A novel compound RY10-4 induces apoptosis and inhibits invasion via inhibiting STAT3 through ERK-, p38-dependent pathways in human lung adenocarcinoma A549 cells

Chemico-Biological Interactions

Volumn 209, Issue 1, 2014, Pages 125-134

  Xue, Pingping ^a   Zhao, Yang ^a   Liu, Yang ^b   Yuan, Qianying ^c   Xiong, Chaomei ^a   Ruan, Jinlan ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b Wuchang University of Technology   (China)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

ERK; Lung cancer; p38; RY10 4; STAT3

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CASPASE 3; CASPASE 9; GELATINASE A; GELATINASE B; MITOGEN ACTIVATED PROTEIN KINASE P38; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; RY 104; STAT3 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL INVASION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; LUNG ADENOCARCINOMA; MALE; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; TUMOR INVASION; UPREGULATION;

EID: 84891536561     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2013.11.014     Document Type: Article

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