Stimulation of g protein-coupled bile acid receptor enhances vascular endothelial barrier function via activation of protein kinase a and rac1s

Journal of Pharmacology and Experimental Therapeutics

Volumn 348, Issue 1, 2014, Pages 125-130

  Kida, Taiki ^a   Omori, Keisuke ^a   Hori, Masatoshi ^a   Ozaki, Hiroshi ^a   Murata, Takahisa ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CROTON OIL; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; G PROTEIN COUPLED BILE ACID RECEPTOR; G PROTEIN COUPLED RECEPTOR; RAC1 PROTEIN; TAUROLITHOCHOLIC ACID; UNCLASSIFIED DRUG; VASCULOTROPIN;

ACTIN POLYMERIZATION; ANIMAL CELL; ARTICLE; BLOOD VESSEL PERMEABILITY; CATTLE; CONTROLLED STUDY; EAR EDEMA; ENDOTHELIUM CELL; EXTRAVASATION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BLOCKING; SIGNAL TRANSDUCTION;

ANIMALS; CATTLE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; MALE; MICE; NEUROPEPTIDES; RAC1 GTP-BINDING PROTEIN; RECEPTORS, G-PROTEIN-COUPLED; TAUROCHOLIC ACID; UP-REGULATION;

EID: 84891648236     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.113.209288     Document Type: Article

References (35)

