Prevalence and associations of potentially inappropriate prescriptions in Austrian nursing home residents: Secondary analysis of a cross-sectional study

Wiener Klinische Wochenschrift

Volumn 125, Issue 7-8, 2013, Pages 180-188

  Mann, Eva ^a   Haastert, Burkhard ^b   Böhmdorfer, Birgit ^a,c   Frühwald, Thomas ^c   Iglseder, Bernhard ^a   Roller Wirnsberger, Regina ^d   Meyer, Gabriele ^e  

^a PARACELSUS MEDICAL UNIVERSITY   (Austria)

^b Neuenrade ^*  (Germany)

^c Krankenhaus Hietzing mit Neurologischem Zentrum Rosenhugel   (Austria)

^d MEDICAL UNIVERSITY OF GRAZ   (Austria)

^e UNIVERSITY OF WITTEN HERDECKE   (Germany)

Author keywords

Dementia; Inappropriate prescribing; Neuropsychiatric symptoms; Nursing home

Indexed keywords

DICLOFENAC; LORAZEPAM; PROTHIPENDYL; PSYCHOTROPIC AGENT;

ADULT; AGED; ARTICLE; ATTITUDE; AUSTRIA; COGNITIVE DEFECT; CROSS-SECTIONAL STUDY; HUMAN; INAPPROPRIATE PRESCRIBING; MALE; MIDDLE AGED; NURSING HOME; NURSING HOME PATIENT; PREVALENCE; RESIDENT; RESTLESSNESS; RURAL AREA; SECONDARY ANALYSIS; STAFF NURSE; URBAN AREA; VERY ELDERLY; AGE DISTRIBUTION; CLINICAL TRIAL; COGNITION DISORDERS; COMORBIDITY; FEMALE; MULTICENTER STUDY; NURSING CARE; PRESCRIPTION; PSYCHOMOTOR AGITATION; RISK ASSESSMENT; STATISTICS AND NUMERICAL DATA; STATISTICS;

ADULT; AGE DISTRIBUTION; AGED; AUSTRIA; COGNITION DISORDERS; COMORBIDITY; CROSS-SECTIONAL STUDIES; DICLOFENAC; FEMALE; HUMANS; INAPPROPRIATE PRESCRIBING; LORAZEPAM; MALE; MIDDLE AGED; NURSING CARE; NURSING HOMES; PRESCRIPTIONS; PREVALENCE; PSYCHOMOTOR AGITATION; PSYCHOTROPIC DRUGS; RISK ASSESSMENT;

EID: 84891374081     PISSN: 00435325     EISSN: 16137671     Source Type: Journal    
DOI: 10.1007/s00508-013-0342-2     Document Type: Article

References (56)

