Characterization of the interleukin 1 receptor-associated kinase 4 (IRAK4)-encoding gene in salmonid fish: The functional copy is rearranged in Oncorhynchus mykiss and that factor can impair TLR signaling in mammalian cells

Fish and Shellfish Immunology

Volumn 36, Issue 1, 2014, Pages 206-214

  Brietzke, Andreas ^a   Goldammer, Tom ^a   Rebl, Henrike ^b   Korytář, Tomáš ^c   Köllner, Bernd ^c   Yang, Wei ^d   Rebl, Alexander ^a   Seyfert, Hans Martin ^a  

^a LEIBNIZ INSTITUTE FOR FARM ANIMAL BIOLOGY FBN   (Germany)

^b ROSTOCK UNIVERSITY MEDICAL CENTER   (Germany)

^c FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Aeromonas salmonicida; Innate immunity; Myddosome; Rainbow trout; Toll like receptor

Indexed keywords

AEROMONAS SALMONICIDA; MAMMALIA; ONCORHYNCHUS MYKISS; SALMONIDAE;

INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE; MESSENGER RNA; ORF; TOLL LIKE RECEPTOR;

AEROMONAS SALMONICIDA; AMINO ACID SEQUENCE; ANIMAL; ANIMAL DISEASE; ARTICLE; CHEMISTRY; DD; DEATH DOMAIN; DNA SEQUENCE; FISH DISEASE; GENE REARRANGEMENT; GENETICS; GRAM NEGATIVE INFECTION; HEK-293; HEK293 CELL LINE; HOURS POST INFECTION; HPI; HUMAN; HUMAN EMBRYONIC KIDNEY 293 CELLS; IMMUNOLOGY; INNATE IMMUNITY; INTERLEUKIN 1 RECEPTOR-ASSOCIATED KINASE 4; IRAK4; IRAK4S; MICROBIOLOGY; MOLECULAR CLONING; MOLECULAR GENETICS; MYDDOSOME; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PHYLOGENY; PKC; PROTEIN KINASE DOMAIN; RAINBOW TROUT; RELATIVE LIGHT UNITS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RLU; SALMONID; SEQUENCE ALIGNMENT; SHORT FORM OF IRAK4; SIGNAL TRANSDUCTION; TIR; TLR; TOLL/INTERLEUKIN-1 RECEPTOR DOMAIN;

AEROMONAS SALMONICIDA; DD; DEATH DOMAIN; HEK-293; HOURS POST INFECTION; HPI; HUMAN EMBRYONIC KIDNEY 293 CELLS; INNATE IMMUNITY; INTERLEUKIN 1 RECEPTOR-ASSOCIATED KINASE 4; IRAK4; IRAK4S; MYDDOSOME; OPEN READING FRAME; ORF; PKC; PROTEIN KINASE DOMAIN; RAINBOW TROUT; RELATIVE LIGHT UNITS; RLU; SHORT FORM OF IRAK4; TIR; TLR; TOLL-LIKE RECEPTOR; TOLL/INTERLEUKIN-1 RECEPTOR DOMAIN;

AEROMONAS SALMONICIDA; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CLONING, MOLECULAR; FISH DISEASES; GENE REARRANGEMENT; GRAM-NEGATIVE BACTERIAL INFECTIONS; HEK293 CELLS; HUMANS; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; MOLECULAR SEQUENCE DATA; PHYLOGENY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SALMONIDAE; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, DNA; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 84891146679     PISSN: 10504648     EISSN: 10959947     Source Type: Journal    
DOI: 10.1016/j.fsi.2013.11.005     Document Type: Article

References (44)

