Treatment of subclinical hypothyroidism reverses ischemia and prevents myocyte loss and progressive LV dysfunction in hamsters with dilated cardiomyopathy

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 289, Issue 6 58-6, 2005, Pages

  Khalife, Wissam I ^a   Tang, Yi Da ^a   Kuzman, James A ^a   Thomas, Tracy A ^a   Anderson, Brent E ^a   Said, Suleman ^a   Tille, Patricia ^a   Schlenker, Evelyn H ^a   Martin Gerdes, A ^a  

^a UNIVERSITY OF SOUTH DAKOTA   (United States)

Author keywords

Blood flow; Fibrosis; Remodeling; Thyroid hormones

Indexed keywords

THYROID HORMONE; THYROTROPIN; THYROXINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL SIZE; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DISEASE COURSE; ECHOCARDIOGRAPHY; HAMSTER; HEART LEFT VENTRICLE FAILURE; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART MUSCLE ISCHEMIA; HEART RATE; HEART VENTRICLE REMODELING; HEMODYNAMICS; HYPOTHYROIDISM; MALE; NONHUMAN; PRIORITY JOURNAL; THYROTROPIN BLOOD LEVEL; TISSUE NECROSIS;

ANIMALS; CARDIOMYOPATHY, DILATED; CELLS, CULTURED; CRICETINAE; DISEASE PROGRESSION; HYPOTHYROIDISM; MESOCRICETUS; MUSCLE CELLS; THYROID HORMONES; TREATMENT OUTCOME; VENTRICULAR DYSFUNCTION, LEFT;

EID: 28144436302     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00483.2005     Document Type: Article

References (38)

