Exercise, nutrition and managing hip fracture in older persons

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 17, Issue 1, 2014, Pages 12-24

  Singh, Maria A Fiatarone ^a,b,c  

^a Faculty of Health Sciences   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Exercise; Hip fracture; Nutrition; Rehabilitation; Sarcopenia

Indexed keywords

VITAMIN D; VITAMIN K GROUP;

BALANCE IMPAIRMENT; BODY WEIGHT; COGNITIVE DEFECT; DEPRESSION; EXERCISE; HIP FRACTURE; HUMAN; MALNUTRITION; MUSCLE FUNCTION; MUSCLE STRENGTH; NUTRITION; NUTRITIONAL COUNSELING; NUTRITIONAL SUPPORT; OUTCOME ASSESSMENT; PROTEIN INTAKE; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL (TOPIC); RESIDENTIAL CARE; RESISTANCE TRAINING; REVIEW; RISK FACTOR; SARCOPENIA; SOCIAL ISOLATION; VITAMIN SUPPLEMENTATION;

BODY WEIGHT; BONE AND BONES; CALCIUM, DIETARY; DIETARY PROTEINS; DIETARY SUPPLEMENTS; EVIDENCE-BASED MEDICINE; EXERCISE; HIP FRACTURES; HUMANS; LIFE STYLE; MALNUTRITION; NEUROPSYCHOLOGY; NUTRITIONAL STATUS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RISK FACTORS; SARCOPENIA; VITAMIN D; VITAMIN K;

EID: 84890989723     PISSN: 13631950     EISSN: 14736519     Source Type: Journal    
DOI: 10.1097/MCO.0000000000000015     Document Type: Review

References (76)

