Inhibition of central angiotensin-converting enzyme with enalapril protects the brain from ischemia/reperfusion injury in normotensive rat

Daru

Volumn 18, Issue 1, 2010, Pages 35-40

  Panahpour, H ^a   Dehghani, G A ^b  

^a ARDABIL UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

ACE inhibition; Cerebral ischemia; Edema; Enalapril; Lesion volume

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE; ENALAPRIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN EDEMA; BRAIN INFARCTION; BRAIN ISCHEMIA; BRAIN PROTECTION; CONTROLLED STUDY; DRUG DOSE COMPARISON; ENZYME INHIBITION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; OCCLUSIVE CEREBROVASCULAR DISEASE; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REPERFUSION INJURY; SCORING SYSTEM; THERAPY EFFECT; TRANSIENT ISCHEMIC ATTACK; TREATMENT RESPONSE;

EID: 77949677155     PISSN: 15608115     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Unger, T., Badoer, E., Ganten, D., Lang, R.E., Retting, R. Brain Angiotensin., pathways and pharmacology. Circulation, 1993; 77: 40-54.
2. Culman, J., Blume, A., Gohlke, P., Unger, T. The renin-angiotensin system in the brain., possible therapeutic implications for AT (1)-receptor blockers. J Hum Hypertens, 2002; 3: S64-S70.
3. Brdon, J., Kaiser S., Hagemann F., Zhao Y., Culman J., Gohlke P. Comparison between early and delayed systemic treatment with candesartan of rats after ischaemic stroke. J hypertens, 2007; 25: 187-196.
4. Ito, T., Yamakawa, H., Bregonzio C., Terrón, J.A., Falcón-Neri, A., Saavedra, J.M. Protection against ischemia and improvement of cerebral blood flow in genetically hypertensive rats by chronic pretreatment with an angiotensin II AT1 antagonist. Stroke, 2002; 33: 2297-303.
5. Zhou, J., Pavel J., Macova, M., Yu, Z.X., Imboden, H., Ge, L., Nishioku, T., Dou, J., Delgiacco, E., Saavedra, J.M. AT1 receptor blockade regulates the local angiotensin II system in cerebral microvessels from spontaneously hypertensive rats. Stroke, 2006; 37: 1271-1276.
6. Lee, R.M., Wang, H., Smeda, J.S. Perindopril treatment in the prevention of stroke in experimental animals. J Hypertens Suppl, 1996; 14: S29-S33.
7. Yamori, Y., Horie, R., Handa, H., Sato, M., Fukase, M. Pathogenetic similarity of stroke-prone spontaneously hypertensive rats and humans. Stroke, 1976; 7: 46-53.
8. Panahpour, H., Nekooeian, A.A., Dehghani, G.A. Inhibition of angiotensin-converting enzyme reduces cerebral infarction size in experimental-induced focal cerebral ischemia in the rat. Iran J Med Sci, 2007; 32: 12-17.
9. Vakili, A., Nekooeian, A.A., Dehghani, G.A. Aminoguanidine reduces infarct volume and improves neurological dysfunction in transient model of focal cerebral ischemia in rat. DARU, 2006; 14: 31-36.
10. Longa, E. Z., Weinstein, P.R., Carlson, S., Cummins, R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke, 1989; 20: 84-91.
11. Swanson, R.A., Morton, MT., Tsao-Wu, G., Savalos, R.A., Davidson, C., Sharp, F.R. Semi automated method for measuring brain LV. J Cereb Blood Flow Metab, 1990; 10: 290-293.
12. Gotoh, O., Asano, T., Koide, T., Takakura, K. Ischemic brain edema following occlusion of the middle cerebral artery in the rat. I: The time courses of the brain water, sodium and potassium contents and blood-brain barrier permeability to 125I-albumin. Stroke, 1985; 16: 101-109.
13. Rothwell, P.M., Buchan, A., Johnston, S.C. Recent advances in management of transient ischaemic attacks and minor ischaemic strokes. Lancet Neurol, 2006; 5: 323-331.
14. Elewa, HF., Kozak, A., Johnson, MH., Ergul, A., Fagan, S.C. Blood pressure lowering after experimental cerebral ischemia provides neurovascular protection. Hypertension, 2007; 25: 743-745.
15. Ravati, A., Junker, V., Kouklei, M., Ahlemeyer, B., Culmsee, C., Krieglstein, J. Enalapril and moexipril protect from free radical-induced neuronal damage in vitro and reduce ischemic brain injury in mice and rats. Eur J Pharmacol, 1999; 373: 21-33.
16. Gohlke, P., Linz, W., Schölkens, B., Van Even, P., Martorana, P., Unger, T. Vascular and cardiac protection by ramipril in spontaneously hypertensive rats, prevention versus regression study. Br J Clin Pract Suppl, 1996; 84: 1-10.
17. Asano, T., Gotoh, O., Koide, T., Takakura, K. Ischemic brain edema following occlusion of the middle cerebral artery in the rat. II, Alteration of the eicosanoid synthesis profile of brain microvessels. Stroke, 1985; 16: 101-109.
18. Rosenberg, G.A. Ischemic brain edema. Prog. Cardiovasc Dis., 1999; 42: 209-216.
19. Tanaka, Y., Koizumi, C., Marumo, T., Omura, T., Yoshida, S. Serum S100B indicates brain edema formation and predicts long-term neurological outcomes in rat transient middle cerebral artery occlusion model. Brain Res, 2007; 1137: 140-145.
20. Nag, S., Kilty, D.W. Cerebrovascular changes in chronic hypertension. Protective effects of enalapril in rats. Stroke, 1997; 28: 1028-1034.