Lipid-modifying enzymes in human tear fluid and corneal epithelial stress response

Investigative Ophthalmology and Visual Science

Volumn 55, Issue 1, 2014, Pages 16-24

  Robciuc, Alexandra ^a,b   Rantam̈aki, Antti H ^a   Jauhiainen, Matti ^b   Holopainen, Juha M ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

Corneal epithelium; Inflammation; Phospholipases C; Stress response; Tear fluid

Indexed keywords

CERAMIDASE; INTERLEUKIN 8; NEUTRAL CERAMIDASE; PHOSPHOLIPASE C; SPHINGOLIPID; SPHINGOMYELIN PHOSPHODIESTERASE;

ADULT; ARTICLE; CELL CULTURE; CELLULAR STRESS RESPONSE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORNEA EPITHELIUM; HUMAN; HUMAN CELL; LACRIMAL FLUID; MALE; NORMAL HUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; WESTERN BLOTTING;

EID: 84891654950     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.13-12577     Document Type: Article

References (45)

1. de Souza GA, Godoy LM, Mann M. Identification of 491 proteins in the tear fluid proteome reveals a large number of proteases and protease inhibitors. Genome Biol. 2006;7:R72.
2. Rantamaki AH, Seppanen-Laakso T, Oresic M, Jauhiainen M, Holopainen JM. Human tear fluid lipidome: from composition to function. PLoS One. 2011;6:e19553.
3. Dean AW, Glasgow BJ. Mass spectrometric identification of phospholipids in human tears and tear lipocalin. Invest Ophthalmol Vis Sci. 2012;53:1773-1782.
4. Butovich IA. Lipidomics of human meibomian gland secretions: chemistry, biophysics, and physiological role of meibomian lipids. Prog Lipid Res. 2011;50:278-301.
5. Telenius J, Kulovesi P, Koivuniemi A, et al. Molecular organization of the tear fluid lipid layer. Biophys J. 2010;99: 2559-2567.
6. Glasgow BJ, Abduragimov AR, Farahbakhsh ZT, Faull KF, Hubbell WL. Tear lipocalins bind a broad array of lipid ligands. Curr Eye Res. 1995;14:363-372.
7. Saaren-Seppala H, Jauhiainen M, Tervo TM, Redl B, Kinnunen PK, Holopainen JM. Interaction of purified tear lipocalin with lipid membranes. Invest Ophthalmol Vis Sci. 2005;46:3649-3656.
8. Lehrer RI, Xu G, Abduragimov A, et al. Lipophilin, a novel heterodimeric protein of human tears. FEBS Lett. 1998;432: 163-167.
9. Jauhiainen M, Setala NL, Ehnholm C, et al. Phospholipid transfer protein is present in human tear fluid. Biochemistry. 2005;44:8111-8116.
10. Aho VV, Paavilainen V, Nevalainen TJ, Peuravuori H, Saari KM. Diurnal variation in group IIa phospholipase A2 content in tears of contact lens wearers and normal controls. Graefes Arch Clin Exp Ophthalmol. 2003;241:85-88.
11. Takahashi I, Takahashi T, Abe T, Watanabe W, Takada G. Distribution of acid sphingomyelinase in human various body fluids. Tohoku J Exp Med. 2000;192:61-66.
12. Hannun YA, Obeid LM. Principles of bioactive lipid signalling: lessons from sphingolipids. Nat Rev Mol Cell Biol. 2008;9: 139-150.
13. Robciuc A, Hyotylainen T, Jauhiainen M, Holopainen JM. Hyperosmolarity-induced lipid droplet formation depends on ceramide production by neutral sphingomyelinase 2. J Lipid Res. 2012;53:2286-2295.
14. Podskochy A, Gan L, Fagerholm P. Apoptosis in UV-exposed rabbit corneas. Cornea. 2000;19:99-103.
15. Magnoni C, Euclidi E, Benassi L, et al. Ultraviolet B radiation induces activation of neutral and acidic sphingomyelinases and ceramide generation in cultured normal human keratinocytes. Toxicol In Vitro. 2002;16:349-355.
16. Grassme H, Gulbins E, Brenner B, et al. Acidic sphingomyelinase mediates entry of N. gonorrhoeae into nonphagocytic cells. Cell. 1997;91:605-615.
17. Devillard R, Galvani S, Thiers JC, et al. Stress-induced sphingolipid signaling: role of type-2 neutral sphingomyelinase in murine cell apoptosis and proliferation. PLoS One. 2010;5: e9826.
18. Rivera J, Proia RL, Olivera A. The alliance of sphingosine-1- phosphate and its receptors in immunity. Nat Rev Immunol. 2008;8:753-763.
19. Haus JM, Kashyap SR, Kasumov T, et al. Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance. Diabetes. 2009;58:337-343.
20. Jenkins RW, Clarke CJ, Canals D, et al. Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase. J Biol Chem. 2011;286:13292-13303.