1. Murad MH, Drake MT, Mullan RJ, et al. Comparative effectiveness of drug treatments to prevent fragility fractures: a systematic review and network meta-analysis. J ClinEndocrinol Metab 2012; 97: 1871-1880.
2. Eriksen EF, Halse J, Moen MH. New developments in the treatment of osteoporosis. Acta Obstet Gynecol Scand 2013; 92: 620-636. Comprehensive review of risks and benefits of pharmacological agents used for osteporotic fracture prevention.
3. Looker AC, Dawson-Hughes B, Tosteson AN, et al. Hip fracture risk in older US adults by treatment eligibility status based on new National Osteoporosis Foundation guidance. Osteoporos Int 2011; 22: 541-549.
4. Curtis JR, Safford MM. Management of osteoporosis among the elderly with other chronic medical conditions. Drugs Aging 2012; 29: 549-564.
5. Chen JS, Sambrook PN. Antiresorptive therapies for osteoporosis: a clinical overview. Nat Rev Endocrinol 2012; 8: 81-91.
6. Dimitriou R, Calori GM, Giannoudis PV. Improving patients' outcomes after osteoporotic fractures. Int J Clin Rheumatol 2012; 7: 109-124.
7. Krishnan M, Beck S, Cowen O, et al. Predicting outcome after hip fracture: using frailty index to integrate comprehensive geriatric assessment results. Age Ageing 2013; 42 (Suppl 3):iii16-iii17. In this prospective cohort study, a Frailty Index most effectively integrated comprehensive geriatric assessment results to predict length of stay, the likelihood of successful return home, and of mortality in the first 30 days.
8. Drake MT, Murad MH, Mauck KF, et al. Risk factors for low bone mass-related fractures in men: a systematic review and meta-analysis. J Clin Endocrinol Metab 2012; 97: 1861-1870.
9. Zucker I, Chodick G, Grunhaus L, et al. Adherence to treatment with selective serotonin reuptake inhibitors and the risk for fractures and bone loss: a population-based cohort study. CNS Drugs 2012; 26: 537-547.
10. Pitts CJD, Kearns AE. Update on medications with adverse skeletal effects. Mayo Clin Proc 2011; 86: 338-343.
11. Khalili H, Huang ES, Jacobson BC, et al. Use of proton pump inhibitors and risk of hip fracture in relation to dietary and lifestyle factors: a prospective cohort study. BMJ 2012; 344:e372.
12. Lau YT, Ahmed N. Fracture risk and bone mineral density reduction associated with proton pump inhibitors. Pharmacotherapy 2012; 32: 67-79.
13. Reider L, Hawkes W, Hebel JR, et al. The association between body mass index, weight loss and physical function in the year following a hip fracture. J Nutr Health Aging 2013; 17: 91-95.
14. Englund U, Nordstrom P, Nilsson J, et al. Physical activity in middle-aged women and hip fracture risk: the UFO study. Osteoporos Int 2011; 22: 499-505.
15. Cauley JA, Harrison S, Cawthon PM, et al. Objective measures of physical activity, fractures and falls: the osteoporotic fractures in men study. J Am Geriatr Soc 2013; 61: 1080-1088. Two thousand seven hundred and thirty-one men in this longitudinal cohort study (averge age 79) were followed for 3.5 years for risk of falls/fractures. Men with less than 33 min/day of moderate activity had a 70% greater risk of fracture, and those over 80 had a 43% increase in falls, extending physical activity guidelines to the oldest old for these indications.
16. Fletcher J. Canadian academy of sport and exercise medicine position statement: osteoporosis and exercise. Clin J Sport Med 2013; 23: 333-338.
17. Zaslavsky O, Cochrane BB, Thompson HJ, et al. Frailty: a review of the first decade of research. Biol Res Nurs 2013; 15: 422-432.
18. Deane AJB, Jaafar AF. An update on frailty diagnosis and management. Rev Clin Gerontol 2013; 23: 196-205.
19. Hida T, Ishiguro N, Shimokata H, et al. High prevalence of sarcopenia and reduced leg muscle mass in Japanese patients immediately after a hip fracture. Geriatr Gerontol Int 2013; 13: 413-420.
20. Rondanelli M, Guido D, Opizzi A, et al. Association of sarcopenia with bone mass loss in elderly subjects. Nutr Ther Metab 2013; 31: 77-82.
21. Moseley KF, Dobrosielski DA, Stewart KJ, et al. Lean mass and fat mass predict bone mineral density in middle-aged individuals with noninsulinrequiring type 2 diabetes mellitus. Clin Endocrinol 2011; 74: 565-571.