1. Medzhitov R., Preston-Hurlburt P., Janeway C.A. Ahuman homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997, 388(6640):394-397.
2. Lemaitre B., Reichhart J.M., Hoffmann J.A. Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms. Proc Natl Acad Sci U S A 1997, 94(26):14614-14619.
3. Hoffmann J.A., Kafatos F.C., Janeway C.A., Ezekowitz R.A. Phylogenetic perspectives in innate immunity. Science 1999, 284(5418):1313-1318.
4. Beutler B., Hoebe K., Du X., Ulevitch R.J. How we detect microbes and respond to them: the Toll-like receptors and their transducers. JLeukoc Biol 2003, 74(4):479-485.
5. Song D.H., Lee J.O. Sensing of microbial molecular patterns by Toll-like receptors. Immunol Rev 2012, 250(1):216-229.
6. Kumar H., Kawai T., Akira S. Toll-like receptors and innate immunity. Biochem Biophys Res Commun 2009, 388(4):621-625.
7. Schnare M., Barton G.M., Holt A.C., Takeda K., Akira S., Medzhitov R. Toll-like receptors control activation of adaptive immune responses. Nat Immunol 2001 Oct, 2(10):947-950.
8. Uematsu S., Akira S. Toll-Like receptors (TLRs) and their ligands. Handb Exp Pharmacol 2008, 183:1-20.
9. Jin M.S., Lee J.O. Structures of the toll-like receptor family and its ligand complexes. Immunity 2008, 29(2):182-191.
10. Akira S., Uematsu S., Takeuchi O. Pathogen recognition and innate immunity. Cell 2006, 124(4):783-801.
11. O'Neill L.A.J., Bowie A.G. The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol 2007, 7(5):353-364.
12. Kawai T., Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 2010, 11(5):373-384.
13. Huxford T., Ghosh G. Astructural guide to proteins of the NF-kappaB signaling module. Cold Spring Harb Perspect Biol 2009, 1(3):a000075.
14. Vallabhapurapu S., Karin M. Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol 2009, 27:693-733.
15. Karin M., Lin A. NF-kappaB at the crossroads of life and death. Nat Immunol 2002, 3(3):221-227.
16. Li S., Strelow A., Fontana E.J., Wesche H. IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase. Proc Natl Acad Sci U S A 2002, 99(8):5567-5572.
17. Suzuki N., Suzuki S., Yeh W.C. IRAK-4 as the central TIR signaling mediator in innate immunity. Trends Immunol 2002, 23(10):503-506.
18. Lye E., Dhanji S., Calzascia T., Elford A.R., Ohashi P.S. IRAK-4 kinase activity is required for IRAK-4-dependent innate and adaptive immune responses. Eur J Immunol 2008, 38(3):870-876.
19. Suzuki N., Chen N.J., Millar D.G., Suzuki S., Horacek T., Hara H., et al. IL-1 receptor-associated kinase 4 is essential for IL-18-mediated NK and Th1 cell responses. JImmunol 2003, 170(8):4031-4035.
20. Lin S.C., Lo Y.C., Wu H. Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. Nature 2010, 465(7300):885-890.
21. Palti Y. Toll-like receptors in bony fish: from genomics to function. Dev Comp Immunol 2011, 35(12):1263-1272.
22. Rebl A., Goldammer T., Seyfert H.M. Toll-like receptor signaling in bony fish. Vet Immunol Immunopathol 2010, 134:139-150.
23. Rebl A., Rebl H., Liu S., Goldammer T., Seyfert H.M. Salmonid Tollip and MyD88 factors can functionally replace their mammalian orthologues in TLR-mediated trout SAA promoter activation. Dev Comp Immunol 2011, 35:81-87.
24. Phelan P.E., Mellon M.T., Kim C.H. Functional characterization of full-length TLR3, IRAK-4, and TRAF6 in zebrafish (Danio rerio). Mol Immunol 2005, 42(9):1057-1071.
25. Yu Y., Zhong Q., Li C., Jiang L., Wang Y., Sun Y., et al. Identification and characterization of IL-1 receptor-associated kinase-4 (IRAK-4) in half-smooth tongue sole Cynoglossus semilaevis. Fish Shellfish Immunol 2012, 32(4):609-615.
