Generation and characterization of a rabbit monoclonal antibody site-specific for tau O-GlcNAcylated at serine 400

FEBS Letters

Volumn 587, Issue 22, 2013, Pages 3722-3728

  Cameron, Andrew ^a   Giacomozzi, Brandy ^a   Joyce, John ^a   Gray, Audrey ^a   Graham, Danielle ^a   Ousson, Solenne ^b   Neny, Maud ^b   Beher, Dirk ^b   Carlson, George ^c   O'Moore, Jill ^c   Shearman, Mark ^a   Hering, Heike ^a  

^a EMD Serono Research Institute   (United States)

^b Asceneuron SA   (Switzerland)

^c MCLAUGHLIN RESEARCH INSTITUTE   (United States)

Author keywords

Monoclonal antibody; O GlcNAc; OGA; Site specific; Tau

Indexed keywords

MONOCLONAL ANTIBODY; N ACETYLGLUCOSAMINE; SERINE; TAU PROTEIN;

ACYLATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN MODIFICATION; PROTEIN PROCESSING;

MONOCLONAL ANTIBODY; O-GLCNAC; OGA; SITE-SPECIFIC; TAU;

ACETYLGLUCOSAMINE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; GLYCOSYLATION; HEK293 CELLS; HUMANS; MICE; MICE, KNOCKOUT; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; RABBITS; SERINE; TAU PROTEINS;

ORYCTOLAGUS CUNICULUS;

EID: 84887404556     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2013.09.042     Document Type: Article

References (20)

1. G. Johnson, and S. Jenkins Tau protein in normal and Alzheimer's disease brain J. Alzheimers Dis. 1 4-5 1999 307 328
2. S.A. Yuzwa, X. Shan, M.S. Macauley, T. Clark, Y. Skorobogatko, K. Vosseller, and D.J. Vocadlo Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation Nat. Chem. Biol. 8 2012 393 399
3. C. Torres, and G. Hart Topography and polypeptide distribution of terminal N-acetylglucosamine residues on the surface of intact lymphocytes. Evidence for O-linked GlcNAc J. Biol. Chem. 259 5 1984 3308 3317
4. D. Dong, and G. Hart Purification and characterization of an O-GlcNAc selective N-acetyl-beta-d-glucosaminidase from rat spleen cytosol J. Biol. Chem. 269 30 1994 19321 19330
5. C. Yu, T. Si, W. Wu, J. Hu, J. Du, Y. Zhao, and Y. Li O-GlcNAcylation modulates the self-aggregation ability of the fourth microtubule-binding repeat of tau Biochem. Biophys. Res. Commun. 375 2008 59 62
6. Z. Wang, M. Gucek, and G. Hart Cross-talk between GlcNAcylation and phosphorylation: site-specific phosphorylation dynamics in response to globally elevated O-GlcNAc Proc. Natl. Acad. Sci. USA 105 37 2008 13793 13798
7. S.A. Yuzwa, A.K. Yadav, Y. Skorobogatko, T. Clark, K. Vosseller, and D.J. Vocadlo Mapping O-GlcNAc modification sites on tau and generation of a site-specific O-GlcNAc tau antibody Amino Acids 40 2011 857 868
8. M.J. Kang, C. Kim, H. Jeong, B.K. Cho, A.L. Ryou, D. Hwang, I. Mook-Jung, and E.C. Yi Synapsin-1 and tau reciprocal O-GlcNAcylation and phosphorylation sites in mouse brain synaptosomes Exp. Mol. Med. 45 2013 e29
9. L. Buee, T. Bussiere, V. Buee-Scherer, A. Delacourte, and P. Hof Tau protein isoforms, phosphorylation and role in neurodegenerative disorders Brain Res. Rev. 33 1 2000 95 130
10. B. Hoover, M. Reed, J. Su, R. Penrod, L. Kotilinek, M. Grant, R. Pitstick, G. Carlson, L. Lanier, L. Yuan, K. Ashe, and D. Liao Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration Neuron 68 2010 1067 1081
11. S.A. Yuzwa, M.S. Macauley, J.E. Heinonen, X. Shan, R.J. Dennis, Y. He, G.E. Whitworth, K.A. Stubbs, E.J. McEachern, G.J. Davies, and D.J. Vocadlo A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo Nat. Chem. Biol. 4 2008 483 490
12. J. Lewis, E. McGowan, J. Rockwood, H. Melrose, P. Nacharaju, M. Van Slegtenhorst, K. Gwinn-Hardy, M. Paul Murphy, M. Baker, X. Yu, K. Duff, J. Hardy, A. Corral, W.L. Lin, S.H. Yen, D.W. Dickson, P. Davies, and M. Hutton Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein Nat. Genet. 25 2000 402 405
13. G. Hart, M. Housley, and C. Slawson Cycling of O-linked b-N-acetylglucosamine on nucleotcytoplasmic proteins Nature 446 2007 1017 1022
14. G. Hart, C. Slawson, G. Ramirez-Correa, and O. Lagerlof Cross talk between O-GlcNAcylation and phosphorylation: roles in signaling, transcription, and chronic disease Annu. Rev. Biochem. 80 2011 825 858
15. P. Banerjee, G. Hart, and J. Cho Chemical approaches to study O-GlcNAcylation Chem. Soc. Rev. 42 10 2012 4345 4357
16. J. Rexach, C. Rogers, S. Yu, J. Tao, Y. Sun, and L. Hsieh-Wilson Quantification of O-GlcNAcylation stoichiometry and dynamics using resolvable mass tags Nat. Chem. Biol. 6 9 2010 645 651
17. F.I. Comer, K. Vosseller, L. Wells, M.A. Accavitti, and G.W. Hart Characterizationof a mouse monoclonal antibody specific for O-linked N-acetylglucosamine Anal. Biochem. 293 2001 169 177
18. C. Teo, S. Ingale, M. Wolfert, G. Elsayed, L. Noet, J. Chatham, L. Wells, and G. Boons Glycopeptide-specific monoclonal antibodies suggest new roles for O-GlcNAc Nat. Chem. Biol. 6 2010 338 343
19. K. Kamemura, B.K. Hayes, F.I. Comer, and G.W. Hart Dyamic interplay between O-glycosylation and O-phosphorylation of nucleocytoplasmic proteins J. Biol. Chem. 277 21 2002 19229 19235
20. A. Klein, M.N. Berkaw, M.G. Buse, and L.E. Ball O-linked N-acetylglucosamine modification of insulin receptor substrate-1 occurs in close proximity to multiple SH2 domain binding motifs Mol. Cell. Proteomics 8 12 2009 2733 2745