22. Dufour AB, HannanMT,Murabito JM, et al. Sarcopenia definitions considering body size and fat mass are associated with mobility limitations: the Framingham study. J Gerontol 2013; 68: 168-174. Seven hundred sixty-seven men and women average 79 from the Framingham Study were assessed for mobility and body composition using dual energy X-ray absorptiometry. Low lean mass was associated with self-reported mobility limitations after accounting for body size and fat, and lean and fat mass had independent effects on mobility in elders, suggesting that sarcopenia definitions should consider body size and fat.
23. Jeejeebhoy KN. Malnutrition, fatigue, frailty, vulnerability, sarcopenia and cachexia: overlap of clinical features. Curr Opin Clin Nutr Metab Care 2012; 15: 213-219.
24. Dhanwal DK, Sahoo S, Gautam VK, et al. Hip fracture patients in India have vitamin D deficiency and secondary hyperparathyroidism. Osteoporos Int 2013; 24: 553-557.
25. Leigheb F, Vanhaecht K, Sermeus W, et al. The effect of care pathways for hip fractures: a systematic overview of secondary studies. Eur J Orthop Surg Traumatol 2013; 23:737-745; Epub Epub 2012 Sep 25.
26. Hagen KB, Dagfinrud H, Moe RH, et al. Exercise therapy for bone and muscle health: an overview of systematic reviews. BMC medicine 2012; 10:167.
27. Gomez-Cabello A, Ara I, Gonzalez-Aguero A, et al. Effects of training on bone mass in older adults: a systematic review. Sports Med 2012; 42: 301-325.
28. Maatta M, Terho E, Jokinen H, et al. Lifestyle factors and site-specific risk of hip fracture in community dwelling older women: a 13-year prospective population- based cohort study. BMC Musculoskelet Disord 2012; 13:173.
29. Gleason L, Menzies I, Mendelson D, et al. Diagnosis and treatment of osteoporosis in high-risk patients prior to hip fracture. Geriatr Orthop Surg Rehabil 2012; 3: 79-83.
30. Lloyd BD, Williamson DA, Singh NA, et al. Recurrent and injurious falls in the year following hip fracture: a prospective study of incidence and risk factors from the Sarcopenia and hip fracture study. J Gerontol A Biol Sci Med Sci 2009; 64: 599-609.
31. Singh NA, Quine S, Clemson LM, et al. Effects of high-intensity progressive resistance training and targeted multidisciplinary treatment of frailty on mortality and nursing home admissions after hip fracture: a randomized controlled trial. J Am Med Dir Assoc 2012; 13: 24-30. Multidisciplinary care targeting 13 reversible contributants to frailty, with a focus on high intensity PRT in 124 hip fracture patients reduced the risk of mortality by 81% and nursing home admission by 84% in the year after surgery.
32. Portegijs E, Read S, Pakkala I, et al. Sense of coherence affects adherence and response to resistance training in older people with hip fracture history. J Aging Phys Act 2013. [Epub ahead of print]
33. Edgren J, Rantanen T, Heinonen A, et al. Effects of progressive resistance training on physical disability among older community-dwelling people with history of hip fracture. Aging Clin Exp Res 2012; 24: 171-175.
34. Sylliaas H, Brovold T, Wyller TB, et al. Prolonged strength training in older patients after hip fracture: a randomised controlled trial. Age Ageing 2012; 41: 206-212.
35. Sylliaas H, Brovold T, Wyller TB, et al. Progressive strength training in older patients after hip fracture: a randomised controlled trial. Age Ageing 2011; 40: 221-227.
36. Pakkala I, Read S, Sipila S, et al. Effects of intensive strength-power training on sense of coherence among 60-85-year-old people with hip fracture: a randomized controlled trial. Aging Clin Exp Res 2012; 24: 295-299.
37. Mikkelsen LR, Mikkelsen SS, Christensen FB. Early, intensified home-based exercise after total hip replacement: a pilot study +. Physiother Res Int 2012; 17: 214-226.
38. Achiniotis G, Evaggelinou C, Noussios G, et al. The effect of an individual muscle strengthening program and dietary assessment in the quality of life in women with osteoporotic hip fracture. J Sci Technol 2011; 6: 57-64.
39. Portegjis E, Edgren J, Salpakoski A, et al. Balance confidence was associatedwith mobility and balance performance in older people with fall-related hip fracture: a cross-sectional study. Arch Phys Med Rehabil 2012; 93: 2340-2346.
40. Radosavljevic N, Nikolic D, Lazovic M, et al. Estimation of functional recovery in patients after hip fracture by Berg Balance Scale regarding the sex, age and comorbidity of participants. Geriatr Gerontol Int 2013; 13: 365-371.
41. Halvarsson A, Franzen E, Faren E, et al. Long-term effects of new progressive group balance training for elderly people with increased risk of falling: a randomized controlled trial. Clin Rehabil 2013; 27: 450-458.
