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Volumn 110, Issue 14, 2013, Pages 5576-5581

Neonatal antibody responses are attenuated by interferon-γ produced by NK and T cells during RSV infection

Author keywords

Bronchiolitis; Lung infection; Viral infection

Indexed keywords

GAMMA INTERFERON; RESPIRATORY SYNCYTIAL VIRUS ANTIBODY;

EID: 84875851044     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1214247110     Document Type: Article
Times cited : (38)

References (56)
  • 1
    • 61349097791 scopus 로고    scopus 로고
    • B-cell responses to vaccination at the extremes of age
    • Siegrist CA, Aspinall R (2009) B-cell responses to vaccination at the extremes of age. Nat Rev Immunol 9(3):185-194.
    • (2009) Nat Rev Immunol , vol.9 , Issue.3 , pp. 185-194
    • Siegrist, C.A.1    Aspinall, R.2
  • 2
    • 70449629815 scopus 로고    scopus 로고
    • Neonatal immunity: Faulty T-helpers and the shortcomings of dendritic cells
    • Zaghouani H, Hoeman CM, Adkins B (2009) Neonatal immunity: Faulty T-helpers and the shortcomings of dendritic cells. Trends Immunol 30(12):585-591.
    • (2009) Trends Immunol , vol.30 , Issue.12 , pp. 585-591
    • Zaghouani, H.1    Hoeman, C.M.2    Adkins, B.3
  • 4
    • 0030932631 scopus 로고    scopus 로고
    • Immature B cells from neonatal mice show a selective inability to up-regulate MHC class II expression in response to antigen receptor ligation
    • Tasker L, Marshall-Clarke S (1997) Immature B cells from neonatal mice show a selective inability to up-regulate MHC class II expression in response to antigen receptor ligation. Int Immunol 9(4):475-484.
    • (1997) Int Immunol , vol.9 , Issue.4 , pp. 475-484
    • Tasker, L.1    Marshall-Clarke, S.2
  • 5
    • 0032995792 scopus 로고    scopus 로고
    • Development of T-B cell collaboration in neonatal mice
    • Astori M, Finke D, Karapetian O, Acha-Orbea H (1999) Development of T-B cell collaboration in neonatal mice. Int Immunol 11(3):445-451.
    • (1999) Int Immunol , vol.11 , Issue.3 , pp. 445-451
    • Astori, M.1    Finke, D.2    Karapetian, O.3    Acha-Orbea, H.4
  • 6
    • 0037443503 scopus 로고    scopus 로고
    • Unresponsiveness to lymphoid-mediated signals at the neonatal follicular dendritic cell precursor level contributes to delayed germinal center induction and limitations of neonatal antibody responses to T-dependent antigens
    • Pihlgren M, et al. (2003) Unresponsiveness to lymphoid-mediated signals at the neonatal follicular dendritic cell precursor level contributes to delayed germinal center induction and limitations of neonatal antibody responses to T-dependent antigens. J Immunol 170(6):2824-2832.
    • (2003) J Immunol , vol.170 , Issue.6 , pp. 2824-2832
    • Pihlgren, M.1
  • 7
    • 0023110564 scopus 로고
    • Fetal and neonatal development of human spleen: An immunohistological study
    • Timens W, Rozeboom T, Poppema S (1987) Fetal and neonatal development of human spleen: an immunohistological study. Immunology 60(4):603-609.
    • (1987) Immunology , vol.60 , Issue.4 , pp. 603-609
    • Timens, W.1    Rozeboom, T.2    Poppema, S.3
  • 8
    • 74249116206 scopus 로고    scopus 로고
    • Respiratory viral infections in infants: Causes, clinical symptoms, virology, and immunology
    • Tregoning JS, Schwarze J (2010) Respiratory viral infections in infants: Causes, clinical symptoms, virology, and immunology. Clin Microbiol Rev 23(1):74-98.
    • (2010) Clin Microbiol Rev , vol.23 , Issue.1 , pp. 74-98
    • Tregoning, J.S.1    Schwarze, J.2
  • 9
    • 59749095702 scopus 로고    scopus 로고
    • The burden of respiratory syncytial virus infection in young children
    • Hall CB, et al. (2009) The burden of respiratory syncytial virus infection in young children. N Engl J Med 360(6):588-598.
    • (2009) N Engl J Med , vol.360 , Issue.6 , pp. 588-598
    • Hall, C.B.1
  • 10
    • 77951653074 scopus 로고    scopus 로고
    • Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: A systematic review and meta-analysis
    • Nair H, et al. (2010) Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: A systematic review and meta-analysis. Lancet 375(9725):1545-1555.
    • (2010) Lancet , vol.375 , Issue.9725 , pp. 1545-1555
    • Nair, H.1
  • 11
    • 84867703987 scopus 로고    scopus 로고
    • Genetic relatedness of infecting and reinfecting respiratory syncytial virus strains identified in a birth cohort from rural Kenya
