Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy

Neuropharmacology

Volumn 79, Issue , 2014, Pages 307-313

  Graham, Danielle L ^a   Gray, Audrey J ^a   Joyce, John A ^a   Yu, Dongzi ^a   O'Moore, Jill ^b   Carlson, George A ^b   Shearman, Mark S ^a   Dellovade, Tammy L ^a   Hering, Heike ^a  

^a EMD Serono Research Institute   (United States)

^b MCLAUGHLIN RESEARCH INSTITUTE   (United States)

Author keywords

Alzheimer's Disease; O GlcNAc; O tau(S400) antibody; OGA; rTg4510; Tau aggregation; ThiametG

Indexed keywords

EPITOPE; GLYCOSIDASE INHIBITOR; N ACETYL BETA GLUCOSAMINIDASE; N ACETYLGLUCOSAMINE; TAU PROTEIN; THIAMETG; UNCLASSIFIED DRUG; MAPT PROTEIN, MOUSE; NEUROPROTECTIVE AGENT; PYRAN DERIVATIVE; THIAMET G; THIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DRUG MECHANISM; ENZYME INHIBITION; FEMALE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN GLYCOSYLATION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; REPEATED DRUG DOSE; SINGLE DRUG DOSE; TAUOPATHY; ANIMAL; ANTAGONISTS AND INHIBITORS; DISEASE MODEL; DRUG EFFECTS; GLYCOSYLATION; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; METABOLISM; NERVE CELL; PATHOLOGY; PHOSPHORYLATION; TAUOPATHIES; TRANSGENIC MOUSE;

ACETYLGLUCOSAMINE; ANIMALS; CA1 REGION, HIPPOCAMPAL; CA3 REGION, HIPPOCAMPAL; DISEASE MODELS, ANIMAL; FEMALE; GLYCOSYLATION; MALE; MICE; MICE, TRANSGENIC; NEURONS; NEUROPROTECTIVE AGENTS; PHOSPHORYLATION; PYRANS; TAU PROTEINS; TAUOPATHIES; THIAZOLES;

EID: 84891619442     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2013.11.025     Document Type: Article

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