Urocortin 2 is associated with abdominal aortic aneurysm and mediates anti-proliferative effects on vascular smooth muscle cells via corticotrophin releasing factor receptor 2

Clinical Science

Volumn 126, Issue 7, 2014, Pages 517-527

  Emeto, Theophilus I ^a   Moxon, Joseph V ^a   Biros, Erik ^a   Rush, Catherine M ^a   Clancy, Paula ^a   Woodward, Lynn ^a   Moran, Corey S ^a   Jose, Roby J ^a   Nguyen, Tam ^a   Walker, Philip J ^a,b   Golledge, Jonathan ^a,c  

^a JAMES COOK UNIVERSITY   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c TOWNSVILLE HOSPITAL   (Australia)

Author keywords

Aneurysm; Corticotrophin releasing factor receptor 2; Inflammation; Proliferation; Urocortin 2

Indexed keywords

CORTICOTROPHIN RELEASING FACTOR RECEPTOR 2; CORTICOTROPIN RELEASING FACTOR; PROTEIN KINASE B; UNCLASSIFIED DRUG; UROCORTIN I; UROCORTIN II; UROCORTIN III;

ABDOMINAL AORTA ANEURYSM; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CARDIOVASCULAR RISK; CELL CYCLE; CELL CYCLE ARREST; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PHENOTYPE; PREVALENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER; UPREGULATION; VASCULAR SMOOTH MUSCLE CELL;

EID: 84891472614     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20130425     Document Type: Article

References (50)

