Changes in thyroid hormone metabolism and gene expression in the failing heart: Therapeutic implications

Thyroid and Heart Failure: From Pathophysiology to Clinics

Volumn , Issue , 2009, Pages 97-107

  Danzi, Sara ^a,b   Klein, Irwin ^a,b  

^a NORTH SHORE UNIVERSITY HOSPITAL   (United States)

^b FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

Author keywords

Amiodarone; Analogues; Atrial fibrillation; Autoimmune; Cardiac myocyte; Deiodinase; Elderly; Heart failure; Hyperlipidemia; Hypertrophy; LDL cholesterol; Low T3 syndrome; Myocardial infarction; Nonthyroidal illness; Pulmonary hypertension; QT; Skeletal muscle; Subclinical thyroid disease

Indexed keywords

EID: 84891458737     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-88-470-1143-4_10     Document Type: Chapter

References (57)

1. Klein I, Danzi S (2007) Thyroid disease and the heart. Circulation 116:1725-1735
2. Klein I, Ojamaa K (2001) Thyroid hormone and the cardiovascular system. N Engl J Med 344:501-509
3. Dillmann WH (2002) Cellular action of thyroid hormone on the heart. Thyroid 12:447-452
4. Kahaly GJ, Dillmann WH (2005) Thyroid hormone action in the heart. Endocrine Rev 26:704-728
5. Levey GS, Klein I (1994) Disorders of the thyroid. In: Stein's Textbook of medicine, 2nd edn. Little Brown, Boston, pp 1383-1396
6. Crowley WF Jr, Ridgway EC, Bough EW et al (1977) Noninvasive evaluation of cardiac function in hypothy-roidism. Response to gradual thyroxine replacement. N Engl J Med 296:1-6
7. Klein I (2008) Endocrine disorders and cardiovascular disease. In: Libby P, Bonow R, Mann D, Zipes D (eds) Braun-wald's Heart disease, 8th edn. Saunders, Philadelphia, pp 2033-2047
8. Danzi S, Klein I (2006) Treatment of hypertension and thyroid disease. In: Mohler ER, Townsend RR (eds) Advanced therapy in hypertension and vascular disease. BC Decker, Hamilton, Ontario, Canada, pp 354-360
9. Cappola AR, Ladenson PW (2003) Hypothyroidism and atherosclerosis. J Clin Endocrinol Metab 88:2438-2444
10. Danzi S, Klein I (2003) Thyroid hormone and blood pressure regulation. Curr Hypertens Rep 5:513-520
11. Biondi B, Palmieri EA, Lombardi G, Fazio S (2002) Effects of thyroid hormone on cardiac function: the relative importance of heart rate, loading conditions, and myocardial contractility in the regulation of cardiac performance in human hyperthyroidism. J Clin Endocrinol Metab 87:968-974
12. Nakazawa H, Lythall DA, Noh J et al (2000) Is there a place for the late cardioversion of atrial fibrillation? A long-term follow-up study of patients with post-thyrotoxic atrial fibrillation. Eur Heart J 21:327-333
13. Olsen B, Klein I, Benner R et al (1991) Hyperthyroid my-opathy and the response to treatment. Thyroid 1:137-141
14. Napoli R, Biondi B, Guardasole V et al (2001) Impact of hyperthyroidism and its correction on vascular reactivity in humans. Circulation 104:3076-3080
15. Prisant LM, Gujral JS, Mulloy AL (2006) Hyperthyroidism: a secondary cause of isolated systolic hypertension. J Clin Hypertens 8:596-599
16. Palmieri EA, Fazio S, Palmieri V et al (2004) Myocardial contractility and total arterial stiffness in patients with overt hyperthyroidism: acute effects of beta1-adrenergic blockade. Eur J Endocrinol 150:757-62.
17. Asvold BO, Bjoro T, Nilsen T, Vatten LJ (2007) Association between blood pressure and serum TSH concentration within the reference range: a population-based study. J Clin Endocrinol Metab 92:841-5
18. Marcisz C, Jonderko G, Kucharz EJ (2001) Influence of short-time application of a low sodium diet on blood pressure in patients with hyperthyroidism or hypothyroidism during therapy. Am J Hypertens 14:995-1002
19. Hoit BD, Khoury SF, Shao Y et al (1997) Effects of thyroid hormone on cardiac b-adrenergic responsiveness in conscious baboons. Circulation 96:592-598
20. Laragh JH, Sealey JE (2003) Relevance of the plasma renin hormonal control system that regulates blood pressure and sodium balance for correctly treating hypertension and for evaluating ALLHAT. Am J Hypertens 16:407-415
21. Hak AE, Pols HA, Visser TJ et al (2000) Subclinical hy-pothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study. Ann Intern Med 132:270-278
22. Razvi S, Ingoe L, Keeka G et al (2007) The beneficial effect of l-thyroxine on cardiovascular risk factors, endothe-lial function and quality of life in subclinical hypothy-roidism: randomised, crossover trial. J Clin Endocrinol Metab 92:1715-1723
23. Biondi B, Klein I (2004) Hypothyroidism as a risk factor for cardiovascular disease. Endocrine 24:1-14
24. Auer J, Scheibner P, Mische T et al (2001) Subclinical hy-perthyroidism as a risk factor for atrial fibrillation. Am Heart J 142:838-842
25. Sawin CT, Geller A, Wolf PA et al (1994) Low serum thy-rotropin concentrations as a risk factor for atrial fibrillation in older persons. N Engl J Med 331:1249-1252
26. Brent G (1994) The molecular basis of thyroid hormone action. N Engl J Med 331:847-853