    • Agoti CN, et al. (2012) Genetic relatedness of infecting and reinfecting respiratory syncytial virus strains identified in a birth cohort from rural Kenya. J Infect Dis 206(10): 1532-1541.
    • (2012) J Infect Dis , vol.206 , Issue.10 , pp. 1532-1541
    • Agoti, C.N.1
  • 12
    • 0022589125 scopus 로고
    • Risk of primary infection and reinfection with respiratory syncytial virus
    • Glezen WP, Taber LH, Frank AL, Kasel JA (1986) Risk of primary infection and reinfection with respiratory syncytial virus. Am J Dis Child 140(6):543-546.
    • (1986) Am J Dis Child , vol.140 , Issue.6 , pp. 543-546
    • Glezen, W.P.1    Taber, L.H.2    Frank, A.L.3    Kasel, J.A.4
  • 13
    • 59449107870 scopus 로고    scopus 로고
    • Respiratory syncytial virus neutralizing antibodies in cord blood, respiratory syncytial virus hospitalization, and recurrent wheeze
    • Stensballe LG, et al. (2009) Respiratory syncytial virus neutralizing antibodies in cord blood, respiratory syncytial virus hospitalization, and recurrent wheeze. J Allergy Clin Immunol 123(2):398-403.
    • (2009) J Allergy Clin Immunol , vol.123 , Issue.2 , pp. 398-403
    • Stensballe, L.G.1
  • 14
    • 0025904896 scopus 로고
    • Immunity to and frequency of reinfection with respiratory syncytial virus
    • Hall CB, Walsh EE, Long CE, Schnabel KC (1991) Immunity to and frequency of reinfection with respiratory syncytial virus. J Infect Dis 163(4):693-698.
    • (1991) J Infect Dis , vol.163 , Issue.4 , pp. 693-698
    • Hall, C.B.1    Walsh, E.E.2    Long, C.E.3    Schnabel, K.C.4
  • 15
    • 0022994523 scopus 로고
    • Effect of age and preexisting antibody on serum antibody response of infants and children to the F and G glycoproteins during respiratory syncytial virus infection
    • Murphy BR, et al. (1986) Effect of age and preexisting antibody on serum antibody response of infants and children to the F and G glycoproteins during respiratory syncytial virus infection. J Clin Microbiol 24(5):894-898.
    • (1986) J Clin Microbiol , vol.24 , Issue.5 , pp. 894-898
    • Murphy, B.R.1
  • 16
    • 0030969150 scopus 로고    scopus 로고
    • Respiratory syncytial virus specific serum antibodies in infants under six months of age: Limited serological response upon infection
    • Brandenburg AH, et al. (1997) Respiratory syncytial virus specific serum antibodies in infants under six months of age: limited serological response upon infection. J Med Virol 52(1):97-104.
    • (1997) J Med Virol , vol.52 , Issue.1 , pp. 97-104
    • Brandenburg, A.H.1
  • 17
    • 0033791293 scopus 로고    scopus 로고
    • Evaluation of a live, cold-passaged, temperature-sensitive, respiratory syncytial virus vaccine candidate in infancy
    • Wright PF, et al. (2000) Evaluation of a live, cold-passaged, temperature-sensitive, respiratory syncytial virus vaccine candidate in infancy. J Infect Dis 182(5):1331-1342.
    • (2000) J Infect Dis , vol.182 , Issue.5 , pp. 1331-1342
    • Wright, P.F.1
  • 18
    • 20144370691 scopus 로고    scopus 로고
    • Identification of a recombinant live attenuated respiratory syncytial virus vaccine candidate that is highly attenuated in infants
    • Karron RA, et al. (2005) Identification of a recombinant live attenuated respiratory syncytial virus vaccine candidate that is highly attenuated in infants. J Infect Dis 191(7):1093-1104.
    • (2005) J Infect Dis , vol.191 , Issue.7 , pp. 1093-1104
    • Karron, R.A.1
  • 19
    • 65649091691 scopus 로고    scopus 로고
    • Innate immune signals modulate antiviral and polyreactive antibody responses during severe respiratory syncytial virus infection
    • Reed JL, et al. (2009) Innate immune signals modulate antiviral and polyreactive antibody responses during severe respiratory syncytial virus infection. J Infect Dis 199(8):1128-1138.
    • (2009) J Infect Dis , vol.199 , Issue.8 , pp. 1128-1138
    • Reed, J.L.1
  • 20
    • 70450225059 scopus 로고    scopus 로고
    • The human neonatal B cell response to respiratory syncytial virus uses a biased antibody variable gene repertoire that lacks somatic mutations
    • Williams JV, Weitkamp JH, Blum DL, LaFleur BJ, Crowe JE, Jr. (2009) The human neonatal B cell response to respiratory syncytial virus uses a biased antibody variable gene repertoire that lacks somatic mutations. Mol Immunol 47(2-3):407-414.
    • (2009) Mol Immunol , vol.47 , Issue.2-3 , pp. 407-414
    • Williams, J.V.1    Weitkamp, J.H.2    Blum, D.L.3    Lafleur, B.J.4    Crowe Jr., J.E.5
