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Volumn 18, Issue 12, 2013, Pages 15600-15612

In vitro evaluation of novel inhibitors against the NS2B-NS3 protease of dengue fever virus type 4

Author keywords

Dengue fever; Inhibitors; NS2B NS3 protease; Virtual screening

Indexed keywords

ANTIVIRUS AGENT; NS3 PROTEASE, DENGUE VIRUS; PROTEINASE INHIBITOR; RECOMBINANT PROTEIN; SERINE PROTEINASE;

EID: 84890893381     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules181215600     Document Type: Article
Times cited : (17)

References (37)
  • 1
    • 0035824539 scopus 로고    scopus 로고
    • Activity of recombinant dengue 2 virus NS3 protease in the presence of a truncated NS2B co-factor, small peptide substrates, and inhibitors
    • Leung, D.; Schroder, K.; White, H.; Fang, N.X.; Stoermer, M.J.; Abbenante, G.; Martin, J.L.; Young, P.R.; Fairlie, D.P. Activity of recombinant dengue 2 virus NS3 protease in the presence of a truncated NS2B co-factor, small peptide substrates, and inhibitors. J. Biol. Chem. 2001, 276, 45762-45771.
    • (2001) J. Biol. Chem. , vol.276 , pp. 45762-45771
    • Leung, D.1    Schroder, K.2    White, H.3    Fang, N.X.4    Stoermer, M.J.5    Abbenante, G.6    Martin, J.L.7    Young, P.R.8    Fairlie, D.P.9
  • 3
    • 77149129868 scopus 로고    scopus 로고
    • Expression of dengue virus e glycoprotein domain III in non-nicotine transgenic tobacco plants
    • Kim, M.Y.; Yang, M.S.; Kim, T.G. Expression of dengue virus e glycoprotein domain III in non-nicotine transgenic tobacco plants. Biotechnol. Bioproc. Eng. 2009, 14, 725-730.
    • (2009) Biotechnol. Bioproc. Eng. , vol.14 , pp. 725-730
    • Kim, M.Y.1    Yang, M.S.2    Kim, T.G.3
  • 6
    • 39749161127 scopus 로고    scopus 로고
    • Biological characteristics of dengue virus and potential targets for drug design
    • Qi, R.F.; Zhang, L.; Chi, C.W. Biological characteristics of dengue virus and potential targets for drug design. Acta Bioch. Bioph. Sin. 2008, 40, 91-101.
    • (2008) Acta Bioch. Bioph. Sin. , vol.40 , pp. 91-101
    • Qi, R.F.1    Zhang, L.2    Chi, C.W.3
  • 7
    • 50949084334 scopus 로고    scopus 로고
    • Identification and biochemical characterization of small-molecule inhibitors of west nile virus serine protease by a high-throughput screen
    • Mueller, N.H.; Pattabiraman, N.; Ansarah-Sobrinho, C.; Viswanathan, P.; Pierson, T.C.; Padmanabhan, R. Identification and biochemical characterization of small-molecule inhibitors of west nile virus serine protease by a high-throughput screen. Antimicrob. Agents Chemother. 2008, 52, 3385-3393.
    • (2008) Antimicrob. Agents Chemother. , vol.52 , pp. 3385-3393
    • Mueller, N.H.1    Pattabiraman, N.2    Ansarah-Sobrinho, C.3    Viswanathan, P.4    Pierson, T.C.5    Padmanabhan, R.6
  • 8
    • 84891551118 scopus 로고    scopus 로고
    • A novel, potential dengue virus NS2B/NS3 protease inhibitor, BP13944, was discovered through high-throughput screening with dengue replicon cells
    • doi:10.1128/AAC.01281-13
    • Yang, C.C.; Hu, H.S.; Wu, R.H.; Wu, S.H.; Lee, S.J.; Jiaang, W.T.; Chern, J.H.; Huang, Z.S.; Wu, H.N.; Chang, C.M.; et al. A novel, potential dengue virus NS2B/NS3 protease inhibitor, BP13944, was discovered through high-throughput screening with dengue replicon cells. Antimicrob. Agents Chemother. 2013, doi:10.1128/AAC.01281-13.
    • (2013) Antimicrob. Agents Chemother.
    • Yang, C.C.1    Hu, H.S.2    Wu, R.H.3    Wu, S.H.4    Lee, S.J.5    Jiaang, W.T.6    Chern, J.H.7    Huang, Z.S.8    Wu, H.N.9    Chang, C.M.10
  • 9
    • 84856093723 scopus 로고    scopus 로고
    • Use of parallel validation high-throughput screens to reduce false positives and identify novel dengue NS2B-NS3 protease inhibitors
