-
1
-
-
78751621217
-
Evolving epidemiology of hepatitis C virus
-
Lavanchy D. 2011. Evolving epidemiology of hepatitis C virus. Clin. Microbiol. Infect. 17:107-115. http://dx.doi.org/10.1111/j.1469-0691.2010 .03432.x.
-
(2011)
Clin. Microbiol. Infect.
, vol.17
, pp. 107-115
-
-
Lavanchy, D.1
-
2
-
-
79953171086
-
Increasing prevalence of HCC and cirrhosis in patients with chronic hepatitis C virus infection
-
Kanwal F, Hoang T, Kramer JR, Asch SM, Goetz MB, Zeringue A, Richardson P, El-Serag HB. 2011. Increasing prevalence of HCC and cirrhosis in patients with chronic hepatitis C virus infection. Gastroenterology 140:1182-1188. http://dx.doi.org/10.1053/j.gastro.2010.12.032.
-
(2011)
Gastroenterology
, vol.140
, pp. 1182-1188
-
-
Kanwal, F.1
Hoang, T.2
Kramer, J.R.3
Asch, S.M.4
Goetz, M.B.5
Zeringue, A.6
Richardson, P.7
El-Serag, H.B.8
-
3
-
-
0024509701
-
Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
-
Choo QL, Kuo G, Weiner AJ, Overby LR, Bradley DW, Houghton M. 1989. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 244:359-362. http://dx.doi.org/10.1126/science.2523562
-
(1989)
Science
, vol.244
, pp. 359-362
-
-
Choo, Q.L.1
Kuo, G.2
Weiner, A.J.3
Overby, L.R.4
Bradley, D.W.5
Houghton, M.6
-
4
-
-
77958487999
-
New insights into structure and replication of the hepatitis C virus and clinical implications
-
Poenisch M, Bartenschlager R. 2010. New insights into structure and replication of the hepatitis C virus and clinical implications. Semin. Liver Dis. 30:333-347. http://dx.doi.org/10.1055/s-0030-1267535.
-
(2010)
Semin. Liver Dis.
, vol.30
, pp. 333-347
-
-
Poenisch, M.1
Bartenschlager, R.2
-
5
-
-
0345188811
-
Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line
-
Lohmann V, Korner F, Koch J, Herian U, Theilmann L, Bartenschlager R. 1999. Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science 285:110-113. http://dx.doi.org/10.1126/science.285.5424.110.
-
(1999)
Science
, vol.285
, pp. 110-113
-
-
Lohmann, V.1
Korner, F.2
Koch, J.3
Herian, U.4
Theilmann, L.5
Bartenschlager, R.6
-
6
-
-
0037370622
-
Efficient replication of hepatitis C virus genotype 1a RNAs in cell culture
-
Blight KJ, McKeating JA, Marcotrigiano J, Rice CM. 2003. Efficient replication of hepatitis C virus genotype 1a RNAs in cell culture. J. Virol. 77:3181-3190. http://dx.doi.org/10.1128/JVI.77.5.3181-3190.2003.
-
(2003)
J. Virol.
, vol.77
, pp. 3181-3190
-
-
Blight, K.J.1
McKeating, J.A.2
Marcotrigiano, J.3
Rice, C.M.4
-
7
-
-
0345223476
-
Efficient replication of the genotype 2a hepatitis C virus subgenomic replicon
-
Kato T, Date T, Miyamoto M, Furusaka A, Tokushige K, Mizokami M, Wakita T. 2003. Efficient replication of the genotype 2a hepatitis C virus subgenomic replicon. Gastroenterology 125:1808-1817. http://dx.doi.org/10.1053/j.gastro. 2003.09.023.
-
(2003)
Gastroenterology
, vol.125
, pp. 1808-1817
-
-
Kato, T.1
Date, T.2
Miyamoto, M.3
Furusaka, A.4
Tokushige, K.5
Mizokami, M.6
Wakita, T.7
-
8
-
-
22544470874
-
Production of infectious hepatitis C virus in tissue culture from a cloned viral genome
-
Wakita T, Pietschmann T, Kato T, Date T, Miyamoto M, Zhao Z, Murthy K, Habermann A, Krausslich HG, Mizokami M, Bartenschlager R, Liang TJ. 2005. Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat. Med. 11:791-796. http://dx.doi.org/10.1038/nm1268.
-
(2005)
Nat. Med.
, vol.11
, pp. 791-796
-
-
Wakita, T.1
Pietschmann, T.2
Kato, T.3
Date, T.4
Miyamoto, M.5
Zhao, Z.6
Murthy, K.7
Habermann, A.8
Krausslich, H.G.9
Mizokami, M.10
Bartenschlager, R.11
Liang, T.J.12
-
9
-
-
23044437222
-
Complete replication of hepatitis C virus in cell culture
-
Lindenbach BD, Evans MJ, Syder AJ, Wolk B, Tellinghuisen TL, Liu CC, Maruyama T, Hynes RO, Burton DR, McKeating JA, Rice CM. 2005. Complete replication of hepatitis C virus in cell culture. Science 309:623-626. http://dx.doi.org/10.1126/science.1114016.
