New concepts of breast cell communication to bone

Trends in Endocrinology and Metabolism

Volumn 25, Issue 1, 2014, Pages 34-41

  Horseman, Nelson D ^a   Hernandez, Laura L ^b  

^a UNIVERSITY OF CINCINNATI   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Breast cancer; Hypocalcemia; Osteocyte; Osteolysis; PMCA2; PTHrP; Serotonin

Indexed keywords

CALCIUM; PARATHYROID HORMONE RELATED PROTEIN; SEROTONIN; SEROTONIN RECEPTOR;

BONE; BREAST CANCER; BREAST CELL; BREAST EPITHELIUM; CALCIUM BALANCE; CALCIUM BONE LEVEL; CALCIUM DEFICIENCY; CALCIUM HOMEOSTASIS; CALCIUM MOBILIZATION; CALCIUM TRANSPORT; CANCER CELL; CELL COMMUNICATION; ENDOCRINE FUNCTION; HUMAN; INTESTINE; LACTATION; MAMMARY GLAND; NONHUMAN; OSTEOCYTE; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVIEW; SEROTONINERGIC SYSTEM;

BREAST CANCER; HYPOCALCEMIA; OSTEOCYTE; OSTEOLYSIS; PMCA2; PTHRP; SEROTONIN;

BONE RESORPTION; BREAST; CALCIUM; CELL COMMUNICATION; FEMALE; HUMANS; LACTATION; OSTEOLYSIS; PARATHYROID HORMONE-RELATED PROTEIN; PREGNANCY; SEROTONIN; SIGNAL TRANSDUCTION;

EID: 84891037302     PISSN: 10432760     EISSN: 18793061     Source Type: Journal    
DOI: 10.1016/j.tem.2013.08.004     Document Type: Review

References (69)

