Relationships between human vitality and mitochondrial respiratory parameters, reactive oxygen species production and dntp levels in peripheral blood mononuclear cells

Aging

Volumn 5, Issue 11, 2013, Pages 850-864

  Maynard, Scott ^a   Keijzers, Guido ^a,b   Gram, Martin ^a   Desler, Claus ^a   Bendix, Laila ^a,b   Budtz Jørgensen, Esben ^a   Molbo, Drude ^a   Croteau, Deborah L ^c   Osler, Merete ^b,d   Stevnsner, Tinna ^b   Rasmussen, Lene Juel ^a   Dela, Flemming ^a   Avlund, Kirsten ^a,b   Bohr, Vilhelm A ^c  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c NATIONAL INSTITUTE ON AGING   (United States)

^d GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Deoxyribonucleotides; Mitochondrial respiration; Reactive oxygen species; Vitality

Indexed keywords

DEOXYRIBONUCLEOTIDE; REACTIVE OXYGEN METABOLITE;

ARTICLE; CELL RESPIRATION; FATIGUE; GLYCOLYSIS; HUMAN; MALE; METABOLISM; MIDDLE AGED; MITOCHONDRION; MONONUCLEAR CELL; OXYGEN CONSUMPTION;

CELL RESPIRATION; DEOXYRIBONUCLEOTIDES; FATIGUE; GLYCOLYSIS; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; MITOCHONDRIA; OXYGEN CONSUMPTION; REACTIVE OXYGEN SPECIES;

EID: 84891509740     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100618     Document Type: Article

References (59)