-
(2005)
Science
, vol.309
, pp. 623-626
-
-
Lindenbach, B.D.1
Evans, M.J.2
Syder, A.J.3
Wolk, B.4
Tellinghuisen, T.L.5
Liu, C.C.6
Maruyama, T.7
Hynes, R.O.8
Burton, D.R.9
McKeating, J.A.10
Rice, C.M.11
-
10
-
-
0036190918
-
Selectable subgenomic and genome-length dicistronic RNAs derived from an infectious molecular clone of the HCV-N strain of hepatitis C virus replicate efficiently in cultured Huh7 cells
-
Ikeda M, Yi M, Li K, Lemon SM. 2002. Selectable subgenomic and genome-length dicistronic RNAs derived from an infectious molecular clone of the HCV-N strain of hepatitis C virus replicate efficiently in cultured Huh7 cells. J. Virol. 76:2997-3006. http://dx.doi.org/10.1128/JVI.76 .6.2997-3006.2002.
-
(2002)
J. Virol.
, vol.76
, pp. 2997-3006
-
-
Ikeda, M.1
Yi, M.2
Li, K.3
Lemon, S.M.4
-
11
-
-
79953173221
-
Boceprevir for untreated chronic HCV genotype 1 infection
-
Poordad F, McCone J, Jr, Bacon BR, Bruno S, Manns MP, Sulkowski MS, Jacobson IM, Reddy KR, Goodman ZD, Boparai N, DiNubile MJ, Sniukiene V, Brass CA, Albrecht JK, Bronowicki JP. 2011. Boceprevir for untreated chronic HCV genotype 1 infection. N. Engl. J. Med. 364: 1195-1206. http://dx.doi.org/10. 1056/NEJMoa1010494.
-
(2011)
N. Engl. J. Med.
, vol.364
, pp. 1195-1206
-
-
Poordad, F.1
McCone, Jr.J.2
Bacon, B.R.3
Bruno, S.4
Manns, M.P.5
Sulkowski, M.S.6
Jacobson, I.M.7
Reddy, K.R.8
Goodman, Z.D.9
Boparai, N.10
DiNubile, M.J.11
Sniukiene, V.12
Brass, C.A.13
Albrecht, J.K.14
Bronowicki, J.P.15
-
12
-
-
79959438789
-
Telaprevir for previously untreated chronic hepatitis C virus infection
-
Jacobson IM, McHutchison JG, Dusheiko G, Di Bisceglie AM, Reddy KR, Bzowej NH, Marcellin P, Muir AJ, Ferenci P, Flisiak R, George J, Rizzetto M, Shouval D, Sola R, Terg RA, Yoshida EM, Adda N, Bengtsson L, Sankoh AJ, Kieffer TL, George S, Kauffman RS, Zeuzem S. 2011. Telaprevir for previously untreated chronic hepatitis C virus infection. N. Engl. J. Med. 364:2405-2416. http://dx.doi.org/10.1056/NEJMoa1012912.
-
(2011)
N. Engl. J. Med.
, vol.364
, pp. 2405-2416
-
-
Jacobson, I.M.1
McHutchison, J.G.2
Dusheiko, G.3
Di Bisceglie, A.M.4
Reddy, K.R.5
Bzowej, N.H.6
Marcellin, P.7
Muir, A.J.8
Ferenci, P.9
Flisiak, R.10
George, J.11
Rizzetto, M.12
Shouval, D.13
Sola, R.14
Terg, R.A.15
Yoshida, E.M.16
Adda, N.17
Bengtsson, L.18
Sankoh, A.J.19
Kieffer, T.L.20
George, S.21
Kauffman, R.S.22
Zeuzem, S.23
more..
-
13
-
-
78149434641
-
DEB025 (Alisporivir) inhibits hepatitisCvirus replication by preventing a cyclophilinAinduced cis-trans isomerisation in domain II of NS5A
-
Coelmont L, Hanoulle X, Chatterji U, Berger C, Snoeck J, Bobardt M, Lim P, Vliegen I, Paeshuyse J, Vuagniaux G, Vandamme AM, Bartenschlager R, Gallay P, Lippens G, Neyts J. 2010. DEB025 (Alisporivir) inhibits hepatitisCvirus replication by preventing a cyclophilinAinduced cis-trans isomerisation in domain II of NS5A. PLoS One 5:e13687. http://dx.doi.org/10.1371/journal.pone. 0013687.