1. Riordan J., Wambach K. Breastfeeding and Human Lactation 2010, Jones and Bartlett Publishers.
2. Niedermeier R.P., et al. Parturient paresis. III. A study of various blood constituents at parturition in mastectomized cows. J. Dairy Sci. 1949, 32:927-934.
3. Kovacs C.S., Kronenberg H.M. Maternal-fetal calcium and bone metabolism during pregnancy, puerperium, and lactation. Endocr. Rev. 1997, 18:832-872.
4. Kovacs C.S. Calcium and bone metabolism during pregnancy and lactation. J. Mammary Gland Biol. Neoplasia 2005, 10:105-118.
5. VanHouten J.N., Wysolmerski J.J. Transcellular calcium transport in mammary epithelial cells. J. Mammary Gland Biol. Neoplasia 2007, 12:223-235.
6. Speakman J.R. The physiological costs of reproduction in small mammals. Philos. Trans. R. Soc. B: Biol. Sci. 2008, 363:375-398.
7. Horst R.L., et al. Calcium and vitamin D metabolism in the dairy cow. J. Dairy Sci. 1994, 77:1936-1951.
8. Horst R.L., et al. Adapting to the transition between gestation and lactation: Differences between rat, human and dairy cow. J. Mammary Gland Biol. Neoplasia 2005, 10:141-156.
9. DeGroot L.J., Jameson J.L. Endocrinology: Adult and Pediatric 2010, Saunders/Elsevier.
10. Khosla S., et al. Estrogen and the skeleton. Trends Endocrinol. Metab. 2012, 23:576-581.
11. Schlechte J.A. Clinical impact of hyperprolactinaemia. Baillieres Clin. Endocrinol. Metab. 1995, 9:359-366.
12. Nicks K.M., et al. Reproductive hormones and bone. Curr. Osteoporos. Rep. 2010, 8:60-67.
13. Carneiro R.M., et al. Lactation and bone turnover: a conundrum of marked bone loss in the setting of coupled bone turnover. J. Clin. Endocrinol. Metab. 2010, 95:1767-1776.
14. Collins J.N., et al. Lactating Ctcgrp nulls lose twice the normal bone mineral content due to fewer osteoblasts and more osteoclasts, whereas bone mass is fully restored after weaning in association with up-regulation of Wnt signaling and other novel genes. Endocrinology 2013, 154:1400-1413.
15. Hodnett D.W., et al. Bone mineral loss during lactation occurs in absence of parathyroid tissue. Am. J. Physiol. Endocrinol. Metab. 1992, 262:E230-E233.
16. Brommage R., DeLuca H.F. Regulation of bone mineral loss during lactation. Am. J. Physiol. Endocrinol. Metab. 1985, 11:E182-E187.
17. Kovacs C.S., Fuleihan G.E. Calcium and bone disorders during pregnancy and lactation. Endocrinol. Metab. Clin. North Am. 2006, 35:21-51.
18. Kovacs C.S. Calcium and bone metabolism disorders during pregnancy and lactation. Endocrinol. Metab. Clin. North Am. 2011, 40:795-826.
19. Ikeda K., et al. Identification of transcripts encoding a parathyroid hormone-like peptide in messenger RNAs from a variety of human and animal tumors associated with humoral hypercalcemia of malignancy. J. Clin. Invest. 1988, 81:2010-2014.
20. Mangin M., et al. Identification of a cDNA encoding a parathyroid hormone-like peptide from a human tumor associated with humoral hypercalcemia of malignancy. Proc. Natl. Acad. Sci. U.S.A. 1988, 85:597-601.
21. Mundy G.R. Mechanisms of osteolytic bone destruction. Bone 1991, 12(Suppl. 1):S1-S6.
22. Budayr A.A., et al. High levels of a parathyroid hormone-like protein in milk. Proc. Natl. Acad. Sci. U.S.A. 1989, 86:7183-7185.
23. Caplan R.H., et al. Serum parathyroid hormone-related protein levels during lactation. J. Reprod. Med. 1995, 40:216-218.
24. Grill V., et al. Parathyroid hormone-related protein: a possible endocrine function in lactation. Clin. Endocrinol. (Oxf.) 1992, 37:405-410.
25. Onda K., et al. Expression of parathyroid hormone-related protein (PTHrP) mRNA in mammary gland of periparturient cows. J. Vet. Med. Sci. 2006, 68:9-13.
26. Sowers M.F., et al. Elevated parathyroid hormone-related peptide associated with lactation and bone density loss. JAMA 1996, 276:549-554.
27. Thiede M.A. Parathyroid hormone-related protein: a regulated calcium-mobilizing product of the mammary gland. J. Dairy Sci. 1994, 77:1952-1963.
28. Thiede M.A., Rodan G.A. Expression of a calcium-mobilizing parathyroid hormone-like peptide in lactating mammary tissue. Science 1988, 242:278-280.
29. Strewler G.J. The parathyroid hormone-related protein. Endocrinol. Metab. Clin. North Am. 2000, 29:629-645.
30. Strewler G.J. The physiology of parathyroid hormone-related protein. N. Engl. J. Med. 2000, 342:177-185.
31. DeMauro S., Wysolmerski J. Hypercalcemia in breast cancer: an echo of bone mobilization during lactationα. J. Mammary Gland Biol. Neoplasia 2005, 10:157-167.
32. Wysolmerski J.J. Parathyroid hormone-related protein: an update. J. Clin. Endocrinol. Metab. 2012, 97:2947-2956.
33. Peyruchaud O. Mechanisms of bone metastasis formation. J. Soc. Biol. 2007, 201:229-236.
34. Li J., et al. PTHrP drives breast tumor initiation, progression, and metastasis in mice and is a potential therapy target. J. Clin. Invest. 2011, 121:4655-4669.
