Long-term pulmonary responses to quadweekly intermittent intratracheal spray instillations of magnetite (Fe3O4) nanoparticles for 52 weeks in fischer 344 rats

Journal of Toxicologic Pathology

Volumn 26, Issue 4, 2013, Pages 393-403

  Tada, Yukie ^a   Yano, Norio ^a   Takahashi, Hiroshi ^a   Yuzawa, Katsuhiro ^a   Ando, Hiroshi ^a   Kubo, Yoshikazu ^a   Nagasawa, Akemichi ^a   Inomata, Akiko ^a   Ogata, Akio ^a   Nakae, Dai ^a,b  

^a TOKYO METROPOLITAN INSTITUTE OF PUBLIC HEALTH   (Japan)

^b TOKYO UNIVERSITY OF AGRICULTURE   (Japan)

Author keywords

Fe3O4; Fischer 344 rat; Intratracheal spray instillation; Lung; Magnetite; Nanoparticles

Indexed keywords

BETA CATENIN; MAGNETITE NANOPARTICLE;

ACUTE PHASE RESPONSE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOPLASM; FEMALE; HISTOPATHOLOGY; HYPERPLASIA; LUNG ALVEOLUS MACROPHAGE; LUNG WEIGHT; LYMPH NODE; MALE; NONHUMAN; PHAGOCYTOSIS; PNEUMONIA; PROTEIN EXPRESSION; RAT; SEX DIFFERENCE;

EID: 84891423050     PISSN: 09149198     EISSN: None     Source Type: Journal    
DOI: 10.1293/tox.2013-0036     Document Type: Article

References (32)