-
(2010)
PLoS One
, vol.5
-
-
Coelmont, L.1
Hanoulle, X.2
Chatterji, U.3
Berger, C.4
Snoeck, J.5
Bobardt, M.6
Lim, P.7
Vliegen, I.8
Paeshuyse, J.9
Vuagniaux, G.10
Vandamme, A.M.11
Bartenschlager, R.12
Gallay, P.13
Lippens, G.14
Neyts, J.15
-
14
-
-
34547913440
-
Cellular cofactors affecting hepatitis C virus infection and replication
-
Randall G, Panis M, Cooper JD, Tellinghuisen TL, Sukhodolets KE, Pfeffer S, Landthaler M, Landgraf P, Kan S, Lindenbach BD, Chien M, Weir DB, Russo JJ, Ju J, Brownstein MJ, Sheridan R, Sander C, Zavolan M, Tuschl T, Rice CM. 2007. Cellular cofactors affecting hepatitis C virus infection and replication. Proc. Natl. Acad. Sci. U. S. A. 104:12884-12889. http://dx.doi.org/10.1073/pnas. 0704894104.
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 12884-12889
-
-
Randall, G.1
Panis, M.2
Cooper, J.D.3
Tellinghuisen, T.L.4
Sukhodolets, K.E.5
Pfeffer, S.6
Landthaler, M.7
Landgraf, P.8
Kan, S.9
Lindenbach, B.D.10
Chien, M.11
Weir, D.B.12
Russo, J.J.13
Ju, J.14
Brownstein, M.J.15
Sheridan, R.16
Sander, C.17
Zavolan, M.18
Tuschl, T.19
Rice, C.M.20
more..
-
15
-
-
80052284074
-
Hepatitis C virus stimulates the phosphatidylinositol 4-kinase III alpha-dependent phosphatidylinositol 4-phosphate production that is essential for its replication
-
Berger KL, Kelly SM, Jordan TX, Tartell MA, Randall G. 2011. Hepatitis C virus stimulates the phosphatidylinositol 4-kinase III alpha-dependent phosphatidylinositol 4-phosphate production that is essential for its replication. J. Virol. 85:8870-8883. http://dx.doi.org/10.1128/JVI.00059-11.
-
(2011)
J. Virol.
, vol.85
, pp. 8870-8883
-
-
Berger, K.L.1
Kelly, S.M.2
Jordan, T.X.3
Tartell, M.A.4
Randall, G.5
-
16
-
-
0037369066
-
Viral and cellular determinants of hepatitis C virus RNA replication in cell culture
-
Lohmann V, Hoffmann S, Herian U, Penin F, Bartenschlager R. 2003. Viral and cellular determinants of hepatitis C virus RNA replication in cell culture. J. Virol. 77:3007-3019. http://dx.doi.org/10.1128/JVI.77.5.3007 -3019.2003.
-
(2003)
J. Virol.
, vol.77
, pp. 3007-3019
-
-
Lohmann, V.1
Hoffmann, S.2
Herian, U.3
Penin, F.4
Bartenschlager, R.5
-
17
-
-
0026725397
-
Electroporation in 'intracellular'buffer increases cell survival
-
van den Hoff MJ, Moorman AF, Lamers WH. 1992. Electroporation in 'intracellular' buffer increases cell survival. Nucleic Acids Res. 20:2902. http://dx.doi.org/10.1093/nar/20.11.2902.
-
(1992)
Nucleic Acids Res.
, vol.20
, pp. 2902
-
-
Van Den Hoff, M.J.1
Moorman, A.F.2
Lamers, W.H.3
-
18
-
-
84859450873
-
Hepatitis C genotype 1a replicon improved through introduction of fitness mutations
-
Voitenleitner C, Bechtel J, Arfsten A, Hamatake R. 2012. Hepatitis C genotype 1a replicon improved through introduction of fitness mutations. Biotechniques 52:273-275. http://dx.doi.org/10.2144/000113841.
-
(2012)
Biotechniques
, vol.52
, pp. 273-275
-
-
Voitenleitner, C.1
Bechtel, J.2
Arfsten, A.3
Hamatake, R.4
-
19
-
-
77951430085
-
Gene expression profiling indicates the roles of host oxidative stress, apoptosis, lipid metabolism, and intracellular transport genes in the replication of hepatitis C virus
-
Blackham S, Baillie A, Al-Hababi F, Remlinger K, You S, Hamatake R, McGarvey MJ. 2010. Gene expression profiling indicates the roles of host oxidative stress, apoptosis, lipid metabolism, and intracellular transport genes in the replication of hepatitis C virus. J. Virol. 84:5404-5414. http://dx.doi.org/10.1128/JVI.02529-09.
-
(2010)
J. Virol.
, vol.84
, pp. 5404-5414
-
-
Blackham, S.1
Baillie, A.2
Al-Hababi, F.3
Remlinger, K.4
You, S.5
Hamatake, R.6
McGarvey, M.J.7
-
20
-
-
3042666256
-
MUSCLE: Multiple sequence alignment with high accuracy and high throughput
-
Edgar RC. 2004. MUSCLE: Multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res. 32:1792-1797. http://dx.doi.org/10.1093/ nar/gkh340.
