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Volumn 75, Issue 5, 2013, Pages 188-198

Molecular basis of drug resistance: Epidermal growth factor receptor tyrosine kinase inhibitors and anaplastic lymphoma kinase inhibitors

Author keywords

Drug resistance; Protein kinase inhibitors; Receptor protein tyrosine kinases; Receptor, epidermal growth factor

Indexed keywords

ANAPLASTIC LYMPHOMA KINASE INHIBITOR; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; SCATTER FACTOR; UNCLASSIFIED DRUG;

EID: 84890931756     PISSN: 17383536     EISSN: None     Source Type: Journal    
DOI: 10.4046/trd.2013.75.5.188     Document Type: Review
Times cited : (8)

References (58)
  • 2
    • 33645052711 scopus 로고    scopus 로고
    • Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features
    • Tam IY, Chung LP, Suen WS, Wang E, Wong MC, Ho KK, et al. Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features. Clin Cancer Res 2006;12:1647-53.
    • (2006) Clin Cancer Res , vol.12 , pp. 1647-1653
    • Tam, I.Y.1    Chung, L.P.2    Suen, W.S.3    Wang, E.4    Wong, M.C.5    Ho, K.K.6
  • 3
    • 15744372810 scopus 로고    scopus 로고
    • KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib
    • Pao W, Wang TY, Riely GJ, Miller VA, Pan Q, Ladanyi M, et al. KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. PLoS Med 2005;2:e17.
    • (2005) PLoS Med , vol.2
    • Pao, W.1    Wang, T.Y.2    Riely, G.J.3    Miller, V.A.4    Pan, Q.5    Ladanyi, M.6
  • 4
    • 24944497744 scopus 로고    scopus 로고
    • Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib
    • Eberhard DA, Johnson BE, Amler LC, Goddard AD, Heldens SL, Herbst RS, et al. Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib. J Clin Oncol 2005;23:5900-9.
    • (2005) J Clin Oncol , vol.23 , pp. 5900-5909
    • Eberhard, D.A.1    Johnson, B.E.2    Amler, L.C.3    Goddard, A.D.4    Heldens, S.L.5    Herbst, R.S.6
  • 6
    • 84863934167 scopus 로고    scopus 로고
    • Recent understanding of the molecular mechanisms for the efficacy and resistance of EGF receptor-specific tyrosine kinase inhibitors in non-small cell lung cancer
    • Nakata A, Gotoh N. Recent understanding of the molecular mechanisms for the efficacy and resistance of EGF receptor-specific tyrosine kinase inhibitors in non-small cell lung cancer. Expert Opin Ther Targets 2012;16:771-81.
    • (2012) Expert Opin Ther Targets , vol.16 , pp. 771-781
    • Nakata, A.1    Gotoh, N.2
  • 8
    • 33745057881 scopus 로고    scopus 로고
    • HER2 mutation and response to trastuzumab therapy in non-small-cell lung cancer [15]
    • DOI 10.1056/NEJMc060020
    • Cappuzzo F, Bemis L, Varella-Garcia M. HER2 mutation and response to trastuzumab therapy in non-small-cell lung cancer. N Engl J Med 2006;354:2619-21. (Pubitemid 43882374)
    • (2006) New England Journal of Medicine , vol.354 , Issue.24 , pp. 2619-2621
    • Cappuzzo, F.1    Bemis, L.2    Varella-Garcia, M.3
  • 11
    • 33746084112 scopus 로고    scopus 로고
    • Signaling via ErbB2 and ErbB3 associates with resistance and epidermal growth factor receptor (EGFR) amplification with sensitivity to EGFR inhibitor gefitinib in head and neck squamous cell carcinoma cells
    • DOI 10.1158/1078-0432.CCR-05-2404
