Macromolecular prodrug of dexamethasone prevents particle-induced peri-implant osteolysis with reduced systemic side effects

Journal of Controlled Release

Volumn 175, Issue 1, 2014, Pages 1-9

  Ren, Ke ^a   Dusad, Anand ^a   Yuan, Fang ^a   Yuan, Hongjiang ^a   Purdue, P Edward ^b   Fehringer, Edward V ^a   Garvin, Kevin L ^a   Goldring, Steven R ^b   Wang, Dong ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b HOSPITAL FOR SPECIAL SURGERY   (United States)

Author keywords

Dexamethasone; ELVIS; HPMA copolymer; Implant loosening; Inflammation targeting; Prodrug

Indexed keywords

DEXAMETHASONES; ELVIS; HPMA COPOLYMERS; IMPLANT LOOSENING; INFLAMMATION TARGETING; PRODRUGS;

CELL CULTURE; CELL PROLIFERATION; COMPUTERIZED TOMOGRAPHY; COPOLYMERS; DRUG INTERACTIONS; JOINT PROSTHESES; MACROMOLECULES; PATHOLOGY; TOXICITY;

DRUG PRODUCTS;

COPOLYMER; DEXAMETHASONE; N (2 HYDROXYPROPYL)METHACRYLAMIDE; POLY(METHYL METHACRYLATE); PRODRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MASS; CONTROLLED STUDY; DRUG CONJUGATION; DRUG SYNTHESIS; FLOW CYTOMETRY; HISTOPATHOLOGY; IN VIVO STUDY; MALE; MECHANICAL TORSION; MICRO-COMPUTED TOMOGRAPHY; MOLECULAR WEIGHT; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; OSTEOPOROSIS; PARTICLE INDUCED PERI IMPLANT OSTEOLYSIS; PRIORITY JOURNAL; PROSTHESIS FAILURE; THREE DIMENSIONAL IMAGING;

DEXAMETHASONE; ELVIS; HPMA COPOLYMER; IMPLANT LOOSENING; INFLAMMATION TARGETING; PRODRUG;

ACRYLAMIDES; ANIMALS; DELAYED-ACTION PREPARATIONS; DEXAMETHASONE; HUMANS; MALE; MICE; OSTEOLYSIS; PRODRUGS; PROSTHESIS FAILURE;

EID: 84890902145     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.11.024     Document Type: Article

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