1. Hood E. Nanotechnology: looking as we leap. Environ Health Perspect. 112: A740-A749. 2004. [Medline] [Cross-Ref]
2. Lin BL, Shen XD, and Cui S. Application of nanosized Fe3O4 in anticancer drug carriers with target-orientation and sustained-release properties. Biomed Mater. 2: 132-134. 2007. [Medline] [CrossRef]
3. Kikumori T, Kobayashi T, Sawaki M, and Imai T. Anti-cancer effect of hyperthermia on breast cancer by magnetite nanoparticle-loaded anti-HER2 immunoliposomes. Breast Cancer Res Treat. 113: 435-441. 2009. [Medline] [Cross-Ref]
4. Hilger I, and Kaiser WA. Iron oxide-based nanostructures for MRI and magnetic hyperthermia. Nanomedicine (Lond). 7: 1443-1459. 2012. [Medline] [CrossRef]
5. Hong SC, Lee JH, Lee J, Kim HY, Park JY, Cho J, Lee J, and Han DW. Subtle cytotoxicity and genotoxicity differences in superparamagnetic iron oxide nanoparticles coated with various functional groups. Int J Nanomedicine. 6: 3219-3231. 2011. [Medline]
6. Könczöl M, Ebeling S, Goldenberg E, Treude F, Gminski R, Gieré R, Grobéty B, Rothen-Rutishauser B, Merfort I, and Mersch-Sundermann V. Cytotoxicity and genotoxicity of size-fractionated iron oxide (magnetite) in A549 human lung epithelial cells: Role of ROS, JNK, and NF-κB. Chem Res Toxicol. 24: 1460-1475. 2011. [Medline] [CrossRef]
7. Slesinski RS, and Turnbull D. Chronic inhalation exposure of rats for up to 104 weeks to a non-carbon-based magnetite photocopying toner. Int J Toxicol. 27: 427-439. 2008. [Medline] [CrossRef]
8. Pauluhn J. Subchronic inhalation toxicity of iron oxide (magnetite, Fe3O4) in rats: pulmonary toxicity is determined by the particle kinetics typical of poorly soluble particles. J Appl Toxicol. 32: 488-504. 2012. [Medline] [CrossRef]
9. Chen BA, Jin N, Wang J, Ding J, Gao C, Cheng J, Xia G, Gao F, Zhou Y, Chen Y, Zhou G, Li X, Zhang Y, Tang M, and Wang X. The effect of magnetic nanoparticles of Fe3O4 on immune function in normal ICR mice. Int J Nanomedicine. 5: 593-599. 2010. [Medline] [CrossRef]
10. Pott F, Ziem U, Reiffer FJ, Huth F, Ernst H, and Mohr U. Carcinogenicity studies on fibres, metal compounds, and some other dusts in rats. Exp Pathol. 32: 129-152. 1987. [Medline] [CrossRef]
11. Steinhoff D, Mohr U, and Hahnemann S. Carcinogenesis studies with iron oxides. Exp Pathol. 43: 189-194. 1991. [Medline] [CrossRef]
12. Tada Y, Yano N, Takahashi H, Yuzawa K, Ando H, Kubo Y, Nagasawa A, Ogata A, and Nakae D. Acute phase pulmonary responses to a single intratracheal spray instillation of magnetite (Fe3O4) nanoparticles in Fischer 344 rats. J Toxicol Pathol. 25: 233-239. 2012. [Medline] [CrossRef]
13. Singh N, Jenkins GJ, Asadi R, and Doak SH. Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION). Nano Rev. 1: 5358-5373. 2010. [Medline]
14. Ramesh V, Ravichandran P, Copeland CL, Gopikrishnan R, Biradar S, Goornavar V, Ramesh GT, and Hall JC. Magnetite induces oxidative stress and apoptosis in lung epithelial cells. Mol Cell Biochem. 363: 225-234. 2012. [Medline] [CrossRef]
15. Organisation for Economic Co-operation and Development (OECD). List of Manufactured Nanomaterials and List of Endpoints for Phase One of the Sponsorship Programme for the Testing of Manufactured Nanomaterials: Revision. Paris. 1-16. 2010.
16. Japanese Association for Laboratory Animal Science (JALAS) Guidelines for animal experimentation. Exp Anim. 36: 285-288. 1987.
17. Driscoll KE, Costa DL, Hatch G, Henderson R, Oberdorster G, Salem H, and Schlesinger RB. Intratracheal instillation as an exposure technique for the evaluation of respiratory tract toxicity: uses and limitations. Toxicol Sci. 55: 24-35. 2000. [Medline] [CrossRef]
18. Gad SC, and Weil CS. Statistics for toxicologist. In: Principles and Methods of Toxicology, 3rd ed. AW Hayes (ed). Raven Press, New York. 221-274. 1994.
19. Nettesheim P, and Szakal AK. Morphogenesis of alveolar bronchiolization. Lab Invest. 26: 210-219. 1972. [Medline]
20. Baskerville A, Thomas G, Wood M, and Harris WJ. Histology and ultrastructure of metaplasia of alveolar epithelium following infection of mice and hamsters with influenza virus. Br J Exp Pathol. 55: 130-137. 1974. [Medline]
21. Pinkerton KE, Dodge DE, Cederdahl-Demmler J, Wong VJ, Peake J, Haselton CJ, Mellick PW, Singh G, and Plopper CG. Differentiated bronchiolar epithelium in alveolar ducts of rats exposed to ozone for 20 months. Am J Pathol. 142: 947-956. 1993. [Medline]
22. Fukuda Y, Takemura T, and Ferrans VJ. Evolution of metaplastic squamous cells of alveolar walls in pulmonary fibrosis produced by paraquat. Virchows Arch B. 58: 27-43. 1989. [Medline] [CrossRef]
23. Jensen-Taubman SM, Steinberg SM, and Linnoila RI. Bronchiolization of the alveoli in lung cancer: pathology, patterns of differentiation and oncogene expression. Int J Cancer. 75: 489-496. 1998. [Medline] [CrossRef]
24. Dixon D, Herbert RA, Sills RC, and Boorman GA. Lungs, pleura, and mediastinum. In: Pathology of the Mouse: Reference and Atlas. RR Maronpot, GA Boorman, and BW Gaul (eds). Cache River, Vienna. 293-332. 1999.
25. Ballaz S, and Mulshine JL. The potential contributions of chronic inflammation to lung carcinogenesis. Clin Lung Cancer. 5: 46-62. 2003. [Medline] [CrossRef]
26. Simon RH, and Paine R. Participation of pulmonary alveolar epithelial cells in lung inflammation. J Lab Clin Med. 126: 108-118. 1995. [Medline]
27. Shacter E, and Weitzman SA. Chronic inflammation and cancer. Oncology. 16: 217-226, 229-232. 2002. [Medline]
28. Kawanishi M, Ogo S, Ikemoto M, Totsuka Y, Ishino K, Wakabayahsi K, and Yagi T. Genotoxicity and reactive oxygen species production induced by magnetite nanoparticles in mammalian cells. J Toxicol Sci. 2013; in press. [Medline] [CrossRef]
29. Ilyas M, and Tomlinson IPM. The interactions of APC, Ecadherin and β-catenin in tumor development and progression. J Pathol. 182: 128-137. 1997. [Medline] [CrossRef]
30. Tsujiuchi T, Tsutsumi M, Sasaki Y, Murata N, and Konishi Y. Mutations of adenomatous polyposis coli and betacatenin genes during progression of lung tumors induced by N-nitrosobis(2-hydroxypropyl)amine in rats. Cancer Res. 60: 6611-6616. 2000. [Medline]
31. Takahashi M, Fukuda K, Sugimura T, and Wakabayashi K. Beta-catenin is frequently mutated and demonstrates altered cellular location in azoxymethane-induced rat colon tumors. Cancer Res. 58: 42-46. 1998. [Medline]
32. Takahashi M, Mutoh M, Kawamori T, Sugimura T, and Wakabayashi K. Altered expression of beta-catenin, inducible nitric oxide synthase and cyclooxygenase-2 in azoxymethane-induced rat colon carcinogenesis. Carcinogenesis. 21: 1319-1327. 2000. [Medline] [CrossRef]