1. Bjorner JB, Wallenstein GV, Martin MC, Lin P, Blaisdell-Gross B, Tak PC, Mody SH. Interpreting score differences in the SF-36 Vitality scale: using clinical conditions and functional outcomes to define the minimally important difference. Curr Med Res Opin. 2007; 23: 731-739.
2. Bjorner JB, Damsgaard MT, Watt T, Groenvold M. Tests of data quality, scaling assumptions, and reliability of the Danish SF-36. J Clin Epidemiol. 1998; 51: 1001-1011.
3. Jhamb M, Argyropoulos C, Steel JL, Plantinga L, Wu AW, Fink NE, Powe NR, Meyer KB, Unruh ML. Correlates and outcomes of fatigue among incident dialysis patients. Clin J Am Soc Nephrol. 2009; 4: 1779-1786.
4. Brown LF, Kroenke K, Theobald DE, Wu J. Comparison of SF-36 vitality scale and Fatigue Symptom Inventory in assessing cancer-related fatigue. Support Care Cancer. 2011; 19: 1255- 1259.
5. Avlund K. Fatigue in older adults: an early indicator of the aging process? Aging Clin Exp Res. 2010; 22: 100-115.
6. Buchwald D, Pearlman T, Umali J, Schmaling K, Katon W. Functional status in patients with chronic fatigue syndrome, other fatiguing illnesses, and healthy individuals. Am J Med. 1996; 101: 364-370.
7. Gladkevich A, Kauffman HF, Korf J. Lymphocytes as a neural probe: potential for studying psychiatric disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2004; 28: 559-576.
8. Gubert C, Stertz L, Pfaffenseller B, Panizzutti BS, Rezin GT, Massuda R, Streck EL, Gama CS, Kapczinski F, Kunz M. Mitochondrial activity and oxidative stress markers in peripheral blood mononuclear cells of patients with bipolar disorder, schizophrenia, and healthy subjects. J Psychiatr Res. 2013.
9. Kunz M, Cereser KM, Goi PD, Fries GR, Teixeira AL, Fernandes BS, Belmonte-Abreu PS, Kauer-Sant'Anna M, Kapczinski F, Gama CS. Serum levels of IL-6, IL-10 and TNF-alpha in patients with bipolar disorder and schizophrenia: differences in pro- and anti-inflammatory balance. Rev Bras Psiquiatr. 2011; 33: 268-274.
10. Cordero MD, Alcocer-Gomez E, Cano-Garcia FJ, de MM, Carrion AM, Navas P, Sanchez Alcazar JA. Clinical symptoms in fibromyalgia are better associated to lipid peroxidation levels in blood mononuclear cells rather than in plasma. PLoS One. 2011; 6: e26915.
11. Leuner K, Schulz K, Schutt T, Pantel J, Prvulovic D, Rhein V, Savaskan E, Czech C, Eckert A, Muller WE. Peripheral mitochondrial dysfunction in Alzheimer's disease: focus on lymphocytes. Mol Neurobiol. 2012; 46: 194-204.
12. Maes M, Mihaylova I, Kubera M, Bosmans E. Not in the mind but in the cell: increased production of cyclo-oxygenase-2 and inducible NO synthase in chronic fatigue syndrome. Neuro Endocrinol Lett. 2007; 28: 463-469.
13. Pieczenik SR, Neustadt J. Mitochondrial dysfunction and molecular pathways of disease. Exp Mol Pathol. 2007; 83: 84-92.
14. Brand MD. The efficiency and plasticity of mitochondrial energy transduction. Biochem Soc Trans. 2005; 33: 897-904.
15. Brand MD, Nicholls DG. Assessing mitochondrial dysfunction in cells. Biochem J. 2011; 435: 297-312.
16. Wu M, Neilson A, Swift AL, Moran R, Tamagnine J, Parslow D, Armistead S, Lemire K, Orrell J, Teich J, Chomicz S, Ferrick DA. Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells. Am J Physiol Cell Physiol. 2007; 292: C125-C136.
17. Brown GC, Borutaite V. There is no evidence that mitochondria are the main source of reactive oxygen species in mammalian cells. Mitochondrion. 2012; 12: 1-4.
18. Droge W. Free radicals in the physiological control of cell function. Physiol Rev. 2002; 82: 47-95.
19. Oka S, Ohno M, Tsuchimoto D, Sakumi K, Furuichi M, Nakabeppu Y. Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs. EMBO J. 2008; 27: 421-432.
20. Brieger K, Schiavone S, Miller FJ, Jr., Krause KH. Reactive oxygen species: from health to disease. Swiss Med Wkly. 2012; 142: w13659.
21. Rampazzo C, Miazzi C, Franzolin E, Pontarin G, Ferraro P, Frangini M, Reichard P, Bianchi V. Regulation by degradation, a cellular defense against deoxyribonucleotide pool imbalances. Mutat Res. 2010; 703: 2-10.
22. Reichard P. Interactions between deoxyribonucleotide and DNA synthesis. Annu Rev Biochem. 1988; 57: 349-374.
23. Mathews CK. DNA precursor metabolism and genomic stability. FASEB J. 2006; 20: 1300-1314.
24. Desler C, Lykke A, Rasmussen LJ. The effect of mitochondrial dysfunction on cytosolic nucleotide metabolism. J Nucleic Acids. 2010; 10.4061/2010/701518 [doi].
25. Ferrick DA, Neilson A, Beeson C. Advances in measuring cellular bioenergetics using extracellular flux. Drug Discov Today. 2008; 13: 268-274.
26. Nobes CD, Lakin-Thomas PL, Brand MD. The contribution of ATP turnover by the Na+/K+-ATPase to the rate of respiration of hepatocytes. Effects of thyroid status and fatty acids. Biochim Biophys Acta. 1989; 976: 241-245.
27. Maes M, Mihaylova I, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E. Coenzyme Q10 deficiency in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is related to fatigue, autonomic and neurocognitive symptoms and is another risk factor explaining the early mortality in ME/CFS due to cardiovascular disorder. Neuro Endocrinol Lett. 2009; 30: 470-476.
28. Meeus M, Nijs J, Hermans L, Goubert D, Calders P. The role of mitochondrial dysfunctions due to oxidative and nitrosative stress in the chronic pain or chronic fatigue syndromes and fibromyalgia patients: peripheral and central mechanisms as therapeutic targets? Expert Opin Ther Targets. 2013; 17: 1081- 1089.