-
(2004)
Nucleic Acids Res
, vol.32
, pp. 1792-1797
-
-
Edgar, R.C.1
-
21
-
-
0344201903
-
An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus
-
Lamarre D, Anderson PC, Bailey M, Beaulieu P, Bolger G, Bonneau P, Bos M, Cameron DR, Cartier M, Cordingley MG, Faucher AM, Goudreau N, Kawai SH, Kukolj G, Lagace L, Laplante SR, Narjes H, Poupart MA, Rancourt J, Sentjens RE, St GR, Simoneau B, Steinmann G, Thibeault D, Tsantrizos YS, Weldon SM, Yong CL, Llinas-Brunet M. 2003. An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus. Nature 426:186-189. http://dx.doi.org/ 10.1038/nature02099.
-
(2003)
Nature
, vol.426
, pp. 186-189
-
-
Lamarre, D.1
Anderson, P.C.2
Bailey, M.3
Beaulieu, P.4
Bolger, G.5
Bonneau, P.6
Bos, M.7
Cameron, D.R.8
Cartier, M.9
Cordingley, M.G.10
Faucher, A.M.11
Goudreau, N.12
Kawai, S.H.13
Kukolj, G.14
Lagace, L.15
Laplante, S.R.16
Narjes, H.17
Poupart, M.A.18
Rancourt, J.19
Sentjens, R.E.20
St, G.R.21
Simoneau, B.22
Steinmann, G.23
Thibeault, D.24
Tsantrizos, Y.S.25
Weldon, S.M.26
Yong, C.L.27
Llinas-Brunet, M.28
more..
-
22
-
-
84896296094
-
Hepatitis C replication inhibitors that target the viral NS4B protein
-
1 April
-
Miller JF, Chong PY, Shotwell JB, Catalano JG, Tai VW, Fang J, Banka AL, Roberts CD, Youngman M, Zhang H, Xiong Z, Mathis A, Pouliot JJ, Hamatake RK, Price DJ, Seal JW, III, Stroup LL, Creech KL, Carballo LH, Todd D, Spaltenstein A, Furst S, Hong Z, Peat AJ. 1 April 2013. Hepatitis C replication inhibitors that target the viral NS4B protein. J. Med. Chem. http://dx.doi.org/10.1021/ jm400125h.
-
(2013)
J. Med. Chem.
-
-
Miller, J.F.1
Chong, P.Y.2
Shotwell, J.B.3
Catalano, J.G.4
Tai, V.W.5
Fang, J.6
Banka, A.L.7
Roberts, C.D.8
Youngman, M.9
Zhang, H.10
Xiong, Z.11
Mathis, A.12
Pouliot, J.J.13
Hamatake, R.K.14
Price, D.J.15
Seal III, J.W.16
Stroup, L.L.17
Creech, K.L.18
Carballo, L.H.19
Todd, D.20
Spaltenstein, A.21
Furst, S.22
Hong, Z.23
Peat, A.J.24
more..
-
23
-
-
26644455085
-
Nm 283, an efficient prodrug of the potent anti-HCV agent 2=-C-methylcytidine
-
Pierra C, Benzaria S, Amador A, Moussa A, Mathieu S, Storer R, Gosselin G. 2005. Nm 283, an efficient prodrug of the potent anti-HCV agent 2=-C-methylcytidine. Nucleosides Nucleotides Nucleic Acids 24: 767-770. http://dx.doi.org/10.1081/NCN-200060112.
-
(2005)
Nucleosides Nucleotides Nucleic Acids
, vol.24
, pp. 767-770
-
-
Pierra, C.1
Benzaria, S.2
Amador, A.3
Moussa, A.4
Mathieu, S.5
Storer, R.6
Gosselin, G.7
-
24
-
-
62949195680
-
Robust antiviral efficacy upon administration of a nucleoside analog to hepatitis C virusinfected chimpanzees
-
Carroll SS, Ludmerer S, Handt L, Koeplinger K, Zhang NR, Graham D, Davies ME, MacCoss M, Hazuda D, Olsen DB. 2009. Robust antiviral efficacy upon administration of a nucleoside analog to hepatitis C virusinfected chimpanzees. Antimicrob. Agents Chemother. 53:926-934. http://dx.doi.org/10.1128/AAC.01032- 08.
-
(2009)
Antimicrob. Agents Chemother.
