Delayed sequelae of neonatal respiratory syncytial virus infection are dependent on cells of the innate immune system

Journal of Virology

Volumn 88, Issue 1, 2014, Pages 604-611

  Harker, James A ^a,b   Yamaguchi, Yuko ^a,c   Culley, Fiona J ^a   Tregoning, John S ^a,b   Openshaw, Peter J M ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CD11B ANTIGEN; CD27 ANTIGEN; CXCL1 CHEMOKINE; EOTAXIN; GAMMA INTERFERON; GLYCOPROTEIN P 15095; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; RANTES; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; EFFECTOR CELL; FEMALE; GRANULOCYTE; INNATE IMMUNITY; LUNG ALVEOLUS MACROPHAGE; MACROPHAGE; MOUSE; NATURAL KILLER CELL; NEWBORN; NEWBORN DISEASE; NONHUMAN; PRIORITY JOURNAL; REINFECTION; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RESPIRATORY SYNCYTIAL VIRUS INFECTION; T CELL DEPLETION; UPREGULATION; VIRAL CLEARANCE; VIRUS LOAD; WEIGHT REDUCTION;

ANIMALS; ANIMALS, NEWBORN; BASE SEQUENCE; CELLS, CULTURED; DNA PRIMERS; IMMUNITY, INNATE; MICE; MICE, INBRED BALB C; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS;

EID: 84890870537     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02620-13     Document Type: Article

References (25)