29. Myhill S, Booth NE, McLaren-Howard J. Chronic fatigue syndrome and mitochondrial dysfunction. Int J Clin Exp Med. 2009; 2: 1-16.
30. Norheim KB, Jonsson G, Omdal R. Biological mechanisms of chronic fatigue. Rheumatology (Oxford). 2011; 50: 1009-1018.
31. Smits B, van Heuvel L, Knoop H, Kusters B, Janssen A, Borm G, Bleijenberg G, Rodenburg R, van EB. Mitochondrial enzymes discriminate between mitochondrial disorders and chronic fatigue syndrome. Mitochondrion. 2011; 11: 735-738.
32. Vermeulen RC, Kurk RM, Visser FC, Sluiter W, Scholte HR. Patients with chronic fatigue syndrome performed worse than controls in a controlled repeated exercise study despite a normal oxidative phosphorylation capacity. J Transl Med. 2010; 8: 93.
33. Chung CP, Titova D, Oeser A, Randels M, Avalos I, Milne GL, Morrow JD, Stein CM. Oxidative stress in fibromyalgia and its relationship to symptoms. Clin Rheumatol. 2009; 28: 435-438.
34. Cordero MD, Cano-Garcia FJ, Alcocer-Gomez E, de MM, Sanchez-Alcazar JA. Oxidative stress correlates with headache symptoms in fibromyalgia: coenzyme Q(1)(0) effect on clinical improvement. PLoS One. 2012; 7: e35677.
35. Kennedy G, Spence VA, McLaren M, Hill A, Underwood C, Belch JJ. Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms. Free Radic Biol Med. 2005; 39: 584-589.
36. Meeus M, Nijs J, Hermans L, Goubert D, Calders P. The role of mitochondrial dysfunctions due to oxidative and nitrosative stress in the chronic pain or chronic fatigue syndromes and fibromyalgia patients: peripheral and central mechanisms as therapeutic targets? Expert Opin Ther Targets. 2013.
37. Maes M, Mihaylova I, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E. Increased 8-hydroxy-deoxyguanosine, a marker of oxidative damage to DNA, in major depression and myalgic encephalomyelitis / chronic fatigue syndrome. Neuro Endocrinol Lett. 2009; 30: 715-722.
38. Bagis S, Tamer L, Sahin G, Bilgin R, Guler H, Ercan B, Erdogan C. Free radicals and antioxidants in primary fibromyalgia: an oxidative stress disorder? Rheumatol Int. 2005; 25: 188-190.
39. Dalle-Donne I, Rossi R, Milzani A, Di SP, Colombo R. The actin cytoskeleton response to oxidants: from small heat shock protein phosphorylation to changes in the redox state of actin itself. Free Radic Biol Med. 2001; 31: 1624-1632.
40. Droge W. Oxidative stress and aging. Adv Exp Med Biol. 2003; 543: 191-200.
41. Kamata H, Hirata H. Redox regulation of cellular signalling. Cell Signal. 1999; 11: 1-14.
42. Puceat M. Role of Rac-GTPase and reactive oxygen species in cardiac differentiation of stem cells. Antioxid Redox Signal. 2005; 7: 1435-1439.
43. Yin F, Boveris A, Cadenas E. Mitochondrial Energy Metabolism and Redox Signaling in Brain Aging and Neurodegeneration. Antioxid Redox Signal. 2012; In Press.
44. Zhang Y, Du Y, Le W, Wang K, Kieffer N, Zhang J. Redox control of the survival of healthy and diseased cells. Antioxid Redox Signal. 2011; 15: 2867-2908.
45. Ray PD, Huang BW, Tsuji Y. Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal. 2012; 24: 981-990.
46. Droge W, Schipper HM. Oxidative stress and aberrant signaling in aging and cognitive decline. Aging Cell. 2007; 6: 361- 370.
47. Chen JJ, Yu BP. Alterations in mitochondrial membrane fluidity by lipid peroxidation products. Free Radic Biol Med. 1994; 17: 411-418.
48. Pamplona R. Membrane phospholipids, lipoxidative damage and molecular integrity: a causal role in aging and longevity. Biochim Biophys Acta. 2008; 1777: 1249-1262.
49. Paradies G, Petrosillo G, Pistolese M, Ruggiero FM. Reactive oxygen species affect mitochondrial electron transport complex I activity through oxidative cardiolipin damage. Gene. 2002; 286: 135-141.
50. Paradies G, Petrosillo G, Paradies V, Ruggiero FM. Oxidative stress, mitochondrial bioenergetics, and cardiolipin in aging. Free Radic Biol Med. 2010; 48: 1286-1295.
51. Desler C, Munch-Petersen B, Stevnsner T, Matsui S, Kulawiec M, Singh KK, Rasmussen LJ. Mitochondria as determinant of nucleotide pools and chromosomal stability. Mutat Res. 2007; 625: 112-124.
52. Yan LJ, Levine RL, Sohal RS. Oxidative damage during aging targets mitochondrial aconitase. Proc Natl Acad Sci U S A. 1997; 94: 11168-11172.
53. Furda AM, Marrangoni AM, Lokshin A, Van HB. Oxidants and not alkylating agents induce rapid mtDNA loss and mitochondrial dysfunction. DNA Repair (Amst). 2012; 11: 684-692.
54. Rolfe DF, Brown GC. Cellular energy utilization and molecular origin of standard metabolic rate in mammals. Physiol Rev. 1997; 77: 731-758.
55. Nicholls DG, Darley-Usmar VM, Wu M, Jensen PB, Rogers GW, Ferrick DA. Bioenergetic profile experiment using C2C12 myoblast cells. J Vis Exp. 2010.
56. Hill BG, Benavides GA, Lancaster JR, Jr., Ballinger S, Dell'Italia L, Jianhua Z, Darley-Usmar VM. Integration of cellular bioenergetics with mitochondrial quality control and autophagy. Biol Chem. 2012; 393: 1485-1512.
57. Ferrick DA, Neilson A, Beeson C. Advances in measuring cellular bioenergetics using extracellular flux. Drug Discov Today. 2008; 13: 268-274.
58. Osler M, Lund R, Kriegbaum M, Christensen U, Andersen AM. Cohort profile: the Metropolit 1953 Danish male birth cohort. Int J Epidemiol. 2006; 35: 541-545.
59. Avlund K, Osler M, Mortensen EL, Christensen U, Bruunsgaard H, Holm-Pedersen P, Fiehn NE, Hansen ÅM, Bachkati KH, Meincke RH, Jepsen EMD, Lund R. Copenhagen Aging and Midlife Biobank (CAMB). An introduction. Journal of Aging and Health. 2013; In Press.