1. Moxon, J. V., Parr, A., Emeto, T. I., Walker, P., Norman, P. E. and Golledge, J. (2010) Diagnosis and monitoring of abdominal aortic aneurysm: current status and future prospects. Curr. Opin. Cardiol. 35, 512-548
2. Golledge, J. and Norman, P. E. (2009) Pathophysiology of abdominal aortic aneurysm relevant to improvements in patients' management. Curr. Opin. Cardiol. 24, 532-538
3. Emeto, T. I., Moxon, J. V., Rush, C., Woodward, L. and Golledge, J. (2011) Relevance of urocortins to cardiovascular disease. J. Mol. Cell Cardiol. 51, 299-307
4. Lewis, K., Li, C., Perrin, M. H., Blount, A., Kunitake, K., Donaldson, C., Vaughan, J., Reyes, T. M., Gulyas, J., Fischer, W. et al. (2001) Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. Proc. Natl. Acad. Sci. U.S.A. 98, 7570-7575
5. Hsu, S. Y. and Hsueh, A. J. W. (2001) Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor. Nat. Med. 7, 605-611
6. Kageyama, K. M. D. P., Furukawa, K.-I. P., Miki, I., Terui, K. M. D. P., Motomura, S. M. D. P. and Suda, T. M. D. P. (2003) Vasodilative effects of urocortin II via protein kinase A and a mitogenactivated protein kinase in rat thoracic aorta. J. Cardiovasc. Pharmacol. 42, 561-565
7. Kageyama, K., Gaudriault, G. E., Suda, T. and Vale, W. W. (2003) Regulation of corticotropin-releasing factor receptor type 2β mRNA via cyclic AMP pathway in A7r5 aortic smooth muscle cells. Cell. Signal. 15, 17-25
8. Tu, H., Kastin, A. J. and Pan, W. (2007) Corticotropin-releasing hormone receptor (CRHR)1 and CRHR2 are both trafficking and signaling receptors for urocortin. Mol. Endocrinol. 21, 700-711
9. Knight, R. A., Chen-Scarabelli, C., Yuan, Z., McCauley, R. B., Di Rezze, J., Scarabelli, G. M., Townsend, P. A., Latchman, D., Saravolatz, L., Faggian, G. et al. (2008) Cardiac release of urocortin precedes the occurrence of irreversible myocardial damage in the rat heart exposed to ischemia/reperfusion injury. FEBS Lett. 582, 984-990
10. Hsu, S. Y. and Hsueh, A. J. (2001) Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor. Nat. Med. 7, 605-611
11. Brar, B. K., Jonassen, A. K., Egorina, E. M., Chen, A., Negro, A., Perrin, M. H., Mjos, O. D., Latchman, D. S., Lee, K.-F. and Vale, W. (2004) Urocortin-II and urocortin-III are cardioprotective against ischemia reperfusion injury: an essential endogenous cardioprotective role for corticotropin releasing factor receptor type 2 in the murine heart. Endocrinology 145, 24-35
12. Huang, M., Pang, X., Karalis, K. and Theoharides, T. C. (2003) Stress-induced interleukin-6 release in mice is mast cell-dependent and more pronounced in apolipoprotein E knockout mice. Cardiovasc. Res. 59, 241-249
13. Topal, E., Yagmur, J., Otlu, B., Atas, H., Cansel, M., Acikgoz, N. and Ermis, N. (2012) Relationship of urocortin-2 with systolic and diastolic functions and coronary artery disease: an observational study. Anadolu Kardiyol. Derg 12, 115
14. Ng, L. L., Loke, I. W., O'Brien, R. J., Squire, I. B. and Davies, J. E. (2004) Plasma urocortin in human systolic heart failure. Clin. Sci. 106, 383-388
15. Honjo, T., Inoue, N., Shiraki, R., Kobayashi, S., Otsui, K., Takahashi, M., Hirata, K., Kawashima, S., Yokozaki, H. and Yokoyama, M. (2006) Endothelial urocortin has potent antioxidative properties and is upregulated by inflammatory cytokines and pitavastatin. J. Vasc. Surg. 43, 131-138
16. Davidson, S. M. and Yellon, D. M. (2009) Urocortin: a protective peptide that targets both the myocardium and vasculature. Pharmacol. Rep. 61, 172-182
17. Rush, C., Nyara, M., Moxon, J., Trollope, A., Cullen, B. and Golledge, J. (2009) Whole genome expression analysis within the angiotensin II-apolipoprotein E deficient mouse model of abdominal aortic aneurysm. BMC Genomics 10, 298
18. Golledge, J., Jayalath, R., Oliver, L., Parr, A., Schurgers, L. and Clancy, P. (2008) Relationship between CT anthropometric measurements, adipokines and abdominal aortic calcification. Atherosclerosis 197, 428-434
19. Parr, A., McCann, M., Bradshaw, B., Shahzad, A., Buttner, P. and Golledge, J. (2011) Thrombus volume is associated with cardiovascular events and aneurysm growth in patients who have abdominal aortic aneurysms. J. Vasc. Surg. 53, 28-35
20. Biros, E., Norman, P. E., Walker, P. J., Nataatmadja, M., West, M. and Golledge, J. (2011) A single nucleotide polymorphism in exon of the kallikrein 1 gene is associated with large but not small abdominal aortic aneurysm. Atherosclerosis 217, 452-457
21. Tao, J., Zhang, Y., Soong, T. W. and Li, S. (2006) Urocortin II inhibits the apoptosis of mesenteric arterial smooth muscle cells via L-type calcium channels in spontaneously hypertensive rats. Cell. Physiol. Biochem. 17, 111-120
22. Kageyama, K., Hanada, K., Nigawara, T., Moriyama, T., Terui, K., Sakihara, S. and Suda, T. (2006) Urocortin induces interleukin-6 gene expression via cyclooxygenase-2 activity in aortic smooth muscle cells. Endocrinology 147, 4454-4462
23. Moran, C. S., McCann, M., Karan, M., Norman, P., Ketheesan, N. and Golledge, J. (2005) Association of osteoprotegerin with human abdominal aortic aneurysm progression. Circulation 111, 3119-3125
24. Grossini, E., Molinari, C., Mary, D. A., Uberti, F., Ribichini, F., Caimmi, P. P. and Vacca, G. (2009) Urocortin II induces nitric oxide production through cAMP and Ca2+ related pathways in endothelial cells. Cell. Physiol. Biochem. 23, 87-96