    • Tomlinson, S.M.; Watowich, S.J. Use of parallel validation high-throughput screens to reduce false positives and identify novel dengue NS2B-NS3 protease inhibitors. Antivir. Res. 2012, 93, 245-252.
    • (2012) Antivir. Res. , vol.93 , pp. 245-252
    • Tomlinson, S.M.1    Watowich, S.J.2
  • 12
    • 75149168873 scopus 로고    scopus 로고
    • Synthesis and disulfide bond connectivity-activity studies of a kalata B1-inspired cyclopeptide against dengue NS2B-NS3 protease
    • Gao, Y.; Cui, T.; Lam, Y. Synthesis and disulfide bond connectivity-activity studies of a kalata B1-inspired cyclopeptide against dengue NS2B-NS3 protease. Bioorg. Med. Chem. 2010, 18, 1331-1336.
    • (2010) Bioorg. Med. Chem. , vol.18 , pp. 1331-1336
    • Gao, Y.1    Cui, T.2    Lam, Y.3
  • 15
    • 84864193750 scopus 로고    scopus 로고
    • Discovery of novel small molecule inhibitors of dengue viral NS2B-NS3 protease using virtual screening and scaffold hopping
    • Deng, J.; Li, N.; Liu, H.; Zuo, Z.; Liew, O.W.; Xu, W.; Chen, G.; Tong, X.; Tang, W.; Zhu, J.; et al. Discovery of novel small molecule inhibitors of dengue viral NS2B-NS3 protease using virtual screening and scaffold hopping. J. Med. Chem. 2012, 55, 6278-6293.
    • (2012) J. Med. Chem. , vol.55 , pp. 6278-6293
    • Deng, J.1    Li, N.2    Liu, H.3    Zuo, Z.4    Liew, O.W.5    Xu, W.6    Chen, G.7    Tong, X.8    Tang, W.9    Zhu, J.10
  • 16
    • 33646177244 scopus 로고    scopus 로고
    • Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease
    • Kiat, T.S.; Pippen, R.; Yusof, R.; Ibrahim, H.; Khalid, N.; Rahman, N.A. Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease. Bioorg. Med. Chem. Lett. 2006, 16, 3337-3340.
    • (2006) Bioorg. Med. Chem. Lett. , vol.16 , pp. 3337-3340
    • Kiat, T.S.1    Pippen, R.2    Yusof, R.3    Ibrahim, H.4    Khalid, N.5    Rahman, N.A.6
  • 18
    • 53249121029 scopus 로고    scopus 로고
    • Towards the design of antiviral inhibitors against flaviviruses: The case for the multifunctional NS3 protein from dengue virus as a target
    • Lescar, J.; Luo, D.; Xu, T.; Sampath, A.; Lim, S.P.; Canard, B.; Vasudevan, S.G. Towards the design of antiviral inhibitors against flaviviruses: The case for the multifunctional NS3 protein from dengue virus as a target. Antivir. Res. 2008, 80, 94-101.
    • (2008) Antivir. Res. , vol.80 , pp. 94-101
    • Lescar, J.1    Luo, D.2    Xu, T.3    Sampath, A.4    Lim, S.P.5    Canard, B.6    Vasudevan, S.G.7
  • 22
    • 84868215288 scopus 로고    scopus 로고
    • Dengue vaccine development: A 75% solution?
    • Halstead, S.B. Dengue vaccine development: A 75% solution? Lancet 2012, 380, 1535-1536.
    • (2012) Lancet , vol.380 , pp. 1535-1536
    • Halstead, S.B.1
  • 23
    • 1642350394 scopus 로고    scopus 로고
    • Recent development and application of virtual screening in drug discovery: An overview
    • Hou, T.; Xu, X. Recent development and application of virtual screening in drug discovery: An overview. Curr. Pharm. Design. 2004, 10, 1011-1033.
    • (2004) Curr. Pharm. Design. , vol.10 , pp. 1011-1033
    • Hou, T.1    Xu, X.2
  • 24
    • 39049094335 scopus 로고    scopus 로고
    • Virtual screening and its integration with modern drug design technologies
    • Guido, R.V.; Oliva, G.; Andricopulo, A.D. Virtual screening and its integration with modern drug design technologies. Curr. Med. Chem. 2008, 15, 37-46.
    • (2008) Curr. Med. Chem. , vol.15 , pp. 37-46
    • Guido, R.V.1    Oliva, G.2    Andricopulo, A.D.3
  • 25
    • 79955549965 scopus 로고    scopus 로고
    • Virtual screening identification of novel severe acute respiratory syndrome 3c-like protease inhibitors and in vitro confirmation