27. Lazar MA, Chin WW (1990) Nuclear thyroid hormone receptors. J Clin Invest 86:1777-1782
28. Hu X, Lazar MA (2000) Transcriptional repression by nuclear hormone receptors. Trends Endocrinol Metab 11:6-10
29. Haddad F, Bodell PW, Qin AX et al (2003) Role of antisense RNA in coordinating cardiac myosin heavy chain gene switching. J Biol Chem 278:37132-37138
30. Danzi S, Klein S, Klein I (2008) Differential regulation of myosin heavy chain genes a and b in the rat atria and ventricles: role of antisense RNA. Thyroid 18:761-768
31. Wu Y, Koenig RJ (2000) Gene regulation by thyroid hormone. Trends Endocrinol Metab 11:207-211
32. Davis PJ, Davis FB (2002) Nongenomic actions of thyroid hormone on the heart. Thyroid 12:459-466
33. Hiroi Y, Kim H-H, Ying H et al (2006) Rapid nongenom-ic actions of thyroid hormone. Proc Natl Acad Sci USA 103:14104-14109
34. Bianco AC, Salvatore D, Gereben B et al (2002) Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocrine Rev 23:38-89
35. Maia AL, Kim BW, Huang SA et al (2005) Type 2 iodothy-ronine deiodinase is the major source of plasma T3 in eu-thyroid humans. J Clin Invest 115:2524-2533
36. Bianco AC, Larsen PR (2005) Cellular and structural biology of the deiodinases. Thyroid 15:777-786
37. Katzeff HL, Powell SR, Ojamaa K (1997) Alterations in cardiac contractility and gene expression during low-T3 syndrome: prevention with T3. Am J Physiol 273:E951-956
38. Schmidt-Ott UM, Ascheim DD (2006) Thyroid hormone and heart failure. Curr Heart Fail Rep 3:114-119
39. Pingitore A, Landi P, Taddei MC et al (2005) Triiodothy-ronine levels for risk stratification of patients with chronic heart failure. Am J Med 118:132-136
40. Yu J, Koenig RJ (2006) Induction of type 1 iodothyronine deiodinase to prevent the nonthyroidal illness syndrome in mice. Endocrinology 147:3580-3585
41. Olivares EL, Marassi MP, Fortunato RS et al (2007) Thyroid function disturbance and type 3 iodothyronine deiod-inase induction after myocardial infarction in rats: a time course study. Endocrinology 148:4786-4792
42. Duntas LH (2002) Thyroid disease and lipids. Thyroid 12:287-293
43. Thompson GR, Soutar AK, Spengel FA et al (1981) Defects of receptor-mediated low density lipoprotein catabolism in homozygous familial hypercholesterolemia and hypothy-roidism in vivo. Proc Natl Acad Sci U S A 78:2591
44. Harjai KJ, Licata AA (2006) Effects of amiodarone on thyroid function. Ann Intern Med 126:63-73
45. Marvisi M, Zambrelli P, Brianti M et al (2006) Pulmonary hypertension is frequent in hyperthyroidism and normalizes after therapy. Eur J Intern Med 17:267-271
46. Paran Y, Nimrod A, Goldin Y, Justo D (2006) Pulmonary hypertension and predominant right heart failure in thyro-toxicosis. Resuscitation 69:339-341
47. Morkin E, Pennock G, Spooner PH et al (2002) Pilot studies on the use of 3, 5-diiodothyropropionic acid, a thyroid hormone analog, in the treatment of congestive heart failure. Cardiology 97:218-225
48. Henderson KK, Danzi S, Klein I, Samarel A (2009) Physiological replacement of T3 improves left ventricular function in an animal model of myocardial infarction-induced congestive heart failure. Circ Heart Fail (in press)
49. Ojamaa K, Kenessey A, Shenoy R, Klein I (2000) Thyroid hormone metabolism and cardiac gene expression after acute myocardial infarction in the rat. Am J Physiol 279:E1319-1324
50. Thomas TA, Kuzman JA, Anderson BE et al (2005) Thyroid hormones induce unique and potentially beneficial changes in cardiac myocyte shape in hypertensive rats near heart failure. Am J Physiol Heart Circ Physiol 288:H2118-2122
51. Khalife WI, Tang YD, Kuzman JA et al (2005) Treatment of subclinical hypothyroidism reverses ischemia and prevents myocyte loss and progressive LV dysfunction in hamsters with dilated cardiomyopathy. Am J Physiol Heart Circ Physiol 289:H2409-2415
52. Danzi S, Klein I (2004) Thyroid hormone and the cardiovascular system. Minerva Endocrinol 29:139-150
53. Morkin E, Pennock GD, Spooner PH et al (2002) Clinical and experimental studies on the use of 3, 5-diiodothyropro-pionic acid, a thyroid hormone analogue, in heart failure. Thyroid 12:527-533
54. Hamilton MA, Stevenson LW, Luu M, Walden JA (1990) Altered thyroid hormone metabolism in advanced heart failure. J Am Coll Cardiol 16:91-95
55. Klemperer J, Klein I, Gomez M et al (1995) Thyroid hormone treatment after coronary-artery bypass surgery. New Engl J Med 333:1522-1527
56. Chowdhury D, Parnell VA, Ojamaa K et al (1999) Usefulness of triiodothyronine (T3) treatment after surgery for complex congenital heart disease in infants and children. Am J Cardiol 84:34-36
57. Pingitore A, Galli E, Barison A et al (2008) Acute effects of triiodothyronine (T3) replacement therapy in patients with chronic heart failure and low-T3 syndrome: a randomized, placebo-controlled study. J Clin Endocrinol Metab 93:1351-1358