Genetic susceptibility loci, environmental exposures, and Parkinson's disease: A case-control study of gene-environment interactions

Parkinsonism and Related Disorders

Volumn 19, Issue 6, 2013, Pages 595-599

  Chung, Sun Ju ^a,b   Armasu, Sebastian M ^b   Anderson, Kari J ^b   Biernacka, Joanna M ^b   Lesnick, Timothy G ^b   Rider, David N ^b   Cunningham, Julie M ^b   Ahlskog, J Eric ^b   Frigerio, Roberta ^c   Maraganore, Demetrius M ^c  

^a University of Ulsan College of Medicine   (South Korea)

^b MAYO CLINIC   (United States)

^c NORTHSHORE UNIVERSITY HEALTHSYSTEM   (United States)

Author keywords

Environment; Genes; Interactions; Parkinson's disease

Indexed keywords

PESTICIDE; ALPHA SYNUCLEIN; LRRK2 PROTEIN, HUMAN; MAPT PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; SNCA PROTEIN, HUMAN; TAU PROTEIN;

ADULT; AGED; ALCOHOL CONSUMPTION; ARTICLE; COFFEE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DRINKING BEHAVIOR; ENVIRONMENTAL EXPOSURE; FEMALE; GENE; GENE INTERACTION; GENE LOCUS; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; LRRK2 GENE; MAJOR CLINICAL STUDY; MALE; MAPT GENE; PARKINSON DISEASE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; SNCA GENE; VARIABLE NUMBER OF TANDEM REPEAT; YOUNG ADULT; CASE CONTROL STUDY; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETIC VARIATION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; MIDDLE AGED; RETROSPECTIVE STUDY; VERY ELDERLY; GENETIC ASSOCIATION;

ADULT; AGED; AGED, 80 AND OVER; ALPHA-SYNUCLEIN; CASE-CONTROL STUDIES; FEMALE; GENE FREQUENCY; GENE-ENVIRONMENT INTERACTION; GENETIC LOCI; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; MALE; MIDDLE AGED; PARKINSON DISEASE; PROTEIN-SERINE-THREONINE KINASES; RETROSPECTIVE STUDIES; TAU PROTEINS;

EID: 84891537762     PISSN: 13538020     EISSN: 18735126     Source Type: Journal    
DOI: 10.1016/j.parkreldis.2013.02.008     Document Type: Article

References (33)

