Proflie of human β-defensins 1,2 and proinflammatory cytokines (TNF-α, IL-6) in patients with chronic kidney disease

Kidney and Blood Pressure Research

Volumn 37, Issue 6, 2013, Pages 602-610

  Oh, Dong Jin ^a   Kim, Hye Ryoun ^b   Lee, Mi Kyung ^b   Woo, Yo Seop ^c  

^a Department of Surgery   (South Korea)

^b Chung Ang University College of Medicine   (South Korea)

^c SolarLight Ltd   (South Korea)

Author keywords

Chronic kidney disease; Diabetic nephropathy; Human defensins; Innate immunity; Pro inflammatory cytokines

Indexed keywords

BETA DEFENSIN 1; BETA DEFENSIN 2; HEMOGLOBIN A1C; INTERLEUKIN 6; SERUM ALBUMIN; TUMOR NECROSIS FACTOR ALPHA; AUTACOID; BETA DEFENSIN; BIOLOGICAL MARKER; DEFB1 PROTEIN, HUMAN; DEFB4A PROTEIN, HUMAN; IL6 PROTEIN, HUMAN; ALBUMIN; C REACTIVE PROTEIN; CREATININE; GLUCOSE; HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; UREA;

ADULT; ALBUMIN BLOOD LEVEL; ARTICLE; BLOOD SAMPLING; CHRONIC GLOMERULONEPHRITIS; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DISEASE EXACERBATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GLOMERULUS FILTRATION RATE; HUMAN; HUMAN TISSUE; INFLAMMATION; KIDNEY FUNCTION; KIDNEY POLYCYSTIC DISEASE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; AGED; BLOOD; CHRONIC KIDNEY FAILURE; INNATE IMMUNITY; PATHOPHYSIOLOGY; PHYSIOLOGY; CHOLESTEROL BLOOD LEVEL; CREATININE BLOOD LEVEL; DISEASE SEVERITY; GLUCOSE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; PROTEIN DETERMINATION; TRIACYLGLYCEROL BLOOD LEVEL; UREA BLOOD LEVEL;

AGED; BETA-DEFENSINS; BIOLOGICAL MARKERS; FEMALE; GLOMERULAR FILTRATION RATE; HUMANS; IMMUNITY, INNATE; INFLAMMATION MEDIATORS; INTERLEUKIN-6; MALE; MIDDLE AGED; RENAL INSUFFICIENCY, CHRONIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84891060448     PISSN: 14204096     EISSN: 14230143     Source Type: Journal    
DOI: 10.1159/000355740     Document Type: Article

References (23)

1. Selsted M, Ouellette A: Mammalian defensins in the antimicrobial immune response. Nat Immunol 2005;6:551-557.
2. Pazgier M, Hoover DM, Yang D, Lu W, Lubkowski J: Human beta-defensins. Cell Mol Life Sci 2006;63:1294-1313.
3. Bensch KW, Raida M, Mgert HJ, Schulz Knappe P, Forssmann WG: hBD-1: a novel beta-defensin from human plasma. FEBS Lett 1995;368:331-335.
4. Valore EV, Park CH, Quayle AJ, Wiles KR, McCray PB, Ganz T: Human beta-defensin-1: an antimicrobial peptide of urogenital tissues. J Clin Invest 1998;101:1633-1642.
5. Zucht HD, Grabowsky J, Schrader M, Liepke C, Jrgens M, Schulz Knappe P, Forssmann WG: Human betadefensin-1: A urinary peptide present in variant molecular forms and its putative functional implication. Eur J Med Res 1998;3:315-323.
6. Raj P, Dentino A: Current status of defensins and their role in innate and adaptive immunity. FEMS Microbiol Lett 2002;206:9-18.
7. Rivero A, Mora C, Muros M, García J, Herrera H, Navarro-González JF: Pathogenic perspectives for the role of inflammation in diabetic nephropathy. Clin Sci (Lond) 2009;116:479-492.
8. Pickup JC, Crook MA: Is type II diabetes mellitus a disease of the innate immune system?. Diabetologia 1998;41:1241-1248.
9. Pickup J: Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care 2004;27:813-823.
10. Kimmel PL, Phillips TM, Simmens SJ, Peterson RA, Weihs KL, Alleyne S, Cruz I, Yanovski JA, Veis JH: Immunologic function and survival in hemodialysis patients. Kidney Int 1998;54:236-244.
11. Stenvinkel P, Ketteler M, Johnson R, Lindholm B, Pecoits Filho R, Riella M, Heimbrger O, Cederholm T, Girndt M: IL-10, IL-6, and TNF-alpha: central factors in the altered cytokine network of uremia-the good, the bad, and the ugly. Kidney Int 2005;67:1216-1233.
12. KDOQI Clinical Practice Guideline for Nutrition in Children with CKD: 2008 update. Executive summary. Am J Kidney Dis 2009;53:S11-S104.
13. Lamb E: United Kingdom guidelines for chronic kidney disease. Scand J Clin Lab Invest Suppl 2008;241:16-22.
14. Stevens L, Coresh J, Feldman H, Greene T, Lash J, Nelson R, Rahman M, Deysher A, Zhang Y, Schmid C, Levey A: Evaluation of the modification of diet in renal disease study equation in a large diverse population. J Am Soc Nephrol 2007;18:2749-2757.
15. Bolton CH, Downs LG, Victory JG, Dwight JF, Tomson CR, Mackness MI, Pinkney JH: Endothelial dysfunction in chronic renal failure: roles of lipoprotein oxidation and pro-inflammatory cytokines. Nephrol Dial Transplant 2001;16:1189-1197.
16. Spoto B, Leonardis D, Parlongo RM, Pizzini P, Pisano A, Cutrupi S, Testa A, Tripepi G, Zoccali C, Mallamaci F: Plasma cytokines, glomerular filtration rate and adipose tissue cytokines gene expression in chronic kidney disease (CKD) patients. Nutr Metab Cardiovasc Dis 2012;22:981-988.
17. Guaní-Guerra E, Santos-Mendoza T, Lugo-Reyes SO, Terán LM: Antimicrobial peptides: general overview and clinical implications in human health and disease. Clin Immunol 2010;135:1-11.
18. Krisanaprakornkit S, Kimball JR, Weinberg A, Darveau RP, Bainbridge BW, Dale BA: Inducible expression of human beta-defensin 2 by Fusobacterium nucleatum in oral epithelial cells: multiple signaling pathways and role of commensal bacteria in innate immunity and the epithelial barrier. Infect Immun 2000;68:2907-2915.
19. Hiratsuka T, Nakazato M, Ihi T, Minematsu T, Chino N, Nakanishi T, Shimizu A, Kangawa K, Matsukura S: Structural analysis of human beta-defensin-1 and its significance in urinary tract infection. Nephron 2000;85:34-40.
20. Pickup JC, Mattock MB, Chusney GD, Burt D: NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X. Diabetologia 1997;40:1286-1292.
21. Malik AN, Al-Kafaji G: Glucose regulation of beta-defensin-1 mRNA in human renal cells. Biochem Biophys Res Commun 2007;353:318-323.
22. Blake GJ, Ridker PM: Inflammatory bio-markers and cardiovascular risk prediction. J Intern Med 2002;252:283-294.
23. Ridker PM, Hennekens CH, Buring JE, Rifai N: C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 2000;342:836-843.