HtrA1 is upregulated during RANKL-induced osteoclastogenesis, and negatively regulates osteoblast differentiation and BMP2-induced Smad1/5/8, ERK and p38 phosphorylation

FEBS Letters

Volumn 588, Issue 1, 2014, Pages 143-150

  Wu, Xinghuo ^a,b   Chim, Shek Man ^b   Kuek, Vincent ^b   Lim, Bay Sie ^b   Chow, Siu To ^b   Zhao, Jinmin ^c   Yang, Shuhua ^a   Rosen, Vicki ^d   Tickner, Jennifer ^b   Xu, Jiake ^b,c  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c FIRST AFFILIATED HOSPITAL OF GUANGXI MEDICAL UNIVERSITY   (China)

^d HARVARD SCHOOL OF DENTAL MEDICINE   (United States)

Author keywords

Crosstalk; HTRA1; Osteoblast; Osteoclast; RANKL

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OSTEOCLAST DIFFERENTIATION FACTOR; PROTEIN HTRA1; REGULATOR PROTEIN; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTOCRINE EFFECT; BONE REMODELING; CELL DIFFERENTIATION; CONTROLLED STUDY; GENE EXPRESSION; HTRA1 GENE; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOCLASTOGENESIS; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; RANKL GENE; REGULATOR GENE; UPREGULATION;

EID: 84891029721     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2013.11.022     Document Type: Article

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