1. Polymeropoulos M.H., Lavedan C., Leroy E., Ide S.E., Dehejia A., Dutra A., et al. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 1997, 276:2045-2047.
2. Yasuda M., Nakamura Y., Kawamata T., Kaneyuki H., Maeda K., Komure O. Phenotypic heterogeneity within a new family with the MAPT p301s mutation. Ann Neurol 2005, 58:920-928.
3. Paisan-Ruiz C., Jain S., Evans E.W., Gilks W.P., Simon J., van der Brug M., et al. Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease. Neuron 2004, 44:595-600.
4. Nalls M.A., Plagnol V., Hernandez D.G., Sharma M., Sheerin U.M., Saad M., et al. Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. Lancet 2011, 377:641-649.
5. Do C.B., Tung J.Y., Dorfman E., Kiefer A.K., Drabant E.M., Francke U., et al. Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. PLoS Genet 2011, 7:e1002141.
6. Lill C.M., Roehr J.T., McQueen M.B., Kavvoura F.K., Bagade S., Schjeide B.M., et al. Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: the PDGene database. PLoS Genet 2012, 8:e1002548.
7. Zimprich A., Biskup S., Leitner P., Lichtner P., Farrer M., Lincoln S., et al. Mutations in LRRK2 cause autosomal-dominant Parkinsonism with pleomorphic pathology. Neuron 2004, 44:601-607.
8. Arima K., Hirai S., Sunohara N., Aoto K., Izumiyama Y., Ueda K., et al. Cellular co-localization of phosphorylated tau- and NACP/alpha-synuclein-epitopes in Lewy bodies in sporadic Parkinson's disease and in dementia with Lewy bodies. Brain Res 1999, 843:53-61.
9. Alegre-Abarrategui J., Ansorge O., Esiri M., Wade-Martins R. LRRK2 is a component of granular alpha-synuclein pathology in the brainstem of Parkinson's disease. Neuropathol Appl Neurobiol 2008, 34:272-283.
10. Benedetti M.D., Bower J.H., Maraganore D.M., McDonnell S.K., Peterson B.J., Ahlskog J.E., et al. Smoking, alcohol, and coffee consumption preceding Parkinson's disease: a case-control study. Neurology 2000, 55:1350-1358.
11. Jimenez-Jimenez F.J., Mateo D., Gimenez-Roldan S. Premorbid smoking, alcohol consumption, and coffee drinking habits in Parkinson's disease: a case-control study. Mov Disord 1992, 7:339-344.
12. Elbaz A., Clavel J., Rathouz P.J., Moisan F., Galanaud J.P., Delemotte B., et al. Professional exposure to pesticides and Parkinson disease. Ann Neurol 2009, 66:494-504.
13. Uversky V.N. Neurotoxicant-induced animal models of Parkinson's disease: understanding the role of rotenone, maneb and paraquat in neurodegeneration. Cell Tissue Res 2004, 318:225-241.
14. Norris E.H., Uryu K., Leight S., Giasson B.I., Trojanowski J.Q., Lee V.M. Pesticide exposure exacerbates alpha-synucleinopathy in an A53T transgenic mouse model. Am J Pathol 2007, 170:658-666.
15. Brighina L., Frigerio R., Schneider N.K., Lesnick T.G., de Andrade M., Cunningham J.M., et al. Alpha-synuclein, pesticides, and Parkinson disease: a case-control study. Neurology 2008, 70:1461-1469.
16. Gatto N.M., Rhodes S.L., Manthripragada A.D., Bronstein J., Cockburn M., Farrer M., et al. alpha-Synuclein gene may interact with environmental factors in increasing risk of Parkinson's disease. Neuroepidemiology 2010, 35:191-195.
17. Chung S.J., Armasu S.M., Biernacka J.M., Lesnick T.G., Rider D.N., Lincoln S.J., et al. Common variants in PARK loci and related genes and Parkinson's disease. Mov Disord 2011, 26:280-288.
18. Biernacka J.M., Armasu S.M., Cunningham J.M., Ahlskog J.E., Chung S.J., Maraganore D.M. Do interactions between SNCA, MAPT, and LRRK2 genes contribute to Parkinson's disease susceptibility?. Parkinsonism Relat Disord 2011, 17:730-736.
19. Hartge P., Brinton L.A., Rosenthal J.F., Cahill J.I., Hoover R.N., Waksberg J. Random digit dialing in selecting a population-based control group. Am J Epidemiol 1984, 120:825-833.
20. Barrett J.C., Fry B., Maller J., Daly M.J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005, 21:263-265.
21. Frigerio R., Sanft K.R., Grossardt B.R., Peterson B.J., Elbaz A., Bower J.H., et al. Chemical exposures and Parkinson's disease: a population-based case-control study. Mov Disord 2006, 21:1688-1692.
22. Facheris M.F., Schneider N.K., Lesnick T.G., de Andrade M., Cunningham J.M., Rocca W.A., et al. Coffee, caffeine-related genes, and Parkinson's disease: a case-control study. Mov Disord 2008, 23:2033-2040.
23. Brighina L., Schneider N.K., Lesnick T.G., de Andrade M., Cunningham J.M., Mrazek D., et al. Alpha-synuclein, alcohol use disorders, and Parkinson disease: a case-control study. Parkinsonism Relat Disord 2009, 15:430-434.
24. Gauderman W.J. Sample size requirements for matched case-control studies of gene-environment interaction. Stat Med 2002, 21:35-50.
25. R2011. R Development Core Team. R: a language and environment for statistical computing [online]. Available from: [accessed 31.03.12]. http://www.R-project.org.
26. Gao J., Nalls M.A., Shi M., Joubert B.R., Hernandez D.G., Huang X., et al. An exploratory analysis on gene-environment interactions for Parkinson disease. Neurobiol Aging 2012, 33(2528):e1-6.
27. Mueller J.C., Fuchs J., Hofer A., Zimprich A., Lichtner P., Illig T., et al. Multiple regions of alpha-synuclein are associated with Parkinson's disease. Ann Neurol 2005, 57:535-541.
28. Mizuta I., Satake W., Nakabayashi Y., Ito C., Suzuki S., Momose Y., et al. Multiple candidate gene analysis identifies alpha-synuclein as a susceptibility gene for sporadic Parkinson's disease. Hum Mol Genet 2006, 15:1151-1158.
29. Goris A., Williams-Gray C.H., Clark G.R., Foltynie T., Lewis S.J., Brown J., et al. Tau and alpha-synuclein in susceptibility to, and dementia in, Parkinson's disease. Ann Neurol 2007, 62:145-153.
30. Hamza T.H., Chen H., Hill-Burns E.M., Rhodes S.L., Montimurro J., Kay D.M., et al. Genome-wide gene-environment study identifies glutamate receptor gene GRIN2A as a Parkinson's disease modifier gene via interaction with coffee. PLoS Genet 2011, 7:e1002237.
31. Kiyohara C., Miyake Y., Koyanagi M., Fujimoto T., Shirasawa S., Tanaka K., et al. APOE and CYP2E1 polymorphisms, alcohol consumption, and Parkinson's disease in a Japanese population. J Neural Transm 2011, 118:1335-1344.
32. Frigerio R., Elbaz A., Sanft K.R., Petersen B.J., Bower J.H., Ahlskog J.E., et al. Education and occupations preceding Parkinson's disease: a population-based case-control study. Neurology 2005, 65:1575-1583.
33. Farrer M., Stone J., Mata I.F., Lincoln S., Kachergus J., Hulihan M., et al. LRRK2 mutations in Parkinson's disease. Neurology 2005, 65:738-740.