35. Guise T.A., et al. Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis. J. Clin. Invest. 1996, 98:1544-1549.
36. Clines G.A., Guise T.A. Molecular mechanisms and treatment of bone metastasis. Expert Rev. Mol. Med. 2008, 10:e7.
37. Karaplis A.C., et al. Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene. Genes Dev. 1994, 8:277-289.
38. Wysolmerski J.J., et al. Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development. Development 1998, 125:1285-1294.
39. VanHouten J.N., et al. Mammary-specific deletion of parathyroid hormone-related protein preserves bone mass during lactation. J. Clin. Invest. 2003, 112:1429-1436.
40. Matsuda M., et al. Serotonin regulates mammary gland development via an autocrine-paracrine loop. Dev. Cell 2004, 6:193-203.
41. Marshall A.M., et al. Serotonin transport and metabolism in the mammary gland modulates secretory activation and involution. J. Clin. Endocrinol. Metab. 2010, 95:837-846.
42. Stull M.A., et al. Mammary gland homeostasis employs serotonergic regulation of epithelial tight junctions. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:16708-16713.
43. Pai V.P., et al. Altered serotonin physiology in human breast cancers favors paradoxical growth and cell survival. Breast Cancer Res. 2009, 11:R81.
44. Pai V.P., Horseman N.D. Biphasic regulation of mammary epithelial resistance by serotonin through activation of multiple pathways. J. Biol. Chem. 2008, 283:30901-30910.
45. Hernandez L.L., et al. The bovine mammary gland expresses multiple functional isoforms of serotonin receptors. J. Endocrinol. 2009, 203:123-131.
46. Kopparapu P.K., et al. Expression and localization of serotonin receptors in human breast cancer. Anticancer Res. 2013, 33:363-370.
47. Hernandez L.L., et al. Mammary gland serotonin regulates parathyroid hormone-related protein and other bone-related signals. Am. J. Physiol. Endocrinol. Metab. 2012, 302:E1009-E1015.
48. Yadav V.K., et al. Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Cell 2008, 135:825-837.
49. Cui Y., et al. Lrp5 functions in bone to regulate bone mass. Nat. Med. 2011, 17:684-691.
50. Chabbi-Achengli Y., et al. Decreased osteoclastogenesis in serotonin-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:2567-2572.
51. Shennan D.B. Calcium transport by mammary secretory cells: mechanisms underlying transepithelial movement. Cell. Mol. Biol. Lett. 2008, 13:514-525.
52. Neville M.C. Calcium secretion into milk. J. Mammary Gland Biol. Neoplasia 2005, 10:119-128.
53. McMahon D.J., Oommen B.S. Supramolecular structure of the casein micelle. J. Dairy Sci. 2008, 91:1709-1721.
54. Faddy H.M., et al. Localization of plasma membrane and secretory calcium pumps in the mammary gland. Biochem. Biophys. Res. Commun. 2008, 369:977-981.
55. 2+-ATPase isoform 2 impairs calcium transport into milk. J. Biol. Chem. 2004, 279:42369-42373.
56. VanHouten J.N., et al. The calcium-sensing receptor regulates plasma membrane calcium adenosine triphosphatase isoform 2 activity in mammary epithelial cells: a mechanism for calcium-regulated calcium transport into milk. Endocrinology 2007, 148:5943-5954.
57. VanHouten J., et al. The calcium-sensing receptor regulates mammary gland parathyroid hormone-related protein production and calcium transport. J. Clin. Invest. 2004, 113:598-608.
58. Ardeshirpour L., et al. The calcium-sensing receptor regulates PTHrP production and calcium transport in the lactating mammary gland. Bone 2006, 38:787-793.
59. Powell W.F., et al. Targeted ablation of the PTH/PTHrP receptor in osteocytes impairs bone structure and homeostatic calcemic responses. J. Endocrinol. 2011, 209:21-32.
60. Nakashima T., et al. Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Nat. Med. 2011, 17:1231-1234.
61. Xiong J., et al. Matrix-embedded cells control osteoclast formation. Nat. Med. 2011, 17:1235-1241.
62. Qing H., et al. Demonstration of osteocytic perilacunar/canalicular remodeling in mice during lactation. J. Bone Miner. Res. 2012, 27:1018-1029.
63. Juhász C., et al. Tryptophan metabolism in breast cancers: Molecular imaging and immunohistochemistry studies. Nucl. Med. Biol. 2012, 39:926-932.
64. Goodman L.S., et al. Goodman & Gilman's The Pharmacological Basis of Therapeutics 2011, McGraw-Hill Medical.
65. Fleming K.H., Heimbach J.T. Consumption of calcium in the U.S.: food sources and intake levels. J. Nutr. 1994, 124:1426S-1430S.
66. Reinhardt T.A., et al. Prevalence of subclinical hypocalcemia in dairy herds. Vet. J. 2011, 188:122-124.
67. Goff J.P., Horst R.L. Milk fever control in the United States. Acta Vet. Scand. Suppl. 2003, 97:145-147.
68. Roberts D. Dr. David Roberts' Practical Home Veterinarian 1913, Dr David Roberts' Veterinary Company.
69. Niedermeier R.P., Smith V.R. Parturient paresis. The effect of udder inflation upon blood levels of calcium, magnesium and phosphorus in cows with parturient paresis. J. Dairy Sci. 1950, 33:38-42.