Overexpression of Bmi-1 induces the malignant transformation of gastric epithelial cells in vitro

Oncology Research

Volumn 21, Issue 1, 2013, Pages 33-41

  Chen, Yinting ^a   Lian, Guoda ^a   Zhang, Qiubo ^a   Zeng, Linjuan ^a   Qian, Chenchen ^a   Chen, Shaojie ^a   Huang, Kaihong ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

B cell specific Moloney murine leukemia virus integration site 1 (Bmi 1); Gastric cancer; Gastric epithelial cells; Malignant transformation

Indexed keywords

BMI1 PROTEIN;

ANCHORAGE INDEPENDENT GROWTH; APOPTOSIS; ARTICLE; CELL GROWTH; CELL IMMORTALIZATION; CELL INVASION; CELL MIGRATION; CELL MOTILITY; CELL PROLIFERATION; CLONOGENESIS; CONTROLLED STUDY; EPITHELIUM CELL; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; STOMACH EPITHELIUM;

ANIMALS; CELL GROWTH PROCESSES; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; EPITHELIAL CELLS; FEMALE; GASTRIC MUCOSA; HUMANS; MICE; MICE, NUDE; POLYCOMB REPRESSIVE COMPLEX 1; PROGNOSIS; STOMACH NEOPLASMS;

EID: 84890941792     PISSN: 09650407     EISSN: 15553906     Source Type: Journal    
DOI: 10.3727/096504013X13786659070316     Document Type: Article

References (32)

