Synthesis and anticancer activities of thieno[3,2-d]pyrimidines as novel HDAC inhibitors

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 1, 2014, Pages 358-365

  Tan, Qiu ^a   Zhang, Zhitao ^a   Hui, Jie ^a   Zhao, Yu ^a   Zhu, Li ^a  

^a NANTONG UNIVERSITY   (China)

Author keywords

Anti proliferative; HDAC; Synthesize; Thieno 3,2 d pyrimidines

Indexed keywords

1 HYDROXYAMINO 4 [3 (4 MORPHOLIN 4 YL THIENO[3,2 D]PYRIMIDINES 2 YL)PHENOXY]HEXANOATE; 1 HYDROXYAMINO 4 [4 (4 MORPHOLIN 4 YL THIENO[3,2 D]PYRIMIDINES 2 YL)PHENOXY]HEXANOATE; 1 HYDROXYAMINO 5 [3 (4 MORPHOLIN 4 YL THIENO[3,2 D]PYRIMIDINES 2 YL)PHENOXY]HEXANOATE; 1 HYDROXYAMINO 5 [4 (4 MORPHOLIN 4 YL THIENO[3,2 D]PYRIMIDINES 2 YL)PHENOXY]HEXANOATE; 1 HYDROXYAMINO 6 [3 (4 MORPHOLIN 4 YL THIENO[3,2 D]PYRIMIDINES 2 YL)PHENOXY]HEXANOATE; 1 HYDROXYAMINO 6 [4 (4 MORPHOLIN 4 YL THIENO[3,2 D]PYRIMIDINES 2 YL)PHENOXY]HEXANOATE; 1 HYDROXYAMINO 7 [3 (4 MORPHOLIN 4 YL THIENO[3,2 D]PYRIMIDINES 2 YL)PHENOXY]HEXANOATE; 1 HYDROXYAMINO 7 [4 (4 MORPHOLIN 4 YL THIENO[3,2 D]PYRIMIDINES 2 YL)PHENOXY]HEXANOATE; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; HISTONE DEACETYLASE INHIBITOR; THIENO[3,2 D]PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; VORINOSTAT;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL STRAIN HCT116; CELL STRAIN MCF 7; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DESIGN; DRUG DETERMINATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; G2 PHASE CELL CYCLE CHECKPOINT; HELA CELL; HUMAN; HUMAN CELL; INFRARED SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANTI-PROLIFERATIVE; HDAC; SYNTHESIZE; THIENO[3,2-D]PYRIMIDINES;

HISTONE DEACETYLASE INHIBITORS; HUMANS; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84891489942     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.11.021     Document Type: Article

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