Acute phase pulmonary responses to a single intratracheal spray instillation of magnetite (Fe3O4) nanoparticles in fischer 344 rats

Journal of Toxicologic Pathology

Volumn 25, Issue 4, 2012, Pages 233-239

  Tada, Yukie ^a   Yano, Norio ^a   Takahashi, Hiroshi ^a   Yuzawa, Katsuhiro ^a   Ando, Hiroshi ^a   Kubo, Yoshikazu ^a   Nagasawa, Akemichi ^a   Ogata, Akio ^a   Nakae, Dai ^a,b  

^a TOKYO METROPOLITAN INSTITUTE OF PUBLIC HEALTH   (Japan)

^b TOKYO UNIVERSITY OF AGRICULTURE   (Japan)

Author keywords

Fe3O4; Fischer 344 rat; Intratracheal spray instillation; Lung; Magnetite; Nanoparticles

Indexed keywords

MAGNETITE NANOPARTICLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHUS MUCOSA; CELL COUNT; CELL INFILTRATION; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; FISCHER 344 RAT; FOREIGN BODY REACTION; GOBLET CELL; HISTOPATHOLOGY; INFLAMMATORY CELL; INTRATRACHEAL DRUG ADMINISTRATION; LUNG ALVEOLUS MACROPHAGE; LUNG GRANULOMA; LUNG INFILTRATE; LUNG WEIGHT; MALE; NONHUMAN; PHAGOCYTOSIS; PNEUMONIA; RAT;

EID: 84871812477     PISSN: 09149198     EISSN: None     Source Type: Journal    
DOI: 10.1293/tox.25.233     Document Type: Article

References (25)