1. Mitelman, F. Catalogue of chromosome aberrations in cancer. Cytogenet. Cell Genet. 36:1-515; 1983.
2. Desai, A. M.; Pareek, M.; Nightingale, P. G.; Fielding, J. W. Improving outcomes in gastric cancer over 20 years. Gastric Cancer 7:196-201; discussion 201-203; 2004.
3. Boyle, P. Global burden of cancer. Lancet 349:23-26; 1997.
4. Neugut, A. I.; Hayek, M.; Howe, G. Epidemiology of gastric cancer. Semin. Oncol. 23:281-291; 1996.
5. Dhar, D. K.; Kubota, H.; Tachibana, M.; Kinugasa, S.; Masunaga, R.; Shibakita, M.; Kohno, H.; Nagasue, N. Prognosis of T4 gastric carcinoma patients: An appraisal of aggressive surgical treatment. J. Surg. Oncol. 76:278-282; 2001.
6. You, W. C.; Zhang, L.; Gail, M. H.; Chang, Y. S.; Liu, W. D.; Ma, J. L.; Li, J. Y.; Jin, M. L.; Hu, Y. R.; Yang, C. S.; Blaser, M. J.; Correa, P.; Blot, W. J.; Fraumeni, J. F. Jr.; Xu, G. W. Gastric dysplasia and gastric cancer: Helicobacter pylori, serum vitamin C, and other risk factors. J. Natl. Cancer Inst. 92:1607-1612; 2000.
7. Bracken, A. P.; Helin, K. Polycomb group proteins: Navigators of lineage pathways led astray in cancer. Nat. Rev. Cancer 9:773-784; 2009.
8. Haupt, Y.; Alexander, W. S.; Barri, G.; Klinken, S. P.; Adams, J. M. Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice. Cell 65:753-763; 1991.
9. van Lohuizen, M.; Verbeek, S.; Scheijen, B.; Wientjens, E.; van der Gulden, H.; Berns, A. Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging. Cell 65:737-752; 1991.
10. Beà, S.; Tort, F.; Pinyol, M.; Puig, X.; Hernández, L.; Hernández, S.; Fernandez, P. L.; van Lohuizen, M.; Colomer, D.; Campo, E. BMI-1 gene amplification and overexpression in hematological malignancies occur mainly in mantle cell lymphomas. Cancer Res. 61:2409-2412; 2001.
11. Vonlanthen, S.; Heighway, J.; Altermatt, H. J.; Gugger, M.; Kappeler, A.; Borner, M. M.; van Lohuizen, M.; Betticher, D. C. The bmi-1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A-ARF locus expression. Br. J. Cancer 84:1372-1376; 2001.
12. Raaphorst, F. M.; Meijer, C. J.; Fieret, E.; Blokzijl, T.; Mommers, E.; Buerger, H.; Packeisen, J.; Sewalt, R. A.; Otte, A. P.; van Diest, P. J. Poorly differentiated breast carcinoma is associated with increased expression of the human polycomb group EZH2 gene. Neoplasia 5:481-488; 2003.
13. Silva, J.; García, J. M.; Peña, C.; García, V.; Domínguez, G.; Suárez, D.; Camacho, F. I.; Espinosa, R.; Provencio, M.; España, P.; Bonilla, F. Implication of polycomb members Bmi-1, Mel-18, and Hpc-2 in the regulation of p16INK4a, p14ARF, h-TERT, and c-Myc expression in primary breast carcinomas. Clin. Cancer Res. 12:6929-6936; 2006.
14. Glinsky, G. V.; Berezovska, O.; Glinskii, A. B. Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer. J. Clin. Invest. 115:1503-1521; 2005.
15. Song, L. B.; Zeng, M. S.; Liao, W. T.; Zhang, L.; Mo, H. Y.; Liu, W. L.; Shao, J. Y.; Wu, Q. L.; Li, M. Z.; Xia, Y. F.; Fu, L. W.; Huang, W. L.; Dimri, G. P.; Band, V.; Zeng, Y. X. Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells. Cancer Res. 66:6225-6232; 2006.
16. Kim, J. H.; Yoon, S. Y.; Kim, C. N.; Joo, J. H.; Moon, S. K.; Choe, I. S.; Choe, Y. K.; Kim, J. W. The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins. Cancer Lett. 203:217-224; 2004.
17. Liu, J. H.; Song, L. B.; Zhang, X.; Guo, B. H.; Feng, Y.; Li, X. X.; Liao, W. T.; Zeng, M. S.; Huang, K. H. Bmi-1 expression predicts prognosis for patients with gastric carcinoma. J. Surg. Oncol. 97:267-272; 2008.
18. Livak, K. J.; Schmittgen, T. D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25:402-408; 2001.
19. Hoenerhoff, M. J.; Chu, I.; Barkan, D.; Liu, Z. Y.; Datta, S.; Dimri, G. P.; Green, J. E. BMI1 cooperates with H-RAS to induce an aggressive breast cancer phenotype with brain metastases. Oncogene 28:3022-3032; 2009.
20. van der Lugt, N. M.; Domen, J.; Linders, K.; van Roon, M.; Robanus-Maandag, E.; te Riele, H.; van der Valk, M.; Deschamps, J.; Sofroniew, M.; van Lohuizen, M. Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes Dev. 8:757-769; 1994.
21. Molofsky, A. V.; Pardal, R.; Iwashita, T.; Park, I. K.; Clarke, M. F.; Morrison, S. J. Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature 425:962-967; 2003.
22. Park, I. K.; Qian, D.; Kiel, M.; Becker, M. W.; Pihalja, M.; Weissman, I. L.; Morrison, S. J.; Clarke, M, F. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 423:302-305; 2003.
23. Brock, H. W.; van Lohuizen, M. The Polycomb group - no longer an exclusive club? Curr. Opin. Genet. Dev. 11: 175-181; 2001.
24. Francis, N. J.; Kingston, R. E. Mechanisms of transcriptional memory. Nat. Rev. Mol. Cell. Biol. 2:409-421; 2001.
25. Ringrose, L.; Paro, R. Remembering silence. BioEssays 23:566-570; 2001.
26. Xiao, J.; Deng, C. Knockdown of Bmi-1 impairs growth and invasiveness of human gastric carcinoma cells. Oncol. Res. 17:613-620; 2009.
27. Li, W.; Li, Y.; Tan, Y.; Ma, K.; Cui, J. Bmi-1 is critical for the proliferation and invasiveness of gastric carcinoma cells. J. Gastroenterol. Hepatol. 25:568-575; 2010.
28. Zhang, X. W.; Sheng, Y. P.; Li, Q.; Qin, W.; Lu, Y. W.; Cheng, Y. F.; Liu, B. Y.; Zhang, F. C.; Li, J.; Dimri, G. P.; Guo, W. J. BMI1 and Mel-18 oppositely regulate carcinogenesis and progression of gastric cancer. Mol. Cancer 9:40-51; 2010.
29. Guo, B. H.; Feng, Y.; Zhang, R.; Xu, L. H.; Li, M. Z.; Kung, H. F.; Song, L. B.; Zeng, M. S. Bmi-1 promotes invasion and metastasis, and its elevated expression is correlated with an advanced stage of breast cancer. Mol. Cancer 10:10; 2011.
30. Wicha, M. S.; Liu, S.; Dontu, G. Cancer stem cells: An old idea - a paradigm shift. Cancer Res. 66:1883-1890; 2006.
31. Pantel, K.; Brakenhoff, R. H. Dissecting the metastatic cascade. Nat. Rev. Cancer 4:448-456; 2004.
32. Song, L. B.; Li, J.; Liao, W. T.; Feng, Y.; Yu, C. P.; Hu, L. J.; Kong, Q. L.; Xu, L. H.; Zhang, X.; Liu, W. L.; Li, M. Z.; Zhang, L.; Kang, T. B.; Fu, L. W.; Huang, W. L.; Xia, Y. F.; Tsao, S. W.; Li, M. F.; Band, V.; Shi, Q. H.; Zeng, Y. X.; Zeng, M. S. The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells. J. Clin. Invest. 119:3626-3636; 2009.