42. Sipila S, Salpakoski A, Edgren J, et al. Promoting mobility after hip fracture (ProMo): study protocol and selected baseline results of a year-long randomized controlled trial among community-dwelling older people. BMC Musculoskelet Disord 2011; 12.
43. Orwig DL, Hochberg M, Yu-Yahiro J, et al. Delivery and outcomes of a yearlong home exercise program after hip fracture: a randomized controlled trial. Arch Intern Med 2011; 171: 323-331.
44. Marks R. Aerobic exercise for preventing osteoporosis in postmenopausal women: an update of its effect on bone mineral density. Curr Rheumatol Rev 2012; 8: 141-159.
45. Narra N, Nikander R, Viik J, et al. Femoral neck cross-sectional geometry and exercise loading. Clin Physiol Funct Imaging 2013; 33: 258-266.
46. Auais MA, Eilayyan O, Mayo NE. Extended exercise rehabilitation after hip fracture improves patients' physical function: a systematic review and metaanalysis. Phys Ther 2012; 92: 1437-1451. Thirteen trials were included in the review and 11 in the meta-analysis. The extended exercise program showed modest effect sizes for knee extension strength, balance, and some physical performance-based tests. Community-based programs had larger effect sizes compared with home-based programs. This is the first meta-analysis to provide evidence that an extended exercise rehabilitation program for patients with hip fractures has a significant impact on various functional abilities.
47. Tung Y-C, Cooke M, Moyle W. Sources older people draw on to nurture, strengthen and improve self-efficacy in managing home rehabilitation following orthopaedic surgery. J Clin Nurs 2013; 22: 1217-1225.
48. Gorman E, Chudyk AM, Hoppmann CA, et al. Exploring older adults' patterns and perceptions of exercise after hip fracture. Physiother Canada 2013; 65:86-93; Winter.
49. Portegijs E, Rantakokko M, Edgren J, et al. Effects of a rehabilitation program on perceived environmental barriers in older patients recovering from hip fracture: a randomized controlled trial. BioMed Res Int 2013; 2013:769645.
50. Morghen S, Bellelli G, Manuele S, et al. Moderate to severe depressive symptoms and rehabilitation outcome in older adults with hip fracture. Int J Geriatr Psychiatry 2011; 26: 1136-1143.
51. Phillips A, Upton J, Duggl N, et al. Depression following hip fracture is associated with increased physical frailty in older adults: the role of the cortisol - dehydroepiandrosterone sulphate ratio. BMC Geriatr 2013; 13:60.
52. Shyu YI, Liang J, Tseng MY, et al. Comprehensive care improves health outcomes among elderly Taiwanese patients with hip fracture. J Gerontol A Biol Sci Med Sci 2013; 68: 188-197. Two hundred ninety-nine patients with hip fracture were randomized to usual care, interdisiplinary care, or comprensive care and followed for 1 year. Patients benefitted more from comprehensive care including interdisciplinary care and nutrition consultation, depression management, and fall prevention than simply interdisciplinary care.
53. Yamada M, Takechi H, Mori S, et al. Global brain atrophy is associated with physical performance and the risk of falls in older adults with cognitive impairment. GeriatrGerontol Int 2013; 13: 437-442.
54. Koren-Hakim T, Weiss A, Hershkovitz A, et al. The relationship between nutritional status of hip fracture operated elderly patients and their functioning, comorbidity and outcome. Clin Nutr 2012; 31: 917-921.
55. Abellan van Kan G, Cesari M, Gillette-Guyonnet S, et al. Sarcopenia and cognitive impairment in elderly women: results from the EPIDOS cohort. Age Ageing 2013; 42: 196-202.
56. Tseng M-Y, Shyu Y-IL, Liang J. Functional recovery of older hip-fracture patients after interdisciplinary intervention follows three distinct trajectories. Gerontologist 2012; 52: 833-842.
57. Schaller F, Sidelnikov E, Theiler R, et al. Mild to moderate cognitive impairment is a major risk factor for mortality and nursing home admission in the first year after hip fracture. Bone 2012; 51: 347-352.
58. Nandi N, Maddula M, Sahota O. Improving hip fracture care: striving for excellence. Rev Clin Gerontol 2013; 23: 223-233.