, vol.53
, pp. 926-934
-
-
Carroll, S.S.1
Ludmerer, S.2
Handt, L.3
Koeplinger, K.4
Zhang, N.R.5
Graham, D.6
Davies, M.E.7
MacCoss, M.8
Hazuda, D.9
Olsen, D.B.10
-
25
-
-
30344464991
-
Preclinical pharmacokinetics and metabolism of a potent non-nucleoside inhibitor of the hepatitis C virus NS5B polymerase
-
Giuliano C, Fiore F, Di MA, Padron VJ, Bishop A, Bonelli F, Gonzalez- Paz O, Marcucci I, Harper S, Narjes F, Pacini B, Monteagudo E, Migliaccio G, Rowley M, Laufer R. 2005. Preclinical pharmacokinetics and metabolism of a potent non-nucleoside inhibitor of the hepatitis C virus NS5B polymerase. Xenobiotica 35:1035-1054. http://dx.doi.org/10.1080/00498250500356548.
-
(2005)
Xenobiotica
, vol.35
, pp. 1035-1054
-
-
Giuliano, C.1
Fiore, F.2
Di, M.A.3
Padron, V.J.4
Bishop, A.5
Bonelli, F.6
Gonzalez- Paz, O.7
Marcucci, I.8
Harper, S.9
Narjes, F.10
Pacini, B.11
Monteagudo, E.12
Migliaccio, G.13
Rowley, M.14
Laufer, R.15
-
26
-
-
50949134232
-
Molecular mechanism of hepatitis C virus replicon variants with reduced susceptibility to a benzofuran inhibitor, HCV-796
-
Howe AY, Cheng H, Johann S, Mullen S, Chunduru SK, Young DC, Bard J, Chopra R, Krishnamurthy G, Mansour T, O'Connell J. 2008. Molecular mechanism of hepatitis C virus replicon variants with reduced susceptibility to a benzofuran inhibitor, HCV-796. Antimicrob. Agents Chemother. 52:3327-3338. http://dx.doi.org/10.1128/AAC.00238-08.
-
(2008)
Antimicrob. Agents Chemother.
, vol.52
, pp. 3327-3338
-
-
Howe, A.Y.1
Cheng, H.2
Johann, S.3
Mullen, S.4
Chunduru, S.K.5
Young, D.C.6
Bard, J.7
Chopra, R.8
Krishnamurthy, G.9
Mansour, T.10
O'Connell, J.11
-
27
-
-
67650003002
-
Substituted benzothiadizine inhibitors of hepatitis C virus polymerase
-
Shaw AN, Tedesco R, Bambal R, Chai D, Concha NO, Darcy MG, Dhanak D, Duffy KJ, Fitch DM, Gates A, Johnston VK, Keenan RM, Lin-Goerke J, Liu N, Sarisky RT, Wiggall KJ, Zimmerman MN. 2009. Substituted benzothiadizine inhibitors of hepatitis C virus polymerase. Bioorg. Med. Chem. Lett. 19:4350-4353. http://dx.doi.org/10.1016/j.bmcl.2009.05.091.
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, pp. 4350-4353
-
-
Shaw, A.N.1
Tedesco, R.2
Bambal, R.3
Chai, D.4
Concha, N.O.5
Darcy, M.G.6
Dhanak, D.7
Duffy, K.J.8
Fitch, D.M.9
Gates, A.10
Johnston, V.K.11
Keenan, R.M.12
Lin-Goerke, J.13
Liu, N.14
Sarisky, R.T.15
Wiggall, K.J.16
Zimmerman, M.N.17
-
28
-
-
0024993530
-
A three-dimensional model to analyze drug-drug interactions
-
Prichard MN, Shipman C, Jr. 1990. A three-dimensional model to analyze drug-drug interactions. Antiviral Res. 14:181-205. http://dx.doi.org /10.1016/0166-3542(90)90001-N.
-
(1990)
Antiviral Res.
, vol.14
, Issue.181-205
-
-
Prichard, M.N.1
Shipman, Jr.C.2
-
29
-
-
84946384873
-
The toxicity of poisons applied jointly
-
Bliss CI. 1939. The toxicity of poisons applied jointly. Ann. Appl. Biol. 26:585-615. http://dx.doi.org/10.1111/j.1744-7348.1939.tb06990.x.
-
(1939)
Ann. Appl. Biol.
, vol.26
, pp. 585-615
-
-
Bliss, C.I.1
-
30
-
-
0037974623
-
Synergistic in vitro interactions between alpha interferon and ribavirin against bovineviral diarrhea virus and yellow fever virus as surrogate models of hepatitis C virus replication
-
Buckwold VE, Wei J, Wenzel-Mathers M, Russell J. 2003. Synergistic in vitro interactions between alpha interferon and ribavirin against bovineviral diarrhea virus and yellow fever virus as surrogate models of hepatitis C virus replication. Antimicrob. Agents Chemother. 47:2293-2298. http://dx.doi.org/10. 1128/AAC.47.7.2293-2298.2003.
-
(2003)
Antimicrob. Agents Chemother.
