008) Land Clearing and the Biofuel Carbon Debt. Science 319, 1235-1238.
42. Greenwell, H. C., Laurens, L. M., Shields, R. J., Lovitt, R. W. and Flynn, K. J. (2010) Placing microalgae on the biofuels priority list: a review of the technological challenges. J. R. Soc. Interface 7, 703-726.
43. Alvarez, H. M. and Steinbuchel, A. (2002) Triacylglycerols in prokaryotic microorganisms. Appl. Microbiol. Biotechnol. 60, 367-376.
44. Alvarez, H. M., Mayer, F., Fabritius, D. and Steinbuchel, A. (1996) Formation of intracytoplasmic lipid inclusions by Rhodococcus opacus strain PD630. Arch. Microbiol. 165, 377-386.
45. Chen, Y., Ding, Y., Yang, L., Yu, J., Liu, G., Wang, X., Zhang, S., Yu, D., Song, L., Zhang, H., Zhang, C., Huo, L., Huo, C., Wang, Y., Du, Y., Zhang, H., Zhang, P., Na, H., Xu, S., Zhu, Y., Xie, Z., He, T., Zhang, Y., Wang, G., Fan, Z., Yang, F., Liu, H., Wang, X., Zhang, X., Zhang, M. Q., Li, Y., Steinbüchel, A., Fujimoto, T., Cichello, S., Yu, J. and Liu, P. (2013) Integrated omics study delineates the dynamics of lipid droplets in Rhodococcus opacus PD630. Nucleic Acids Res. 22 [Epub ahead of print].
46. Grillitsch, K., Connerth, M., Kofeler, H., Arrey, T. N., Rietschel, B., Wagner, B., Karas, M. and Daum, G. (2011) Lipid particles/droplets of the yeast Saccharomyces cerevisiae revisited: lipidome meets proteome. Biochim. Biophys. Acta. 1811, 1165-1176.
47. Leber, R., Zinser, E., Zellnig, G., Paltauf, F. and Daum, G. (1994) Characterization of lipid particles of the yeast, Saccharomyces cerevisiae. Yeast 10, 1421-1428.
48. Athenstaedt, K., Zweytick, D., Jandrositz, A., Kohlwein, S. D. and Daum, G. (1999) Identification and characterization of major lipid particle proteins of the yeast Saccharomyces cerevisiae. J. Bacteriol. 181, 6441-6448.
49. Binns, D., Januszewski, T., Chen, Y., Hill, J., Markin, V. S., Zhao, Y., Gilpin, C., Chapman, K. D., Anderson, R. G. and Goodman, J. M. (2006) An intimate collaboration between peroxisomes and lipid bodies. J. Cell. Biol. 173, 719-731.
50. Szymanski, K. M., Binns, D., Bartz, R., Grishin, N. V., Li, W. P., Agarwal, A. K., Garg, A., Anderson, R. G. and Goodman, J. M. (2007) The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology. Proc. Natl. Acad. Sci. U. S. A. 104, 20890-20895.
51. Beopoulos, A., Cescut, J., Haddouche, R., Uribelarrea, J. L., Molina-Jouve, C. and Nicaud, J. M. (2009) Yarrowia lipolytica as a model for bio-oil production. Prog. Lipid Res. 48, 375-387.
52. Athenstaedt, K., Jolivet, P., Boulard, C., Zivy, M., Negroni, L., Nicaud, J. M. and Chardot, T. (2006) Lipid particle composition of the yeast Yarrowia lipolytica depends on the carbon source. Proteomics. 6, 1450-1459.
53. Ivashov, V. A., Grillitsch, K., Koefeler, H., Leitner, E., Baeumlisberger, D., Karas, M. and Daum, G. (2013) Lipidome and proteome of lipid droplets from the methylotrophic yeast Pichia pastoris. Biochim. Biophys. Acta. 1831, 282-290.
54. Liu, H., Zhao, X., Wang, F., Li, Y., Jiang, X., Ye, M., Zhao, Z. K. and Zou, H. (2009) Comparative proteomic analysis of Rhodosporidium toruloides during lipid accumulation. Yeast. 26, 553-566.
55. Ytterberg, A. J., Peltier, J. B. and van Wijk, K. J. (2006) Protein profiling of plastoglobules in chloroplasts and chromoplasts. A surprising site for differential accumulation of metabolic enzymes. Plant. Physiol. 140, 984-997.
56. Ramanan, R., Kim, B.-H., Cho, D.-H., Ko, S.-R., Oh, H.-M. and Kim, H.-S. (2013) Lipid droplet synthesis is limited by acetate availability in starchless mutant of Chlamydomonas reinhardtii. FEBS Lett. 587, 370-377.
57. Moellering, E. R. and Benning, C. (2010) RNA interference silencing of a major lipid droplet protein affects lipid droplet size in Chlamydomonas reinhardtii. Eukaryot. Cell 9, 97-106.
58. Davidi, L., Katz, A. and Pick, U. (2012) Characterization of major lipid droplet proteins from Dunaliella. Planta 236, 19-33.
59. Huang, N. L., Huang, M. D., Chen, T. L. and Huang, A. H. (2013) Oleosin of subcellular lipid droplets evolved in green algae. Plant. Physiol. 161, 1862-1874.