59. Stenvall M, Berggren M, Lundstrom M, et al. A multidisciplinary intervention program improved the outcome after hip fracture for people with dementia: subgroup analyses of a randomized controlled trial. Arch Gerontol Geriatr 2012; 54:e284-e289. Sixty-four patients with hip fracture and dementia were randomized to usual care or a multidiciplinary intervention consisting of staff education, care planning, and prevention of delirium and other postoperative complications. Experimental group had fewer complications, better mobility, and higher functional performance at 12 months than the usual care group, providing evidence that patients with dementia can benefit from multidisciplinary geriatric assessment and rehabilitation and should not be excluded from rehabilitation programs.
60. Langlois F, Vu TTM, Chasse K, et al. Benefits of physical exercise training on cognition and quality of life in frail older adults. J GerontolBPsychol Sci Soc Sci 2013; 68: 400-404.
61. Handoll HH, Sherrington C, Mak JC. Interventions for improving mobility after hip fracture surgery in adults. Cochrane Database of Syst Rev 2011; CD001704.
62. Botella-Carretero JI, Gomez-Martin JM, Calanas A, et al. Oral supplementation in elderly patients with hip fracture: a review. Nutr Ther Metab 2012; 30: 170-175. This article reviews the evidence that high protein nutritional supplements are effective during the perioperative period in elderly patients with hip fractures, even in those without malnutrition.
63. Gumieiro DN, Rafacho BP, Goncalves AF, et al. Mini nutritional assessment predicts gait status and mortality 6 months after hip fracture. Br J Nutr 2013; 109: 1657-1661.
64. Li H-JPRN, Cheng H-SMD, Liang JP, et al. Functional recovery of older people with hip fracture: does malnutrition make a difference? J Adv Nurs 2013; 69: 1691-1703.
65. Hinton PS, Rector RS, Linden MA, et al. Weight-loss-associated changes in bone mineral density and bone turnover after partial weight regain with or without aerobic exercise in obese women. Eur J Clin Nutr 2012; 66: 606-612.
66. Bell J, Bauer J, Capra S, et al. Barriers to nutritional intake in patients with acute hip fracture: time to treat malnutrition as a disease and food as a medicine? (Special Issue: Food as medicine.). Can J Physiol Pharmacol 2013; 91: 489-495.
67. Tappenden KA, Quatrara B, Parkhurst ML, et al. Critical role of nutrition in improving quality of care: an interdisciplinary call to action to address adult hospital malnutrition. MEDSURG Nursing: The J of Adult Health 2013; 22: 147-165.
68. Myint MWW, Wu J, Wong E, et al. Clinical benefits of oral nutritional supplementation for elderly hip fracture patients: a single blind randomised controlled trial. Age Ageing 2013; 42: 39-45. A single oral multinutrient supplement during hospitalization in 126 patients with hip fracture reduced length of stay and infection rate, but did not improve functional outcomes at any timpoint over 6 months compared with usual care, emphasizing the need for more comprensive, robust, and lasting nutritional interventions in at-risk individuals.
69. Wyers CE, Reijven PLM, Evers SMAA, et al. Cost-effectiveness of nutritional intervention in elderly subjects after hip fracture. A randomized controlled trial. Osteoporos Int 2013; 24: 151-162. One hundred fifty-two patients were randomized to dietary counseling and supplementation after hip fracture or usual care for 3 months after discharge. The nutritional intervention appeared to have cost-effectiveness for weight gain, but not quality-adjusted life years, and further cost-effectiveness studies focusing on clinically relevant outcomes such as function are recommended.
70. Kerstetter JE, Kenny AM, Insogna KL. Dietary protein and skeletal health: a review of recent human research. Curr Opin Lipidol 2011; 22: 16-20.
71. Bonjour JP. Protein intake and bone health. Int J Vitam Nutr Res 2011; 81: 134-142.
72. Apalset EM, Gjesdal CG, Eide GE, et al. Intake of vitamin K1 and K2 and risk of hip fractures: the Hordaland Health Study. Bone 2011; 49: 990-995.
73. Chan R, Leung J, Woo J. No association between dietary vitamin K intake and fracture risk in Chinese community-dwelling older men and women: a prospective study. Calcif Tissue Int 2012; 90: 396-403.
74. Cheung AM, Tile L, Lee Y, et al. Vitamin K supplementation in postmenopausal women with osteopenia (ECKOtrial): a randomized controlled trial. PLoS Med 2008; 5:e196.
75. Skorupski N, Alexander IM. Multidisciplinary osteoporosis management of post low-energy trauma hip-fracture patients. J Am Acad Nurse Pract 2013; 25: 3-10.
76. Sivakumar BS, McDermott LM, Bell JJ, et al. Dedicated hip fracture service: implementing a novel model of care. ANZ J Surg 2013; 83: 559-563.