    • Erjala K, Sundvall M, Junttila TT, Zhang N, Savisalo M, Mali P, et al. Signaling via ErbB2 and ErbB3 associates with resistance and epidermal growth factor receptor (EGFR) amplification with sensitivity to EGFR inhibitor gefitinib in head and neck squamous cell carcinoma cells. Clin Cancer Res 2006;12:4103-11. (Pubitemid 44078099)
    • (2006) Clinical Cancer Research , vol.12 , Issue.13 , pp. 4103-4111
    • Erjala, K.1    Sundvall, M.2    Junttila, T.T.3    Zhang, N.4    Savisalo, M.5    Mali, P.6    Kulmala, J.7    Pulkkinen, J.8    Grenman, R.9    Elenius, K.10
  • 13
  • 17
    • 33947287270 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutants from human lung cancers exhibit enhanced catalytic activity and increased sensitivity to gefitinib
    • DOI 10.1158/0008-5472.CAN-06-4293
    • Mulloy R, Ferrand A, Kim Y, Sordella R, Bell DW, Haber DA, et al. Epidermal growth factor receptor mutants from human lung cancers exhibit enhanced catalytic activity and increased sensitivity to gefitinib. Cancer Res 2007;67:2325-30. (Pubitemid 46424253)
    • (2007) Cancer Research , vol.67 , Issue.5 , pp. 2325-2330
    • Mulloy, R.1    Ferrand, A.2    Kim, Y.3    Sordella, R.4    Bell, D.W.5    Haber, D.A.6    Anderson, K.S.7    Settleman, J.8
  • 18
    • 34547625913 scopus 로고    scopus 로고
    • Oncogenic activity of epidermal growth factor receptor kinase mutant alleles is enhanced by the T790M drug resistance mutation
    • DOI 10.1158/0008-5472.CAN-06-4625
    • Godin-Heymann N, Bryant I, Rivera MN, Ulkus L, Bell DW, Riese DJ 2nd, et al. Oncogenic activity of epidermal growth factor receptor kinase mutant alleles is enhanced by the T790M drug resistance mutation. Cancer Res 2007;67:7319-26. (Pubitemid 47206561)
    • (2007) Cancer Research , vol.67 , Issue.15 , pp. 7319-7326
    • Godin-Heymann, N.1    Bryant, I.2    Rivera, M.N.3    Ulkus, L.4    Bell, D.W.5    Riese II, D.J.6    Settleman, J.7    Haber, D.A.8
  • 19
    • 28444478439 scopus 로고    scopus 로고
    • Oncogenic transformation by inhibitor-sensitive and -Resistant EGFR mutants
    • Greulich H, Chen TH, Feng W, Janne PA, Alvarez JV Zappaterra M, et al. Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants. PLoS Med 2005;2:e313.
    • (2005) PLoS Med , vol.2
    • Greulich, H.1    Chen, T.H.2    Feng, W.3    Janne, P.A.4    Alvarez, J.V.Z.M.5
  • 22
    • 35648949422 scopus 로고    scopus 로고
    • BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations
    • Costa DB, Halmos B, Kumar A, Schumer ST, Huberman MS, Boggon TJ, et al. BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations. PLoS Med 2007;4:1669-79.
    • (2007) PLoS Med , vol.4 , pp. 1669-1679
    • Costa, D.B.1    Halmos, B.2    Kumar, A.3    Schumer, S.T.4    Huberman, M.S.5    Boggon, T.J.6
  • 23
    • 84858669035 scopus 로고    scopus 로고
    • Second-generation irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs): A better mousetrap? A review of the clinical evidence
    • Ou SH. Second-generation irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs): a better mousetrap? A review of the clinical evidence. Crit Rev Oncol Hematol 2012;83:407-21.
    • (2012) Crit Rev Oncol Hematol , vol.83 , pp. 407-421
    • Ou, S.H.1
  • 24
    • 84871721867 scopus 로고    scopus 로고
    • Overcoming acquired resistance to kinase inhibition: The cases of EGFR, ALK and BRAF
    • Giroux S. Overcoming acquired resistance to kinase inhibition: the cases of EGFR, ALK and BRAF. Bioorg Med Chem Lett 2013;23:394-401.