, vol.47
, pp. 2293-2298
-
-
Buckwold, V.E.1
Wei, J.2
Wenzel-Mathers, M.3
Russell, J.4
-
31
-
-
84855509792
-
Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance
-
Powdrill MH, Tchesnokov EP, Kozak RA, Russell RS, Martin R, Svarovskaia ES, Mo H, Kouyos RD, Gotte M. 2011. Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance. Proc. Natl. Acad. Sci. U. S. A. 108:20509- 20513. http://dx.doi.org/10.1073/pnas.1105797108.
-
(2011)
Proc. Natl. Acad. Sci. U. S. A.
, vol.108
, pp. 20509-20513
-
-
Powdrill, M.H.1
Tchesnokov, E.P.2
Kozak, R.A.3
Russell, R.S.4
Martin, R.5
Svarovskaia, E.S.6
Mo, H.7
Kouyos, R.D.8
Gotte, M.9
-
32
-
-
77952035218
-
Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect
-
Gao M, Nettles RE, Belema M, Snyder LB, Nguyen VN, Fridell RA, Serrano-Wu MH, Langley DR, Sun JH, O'Boyle DR, Lemm JA, Wang C, Knipe JO, Chien C, Colonno RJ, Grasela DM, Meanwell NA, Hamann LG. 2010. Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect. Nature 465:96-100. http://dx.doi.org /10.1038/nature08960.
-
(2010)
Nature
, vol.465
, pp. 96-100
-
-
Gao, M.1
Nettles, R.E.2
Belema, M.3
Snyder, L.B.4
Nguyen, V.N.5
Fridell, R.A.6
Serrano-Wu, M.H.7
Langley, D.R.8
Sun, J.H.9
O'Boyle, D.R.10
Lemm, J.A.11
Wang, C.12
Knipe, J.O.13
Chien, C.14
Colonno, R.J.15
Grasela, D.M.16
Meanwell, N.A.17
Hamann, L.G.18
-
33
-
-
82455192239
-
Genotypic and phenotypic analysis of variants resistant to hepatitisCvirus nonstructural protein 5A replication complex inhibitor BMS-790052 in humans: In vitro and in vivo correlations
-
Fridell RA, Wang C, Sun JH, O'Boyle DR, Nower P, Valera L, Qiu D, Roberts S, Huang X, Kienzle B, Bifano M, Nettles RE, Gao M. 2011. Genotypic and phenotypic analysis of variants resistant to hepatitisCvirus nonstructural protein 5A replication complex inhibitor BMS-790052 in humans: In vitro and in vivo correlations. Hepatology 54:1924-1935. http://dx.doi.org/10.1002/hep.24594.
-
(2011)
Hepatology
, vol.54
, pp. 1924-1935
-
-
Fridell, R.A.1
Wang, C.2
Sun, J.H.3
O'Boyle, D.R.4
Nower, P.5
Valera, L.6
Qiu, D.7
Roberts, S.8
Huang, X.9
Kienzle, B.10
Bifano, M.11
Nettles, R.E.12
Gao, M.13
-
34
-
-
77956116880
-
Resistance analysis of the hepatitisCvirus NS5A inhibitor BMS-790052 in an in vitro replicon system
-
Fridell RA, Qiu D, Wang C, Valera L, Gao M. 2010. Resistance analysis of the hepatitisCvirus NS5A inhibitor BMS-790052 in an in vitro replicon system. Antimicrob. Agents Chemother. 54:3641-3650. http://dx.doi.org/10.1128/AAC.00556- 10.
-
(2010)
Antimicrob. Agents Chemother.
, vol.54
, pp. 3641-3650
-
-
Fridell, R.A.1
Qiu, D.2
Wang, C.3
Valera, L.4
Gao, M.5
-
35
-
-
84867253952
-
Antiviral resistance and directacting antiviral agents for HCV
-
Aloia AL, Locarnini S, Beard MR. 2012. Antiviral resistance and directacting antiviral agents for HCV. Antivir. Ther. 17:1147-1162. http://dx.doi.org/10.3851/IMP2426.
-
(2012)
Antivir. Ther.
, vol.17
, pp. 1147-1162
-
-
Aloia, A.L.1
Locarnini, S.2
Beard, M.R.3
-
36
-
-
0034120427
-
Clinical significance of hepatitis C virus genotypes
-
Zein NN. 2000. Clinical significance of hepatitis C virus genotypes. Clin. Microbiol. Rev. 13:223-235. http://dx.doi.org/10.1128/CMR.13.2.223 -235.2000
-
(2000)
Clin. Microbiol. Rev.
, vol.13
, pp. 223-235
-
-
Zein, N.N.1
-
37
-
-
0027522145
-
Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region
-
Simmonds P, Holmes EC, Cha TA, Chan SW, McOmish F, Irvine B, Beall E, Yap PL, Kolberg J, Urdea MS. 1993. Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region. J. Gen. Virol. 74:2391-2399. http://dx.doi.org/10.1099/0022-1317-74-11- 2391.