1. Hall CB, Weinberg GA, Iwane MK, Blumkin AK, Edwards KM, Staat MA, Auinger P, Griffin MR, Poehling KA, Erdman D, Grijalva CG, Zhu Y, Szilagyi P. 2009. The burden of respiratory syncytial virus infection in young children. N. Engl. J. Med. 360:588-598. http://dx.doi.org/10.1056 /NEJMoa0804877.
2. Simoes EA, Carbonell-Estrany X, Rieger CH, Mitchell I, Fredrick L, Groothuis JR. 2010. The effect of respiratory syncytial virus on subsequent recurrent wheezing in atopic and nonatopic children. J. Allergy Clin. Immunol. 126:256-262. http://dx.doi.org/10.1016/j.jaci.2010.05.026.
3. Tregoning JS, Schwarze J. 2010. Respiratory viral infections in infancy: causes, clinical symptoms, virology, and immunology. Clin. Microbiol. Rev. 23:74-98. http://dx.doi.org/10.1128/CMR.00032-09.
4. Blanken MO, Rovers MM, Molenaar JM, Winkler-Seinstra PL, Meijer A, Kimpen JL, Bont L. 2013. Respiratory syncytial virus and recurrent wheeze in healthy preterm infants. N. Engl. J. Med. 368:1791-1799. http: //dx.doi.org/10.1056/NEJMoa1211917.
5. Culley FJ, Pollott J, Openshaw PJ. 2002. Age at first viral infection determines the pattern of T cell-mediated disease during reinfection in adulthood. J. Exp. Med. 196:1381-1386. http://dx.doi.org/10.1084/jem .20020943.
6. Tregoning JS, Yamaguchi Y, Harker J, Wang B, Openshaw PJ. 2008. The role of T cells in the enhancement of RSV infection severity during adult re-infection of neonatally sensitized mice. J. Virol. 82:4115-4124. http: //dx.doi.org/10.1128/JVI.02313-07.
7. Tregoning JS, Yamaguchi Y, Wang B, Mihm D, Harker JA, Bushell ES, Zheng M, Liao G, Peltz G, Openshaw PJ. 2010. Genetic susceptibility to the delayed sequelae of neonatal respiratory syncytial virus infection is MHC dependent. J. Immunol. 185:5384-5391. http://dx.doi.org/10.4049 /jimmunol.1001594.
8. Harker JA, Lee DC, Yamaguchi Y, Wang B, Bukreyev A, Collins PL, Tregoning JS, Openshaw PJ. 2010. The delivery of cytokines by recombinant virus in early life alters the immune response to adult lung infection. J. Virol. 84:5294-5302. http://dx.doi.org/10.1128/JVI.02503-09.
9. Harker JA, Godlee A, Wahlsten JL, Lee DC, Thorne LG, Sawant D, Tregoning JS, Caspi RR, Bukreyev A, Collins PL, Openshaw PJ. 2010. Interleukin 18 co-expression during respiratory syncytial virus infection results in enhanced disease mediated by natural killer cells. J. Virol. 84: 4073-4082. http://dx.doi.org/10.1128/JVI.02014-09.
10. Li F, Zhu H, Sun R, Wei H, Tian Z. 2012. Natural killer cells are involved in acute lung immune injury caused by respiratory syncytial virus infection. J. Virol. 86:2251-2258. http://dx.doi.org/10.1128/JVI.06209-11.
11. Tregoning JS, Pribul PK, Pennycook AMJ, Hussell T, Wang B, Lukacs N, Schwarze J, Culley FJ, Openshaw PJM. 2010. The chemokine MIP1a/ CCL3 determines pathology in primary RSV infection by regulating the balance of T cell populations in the murine lung. PLoS One 5:e9381. http: //dx.doi.org/10.1371/journal.pone.0009381.
12. Hayakawa Y, Smyth MJ. 2006. CD27 dissects mature NK cells into two subsets with distinct responsiveness and migratory capacity. J. Immunol. 176:1517-1524. http://www.jimmunol.org/content/176/3/1517.long.
13. Nishikado H, Mukai K, Kawano Y, Minegishi Y, Karasuyama H. 2011. NK cell-depleting anti-asialo GM1 antibody exhibits a lethal off-target effect on basophils in vivo. J. Immunol. 186:5766-5771. http://dx.doi.org /10.4049/jimmunol.1100370.
14. Pribul PK, Harker J, Wang B, Wang H, Tregoning JS, Schwarze J, Openshaw PJ. 2008. Alveolar macrophages are a major determinant of early responses to viral lung infection but do not influence subsequent disease development. J. Virol. 82:4441-4448. http://dx.doi.org/10.1128 /JVI.02541-07.
15. Jakubzick C, Tacke F, Llodra J, van Rooijen N, Randolph GJ. 2006. Modulation of dendritic cell trafficking to and from the airways. J. Immunol. 176:3578-3584. http://www.jimmunol.org/content/176/6/3578.long.
16. Yamaguchi Y, Harker JA, Wang B, Openshaw PJ, Tregoning JS, Culley FJ. 2012. Preexposure to CpG protects against the delayed effects of neonatal respiratory syncytial virus infection. J. Virol. 86:10456-10461. http: //dx.doi.org/10.1128/JVI.01082-12.
17. Snelgrove RJ, Goulding J, Didierlaurent AM, Lyonga D, Vekaria S, Edwards L, Gwyer E, Sedgwick JD, Barclay AN, Hussell T. 2008. A critical function for CD200 in lung immune homeostasis and the severity of influenza infection. Nat. Immunol. 9:1074-1083. http://dx.doi.org/10 .1038/ni.1637.
18. Grigg J, Riedler J, Robertson CF, Boyle W, Uren S. 1999. Alveolar macrophage immaturity in infants and young children. Eur. Respir. J. 14:1198-1205. http://dx.doi.org/10.1183/09031936.99.14511989.
19. Shirey KA, Pletneva LM, Puche AC, Keegan AD, Prince GA, Blanco JCG, Vogel SN. 2010. Control of RSV-induced lung injury by alternatively activated macrophages is IL-4R[alpha]-, TLR4-, and IFN-[beta]- dependent. Mucosal Immunol. 3:291-300. http://dx.doi.org/10.1038/mi .2010.6.
20. Reed JL, Brewah YA, Delaney T, Welliver T, Burwell T, Benjamin E, Kuta E, Kozhich A, McKinney L, Suzich J, Kiener PA, Avendano L, Velozo L, Humbles A, Welliver RC, Coyle AJ. 2008. Macrophage impairment underlies airway occlusion in primary respiratory syncytial virus bronchiolitis. J. Infect. Dis. 198:1783-1793. http://dx.doi.org/10.1086 /593173.
21. Culley FJ. 2009. Natural killer cells in infection and inflammation of the lung. Immunology 128:151-163. http://dx.doi.org/10.1111/j.1365-2567 .2009.03167.x.
22. Moore ML, Chi MH, Goleniewska K, Durbin JE, Peebles RS, Jr. 2008. Differential regulation of GM1 and asialo-GM1 expression by T cells and natural killer (NK) cells in respiratory syncytial virus infection. Viral Immunol. 21:327-339. http://dx.doi.org/10.1089/vim.2008.0003.
23. Kaiko GE, Phipps S, Angkasekwinai P, Dong C, Foster PS. 2010. NK cell deficiency predisposes to viral-induced Th2-type allergic inflammation via epithelial-derived IL-25. J. Immunol. 185:4681-4690. http://dx.doi .org/10.4049/jimmunol.1001758.
24. Zhou G, Juang SW, Kane KP. 2013. NK cells exacerbate the pathology of influenza virus infection in mice. Eur. J. Immunol. 43:929-938. http://dx .doi.org/10.1002/eji.201242620.
25. Tregoning JS, Wang BL, McDonald JU, Yamaguchi Y, Harker JA, Goritzka M, Johansson C, Bukreyev A, Collins PL, Openshaw PJ. 2013. Neonatal antibody responses are attenuated by interferon-gamma produced by NK and T cells during RSV infection. Proc. Natl. Acad. Sci. U. S. A. 110:5576-5581. http://dx.doi.org/10.1073/pnas.1214247110.