    • (2013) Bioorg Med Chem Lett , vol.23 , pp. 394-401
    • Giroux, S.1
  • 25
    • 72949092456 scopus 로고    scopus 로고
    • Novel mutant-selective EGFR kinase inhibitors against EGFR T790M
    • Zhou W, Ercan D, Chen L, Yun CH, Li D, Capelletti M, et al. Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. Nature 2009;462:1070-4.
    • (2009) Nature , vol.462 , pp. 1070-1074
    • Zhou, W.1    Ercan, D.2    Chen, L.3    Yun, C.H.4    Li, D.5    Capelletti, M.6
  • 27
    • 38049150665 scopus 로고    scopus 로고
    • MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
    • Bean J, Brennan C, Shih JY, Riely G, Viale A, Wang L, et al. MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci U S A 2007;104:20932-7.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 20932-20937
    • Bean, J.1    Brennan, C.2    Shih, J.Y.3    Riely, G.4    Viale, A.5    Wang, L.6
  • 29
    • 55449116539 scopus 로고    scopus 로고
    • Met gene copy number predicts the prognosis for completely resected non-small cell lung cancer
    • Okuda K, Sasaki H, Yukiue H, Yano M, Fujii Y. Met gene copy number predicts the prognosis for completely resected non-small cell lung cancer. Cancer Sci 2008;99:2280-5.
    • (2008) Cancer Sci , vol.99 , pp. 2280-2285
    • Okuda, K.1    Sasaki, H.2    Yukiue, H.3    Yano, M.4    Fujii, Y.5
  • 30
    • 61549138135 scopus 로고    scopus 로고
    • Activation of MET by gene amplification or by splice mutations deleting the juxtamembrane domain in primary resected lung cancers
    • Onozato R, Kosaka T, Kuwano H, Sekido Y, Yatabe Y, Mitsudomi T. Activation of MET by gene amplification or by splice mutations deleting the juxtamembrane domain in primary resected lung cancers. J Thorac Oncol 2009;4:5-11.
    • (2009) J Thorac Oncol , vol.4 , pp. 5-11
    • Onozato, R.1    Kosaka, T.2    Kuwano, H.3    Sekido, Y.4    Yatabe, Y.5    Mitsudomi, T.6
  • 31
    • 56449089812 scopus 로고    scopus 로고
    • Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutations
    • Yano S, Wang W, Li Q, Matsumoto K, Sakurama H, Nakamura T, et al. Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutations. Cancer Res 2008;68:9479-87.
    • (2008) Cancer Res , vol.68 , pp. 9479-9487
    • Yano, S.1    Wang, W.2    Li, Q.3    Matsumoto, K.4    Sakurama, H.5    Nakamura, T.6
  • 32
    • 70350721786 scopus 로고    scopus 로고
    • Crosstalk to stromal fibroblasts induces resistance of lung cancer to epidermal growth factor receptor tyrosine kinase inhibitors
    • Wang W, Li Q, Yamada T, Matsumoto K, Matsumoto I, Oda M, et al. Crosstalk to stromal fibroblasts induces resistance of lung cancer to epidermal growth factor receptor tyrosine kinase inhibitors. Clin Cancer Res 2009;15:6630-8.
    • (2009) Clin Cancer Res , vol.15 , pp. 6630-6638
    • Wang, W.1    Li, Q.2    Yamada, T.3    Matsumoto, K.4    Matsumoto, I.5    Oda, M.6
  • 33
    • 77950460014 scopus 로고    scopus 로고
    • Acquired resistance to gefitinib: The contribution of mechanisms other than the T790M, MET, and HGF status
    • Onitsuka T, Uramoto H, Nose N, Takenoyama M, Hanagiri T, Sugio K, et al. Acquired resistance to gefitinib: the contribution of mechanisms other than the T790M, MET, and HGF status. Lung Cancer 2010;68:198-203.