60. Wang, Z. T., Ullrich, N., Joo, S., Waffenschmidt, S. and Goodenough, U. (2009) Algal lipid bodies: stress induction, purification, and biochemical characterization in wild-type and starchless Chlamydomonas reinhardtii. Eukaryot. Cell 8, 1856-1868.
61. James, G. O., Hocart, C. H., Hillier, W., Chen, H., Kordbacheh, F., Price, G. D. and Djordjevic, M. A. (2011) Fatty acid profiling of Chlamydomonas reinhardtii under nitrogen deprivation. Bioresour. Technol. 102, 3343-3351.
62. Waltermann, M. and Steinbuchel, A. (2005) Neutral lipid bodies in prokaryotes: recent insights into structure, formation, and relationship to eukaryotic lipid depots. J. Bacteriol. 187, 3607-3619.
63. Low, K. L., Shui, G., Natter, K., Yeo, W. K., Kohlwein, S. D., Dick, T., Rao, S. P. and Wenk, M. R. (2010) Lipid droplet-associated proteins are involved in the biosynthesis and hydrolysis of triacylglycerol in Mycobacterium bovis bacillus Calmette-Guerin. J. Biol. Chem. 285, 21662-21670.
64. Kalscheuer, R., Waltermann, M., Alvarez, M. and Steinbuchel, A. (2001) Preparative isolation of lipid inclusions from Rhodococcus opacus and Rhodococcus ruber and identification of granule-associated proteins. Arch. Microbiol. 177, 20-28.
65. McLeod, M. P., Warren, R. L., Hsiao, W. W., Araki, N., Myhre, M., Fernandes, C., Miyazawa, D., Wong, W., Lillquist, A. L., Wang, D., Dosanjh, M., Hara, H., Petrescu, A., Morin, R. D., Yang, G., Stott, J. M., Schein, J. E., Shin, H., Smailus, D., Siddiqui, A. S., Marra, M. A., Jones, S. J., Holt, R., Brinkman, F. S., Miyauchi, K., Fukuda, M., Davies, J. E., Mohn, W. W. and Eltis, L. D. (2006) The complete genome of Rhodococcus sp. RHA1 provides insights into a catabolic powerhouse. Proc. Natl. Acad. Sci. U. S. A. 103, 15582-15587.
66. Holder, J. W., Ulrich, J. C., DeBono, A. C., Godfrey, P. A., Desjardins, C. A., Zucker, J., Zeng, Q., Leach, A. L., Ghiviriga, I., Dancel, C., Abeel, T., Gevers, D., Kodira, C. D., Desany, B., Affourtit, J. P., Birren, B. W. and Sinskey, A. J. (2011) Comparative and functional genomics of Rhodococcus opacus PD630 for biofuels development. PLoS Genet. 7, 8.
67. Hoiczyk, E., Ring, M. W., McHugh, C. A., Schwar, G., Bode, E., Krug, D., Altmeyer, M. O., Lu, J. Z. and Bode, H. B. (2009) Lipid body formation plays a central role in cell fate determination during developmental differentiation of Myxococcus xanthus. Mol. Microbiol. 74, 497-517.
68. Nojima, D., Yoshino, T., Maeda, Y., Tanaka, M., Nemoto, M. and Tanaka, T. (2013) Proteomics analysis of oil body-associated proteins in the oleaginous diatom. J. Proteome. Res. 12, 5293-5301.
69. Vieler, A., Brubaker, S. B., Vick, B. and Benning, C. (2012) A lipid droplet protein of Nannochloropsis with functions partially analogous to plant oleosins. Plant. physiol. 158, 1562-1569.
70. Guarnieri, M. T., Nag, A., Smolinski, S. L., Darzins, A., Seibert, M. and Pienkos, P. T. (2011) Examination of triacylglycerol biosynthetic pathways via de novo transcriptomic and proteomic analyses in an unsequenced microalga. PloS One. 6, e25851.
71. Guarnieri, M. T., Nag, A., Yang, S. and Pienkos, P. T. (2013) Proteomic analysis of Chlorella vulgaris: Potential targets for enhanced lipid accumulation. J. Proteomics. 93, 245-253.
72. Fei, W., Zhong, L., Ta, M. T., Shui, G., Wenk, M. R. and Yang, H. (2011) The size and phospholipid composition of lipid droplets can influence their proteome. Biochem. Biophys. Res. Commun. 415, 455-462.
73. Leber, R., Landl, K., Zinser, E., Ahorn, H., Spok, A., Kohlwein, S. D., Turnowsky, F. and Daum, G. (1998) Dual localization of squalene epoxidase, Erg1p, in yeast reflects a relationship between the endoplasmic reticulum and lipid particles. Mol. Biol. Cell. 9, 375-386.
74. Natter, K., Leitner, P., Faschinger, A., Wolinski, H., McCraith, S., Fields, S. and Kohlwein, S. D. (2005) The spatial organization of lipid synthesis in the yeast Saccharomyces cerevisiae derived from large scale green fluorescent protein tagging and high resolution microscopy. Mol. Cell. Proteomics. 4, 662-672.
75. Noothalapati Venkata, H. N. and Shigeto, S. (2012) Stable isotope-labeled Raman imaging reveals dynamic proteome localization to lipid droplets in single fission yeast cells. Chem. Biol. 19, 1373-1380.