1. Campbell SE and Gerdes AM. Regional differences in cardiac myocyte dimensions and number in Sprague-Dawley rats from different suppliers. Proc Soc Exp Biol Med 186: 211-217, 1987.
2. 2+-ATPaSe and α-myosin heavy chain in rat hearts. J Clin Invest 100: 1742-1749, 1997.
3. Chen WJ, Lin KH, and Lee YS. Molecular characterization of myocardial fibrosis during hypothyroidism: evidence for negative regulation of the pro-α1(I) collagen gene expression by thyroid hormone receptor. Mol Cell Endocrinol 162: 45-55, 2000.
4. Chilian WM, Wangler RD, Peters KG, Tomanek RJ, and Marcus ML. Thyroxine-induced left ventricular hypertrophy in the rat. Anatomical and physiological evidence for angiogenesis. Circ Res 57: 591-598, 1985.
5. Davis FB, Mousa SA, O'Connor L, Mohamed S, Lin HY, Cao HJ, and Davis PJ. Proangiogenic action of thyroid hormone is fibroblast growth factor-dependent and is initiated at the cell surface. Circ Res 94: 1500-1506, 2004.
6. Franklyn JA, Gammage MD, Ramsden DB, and Sheppard MC. Thyroid status in patients after acute myocardial infarction. Clin Sci (Lond) 67: 585-590, 1984.
7. Gerdes AM and Kasten FH. Morphometric study of endomyocardium and epimyocardium of the left ventricle in adult dogs. Am J Anat 159: 389-394, 1980.
8. Gerdes AM, Moore JA, Hines JM, Kirkland PA, and Bishop SP. Regional differences in myocyte size in normal rat heart. Anat Rec 215: 420-426, 1986.
9. Graettinger JS, Muenster JJ, Checchia CS, Grissom RL, and Campbell JA. A correlation of clinical and hemodynamic studies in patients with hypothyroidism. J Clin Invest 37: 502-510, 1958.
10. Hak AE, Pols HA, Visser TJ, Drexhage HA, Hofman A, and Witteman JC. Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study. Ann Intern Med 132: 270-278, 2000.
11. Hamilton MA, Stevenson LW, Fonarow GC, Steimle A, Goldhaber JI, Child JS, Chopra IJ, Moriguchi JD, and Hage A. Safety and hemodynamic effects of intravenous triiodothyronine in advanced congestive heart failure. Am J Cardiol 81: 443-447, 1998.
12. Hamilton MA, Stevenson LW, Luu M, and Walden JA. Altered thyroid hormone metabolism in advanced heart failure. J Am Coll Cardiol 16: 91-95, 1990.
13. Heron MI and Rakusan K. Short- and long-term effects of neonatal hypo- and hyperthyroidism on coronary arterioles in rat. Am J Physiol Heart Circ Physiol 271: H1746-H1754, 1996.
14. 3 syndrome: a strong prognostic predictor of death in patients with heart disease. Circulation 107: 708-713, 2003.
15. Kinugawa K, Minobe WA, Wood WM, Ridgway EC, Baxter JD, Ribeiro RC, Tawadrous MF, Lowes BA, Long CS, and Bristow MR. Signaling pathways responsible for fetal gene induction in the failing human heart: evidence for altered thyroid hormone receptor gene expression. Circulation 103: 1089-1094, 2001.
16. Kinugawa K, Yonekura K, Ribeiro RC, Eto Y, Aoyagi T, Baxter JD, Camacho SA, Bristow MR, Long CS, and Simpson PC. Regulation of thyroid hormone receptor isoforms in physiological and pathological cardiac hypertrophy. Circ Res 89: 591-598, 2001.
17. Klein I and Ojamaa K. Thyroid hormone and the cardiovascular system. N Engl J Med 344: 501-509, 2001.
18. Klein I and Ojamaa K. Thyroid hormone and the cardiovascular system: from theory to practice. J Clin Endocrinol Metab 78: 1026-1027, 1994.
19. Kopecky J, Sigurdson L, Park IR, and Himms-Hagen J. Thyroxine 5′-deiodinase in brown adipose tissue of myopathic hamsters. Am J Physiol Endocrinol Metab 251: E8-E13, 1986.
20. Liu Z, Hilbelink DR, Crockett WB, and Gerdes AM. Regional changes in hemodynamics and cardiac myocyte size in rats with aortocaval fistulas. 1. Developing and established hypertrophy. Circ Res 69: 52-58, 1991.
21. Manowitz NR, Mayor GH, Klepper MJ, and DeGroot LJ. Subclinical hypothyroidism and euthyroid sick syndrome in patients with moderate-to-severe congestive heart failure. Am J Ther 3: 797-801, 1996.
22. Moruzzi P, Doria E, and Agostoni PG. Medium-term effectiveness of L-thyroxine treatment in idiopathic dilated cardiomyopathy. Am J Med 101: 461-467, 1996.
23. Ojamaa K, Kenessey A, Shenoy R, and Klein I. Thyroid hormone metabolism and cardiac gene expression after acute myocardial infarction in the rat. Am J Physiol Endocrinol Metab 279: E1319-E1324, 2000.
24. Panchal BC and Trippodo NC. Systemic and regional haemodynamics in conscious BIO T0-2 cardiomyopathic hamsters. Cardiovasc Res 27: 2264-2269, 1993.
25. Raab S, Thein E, Harris AG, and Messmer K. A new sample-processing unit for the fluorescent microsphere method. Am J Physiol Heart Circ Physiol 276: H1801-H1806, 1999.
26. Ryoke T, Gu Y, Ikeda Y, Martone ME, Oh SS, Jeon ES, Knowlton KU, and Ross J Jr. Apoptosis and oncosis in the early progression of left ventricular dysfunction in the cardiomyopathic hamster. Basic Res Cardiol 97: 65-75, 2002.
27. Sakamoto A, Ono K, Abe M, Jasmin G, Eki T, Murakami Y, Masaki T, Toyo-oka T, and Hanaoka F. Both hypertrophic and dilated cardiomyopathies are caused by mutation of the same gene, δ-sarcoglycan, in hamster: an animal model of disrupted dystrophin-associated glycoprotein complex. Proc Natl Acad Sci USA 94: 13873-13878, 1997.
28. Schlenker EH, Tamura T, and Gerdes AM. Gender-specific effects of thyroid hormones on cardiopulmonary function in SHHF rats. J Appl Physiol 95: 2292-2298, 2003.
29. Sole MJ and Liew CC. Catecholamines, calcium and cardiomyopathy. Am J Cardiol 62: 20G-24G, 1988.
30. Thomas TA, Kuzman JA, Anderson BE, Andersen SM, Schlenker EH, Holder MS, and Gerdes AM. Thyroid hormones induce unique and potentially beneficial changes in cardiac myocyte shape in hypertensive rats near heart failure. Am J Physiol Heart Circ Physiol 288: H2118-H2122, 2005.
31. Tidholm A, Falk T, Gundler S, Svensson H, Ablad B, and Sylven C. Effect of thyroid hormone supplementation on survival of euthyroid dogs with congestive heart failure due to systolic myocardial dysfunction: a double-blind, placebo-controlled trial. Res Vet Sci 75: 195-201, 2003.
32. Tomanek RJ, Connell PM, Butters CA, and Torry RJ. Compensated coronary microvascular growth in senescent rats with thyroxine-induced cardiac hypertrophy. Am J Physiol Heart Circ Physiol 268: H419-H425, 1995.
33. Tomanek RJ, Zimmerman MB, Suvarna PR, Morkin E, Pennock GD, and Goldman S. A thyroid hormone analog stimulates angiogenesis in the post-infarcted rat heart. J Mol Cell Cardiol 30: 923-932, 1998.
34. Wang X, Zheng W, Christensen LP, and Tomanek RJ. DITPA stimulates bFGF, VEGF, angiopoietin, and Tie-2 and facilitates coronary arteriolar growth. Am J Physiol Heart Circ Physiol 284: H613-H618, 2003.
35. Wassen FW, Schiel AE, Kuiper GG, Kaptein E, Bakker O, Visser TJ, and Simonides WS. Induction of thyroid hormone-degrading deiodinase in cardiac hypertrophy and failure. Endocrinology 143: 2812-2815, 2002.
36. Wilson TA, Nicolosi RJ, Lawton CW, and Babiak J. Gender differences in response to a hypercholesterolemic diet in hamsters: effects on plasma lipoprotein cholesterol concentrations and early aortic atherosclerosis. Atherosclerosis 146: 83-91, 1999.
37. Yao J and Eghbali M. Decreased collagen gene expression and absence of fibrosis in thyroid hormone-induced myocardial hypertrophy. Response of cardiac fibroblasts to thyroid hormone in vitro. Circ Res 71: 831-839, 1992.
38. Zheng W, Weiss RM, Wang X, Zhou R, Arlen AM, Lei L, Lazartigues E, and Tomanek RJ. DITPA stimulates arteriolar growth and modifies myocardial postinfarction remodeling. Am J Physiol Heart Circ Physiol 286: H1994-H2000, 2004.