21. Araki-Sasaki K, Ohashi Y, Sasabe T, et al. An SV40-immortalized human corneal epithelial cell line and its characterization. Invest Ophthalmol Vis Sci. 1995;36:614-621.
22. Romiti E, Meacci E, Donati C, et al. Neutral ceramidase secreted by endothelial cells is released in part associated with caveolin-1. Arch Biochem Biophys. 2003;417:27-33.
23. Thery C, Ostrowski M, Segura E. Membrane vesicles as conveyors of immune responses. Nat Rev Immunol. 2009;9: 581-593.
24. Li N, Wang N, Zheng J, et al. Characterization of human tear proteome using multiple proteomic analysis techniques. J Proteome Res. 2005;4:2052-2061.
25. Zhou L, Beuerman RW, Foo Y, Liu S, Ang LP, Tan DT. Characterisation of human tear proteins using high-resolution mass spectrometry. Ann Acad Med Singapore. 2006;35:400-407.
26. Zhou L, Beuerman RW, Chan CM, et al. Identification of tear fluid biomarkers in dry eye syndrome using iTRAQ quantitative proteomics. J Proteome Res. 2009;8:4889-4905.
27. Lei Z, Beuerman RW, Chew AP, et al. Quantitative analysis of Nlinked glycoproteins in tear fluid of climatic droplet keratopathy by glycopeptide capture and iTRAQ. J Proteome Res. 2009;8:1992-2003.
28. Butovich IA. On the lipid composition of human meibum and tears: comparative analysis of nonpolar lipids. Invest Ophthalmol Vis Sci. 2008;49:3779-3789.
29. Butovich IA, Millar TJ, Ham BM. Understanding and analyzing meibomian lipids-a review. Curr Eye Res. 2008;33:405-420.
30. Shine WE, McCulley JP. Polar lipids in human meibomian gland secretions. Curr Eye Res. 2003;26:89-94.
31. Rantamaki AH, Telenius J, Koivuniemi A, Vattulainen I, Holopainen JM. Lessons from the biophysics of interfaces: lung surfactant and tear fluid. Prog Retin Eye Res. 2011;30: 204-215.
32. Ferlinz K, Hurwitz R, Vielhaber G, Suzuki K, Sandhoff K. Occurrence of two molecular forms of human acid sphingomyelinase. Biochem J. 1994;301:855-862.
33. Rigogliuso S, Donati C, Cassara D, et al. An active form of sphingosine kinase-1 is released in the extracellular medium as component of membrane vesicles shed by two human tumor cell lines. J Oncol. 2010;2010:509329.
34. Dominiecki ME, Weiss J. Antibacterial action of extracellular mammalian group IIA phospholipase A2 against grossly clumped staphylococcus aureus. Infect Immun. 1999;67: 2299-2305.
35. Grassme H, Jendrossek V, Riehle A, et al. Host defense against pseudomonas aeruginosa requires ceramide-rich membrane rafts. Nat Med. 2003;9:322-330.
36. Robciuc A, Hyotylainen T, Jauhiainen M, Holopainen JM. Ceramides in the pathophysiology of the anterior segment of the eye. Curr Eye Res. 2013;38:1006-1016.
37. Cocucci E, Racchetti G, Meldolesi J. Shedding microvesicles: Artefacts no more. Trends Cell Biol. 2009;19:43-51.
38. Gyorgy B, Szabo TG, Pasztoi M, et al. Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles. Cell Mol Life Sci. 2011;68:2667-2688.
39. Antonucci F, Turola E, Riganti L, et al. Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid metabolism. EMBO J. 2012;31:1231-1240.
40. Kosaka N, Iguchi H, Hagiwara K, Yoshioka Y, Takeshita F, Ochiya T. Neutral sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic MicroRNAs regulate cancer cell metastasis. J Biol Chem. 2013;288:10849-10859.
41. Ludwig AK, Giebel B. Exosomes: small vesicles participating in intercellular communication. Int J Biochem Cell Biol. 2012;44: 11-15.
42. Kim JW, Wieckowski E, Taylor DD, Reichert TE, Watkins S, Whiteside TL. Fas ligand-positive membranous vesicles isolated from sera of patients with oral cancer induce apoptosis of activated T lymphocytes. Clin Cancer Res. 2005;11:1010-1020.
43. Peche H, Renaudin K, Beriou G, Merieau E, Amigorena S, Cuturi MC. Induction of tolerance by exosomes and short-term immunosuppression in a fully MHC-mismatched rat cardiac allograft model. Am J Transplant. 2006;6:1541-1550.
44. Hristov M, Erl W, Linder S, Weber PC. Apoptotic bodies from endothelial cells enhance the number and initiate the differentiation of human endothelial progenitor cells in vitro. Blood. 2004;104:2761-2766.
45. Verderio C, Muzio L, Turola E, et al. Myeloid microvesicles are a marker and therapeutic target for neuroinflammation. Ann Neurol. 2012;72:610-624.