-
(1993)
J. Gen. Virol.
, vol.74
, pp. 2391-2399
-
-
Simmonds, P.1
Holmes, E.C.2
Cha, T.A.3
Chan, S.W.4
McOmish, F.5
Irvine, B.6
Beall, E.7
Yap, P.L.8
Kolberg, J.9
Urdea, M.S.10
-
38
-
-
75149151884
-
Resistance to direct antiviral agents in patients with hepatitis C virus infection
-
Sarrazin C, Zeuzem S. 2010. Resistance to direct antiviral agents in patients with hepatitis C virus infection. Gastroenterology 138:447-462. http://dx.doi.org/10.1053/j.gastro.2009.11.055.
-
(2010)
Gastroenterology
, vol.138
, pp. 447-462
-
-
Sarrazin, C.1
Zeuzem, S.2
-
39
-
-
38349162328
-
Identification of residues required for RNA replication in domains II and III of the hepatitis C virus NS5A protein
-
Tellinghuisen TL, Foss KL, Treadaway JC, Rice CM. 2008. Identification of residues required for RNA replication in domains II and III of the hepatitis C virus NS5A protein. J. Virol. 82:1073-1083. http://dx.doi.org/10.1128/JVI.00328- 07.
-
(2008)
J. Virol.
, vol.82
, pp. 1073-1083
-
-
Tellinghuisen, T.L.1
Foss, K.L.2
Treadaway, J.C.3
Rice, C.M.4
-
40
-
-
42949145532
-
Regulation of hepatitis C virion production via phosphorylation of the NS5A protein
-
Tellinghuisen TL, Foss KL, Treadaway J. 2008. Regulation of hepatitis C virion production via phosphorylation of the NS5A protein. PLoS Pathog. 4:e1000032. http://dx.doi.org/10.1371/journal.ppat.1000032.
-
(2008)
PLoS Pathog.
, vol.4
-
-
Tellinghuisen, T.L.1
Foss, K.L.2
Treadaway, J.3
-
41
-
-
67649197727
-
Domain III of NS5A contributes to both RNA replication and assembly of hepatitis C virus particles
-
Hughes M, Griffin S, Harris M. 2009. Domain III of NS5A contributes to both RNA replication and assembly of hepatitis C virus particles. J. Gen. Virol. 90:1329-1334. http://dx.doi.org/10.1099/vir.0.009332-0.
-
(2009)
J. Gen. Virol.
, vol.90
, pp. 1329-1334
-
-
Hughes, M.1
Griffin, S.2
Harris, M.3
-
42
-
-
0034623816
-
Efficient initiation of HCV RNA replication in cell culture
-
Blight KJ, Kolykhalov AA, Rice CM. 2000. Efficient initiation of HCV RNA replication in cell culture. Science 290:1972-1974. http://dx.doi.org/10.1126/ science.290.5498.1972.
-
(2000)
Science
, vol.290
, pp. 1972-1974
-
-
Blight, K.J.1
Kolykhalov, A.A.2
Rice, C.M.3
-
43
-
-
84952980130
-
Targeting the NS5A protein of HCV: An emerging option
-
Cordek DG, Bechtel JT, Maynard AT, Kazmierski WM, Cameron CE. 2011. Targeting the NS5A protein of HCV: An emerging option. Drugs Future 36:691-711.
-
(2011)
Drugs Future
, vol.36
, pp. 691-711
-
-
Cordek, D.G.1
Bechtel, J.T.2
Maynard, A.T.3
Kazmierski, W.M.4
Cameron, C.E.5
-
44
-
-
66149115122
-
Crystal structure of a novel dimeric form of NS5A domain I protein from hepatitis C virus
-
Love RA, Brodsky O, Hickey MJ, Wells PA, Cronin CN. 2009. Crystal structure of a novel dimeric form of NS5A domain I protein from hepatitis C virus. J. Virol. 83:4395- 4403. http://dx.doi.org/10.1128/JVI.02352-08.
-
(2009)
J. Virol.
, vol.83
, pp. 4395-4403
-
-
Love, R.A.1
Brodsky, O.2
Hickey, M.J.3
Wells, P.A.4
Cronin, C.N.5
-
45
-
-
19644393931
-
Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase
-
Tellinghuisen TL, Marcotrigiano J, Rice CM. 2005. Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase. Nature 435:374-379. http://dx.doi.org/10.1038/nature03580.
