Human serine protease HTRA1 positively regulates osteogenesis of human bone marrow-derived mesenchymal stem cells and mineralization of differentiating bone-forming cells through the modulation of extracellular matrix protein

Stem Cells

Volumn 30, Issue 10, 2012, Pages 2271-2282

  Tiaden, André N ^a   Breiden, Maike ^c   Mirsaidi, Ali ^a,b   Weber, Fabienne A ^b   Bahrenberg, Gregor ^a,b   Glanz, Stephan ^a,b   Cinelli, Paolo ^b   Ehrmann, Michael ^c   Richards, Peter J ^a,b  

^a CABMM   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

Bone mineralization; Differentiation; HTRA1 protein; Mesenchymal stem cell

Indexed keywords

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 5; BONE SIALOPROTEIN; FATTY ACID BINDING PROTEIN 4; HIGH TEMPERATURE REQUIREMENT SERINE PROTEASE A1; OSTEOPONTIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; SCLEROPROTEIN; SCLEROSTIN; SERINE PROTEINASE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG;

ADIPOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; BONE MINERALIZATION; BONE REGENERATION; CELL DIFFERENTIATION; CONTROLLED STUDY; EMBRYONIC STEM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IN VITRO STUDY; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SECRETION; UPREGULATION;

ADIPOSE TISSUE; ANIMALS; BONE MARROW CELLS; BONE MORPHOGENETIC PROTEIN 5; CALCIFICATION, PHYSIOLOGIC; CELL DIFFERENTIATION; EMBRYONIC STEM CELLS; EXTRACELLULAR MATRIX PROTEINS; GENE EXPRESSION REGULATION; GLYCOPROTEINS; HUMANS; INTEGRIN-BINDING SIALOPROTEIN; MESENCHYMAL STROMAL CELLS; MICE; OSTEOBLASTS; OSTEOGENESIS; RECOMBINANT PROTEINS; RNA, SMALL INTERFERING; SERINE ENDOPEPTIDASES; STROMAL CELLS;

MAMMALIA;

EID: 84866709537     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1190     Document Type: Article

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