Knockout of the Trpc1 gene reveals that TRPC1 can promote recovery from anaphylaxis by negatively regulating mast cell TNF-α production

Cell Calcium

Volumn 53, Issue 5-6, 2013, Pages 315-326

  Medic, Nevenka ^a   Desai, Avanti ^a   Olivera, Ana ^b   Abramowitz, Joel ^c   Birnbaumer, Lutz ^c   Beaven, Michael A ^d   Gilfillan, Alasdair M ^a   Metcalfe, Dean D ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^d NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

Anaphylaxis; Calcium; Degranulation; Fce open RI; JUN; KIT; Mast cells; NFAT; SCF; TNF ; TRPC1

Indexed keywords

CALCIUM; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 6; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR JUNA; TRANSCRIPTION FACTOR JUNB; TRANSCRIPTION FACTOR NFAT; TRANSIENT RECEPTOR POTENTIAL CHANNEL 1; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; UNCLASSIFIED DRUG; ALLERGEN; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY C, MEMBER 1; TRANSIENT RECEPTOR POTENTIAL CHANNEL C; TRPC6 PROTEIN, MOUSE;

ANAPHYLAXIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; CALCIUM SIGNALING; CELL ACTIVATION; CONTROLLED STUDY; CONVALESCENCE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; GENE INACTIVATION; HUMAN; HUMAN CELL; IN VIVO STUDY; MAST CELL; MAST CELL DEGRANULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRPC1 GENE; WILD TYPE; 129 MOUSE; ANIMAL; C57BL MOUSE; CELL CULTURE; DEGRANULATION; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM;

MUS;

ALLERGENS; ANAPHYLAXIS; ANIMALS; CALCIUM SIGNALING; CELL DEGRANULATION; CELLS, CULTURED; HUMANS; MAST CELLS; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; TRPC CATION CHANNELS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84891510125     PISSN: 01434160     EISSN: 15321991     Source Type: Journal    
DOI: 10.1016/j.ceca.2013.02.001     Document Type: Article

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