Comparative effects of Rauwolfia vomitoria and chlorpromazine on locomotor behaviour and anxiety in mice

Journal of Ethnopharmacology

Volumn 132, Issue 1, 2010, Pages 334-339

  Bisong, Sunday Agba ^a   Brown, Richard ^b   Osim, Eme Effiom ^a  

^a UNIVERSITY OF CALABAR   (Nigeria)

^b DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Anxiety; Chlorpromazine; Locomotor behaviour; Rauwolfia vomitoria; Reserpine

Indexed keywords

CHLORPROMAZINE; PLANT EXTRACT; RAUWOLFIA VOMITORIA EXTRACT; RESERPINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECT; LOCOMOTION; MALE; MOTOR COORDINATION; MOUSE; NONHUMAN; OPEN FIELD TEST;

ANIMALS; ANTIPSYCHOTIC AGENTS; ANXIETY; BEHAVIOR, ANIMAL; CHLORPROMAZINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EXPLORATORY BEHAVIOR; MALE; MICE; MICE, INBRED STRAINS; MOTOR ACTIVITY; PLANT BARK; PLANT EXTRACTS; PLANT ROOTS; RAUWOLFIA; RESERPINE; ROTAROD PERFORMANCE TEST; SECOLOGANIN TRYPTAMINE ALKALOIDS;

MUS; RAUVOLFIA VOMITORIA;

EID: 77957793980     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2010.08.045     Document Type: Article

References (29)

1. Adams C.E., Awad G., Rathbone J., Thornley B. Chlorpromazine versus placebo for schizophrenia. Cochrane Database of Systematic Reviews 2007, 2:284.
2. Akpanabiatu M.I., Umoh I.B., Eyong E.U. Influence of Rauwolfia vomitoria root bark on cardiac enzymes o normal Wistar albino rats. Recent Progress in Medicinal Plants 2006, 14:273-278.
3. Aminoff M.J. Pharmacologic management of Parkinsonism and other movement disorders. Basic and Clinical Pharmacology 2004, 447-461. McGraw-Hill, Singapore. 9th edition. B.G. Katzung (Ed.).
4. Amole O.O., Onabanjo A.O. Reserpine: the effect and uses of Rauwolfia vomitoria. Journal of Chemotherapy 1999, 3:45-47.
5. Amole O.O., Yemitan O.K., Oshikoya K.A. Anticonvulsant activity of Rauvolfia Vomitoria (Afzel). African Journal of Pharmacy and Pharmacology 2009, 3:319-322.
6. Awad G., Rathbone J., Thornley B. Chlorpromazine Versus Placebo for Schizophrenia 1992, Harper Perennial, New York, pp. 326.
7. Bemis D.L., Capodice J.L., Gorroocurn P., Katz A.E., Buttyan R. Anti-prostate cancer activity of β-carboline alkaloid enriched extract from Rauwolfia vomitoria. International Journal of Oncology 2006, 29:1065-1073.
8. Bourin M., Hascoet M. The mouse light/dark box test. European Journal of Pharmacology 2003, 463:55-65.
9. Brown R.E., Corey S.C., Moore A.K. Differences in measures of exploration and fear in MHC-congenic C57BL/6J and B6-H-2K mice. Behavior Genetics 1999, 26:263-271.
10. Campbell J.I.A., Mortensen A., Molgaard P. Tissue lipid lowering-effect of a traditional Nigeian anti-diabetic infusion of Rauwolfia vomitoria foliage and Citrus aurantium fruit. Journal of Ethnopharmacology 2006, 104:379-386.
11. Caston J., Devulder B., Jouen F., Lalonde R. Role of an enriched environment on the restoration of behavioural deficits in Lurcher mutant mice. Developmental Psychobiology 1999, 35:291-303.
12. Chong M.Y., Tan C.H., Fujii S., Yang S., Ungvari G.S., Si T., Chung E.K., Sim K., Tsang H.Y., Shinfuku N. Antipsychotic drug prescription for schizophrenia in East Asia: rationale for change. Psychiatry and Clinical Neurosciences 2004, 58:61-67.
13. Costa-Campos L., Dassoler S.C., Rigo A.P., Iwu M., Elisabetsky E. Anxiolytic properties of the antipsychotic alkaloid alstonine. Pharmacology Biochemistry and Behavior 2004, 77:481-489.
14. Elisabetsky E., Costa-Campos L. The alkaloid alstonine: a review of its pharmacological properties. eCAM 2006, 3:39-48.
15. Greenberg H.R. Inhibition of ejaculation by chlorpromazine. Journal of Nervous and Mental Disease 1971, 152:364-366.
16. Gureje O., Acha R.A., Odejide O.A. Pathways to psychiatric care in Ibadan, Nigeria. Tropical Medicine & International Health 1995, 47:125-129.
17. Halliburton M. Finding a fit: psychiatric pluralism in South India and its implications for WHO studies of mental disorders. Transcultural Psychiatry 2004, 41:80-98.
18. Kanba S., Yamada K., Mizushima H., Asai M. Use of herbal medicine for treating psychiatric disorders in Japan. Journal of Neuropsychiatry and Clinical Neurosciences 1998, 52:331-333.
19. Klyushnichenko V.E., Yakimov S.A., Tuzova T.P., Syagailo Y.V., Kuzovkina I.N., Wulfson A.N., Miroshnikov A.I. Determination of indole alkaloids from R. serpentina and R. vomitoria by high-performance liquid chromatography and high-performance thin-layer chromatography. Journal of Chromatography 1995, 704:357-362.
20. Kweifio-Okai G., Bird D., Field B., Ambrose R., Carol A.R., Smith P., Valdes R. Anti-inflammatory activity of a Ghanaian antiarthritic herbal preparation: III. Journal of Ethnopharmacology 1995, 46:7-15.
21. LaBuda C.J., Fuchs P.N. Catecholamine depletion by reserpine blocks the anxiolytic actions of ethanol in the rat. Alcohol 2002, 26:55-59.
22. Lopez-Munoz F., Bhatara V.S., Alamo C., Cuenca E. Historical approach to reserpine discovery and its introduction in psychiatry. Actas Espanolas De Psiquiatria 2004, 32:387-395.
23. Makanjuola R.O.A. Yoruba traditional healer in psychaitry. Healers' concept of the nature and aetiology of mental disorders. African Journal of Medicine and Medical Science 1987, 16:53-59.
24. Naidu P.S., Singh A., Kulkarin S.K. Effect of Withania somnifera root extract on reserpine-induced orofacial dyskinesia and cognitive dysfunction. Phytotherapy Research 2006, 20:140-146.
25. Peirre J.M. Extrapyramidal symptoms with atypical antipsychotics: incidence, prevention and management. Drug Safety 2005, 28:191-208.
26. Pilliai A., Terry A.V., Mahandik S.P. Differential effects of long-term treatment with typical and atypical antipsychotics on nerve growth factor (NGF) and brain-derived neurotropic factor (BDNF) levels in rats striatum and hippocampus. Schizophrenia Research 2006, 82:95-106.
27. Unützer J., Klap R., Sturm R., Young A.S., Marmon T., Shatkin J., Wells K.B. Mental disorders and the use of alternative medicine: results from a national survey. American Journal of Psychiatry 2000, 157:1851-1857.
28. Walsh R.N., Cummins R.A. The open-field test: a critical review. Psychological Bulletin 1976, 83:482-504.
29. World Health organization (WHO), 2007: Essential Medicines (13th edition). WHO Model List. Available at (accessed 23.10.2007). http://www.who.int/hac/techguidance/pht/essentialmed/en.