26. Liu Y., Yu S., Chai Y., Yang H., Zhu Q. Lipopolysaccharide-induced gene expression of interleukin-1 receptor-associated kinase 4 and interleukin-1β in roughskin sculpin (Trachidermus fasciatus). Fish Shellfish Immunol 2012, 33:690-698.
27. Leong J., Jantzen S., von Schalburg K., Cooper G., Messmer A., Liao N., et al. Salmo salar and Esox lucius full-length cDNA sequences reveal changes in evolutionary pressures on a post-tetraploidization genome. BMC Genomics 2010, 11(1):279.
28. Rebl A., Siegl E., Köllner B., Fischer U., Seyfert H.M. Characterization of twin toll-like receptors from rainbow trout (Oncorhynchus mykiss): evolutionary relationship and induced expression by Aeromonas salmonicida salmonicida. Dev Comp Immunol 2007, 31(5):499-510.
29. Rebl A., Hoyheim Br, Fischer U., Köllner B., Siegl E., Seyfert H.M. Tollip, a negative regulator of TLR-signalling, is encoded by twin genes in salmonid fish. Fish Shellfish Immunol 2008, 25(1-2):153-162.
30. Kongchum P., Hallerman E.M., Hulata G., David L., Palti Y. Molecular cloning, characterization and expression analysis of TLR9, MyD88 and TRAF6 genes in common carp (Cyprinus carpio). Fish Shellfish Immunol 2011, 30(1):361-371.
31. Sambrook J., Fritsch E.F., Maniatis T. Molecular cloning: a laboratory manual 1989, Cold Spring Harbor Laboratory Press, Cold Spring Harbor. 2 ed.
32. Yang W., Zerbe H., Petzl W., Brunner R.M., Günther J., Draing C., et al. Bovine TLR2 and TLR4 properly transduce signals from Staphylococcus aureus and E.coli, but S.aureus fails to both activate NF-[kappa]B in mammary epithelial cells and to quickly induce TNF[alpha] and interleukin-8 (CXCL8) expression in the udder. Mol Immunol 2008, 45(5):1385-1397.
33. Underhill D.M., Ozinsky A., Smith K.D., Aderem A. Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages. Proc Natl Acad Sci U S A 1999, 96(25):14459-14463.
34. Yang W. The role of Toll-receptors and related factors for pathogen-induced expression of beta-defensin-encoding genes in mammary epithelial cells 2005, [PhD thesis], University of Rostock, Germany.
35. Shi X., Liu S., Metges C.C., Seyfert H.M. C/EBP-beta drives expression of the nutritionally regulated promoter IA of the acetyl-CoA carboxylase-alpha gene in cattle. Biochim Biophys Acta 2010, 1799:561-567.
36. Kumar S., Tamura K., Nei M. MEGA3: integrated software for molecular evolutionary genetics analysis and sequence alignment. Brief Bioinform 2004, 5(2):150-163.
37. Hata F., Muroi M., Hiki N., Ogawa T., Mimura Y., Kaminishi M., et al. Prolonged Toll-like receptor stimulation leads to down-regulation of IRAK-4 protein. JLeukoc Biol 2004, 76.
38. Kramerov D.A., Vassetzky N.S. Short retroposons in eukaryotic genomes. Asurvey of cell biology 2005, vol. 247:165-221. Academic Press. W.J. Kwang (Ed.).
39. Koop B.F., Davidson W.S. Genomics and the genome duplication in salmonids: fisheries for global welfare and environment 2008, 77-86. 5th World Fisheries Congress.
40. Gosu V., Basith S., Durai P., Choi S. Molecular evolution and structural features of IRAK family members. PLoS ONE 2012, 7(11):e49771.
41. Yang W., Molenaar A.J., Kurts-Ebert B., Seyfert H.M. NFKB factors are essential, but not the switch, for pathogen-related induction of the bovine beta-defensin 5-encoding gene in mammary epithelial cells. Mol Immunol 2006, 43:210-225.
42. Oeckinghaus A., Hayden M.S., Ghosh S. Crosstalk in NF-[kappa]B signaling pathways. Nat Immunol 2011, 12(8):695-708.
43. Hayden M.S., Ghosh S. NF-[kappa]B in immunobiology. Cell Res 2011, 21(2):223-244.
44. Scheidereit C. IkappaB kinase complexes: gateways to NF-kappaB activation and transcription. Oncogene 2006, 25(51):6685-6705.