-
(2005)
Nature
, vol.435
, pp. 374-379
-
-
Tellinghuisen, T.L.1
Marcotrigiano, J.2
Rice, C.M.3
-
46
-
-
84892588133
-
Pharmacologic disruption of hepatitis C non-structural 5A (NS5A) intra and intermolecular conformations
-
30 August
-
Bhattacharya D, Ansari IU, Hamatake R, Walker J, Kazmierski W, Striker R. 30 August 2013. Pharmacologic disruption of hepatitis C non-structural 5A (NS5A) intra and intermolecular conformations. J. Gen. Virol. http://dx.doi.org/10.1099/vir.0.054569-0.
-
(2013)
J. Gen. Virol.
-
-
Bhattacharya, D.1
Ansari, I.U.2
Hamatake, R.3
Walker, J.4
Kazmierski, W.5
Striker, R.6
-
47
-
-
84874644131
-
Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life
-
Guedj J, Dahari H, Rong L, Sansone ND, Nettles RE, Cotler SJ, Layden TJ, Uprichard SL, Perelson AS. 2013. Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life. Proc. Natl. Acad. Sci. U. S. A. 110:3991- 3996. http://dx.doi.org/10.1073/pnas.1203110110.
-
(2013)
Proc. Natl. Acad. Sci. U. S. A.
, vol.110
, pp. 3991-3996
-
-
Guedj, J.1
Dahari, H.2
Rong, L.3
Sansone, N.D.4
Nettles, R.E.5
Cotler, S.J.6
Layden, T.J.7
Uprichard, S.L.8
Perelson, A.S.9
-
48
-
-
84884239818
-
Safety, tolerability, pharmacokinetics, and antiviral activity of GSK2336805, aninhibitor of hepatitis C virus (HCV) NS5A, in healthy subjects and subjects chronically infected with HCV genotype 1
-
Wilfret D, Walker J, Adkison K, Jones L, Lou Y, Gan J, Castellino S, Moseley C, Horton J, SMde Culp A, Goljer I, Spreen W. 2013. Safety, tolerability, pharmacokinetics, and antiviral activity of GSK2336805, aninhibitor of hepatitis C virus (HCV) NS5A, in healthy subjects and subjects chronically infected with HCV genotype 1. Antimicrob. Agents Chemother. 57:5037-5044. http://dx.doi.org/10.1128/AAC.00910-13.
-
(2013)
Antimicrob. Agents Chemother.
, vol.57
, pp. 5037-5044
-
-
Wilfret, D.1
Walker, J.2
Adkison, K.3
Jones, L.4
Lou, Y.5
Gan, J.6
Castellino, S.7
Moseley, C.8
Horton, J.9
Smde Culp, A.10
Goljer, I.11
Spreen, W.12
-
49
-
-
84902553184
-
A double-blind, randomized, placebo-controlled study to assess the safety, antiviral activity, and pharmacokinetics of GSK2336805 when given as monotherapy and in combination with peginterferon alfa-2a and ribavirin in hepatitis Cvirus genotype 1-infected treatment-naive subjects
-
25 September
-
Gardner S, Cutrell A, Elko-Simms C, Adkison K, Hamatake R, Walker J, Rodriguez-Torres M, Hong Z. 25 September 2013. A double-blind, randomized, placebo-controlled study to assess the safety, antiviral activity, and pharmacokinetics of GSK2336805 when given as monotherapy and in combination with peginterferon alfa-2a and ribavirin in hepatitis Cvirus genotype 1-infected treatment-naive subjects. Liver Int. http://dx.doi.org/10.1111/liv.12334.
-
(2013)
Liver Int.
-
-
Gardner, S.1
Cutrell, A.2
Elko-Simms, C.3
Adkison, K.4
Hamatake, R.5
Walker, J.6
Rodriguez-Torres, M.7
Hong, Z.8
-
50
-
-
79959381354
-
Telaprevir for retreatment of HCV infection
-
Zeuzem S, Andreone P, Pol S, Lawitz E, Diago M, Roberts S, Focaccia R, Younossi Z, Foster GR, Horban A, Ferenci P, Nevens F, Mullhaupt B, Pockros P, Terg R, Shouval D, HBvan Weiland O, Van HR, De MS, Luo D, Boogaerts G, Polo R, Picchio G, Beumont M. 2011. Telaprevir for retreatment of HCV infection. N. Engl. J. Med. 364:2417-2428. http://dx.doi.org/10.1056/NEJMoa1013086.
-
(2011)
N. Engl. J. Med.
, vol.364
, pp. 2417-2428
-
-
Zeuzem, S.1
Andreone, P.2
Pol, S.3
Lawitz, E.4
Diago, M.5
Roberts, S.6
Focaccia, R.7
Younossi, Z.8
Foster, G.R.9
Horban, A.10
Ferenci, P.11
Nevens, F.12
Mullhaupt, B.13
Pockros, P.14
Terg, R.15
Shouval, D.16
Hbvan Weiland, O.17
Van, H.R.18
De, M.S.19
Luo, D.20
Boogaerts, G.21
Polo, R.22
Picchio, G.23
Beumont, M.24
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