    • Nguyen, T.T.H.; Ryu, H.J.; Lee, S.H.; Hwang, S.; Breton, V.; Rhee, J.H.; Kim, D. Virtual screening identification of novel severe acute respiratory syndrome 3c-like protease inhibitors and in vitro confirmation. Bioorg. Med. Chem. Lett. 2011, 21, 3088-3091.
    • (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 3088-3091
    • Nguyen, T.T.H.1    Ryu, H.J.2    Lee, S.H.3    Hwang, S.4    Breton, V.5    Rhee, J.H.6    Kim, D.7
  • 26
    • 78049348189 scopus 로고    scopus 로고
    • Gvss: A high throughput drug discovery service of avian flu and dengue fever for egee and euasiagrid
    • Chen, H.Y.; Hsiung, M.; Lee, H.C.; Yen, E.; Lin, S.C.; Wu, Y.T. Gvss: A high throughput drug discovery service of avian flu and dengue fever for egee and euasiagrid. J. Grid. Comput. 2010, 8, 529-541.
    • (2010) J. Grid. Comput. , vol.8 , pp. 529-541
    • Chen, H.Y.1    Hsiung, M.2    Lee, H.C.3    Yen, E.4    Lin, S.C.5    Wu, Y.T.6
  • 27
    • 37349023165 scopus 로고    scopus 로고
    • Crystal structure of the NS3 protease-helicase from dengue virus
    • Luo, D.; Xu, T.; Hunke, C.; Gruber, G.; Vasudevan, S.G.; Lescar, J. Crystal structure of the NS3 protease-helicase from dengue virus. J. Virol. 2008, 82, 173-183.
    • (2008) J. Virol. , vol.82 , pp. 173-183
    • Luo, D.1    Xu, T.2    Hunke, C.3    Gruber, G.4    Vasudevan, S.G.5    Lescar, J.6
  • 28
    • 84857923737 scopus 로고    scopus 로고
    • Recombination in the nonstructural gene region in type 2 dengue viruses
    • Su, M.W.; Yuan, H.S.; Chu, W.C. Recombination in the nonstructural gene region in type 2 dengue viruses. Intervirology 2011, 55, 225-230.
    • (2011) Intervirology , vol.55 , pp. 225-230
    • Su, M.W.1    Yuan, H.S.2    Chu, W.C.3
  • 29
    • 84865784436 scopus 로고    scopus 로고
    • Efficient expression and purification of recombinant alcohol oxidase in Pichia pastoris
    • Liu, Y.P.; Pan, J.F.; Wei, P.L.; Zhu, J.Z.; Huang, L.; Cai, J.; Xu, Z.N. Efficient expression and purification of recombinant alcohol oxidase in Pichia pastoris. Biotechnol. Bioproc. Eng. 2012, 17, 693-702.
    • (2012) Biotechnol. Bioproc. Eng. , vol.17 , pp. 693-702
    • Liu, Y.P.1    Pan, J.F.2    Wei, P.L.3    Zhu, J.Z.4    Huang, L.5    Cai, J.6    Xu, Z.N.7
  • 32
    • 11644261806 scopus 로고    scopus 로고
    • Automated docking using a lamarckian genetic algorithm and an empirical binding free energy function
    • Morris, G.M.; Goodsell, D.S.; Halliday, R.S.; Huey, R.; Hart, W.E.; Belew, R.K.; Olson, A.J. Automated docking using a lamarckian genetic algorithm and an empirical binding free energy function. J. Comput. Chem. 1998, 19, 1639-1662.
    • (1998) J. Comput. Chem. , vol.19 , pp. 1639-1662
    • Morris, G.M.1    Goodsell, D.S.2    Halliday, R.S.3    Huey, R.4    Hart, W.E.5    Belew, R.K.6    Olson, A.J.7
  • 35
    • 0028922586 scopus 로고
    • Ligplot: A program to generate schematic diagrams of protein-ligand interactions
    • Wallace, A.C.; Laskowski, R.A.; Thornton, J.M. Ligplot: A program to generate schematic diagrams of protein-ligand interactions. Protein Eng. 1995, 8, 127-134.
    • (1995) Protein Eng. , vol.8 , pp. 127-134
    • Wallace, A.C.1    Laskowski, R.A.2    Thornton, J.M.3
  • 36
    • 80053205763 scopus 로고    scopus 로고
    • Discovery of novel inhibitors for human intestinal maltase: Virtual screening in a wisdom environment and in vitro evaluation
    • Nguyen, T.T.; Ryu, H.J.; Lee, S.H.; Hwang, S.; Cha, J.; Breton, V.; Kim, D. Discovery of novel inhibitors for human intestinal maltase: Virtual screening in a wisdom environment and in vitro evaluation. Biotechnol. Lett. 2011, 33, 2185-2191.
    • (2011) Biotechnol. Lett. , vol.33 , pp. 2185-2191
    • Nguyen, T.T.1    Ryu, H.J.2    Lee, S.H.3    Hwang, S.4    Cha, J.5    Breton, V.6    Kim, D.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.