    • (2010) Lung Cancer , vol.68 , pp. 198-203
    • Onitsuka, T.1    Uramoto, H.2    Nose, N.3    Takenoyama, M.4    Hanagiri, T.5    Sugio, K.6
  • 35
    • 77950809059 scopus 로고    scopus 로고
    • A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations
    • Sharma SV, Lee DY, Li B, Quinlan MP, Takahashi F, Maheswaran S, et al. A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations. Cell 2010;141:69-80.
    • (2010) Cell , vol.141 , pp. 69-80
    • Sharma, S.V.1    Lee, D.Y.2    Li, B.3    Quinlan, M.P.4    Takahashi, F.5    Maheswaran, S.6
  • 41
    • 78049515002 scopus 로고    scopus 로고
    • Lung adenocarcinoma from East Asian never-smokers is a disease largely defined by targetable oncogenic mutant kinases
    • Sun Y, Ren Y, Fang Z, Li C, Fang R, Gao B, et al. Lung adenocarcinoma from East Asian never-smokers is a disease largely defined by targetable oncogenic mutant kinases. J Clin Oncol 2010;28:4616-20.
    • (2010) J Clin Oncol , vol.28 , pp. 4616-4620
    • Sun, Y.1    Ren, Y.2    Fang, Z.3    Li, C.4    Fang, R.5    Gao, B.6
  • 42
    • 58049200145 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition derived from repeated exposure to gefitinib determines the sensitivity to EGFR inhibitors in A549, a non-small cell lung cancer cell line
    • Rho JK, Choi YJ, Lee JK, Ryoo BY, Na II, Yang SH, et al. Epithelial to mesenchymal transition derived from repeated exposure to gefitinib determines the sensitivity to EGFR inhibitors in A549, a non-small cell lung cancer cell line. Lung Cancer 2009;63:219-26.
    • (2009) Lung Cancer , vol.63 , pp. 219-226
    • Rho, J.K.1    Choi, Y.J.2    Lee, J.K.3    Ryoo, B.Y.4    Na, I.I.5    Yang, S.H.6
  • 43
    • 84860352732 scopus 로고    scopus 로고
    • Treating ALK-positive lung cancer: Early successes and future challenges
    • Camidge DR, Doebele RC. Treating ALK-positive lung cancer: early successes and future challenges. Nat Rev Clin Oncol 2012;9:268-77.
    • (2012) Nat Rev Clin Oncol , vol.9 , pp. 268-277
    • Camidge, D.R.1    Doebele, R.C.2
  • 44
    • 78049429691 scopus 로고    scopus 로고
    • Crizotinib: Latest champion in the cancer wars?
    • Hallberg B, Palmer RH. Crizotinib: latest champion in the cancer wars? N Engl J Med 2010;363:1760-2.
    • (2010) N Engl J Med , vol.363 , pp. 1760-1762
    • Hallberg, B.1    Palmer, R.H.2
  • 45
  • 48
    • 0020677360 scopus 로고
    • Characterization of a human colon/lung carcinoma oncogene
    • McCoy MS, Toole JJ, Cunningham JM, Chang EH, Lowy DR, Weinberg RA. Characterization of a human colon/lung carcinoma oncogene. Nature 1983;302:79-81. (Pubitemid 13138483)
    • (1983) Nature , vol.302 , Issue.5903 , pp. 79-81
    • McCoy, M.S.1    Toole, J.J.2    Cunningham, J.M.3
  • 49
  • 50
    • 79956318797 scopus 로고    scopus 로고
    • Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK
    • Katayama R, Khan TM, Benes C, Lifshits E, Ebi H, Rivera VM, et al. Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK. Proc Natl Acad Sci U S A 2011;108:7535-40.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 7535-7540
    • Katayama, R.1    Khan, T.M.2    Benes, C.3    Lifshits, E.4    Ebi, H.5    Rivera, V.M.6
  • 51
    • 78649475696 scopus 로고    scopus 로고
    • The neuroblastoma-associated F1174L ALK mutation causes resistance to an ALK kinase inhibitor in ALK-translocated cancers
    • Sasaki T, Okuda K, Zheng W, Butrynski J, Capelletti M, Wang L, et al. The neuroblastoma-associated F1174L ALK mutation causes resistance to an ALK kinase inhibitor in ALK-translocated cancers. Cancer Res 2010;70:10038-43.
