Ins and outs of aldosterone-producing adenomas of the adrenal: From channelopathy to common curable cause of hypertension

Hypertension

Volumn 63, Issue 1, 2014, Pages 24-26

  Brown, Morris J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; SPIRONOLACTONE;

ADRENAL CORTEX ADENOMA; ALDOSTERONE RELEASE; CHANNELOPATHY; GAIN OF FUNCTION MUTATION; GENE MUTATION; GENOTYPE PHENOTYPE CORRELATION; HUMAN; HYPERTENSION; MEMBRANE DEPOLARIZATION; NOTE; PRIMARY HYPERALDOSTERONISM; PRIORITY JOURNAL; RESISTANT HYPERTENSION; SOMATIC MUTATION; VASOCONSTRICTION;

ADRENAL CORTEX NEOPLASMS; ADRENOCORTICAL ADENOMA; ALDOSTERONE; FEMALE; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; HUMANS; HYPERALDOSTERONISM; MALE; PLASMA MEMBRANE CALCIUM-TRANSPORTING ATPASES; SODIUM-POTASSIUM-EXCHANGING ATPASE;

EID: 84891626363     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.113.01833     Document Type: Note

References (17)

1. Padmanabhan S, Newton-Cheh C, Dominiczak AF. Genetic basis of blood pressure and hypertension. Trends Genet. 2012;28:397-408
2. Laragh JH. Modern system for treating high blood pressure based on renin profiling and vasoconstriction-volume analysis: A primary role for beta blocking drugs such as propranolol. Am J Med. 1976;61: 797-810
3. Brown MJ. Renin: Friend or foe? Heart. 2007;93:1026-1033
4. Rossi GP, Bernini G, Caliumi C, et al PAPY Study Investigators. A prospective study of the prevalence of primary aldosteronism in 1,125 hypertensive patients. J Am Coll Cardiol. 2006;48:2293-2300
5. Funder JW. Primary aldosteronism: Clinical lateralization and costs. J Clin Endocrinol Metab. 2012;97:3450-3452
6. Pang TC, Bambach C, Monaghan JC, Sidhu SB, Bune A, Delbridge LW, Sywak MS. Outcomes of laparoscopic adrenalectomy for hyperaldosteronism. ANZ J Surg. 2007;77:768-773
7. Choi M, Scholl UI, Yue P, et al. K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension. Science. 2011;331:768-772
8. Beuschlein F, Boulkroun S, Osswald A, et al. Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension. Nat Genet. 2013;45:440-444, 444e1
9. Azizan EA, Poulsen H, Tuluc P, et al. Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension. Nat Genet. 2013;45:1055-1060
10. Scholl UI, Goh G, Stölting G, et al. Somatic and germline CACNA1D calcium channel mutations in aldosterone-producing adenomas and primary aldosteronism. Nat Genet. 2013;45:1050-1054
11. Brown MJ, Hopper RV. Calcium-channel blockade can mask the diagnosis of Conn's syndrome. Postgrad Med J. 1999;75:235-236
12. Kau MM, Kan SF, Wang JR, Wang PS. Inhibitory effects of digoxin and ouabain on aldosterone synthesis in human adrenocortical NCI-H295 cells. J Cell Physiol. 2005;205:393-401
13. Azizan EA, Lam BY, Newhouse SJ, Zhou J, Kuc RE, Clarke J, Happerfield L, Marker A, Hoffman GJ, Brown MJ. Microarray, qPCR, and KCNJ5 sequencing of aldosterone-producing adenomas reveal differences in genotype and phenotype between zona glomerulosa-and zona fasciculatalike tumors. J Clin Endocrinol Metab. 2012;97:E819-E829
14. Schiffrin EL, Gutkowska J, Lis M, Genest J. Relative roles of sodium and calcium ions in the steroidogenic response of isolated rate adrenal glomerulosa cells. Hypertension. 1982;4(3 Pt 2):36-42
15. Schiffrin EL, Lis M, Gutkowska J, Genest J. Role of Ca2+ in response of adrenal glomerulosa cells to angiotensin II, ACTH, K+, and ouabain. Am J Physiol. 1981;241:E42-E46
16. Shigematsu K, Nishida N, Sakai H, Igawa T, Suzuki S, Kawai K, Takahara O. Primary aldosteronism with aldosterone-producing adenoma consisting of pure zona glomerulosa-type cells in a pregnant woman. Endocr Pathol. 2009;20:66-72
17. Lee G, Makhanova N, Caron K, Lopez ML, Gomez RA, Smithies O, Kim HS. Homeostatic responses in the adrenal cortex to the absence of aldosterone in mice. Endocrinology. 2005;146:2650-2656