The design, synthesis and structure-activity relationships of novel isoindoline-based histone deacetylase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 16, 2011, Pages 4909-4912

  Shultz, Michael ^a   Fan, Jianmei ^a   Chen, Christine ^a   Cho, Young Shin ^a   Davis, Nicole ^a   Bickford, Sheri ^a   Buteau, Kristen ^a   Cao, Xueying ^a   Holmqvist, Mats ^a   Hsu, Meier ^a   Jiang, Lei ^a   Liu, Gang ^a   Lu, Qiang ^a   Patel, Chetan ^b   Suresh, Joghee Raju ^b   Selvaraj, Mannangatti ^b   Urban, Laszlo ^a   Wang, Ping ^a   Yan, Yan Neale ^a   Whitehead, Lewis ^a   Zhang, Haiyan ^a   Zhou, Liping ^a   Atadja, Peter ^a   more..

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b SYNGENE INTERNATIONAL LTD   (India)

Author keywords

Cancer; HDAC; hERG; Histone deacetylase; Isoindoline; SAR

Indexed keywords

BELINOSTAT; DACINOSTAT; ENTINOSTAT; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID DERIVATIVE; MOCETINOSTAT; VORINOSTAT;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CANCER THERAPY; CELL PROLIFERATION; CELL STRAIN HCT116; COLON CANCER; DRUG ACTIVITY; DRUG DESIGN; DRUG SAFETY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; NEOPLASM; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE INHIBITORS; HUMANS; HYDROXAMIC ACIDS; ISOINDOLES; MOLECULAR STRUCTURE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79960902512     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.06.015     Document Type: Article

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