1. Onder G, Liperoti R, Fialova D, et al. SHELTER project. J Gerontol A Biol Sci Med Sci. 2012;67(6):698-704.
2. Kojima G, Bell C, Tamura B, et al. Reducing cost by reducing polypharmacy: the polypharmacy outcomes project. JAMDA. 2012;13(9):818e11-5.
3. Mangoni AA, Jackson SH. Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications. Br J Clin Pharmacol. 2004;57(1):6-14.
4. Leendertse AJ, Egberts AC, Stoker LJ, Van Den Bernt PM. HARM study Group. Frequency of and risk factors for preventable medication-related hospital admissions in the Netherlands. Arch Intern Med. 2008;168(17):1890-6.
5. Berdot S, Bertrand M, Dartigues JF, et al. Inappropriate medication use and risk of falls-A prospective study in a large community-dwelling elderly cohort. BMC Geriatr. 2009;9:30.
6. Fick DM, Mion LC, Beers MH, Waller JL. Health outcomes associated with potentially inappropriate medication use in older adults. Res Nurs Health. 2008;31(1):42-51.
7. Albert SM, Colombi A, Hanlon J. Potentially inappropriate medications and risk of hospitalization in retirees: analysis of a US retiree health claims database. Drugs Aging. 2010;27(5):407-15.
8. Ruggiero C, Dell'Auilla G, Gasperini B, et al. Potentially inappropriate drug prescriptions and risk of hospitalizations among older, Italian, nursing home residents: the ULISSE project. Drugs Aging. 2010;27(9):747-58.
9. Lin HY, Liao CC, Cheng SH, Wang PC, Hsueh YS. Association of potentially inappropriate medication use with adverse outcomes in ambulatory elderly patients with chronic diseases: experience in a Taiwanese medical setting. Drugs Aging. 2008;25(1):49-59.
10. Lau DT, Kasper JD, Potter EB, Lyles A, Bennett RG. Hospitalization and death associated with potentially inappropriate medication prescriptions among elderly nursing home residents. Arch Intern Med. 2005;165(1):68-74.
11. Fu AZ, Jiang JZ, Reeves JH, Fincham JE, Liu GG, Perri M 3rd. Potentially inappropriate medication use and healthcare expenditures in the US community-dwelling elderly. Med Care. 2007;45(5):472-6.
12. Barnett K, McCowan C, Evans JM, Gillespie ND, Davey PG, Fahey T. Prevalence and outcomes of use of potentially inappropriate medications in older people: cohort study stratified by residence in nursing home or in the community. BMJ Qual Saf. 2011;20(3):275-81.
13. Niwata S, Yamada Y, Ikegami N. Prevalence of inappropriate medication using Beers criteria in Japanese long-term care facilities. BMC Geriatr. 2006;6:1.
14. Stafford AC, Alswayan MS, Tenni PC. Inappropriate prescribing in older residents of Australian care homes. J Clin Pharm Ther. 2011;36(1):33-44.
15. Kölzsch M, Kopke K, Fischer T, et al. Prescribing of inappropriate medication in nursing home residents in Germany according to a French consensus list: a crosssectional cohort study. Pharmacoepidemiol Drug Saf. 2011;20(1):12-9.
16. Haasum Y, Fastbom J, Johnell K. Institutionalization as a risk factor for inappropriate drug use in the elderly: a Swedish nationwide register-based study. Ann Pharmacother. 2012;46(3):339-46.
17. Johnell K, Weithoft GR, Fastbom, J. Sex differences in inappropriate drug use: a register-based study of over 600,000 older people. Ann Pharmacother. 2009;43(7):1233-8.
18. Mann E, Köpke S, Haastert B, Pitkälä K, Meyer G. Psychotropic drug use among nursing home residents in Austria: a cross-sectional study. BMC Geriatr. 2009;9:18.
19. Richter T, Mann E, Meyer G, Haastert B, Köpke S. Prevalence of psychotropic medication use among German and Austrian nursing home residents: a comparison of 3 cohorts. JAMDA. 2012;13(2):187.e7-187.e13.
20. Austrian Ministry of Social Welfare. Federal Act on Nursing Care, 110, 51. (Bundespflegegesetz, BGBl. 110/1993, text of 19 Jan. 1993) (SOZDOK ed.). Vienna, 51. 1998.
21. Köhler L, Weyerer S, Schäufele M. Proxy screening tools improve the recognition of dementia in old-Age homes: results of a validation study. Age Aging. 2007;36:549-54.
22. Cohen-Mansfield J. Agitated behaviours in the elderly. II. Preliminary results in the cognitively deteriorated. JAGS. 1986;34(10):722-7.
23. Mann E, Böhmdorfer B, Frühwald T, Roller-Wirnsberger RE, Dovjak P, Hofer-Dückelmann C, et al. Potentially inappropriate medication in geriatric patients: the Austrian consensus panel list. WKW. 2012;124(5-6):160-9.
24. Donner A, Klar N. Design and Analysis of Cluster Randomization. Trials in health research. London: Arnold; 2000.
25. Rogers WH. Regression standard errors in clustered samples. Stat Tech Bull. 1993;13:19-23.
26. Williams RL. A note on robust variance estimation for cluster- correlated data. Biometrics. 2000;56(2):645-6.
27. Bergman A, Olsson J, Carlstein A, Waern M, Fastbom J. Evaluation of the quality of drug therapy among elderly patients in nursing homes. Scand J Prim Health Care. 2007;25(1):9-14.
28. Douglas IJ, Smeeth L. Exposure to antipsychotics and risk of stroke: self-controlled case series studies. BMJ. 2008;337:a1227.
29. Gill SS, Bronskill SE, Normand SL, et al. Antipsychotic drug use and mortality in older adults with dementia. Ann Intern Med. 2007;146(11):775-86.
30. Schneider LS, Dagerman KS, Insel P. Risk of death with atypical antipsychotic drug treatment for dementia: metaanalysis of randomized placebo-controlled trials. JAMA. 2005;294(15):1934-43.