1. Hood E. Nanotechnology: looking as we leap. Environ Health Perspect. 112: A740-A749. 2004. [Medline] [Cross-Ref]
2. Torres-Martínez CL, Kho R, Mian OI, and Mehra RK. Efficient photocatalytic degradation of environmental pollutants with mass-produced ZnS nanocrystals. J Colloid Interface Sci. 240: 525-532. 2001. [Medline] [CrossRef]
3. Lin BL, Shen XD, and Cui S. Application of nanosized Fe3O4 in anticancer drug carriers with target-orientation and sustained-release properties. Biomed Mater. 2: 132-134. 2007. [Medline] [CrossRef]
4. Gang J, Park SB, Hyung W, Choi EH, Wen J, Kim HS, Shul YG, Haam S, and Song SY. Magnetic poly epsilon-caprolactone nanoparticles containing Fe3O4 and gemcitabine enhance anti-tumor effect in pancreatic cancer xenograft mouse model. J Drug Target. 15: 445-453. 2007. [Medline] [CrossRef]
5. Kikumori T, Kobayashi T, Sawaki M, and Imai T. Anti-cancer effect of hyperthermia on breast cancer by magnetite nanoparticle-loaded anti-HER2 immunoliposomes. Breast Cancer Res Treat. 113: 435-441. 2009. [Medline] [Cross-Ref]
6. Takada T, Yamashita T, Sato M, Sato A, Ono I, Tamura Y, Sato N, Miyamoto A, Ito A, Honda H, Wakamatsu K, Ito S, and Jimbow K. Growth inhibition of re-challenge B16 melanoma transplant by conjugates of melanogenesis substrate and magnetite nanoparticles as the basis for developing melanoma-targeted chemo-thermo-immunotherapy. J Biomed Biotechnol. 2009: 457936. 2009. [Medline] [Cross-Ref]
7. Kawai N, Futakuchi M, Yoshida T, Ito A, Sato S, Naiki T, Honda H, Shirai T, and Kohri K. Effect of heat therapy using magnetic nanoparticles conjugated with cationic liposomes on prostate tumor in bone. Prostate. 68: 784-792. 2008. [Medline] [CrossRef]
8. Ito A, Tanaka K, Honda H, Abe S, Yamaguchi H, and Kobayashi T. Complete regression of mouse mammary carcinoma with a size greater than 15 mm by frequent repeated hyperthermia using magnetite nanoparticles. J Biosci Bioeng. 96: 364-369. 2003. [Medline]
9. Xia Z, Wang G, Tao K, Li J, and Tian Y. Preparation and acute toxicology of nano-magnetic ferrofluid. J Huazhong Univ Sci Technolog Med Sci. 25: 59-61. 2005. [Medline] [CrossRef]
10. Jeng HA, and Swanson J. Toxicity of metal oxide nanoparticles in mammalian cells. J Environ Sci Health A Tox Hazard Subst Environ Eng. 41: 2699-2711. 2006. [Medline] [CrossRef]
11. Chen BA, Jin N, Wang J, Ding J, Gao C, Cheng J, Xia G, Gao F, Zhou Y, Chen Y, Zhou G, Li X, Zhang Y, Tang M, and Wang X. The effect of magnetic nanoparticles of Fe(3) O(4) on immune function in normal ICR mice. Int J Nanomedicine. 5: 593-599. 2010. [Medline] [CrossRef]
12. Pott F, Ziem U, Reiffer FJ, Huth F, Ernst H, and Mohr U. Carcinogenicity studies on fibres, metal compounds, and some other dusts in rats. Exp Pathol. 32: 129-152. 1987. [Medline] [CrossRef]
13. Steinhoff D, Mohr U, and Hahnemann S. Carcinogenesis studies with iron oxides. Exp Pathol. 43: 189-194. 1991. [Medline] [CrossRef]
14. Slesinski RS, and Turnbull D. Chronic inhalation exposure of rats for up to 104 weeks to a non-carbon-based magnetite photocopying toner. Int J Toxicol. 27: 427-439. 2008. [Medline] [CrossRef]
15. Zhu MT, Feng WY, Wang B, Wang TC, Gu YQ, Wang M, Wang Y, Ouyang H, Zhao YL, and Chai ZF. Comparative study of pulmonary responses to nano-and submicronsized ferric oxide in rats. Toxicology. 247: 102-111. 2008. [Medline] [CrossRef]
16. Zhou YM, Zhong CY, Kennedy IM, and Pinkerton KE. Pulmonary responses of acute exposure to ultrafine iron particles in healthy adult rats. Environ Toxicol. 18: 227-235. 2003. [Medline] [CrossRef]
17. Japanese Association for Laboratory Animal Science (JALAS) Guidelines for animal experimentation. Exp Anim. 36: 285-288. 1987.
18. Driscoll KE, Costa DL, Hatch G, Henderson R, Oberdorster G, Salem H, and Schlesinger RB. Intratracheal instillation as an exposure technique for the evaluation of respiratory tract toxicity: uses and limitations. Toxicol Sci. 55: 24-35. 2000. [Medline] [CrossRef]
19. Gad SC, and Weil CS. Statistics for toxicologist. In: Principles and Methods of Toxicology, 3rd ed. AW Hayes (ed). Raven Press, New York. 221-274. 1994.
20. Pauluhn J. Subchronic inhalation toxicity of iron oxide (magnetite, Fe(3) O(4) in rats: pulmonary toxicity is determined by the particle kinetics typical of poorly soluble particles. J Appl Toxicol. 32: 488-504. 2012. [Medline] [CrossRef]
21. Osier M, and Oberdorster G. Intratracheal inhalation vs intratracheal instillation: differences in particle effects. Fundam Appl Toxicol. 40: 220-227. 1997. [Medline] [Cross-Ref]
22. Yokohira M, Kuno T, Yamakawa K, Hashimoto N, Ninomiya F, Suzuki S, Saoo K, and Imaida K. An intratracheal instillation bioassay system for detection of lung toxicity due to fine particles in F344 rats. J Toxicol Pathol. 22: 1-10. 2009. [Medline]
23. Haschek WM, and Witschi HR. Respiratory system. In: Handbook of Toxicologic Pathology, Haschek WM, and Rousseaux CG (eds). Academic Press, San Diego. 761-827. 1991.
24. Lam CW, James JT, McCluskey R, and Hunter RL. Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation. Toxicol Sci. 77: 126-134. 2004. [Medline] [CrossRef]
25. Donaldson K, Li XY, and MacNee W. Ultrafine (nanometre particle mediated lung injury. J Aerosol Sci. 29: 553-560. 1998. [CrossRef]