    • (2010) Cancer Res , vol.70 , pp. 10038-10043
    • Sasaki, T.1    Okuda, K.2    Zheng, W.3    Butrynski, J.4    Capelletti, M.5    Wang, L.6
  • 52
    • 80052793410 scopus 로고    scopus 로고
    • A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors
    • Sasaki T, Koivunen J, Ogino A, Yanagita M, Nikiforow S, Zheng W, et al. A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors. Cancer Res 2011;71:6051-60.
    • (2011) Cancer Res , vol.71 , pp. 6051-6060
    • Sasaki, T.1    Koivunen, J.2    Ogino, A.3    Yanagita, M.4    Nikiforow, S.5    Zheng, W.6
  • 53
    • 82555205478 scopus 로고    scopus 로고
    • ALK mutations conferring differential resistance to structurally diverse ALK inhibitors
    • Heuckmann JM, Holzel M, Sos ML, Heynck S, Balke-Want H, Koker M, et al. ALK mutations conferring differential resistance to structurally diverse ALK inhibitors. Clin Cancer Res 2011;17:7394-401.
    • (2011) Clin Cancer Res , vol.17 , pp. 7394-7401
    • Heuckmann, J.M.1    Holzel, M.2    Sos, M.L.3    Heynck, S.4    Balke-Want, H.5    Koker, M.6
  • 54
    • 84863336092 scopus 로고    scopus 로고
    • Paracrine receptor activation by microenvironment triggers bypass survival signals and ALK inhibitor resistance in EML4-ALK lung cancer cells
    • Yamada T, Takeuchi S, Nakade J, Kita K, Nakagawa T, Nanjo S, et al. Paracrine receptor activation by microenvironment triggers bypass survival signals and ALK inhibitor resistance in EML4-ALK lung cancer cells. Clin Cancer Res 2012;18:3592-602.
    • (2012) Clin Cancer Res , vol.18 , pp. 3592-3602
    • Yamada, T.1    Takeuchi, S.2    Nakade, J.3    Kita, K.4    Nakagawa, T.5    Nanjo, S.6
  • 55
    • 84863304804 scopus 로고    scopus 로고
    • Ligand-triggered resistance to molecular targeted drugs in lung cancer: Roles of hepatocyte growth factor and epidermal growth factor receptor ligands
    • Yano S, Takeuchi S, Nakagawa T, Yamada T. Ligand-triggered resistance to molecular targeted drugs in lung cancer: roles of hepatocyte growth factor and epidermal growth factor receptor ligands. Cancer Sci 2012;103:1189-94.
    • (2012) Cancer Sci , vol.103 , pp. 1189-1194
    • Yano, S.1    Takeuchi, S.2    Nakagawa, T.3    Yamada, T.4
  • 58
    • 77958478674 scopus 로고    scopus 로고
    • Rational, biologically based treatment of EGFR-mutant non-small-cell lung cancer
    • Pao W, Chmielecki J. Rational, biologically based treatment of EGFR-mutant non-small-cell lung cancer. Nat Rev Cancer 2010;10:760-74.
    • (2010) Nat Rev Cancer , vol.10 , pp. 760-774
    • Pao, W.1    Chmielecki, J.2


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