31. Tannenbaum C, Paquette A, Hilmer S, Holroyd-Leduc J, Carnahan R. A systematic review of amnestic and nonamnestic mild cognitive impairment induced by anticholinergic, antihistamine, GABAergic and opioid drugs. Drugs Aging. 2012;29(8):639-58.
32. Lader M. Benzodiazepine harm: how can it be reduced. Brit J Clin Pharmacol. 2012;doi:10.1111/j.1365-2125.2012. 04418.x (Epub ahead of print).
33. Huang AR, Mallet L, Rochefort CM, Equale T, Buckeridge DL, Tamblyn R. Medication-related falls in the elderly: causative factors and preventive strategies. Drugs Aging. 2012;29(5):359-76.
34. Hosia-Randell HM, Muuringen SM, Pitkälä KH. Exposure to potentially inappropriate drugs and drug-drug interactions in elderly nursing home residents in Helsinki, Finland: a cross-sectional study. Drugs Aging. 2008;25(8):683-92.
35. Raschetti R, Morgutti M, Menniti-Ippolit F, et al. Suspected adverse drug events requiring emergency department visits or hospital admissions. Eur J Clin Pharmacol. 1999;54(12):959-63.
36. Yu MK, Lyles CR, Bent-Shaw LA, Young BA. Risk factor, age and sex difference in chronic kidney disease prevalence in a diabetic cohort. Am J Nephrol. 2012;36(3):245-51.
37. Vega J, Goecke H, Méndez GP, Guarda FJ. Nephrotic syndrome and acute tubular necrosis due to meloxicam use. Ren Fail. 2012;34(10):1344-7.
38. Kristensen SL, Fosbol EL, Kamper AL, et al. Use of nonsteroidal anti-inflammarotry drugs prior to chronic renal replacement therapy initiation: a nationwide study. Pharmacoepidemiol Drug Saf. 2012;21(4):428-34.
39. Savva GM, Matthews FE, Davidson JE, McKeith I, Brayne C. Prevalence, correlates and course of behavioural and psychological symptoms of dementia in the population. Br J Psychiatry. 2009;194(3):212-9.
40. Cerejeira J, Lagarto L, Mukaetova-Ladinska EB. Behavioural and psychological symptoms of dementia. Front Neurol. 2012;3:73 (Epub ahead of print).
41. Levy K, Lanctot KL, Farber SB, Li A, Herrmann, N. Does pharmacological treatment of neuropsychiatric symptoms in Alzheimer's disease relieve caregiver burden. Drugs Aging. 2012;29(3):167-79.
42. Zuidema SU, De Jonghe JF, Verhey FR, Koopmans RT. Psychotropic drug prescription in nursing home patients with dementia: influence of environmental correlates and staff distress on physicians' prescription behaviour. Int Psychogeriatr. 2011;23(10):1632-9.
43. Gauthier S, Cummings J, Ballard C, et al. Management of behavioural symptoms in Alzheimer's disease. Int Psychogeriatr. 2010;22(3):346-72.
44. Ballard C, Day S, Sharp S, Wing C, Sorensen S. Neuropsychiatric symptoms in dementia: importance and treatment considerations. Int Rev Psychiatry. 2008;20(4):396-404.
45. Beers MH, Ouslander JG, Rollingher J, Reuben DB, Brooks J, Beck JC. Explicit criteria for determining inappropriate medication use in nursing home residents. Arch Int Med. 1991;151(9):1825-32.
46. McLeod PJ, Huang A, Tamblyn RM, Gayton DC. Defining inappropriate practices in prescribing for elderly people: a national consensus panel. CMAJ. 1997;156:385-91.
47. Laroche ML, Charmes JP, Merle L. Potentially inappropriate medications in the elderly: a French consensus panel list. Eur J Clin Pharmacol. 2007;63(8):725-31.
48. Gallagher P, Ryan C, Byrne S, Kennedy J, O'Mahony D. Screening tool of older person's prescriptions (STOPP) and screening tool to alert doctors to right treatment (START). Consensus validation. Int J Clin Pharmacol Therap. 2008;46(2):72-83.
49. Holt S, Schmiedl S, Thürmann PA. Potentially inappropriate medications in the elderly: the PRISCUS List. Dtsch Arztebl. 2010;107(31-32):543-51.
50. American Geriatrics Society 2012 Beers Criteria update expert panel. American Society updated Beers Criteria for potentially inappropriate medication use in older adults. JAGS. 2012;60(4):616-31.
51. Department of Health. 291591a/Living well with dementia: a national dementia strategy. DH Publications Orderline, PO Box 777, London SE1 6XH. www.orderline.dh.gov.uk. Accessed 4 Feb 2013.
52. Richter T, Meyer G, Möhler R, Köpke S. Psychosocial interventions for reducing antipsychotic medication in care home residents. Cochrane Database Syst Rev. 2012 Dec;12:12:CD008634. doi:10.1002/14651858.CD008634. pub2.
53. Fossey J, Ballard C, Juszczak E, James I, Alder N, Jacoby R, Howard R. Effect of enhanced psychosocial care on antipsychotic use in nursing home residents. BMJ. 2006;332:756-61.
54. Pitkälä K, Juola A, Soini H, Laakkonen M, Kauriainen H, Teramura-Gronblad M, Finne-Soveri H, Bjorkman M. Reducing inappropriate, anticholinergic and psychotropic drugs among older residents in assisted living facilities: study protocol for a randomized controlled trial. Trials 2102;13:85.
55. Müller C, Wilm S, Thürmann P, Thiem U, Hummers-Pradier E, Theile G. Die RIME Studie-eine clusterrandomisierte kontrollierte Studie zur Reduktion von potentiell inadäquater Medikation in der Hausarztpraxis. Düsseldorf: German Medical Science GMS Publishing House; 2011 (Doc1 1form067).
56. PRIMA-eDS. Polypharmacy in chronic diseases: reduction of inappropriate medication and adverse drug events in elderly populations by electronic decision support. European Commission Project Number 305388. http:// ec.europa.eu/research/health/medical-research/humandevelopment- and-Ageing/projects/prima-eds-en.html. Accessed 8 Feb 2013.