1. Binstadt BA, Patel PR, Alencar H, Nigrovic PA, Lee DM, Mahmood U, Weissleder R, Mathis D, and Benoist C (2006) Particularities of the vasculature can promote the organ specificity of autoimmune attack. Nat Immunol 7:284-292.
2. Boermeester MA, Houdijk AP, Meyer S, Cuesta MA, Appelmelk BJ, Wesdorp RI, Hack CE, and Van Leeuwen PA (1995) Liver failure induces a systemic inflammatory response: prevention by recombinant N-terminal bactericidal/ permeability-increasing protein. Am J Pathol 147:1428-1440.
3. Chang SW and Ohara N (1993) Increased pulmonary vascular permeability in rats with biliary cirrhosis: role of thromboxane A2. Am J Physiol 264:L245-L252.
4. Cheng HC, Kemp BE, Pearson RB, Smith AJ, Misconi L, Van Patten SM, and Walsh DA (1986) A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase. J Biol Chem 261:989-992.
5. Cipriani S, Mencarelli A, Chini MG, Distrutti E, Renga B, Bifulco G, Baldelli F, Donini A, and Fiorucci S (2011) The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis. PLoS ONE 6:e25637.
6. Esser S, Lampugnani MG, Corada M, Dejana E, and Risau W (1998) Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells. J Cell Sci 111:1853-1865.
7. Everson GT (1987) Steady-state kinetics of serum bile acids in healthy human subjects: single and dual isotope techniques using stable isotopes and mass spectrometry. J Lipid Res 28:238-252.
8. Fukuhara S, Sakurai A, Sano H, Yamagishi A, Somekawa S, Takakura N, Saito Y, Kangawa K, and Mochizuki N (2005) Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway. Mol Cell Biol 25:136-146.
9. Gao Y, Dickerson JB, Guo F, Zheng J, and Zheng Y (2004) Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proc Natl Acad Sci USA 101:7618-7623.
10. Goel S, Duda DG, Xu L, Munn LL, Boucher Y, Fukumura D, and Jain RK (2011) Normalization of the vasculature for treatment of cancer and other diseases. Physiol Rev 91:1071-1121.
11. Greenwood J, Adu J, Davey AJ, Abbott NJ, and Bradbury MW (1991) The effect of bile salts on the permeability and ultrastructure of the perfused, energy-depleted, rat blood-brain barrier. J Cereb Blood Flow Metab 11:644-654.
12. Hylemon PB, Zhou H, Pandak WM, Ren S, Gil G, and Dent P (2009) Bile acids as regulatory molecules. J Lipid Res 50:1509-1520.
13. Kawamata Y, Fujii R, Hosoya M, Harada M, Yoshida H, Miwa M, Fukusumi S, Habata Y, Itoh T, and Shintani Y, et al. (2003) A G protein-coupled receptor responsive to bile acids. J Biol Chem 278:9435-9440.
14. Keitel V, Donner M, Winandy S, Kubitz R, and Häussinger D (2008) Expression and function of the bile acid receptor TGR5 in Kupffer cells. Biochem Biophys Res Commun 372:78-84.
15. Keitel V, Reinehr R, Gatsios P, Rupprecht C, Görg B, Selbach O, Häussinger D, and Kubitz R (2007) The G-protein coupled bile salt receptor TGR5 is expressed in liver sinusoidal endothelial cells. Hepatology 45:695-704.
16. Kida T, Murata T, Hori M, and Ozaki H (2009) Chronic stimulation of farnesoid X receptor impairs nitric oxide sensitivity of vascular smooth muscle. Am J Physiol Heart Circ Physiol 296:H195-H201.
17. Kida T, Tsubosaka Y, Hori M, Ozaki H, and Murata T (2013) Bile acid receptor TGR5 agonism induces NO production and reduces monocyte adhesion in vascular endothelial cells. Arterioscler Thromb Vasc Biol 33:1663-1669.
18. Komarova Y and Malik AB (2010) Regulation of endothelial permeability via paracellular and transcellular transport pathways. Annu Rev Physiol 72:463-493.
19. Lefebvre P, Cariou B, Lien F, Kuipers F, and Staels B (2009) Role of bile acids and bile acid receptors in metabolic regulation. Physiol Rev 89:147-191.
20. Lum H, Jaffe HA, Schulz IT, Masood A, RayChaudhury A, and Green RD (1999) Expression of PKA inhibitor (PKI) gene abolishes cAMP-mediated protection to endothelial barrier dysfunction. Am J Physiol 277:C580-C588.
21. Makishima M, Okamoto AY, Repa JJ, Tu H, Learned RM, Luk A, Hull MV, Lustig KD, Mangelsdorf DJ, and Shan B (1999) Identification of a nuclear receptor for bile acids. Science 284:1362-1365.
22. Maruyama T, Miyamoto Y, Nakamura T, Tamai Y, Okada H, Sugiyama E, Nakamura T, Itadani H, and Tanaka K (2002) Identification of membrane-type receptor for bile acids (M-BAR). Biochem Biophys Res Commun 298:714-719.
23. Mashige F, Tanaka N, Maki A, Kamei S, and Yamanaka M (1981) Direct spectrophotometry of total bile acids in serum. Clin Chem 27:1352-1356.
24. Murata T, Lin MI, Aritake K, Matsumoto S, Narumiya S, Ozaki H, Urade Y, Hori M, and Sessa WC (2008) Role of prostaglandin D2 receptor DP as a suppressor of tumor hyperpermeability and angiogenesis in vivo. Proc Natl Acad Sci USA 105:20009-20014.
25. Nonas S, Miller I, Kawkitinarong K, Chatchavalvanich S, Gorshkova I, Bochkov VN, Leitinger N, Natarajan V, Garcia JG, and Birukov KG (2006) Oxidized phospholipids reduce vascular leak and inflammation in rat model of acute lung injury. Am J Respir Crit Care Med 173:1130-1138.
26. Ohara N, Voelkel NF, and Chang SW (1993) Tissue eicosanoids and vascular permeability in rats with chronic biliary obstruction. Hepatology 18:111-118.
27. Pols TW, Nomura M, Harach T, Lo Sasso G, Oosterveer MH, Thomas C, Rizzo G, Gioiello A, Adorini L, and Pellicciari R, et al. (2011) TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading. Cell Metab 14:747-757.
28. Singleton PA, Dudek SM, Chiang ET, and Garcia JG (2005) Regulation of sphingosine 1-phosphate-induced endothelial cytoskeletal rearrangement and barrier enhancement by S1P1 receptor, PI3 kinase, Tiam1/Rac1, and alpha-actinin. FASEB J 19:1646-1656.
29. Spindler V, Schlegel N, and Waschke J (2010) Role of GTPases in control of microvascular permeability. Cardiovasc Res 87:243-253.
30. Tauseef M, Kini V, Knezevic N, Brannan M, Ramchandaran R, Fyrst H, Saba J, Vogel SM, Malik AB, and Mehta D (2008) Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1- phosphate receptor signaling in endothelial cells. Circ Res 103:1164-1172.
31. Thomas C, Gioiello A, Noriega L, Strehle A, Oury J, Rizzo G, Macchiarulo A, Yamamoto H, Mataki C, and Pruzanski M,, et al. (2009) TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab 10:167-177.
32. Vandenbroucke E, Mehta D, Minshall R, and Malik AB (2008) Regulation of endothelial junctional permeability. Ann N Y Acad Sci 1123:134-145.
33. Vestweber D, Winderlich M, Cagna G, and Nottebaum AF (2009) Cell adhesion dynamics at endothelial junctions: VE-cadherin as a major player. Trends Cell Biol 19:8-15.
34. Wang YD, Chen WD, Yu D, Forman BM, and Huang W (2011) The G-protein coupled bile acid receptor Gpbar1 (TGR5) negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light-chain enhancer of activated B cells (NF-kB) in mice. Hepatology 54:1421-1432.
35. Watanabe M, Houten SM,Mataki C, Christoffolete MA, Kim BW, Sato H, Messaddeq N, Harney JW, Ezaki O, and Kodama T, et al. (2006) Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature 439:484-489.