25. Brazil, D. P., Yang, Z.-Z. and Hemmings, B. A. (2004) Advances in protein kinase B signalling: AKTion on multiple fronts. Trends Biochem. Sci. 29, 233-242
26. Hausenloy, D. J. and Yellon, D. M. (2009) Cardioprotective growth factors. Cardiovasc. Res. 83, 179-194
27. Reference deleted
28. Guha, M. and Mackman, N. (2002) The Phosphatidylinositol 3-Kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells. J. Biol. Chem. 277, 32124-32132
29. Martin, M., Rehani, K., Jope, R. S. and Michalek, S. M. (2005) Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3. Nat. Immunol. 6, 777-784
30. Dawson, J., Cockerill, G. W., Choke, E., Belli, A. M., Loftus, I. and Thompson, M. M. (2007) Aortic aneurysms secrete interleukin-6 into the circulation. J. Vasc. Surg. 45, 350-356
31. Donovan, M., Doonan, F. and Cotter, T. G. (2006) Decreased expression of pro-apoptotic Bcl-2 family members during retinal development and differential sensitivity to cell death. Dev. Biol. 291, 154-169
32. Spin, J. M., Maegdefessel, L. and Tsao, P. S. (2012) Vascular smooth muscle cell phenotypic plasticity: focus on chromatin remodelling. Cardiovasc. Res. 95, 147-155
33. Rajaram, M. V. S., Ganesan, L. P., Parsa, K. V. L., Butchar, J. P., Gunn, J. S. and Tridandapani, S. (2006) Akt/Protein Kinase B modulates macrophage inflammatory response to francisella infection and confers a survival advantage in mice. J. Immunol. 177, 6317-6324
34. Tsatsanis, C., Androulidaki, A., Dermitzaki, E., Charalampopoulos, I., Spiess, J., Gravanis, A. and Margioris, A. N. (2005) Urocortin 1 and urocortin 2 induce macrophage apoptosis via CRFR2. FEBS Lett. 579, 4259-4264
35. Golledge, J., Clancy, P., Moran, C., Biros, E., Rush, C., Walker, P. and Norman, P. (2010) The novel association of the chemokine CCL22 with abdominal aortic aneurysm. Am. J. Pathol. 176, 2098-2106
36. Davis, M. E., Pemberton, C. J., Yandle, T. G., Fisher, S. F., Lainchbury, J. G., Frampton, C. M., Rademaker, M. T. and Richards, A. M. (2007) Urocortin 2 infusion in healthy humans hemodynamic, neurohormonal, and renal responses. J. Am. Coll. Cardiol. 49, 461-471
37. Wang, J., Jin, L., Chen, J. and Li, S. (2010) Activation of Corticotropin-Releasing factor receptor 2 inhibits the growth of human small cell lung carcinoma cells. Cancer Invest. 28, 146-155
38. Chen, A., Brar, B., Choi, C. S., Rousso, D., Vaughan, J., Kuperman, Y., Kim, S. N., Donaldson, C., Smith, S. M., Jamieson, P. et al. (2006) Urocortin 2 modulates glucose utilization and insulin sensitivity in skeletal muscle. Proc. Natl. Acad. Sci. U.S.A. 103, 16580-16585
39. Jin, L., Zhang, Q., Guo, R., Wang, L., Wang, J., Wan, R., Zhang, R., Xu, Y. and Li, S. (2011) Different effects of corticotrophin-releasing hormone and urocortin 2 on apoptosis of prostate cancer cells in vitro. J. Mol. Endocrinol. 47, 219-227
40. Chamorro, A. and Hallenbeck, J. (2006) The harms and benefits of inflammatory and immune responses in vascular disease. Stroke 37, 291-293
41. Moss, A. C., Anton, P., Savidge, T., Newman, P., Cheifetz, A. S., Gay, J., Paraschos, S., Winter, M. W., Moyer, M. P., Karalis, K. et al. (2007) Urocortin II mediates pro-inflammatory effects in human colonocytes via corticotropin-releasing hormone receptor 2α. Gut 56, 1210-1217
42. Shimizu, K., Mitchell, R. N. and Libby, P. (2006) Inflammation and cellular immune responses in abdominal aortic aneurysms. Arterioscler. Thromb. Vasc. Biol. 26, 987-994
43. Sherr, C. J. (1994) G1 phase progression: cycling on cue. Cell 79, 551-555
44. Kandel, E. S., Skeen, J., Majewski, N., Di Cristofano, A., Pandolfi, P. P., Feliciano, C. S., Gartel, A. and Hay, N. (2002) Activation of Akt/protein kinase B overcomes a G2/m cell cycle checkpoint induced by DNA damage. Mol. Cell Biol. 22, 7831-7841
45. Allaire, E., Muscatelli-Groux, B., Mandet, C., Guinault, A.-M., Bruneval, P., Desgranges, P., Clowes, A., Méllière, D. and Becquemin, J.-P. (2002) Paracrine effect of vascular smooth muscle cells in the prevention of aortic aneurysm formation. J. Vasc. Surg. 36, 1018-1026
46. Allaire, E., Schneider, F., Saucy, F., Dai, J., Cochennec, F., Michineau, S., Zidi, M., Becquemin, J. P., Kirsch, M. and Gervais, M. (2009) New insight in aetiopathogenesis of aortic diseases. Eur. J. Vasc. Endovasc. Surg. 37, 531-537
47. Hao, Z., Huang, Y., Cleman, J., Jovin, I. S., Vale, W. W., Bale, T. L. and Giordano, F. J. (2008) Urocortin2 inhibits tumor growth via effects on vascularization and cell proliferation. Proc. Natl. Acad. Sci. U.S.A. 105, 3939-3944
48. Golledge, J., Karan, M., Moran, C. S., Muller, J., Clancy, P., Dear, A. E. and Norman, P. E. (2008) Reduced expansion rate of abdominal aortic aneurysms in patients with diabetes may be related to aberrant monocyte-matrix interactions. Eur. Heart J. 29, 665-672
49. Shimizu, K., Shichiri, M., Libby, P., Lee, R. T. and Mitchell, R. N. (2004) Th2-predominant inflammation and blockade of IFN-γ signaling induce aneurysms in allografted aortas. J. Clin. Invest. 114, 300-308
50. Xiong, W., Zhao, Y., Prall, A., Greiner, T. C. and Baxter, B. T. (2004) Key roles of CD4+ T cells and IFN-γ in the development of abdominal aortic aneurysms in a murine model. J. Immunol. 172, 2607-2612