  • 21
    • 0037131968 scopus 로고    scopus 로고
    • Age at first viral infection determines the pattern of T cell-mediated disease during reinfection in adulthood
    • Culley FJ, Pollott J, Openshaw PJ (2002) Age at first viral infection determines the pattern of T cell-mediated disease during reinfection in adulthood. J ExpMed 196(10):1381-1386.
    • (2002) J ExpMed , vol.196 , Issue.10 , pp. 1381-1386
    • Culley, F.J.1    Pollott, J.2    Openshaw, P.J.3
  • 22
    • 41949112297 scopus 로고    scopus 로고
    • The role of T cells in the enhancement of RSV infection severity during adult re-infection of neonatally sensitized mice
    • Tregoning JS, et al. (2008) The role of T cells in the enhancement of RSV infection severity during adult re-infection of neonatally sensitized mice. J Virol 82(8):4115-4124.
    • (2008) J Virol , vol.82 , Issue.8 , pp. 4115-4124
    • Tregoning, J.S.1
  • 23
    • 78149471962 scopus 로고    scopus 로고
    • Genetic susceptibility to the delayed sequelae of neonatal respiratory syncytial virus infection is MHC dependent
    • Tregoning JS, et al. (2010) Genetic susceptibility to the delayed sequelae of neonatal respiratory syncytial virus infection is MHC dependent. J Immunol 185(9):5384-5391.
    • (2010) J Immunol , vol.185 , Issue.9 , pp. 5384-5391
    • Tregoning, J.S.1
  • 24
    • 47249161651 scopus 로고    scopus 로고
    • Infection of mice with respiratory syncytial virus during neonatal life primes for enhanced antibody and T cell responses on secondary challenge
    • Tasker L, Lindsay RW, Clarke BT, Cochrane DW, Hou S (2008) Infection of mice with respiratory syncytial virus during neonatal life primes for enhanced antibody and T cell responses on secondary challenge. Clin Exp Immunol 153(2):277-288.
    • (2008) Clin Exp Immunol , vol.153 , Issue.2 , pp. 277-288
    • Tasker, L.1    Lindsay, R.W.2    Clarke, B.T.3    Cochrane, D.W.4    Hou, S.5
  • 25
    • 0020638885 scopus 로고
    • Recombinant mouse interferon-gamma regulation of antibody production
    • Johnson HM, Torres BA (1983) Recombinant mouse interferon-gamma regulation of antibody production. Infect Immun 41(2):546-548.
    • (1983) Infect Immun , vol.41 , Issue.2 , pp. 546-548
    • Johnson, H.M.1    Torres, B.A.2
  • 26
    • 84863707107 scopus 로고    scopus 로고
    • Stimulation of immature lung macrophages with intranasal interferon gamma in a novel neonatal mouse model of respiratory syncytial virus infection
    • Empey KM, et al. (2012) Stimulation of immature lung macrophages with intranasal interferon gamma in a novel neonatal mouse model of respiratory syncytial virus infection. PLoS ONE 7(7):e40499.
    • (2012) PLoS ONE , vol.7 , Issue.7
    • Empey, K.M.1
  • 27
    • 0025938113 scopus 로고
    • Role of T lymphocyte subsets in the pathogenesis of primary infection and rechallenge with respiratory syncytial virus in mice
    • Graham BS, Bunton LA, Wright PF, Karzon DT (1991) Role of T lymphocyte subsets in the pathogenesis of primary infection and rechallenge with respiratory syncytial virus in mice. J Clin Invest 88(3):1026-1033.
    • (1991) J Clin Invest , vol.88 , Issue.3 , pp. 1026-1033
    • Graham, B.S.1    Bunton, L.A.2    Wright, P.F.3    Karzon, D.T.4
  • 28
    • 0020520969 scopus 로고
    • Homeostasis of the antibody response: Immunoregulation by NK cells
    • Abruzzo LV, Rowley DA (1983) Homeostasis of the antibody response: immunoregulation by NK cells. Science 222(4624):581-585.
    • (1983) Science , vol.222 , Issue.4624 , pp. 581-585
    • Abruzzo, L.V.1    Rowley, D.A.2
  • 29
    • 0022253299 scopus 로고
    • Dendritic cells that have interacted with antigen are targets for natural killer cells
    • Shah PD, Gilbertson SM, Rowley DA (1985) Dendritic cells that have interacted with antigen are targets for natural killer cells. J Exp Med 162(2):625-636.
    • (1985) J Exp Med , vol.162 , Issue.2 , pp. 625-636
    • Shah, P.D.1    Gilbertson, S.M.2    Rowley, D.A.3
  • 30
    • 84863404119 scopus 로고    scopus 로고
    • Natural killer cells are involved in acute lung immune injury caused by respiratory syncytial virus infection
    • Li F, Zhu H, Sun R, Wei H, Tian Z (2012) Natural killer cells are involved in acute lung immune injury caused by respiratory syncytial virus infection. J Virol 86(4):2251-2258.
    • (2012) J Virol , vol.86 , Issue.4 , pp. 2251-2258
    • Li, F.1    Zhu, H.2    Sun, R.3    Wei, H.4    Tian, Z.5
  • 31
    • 77951449856 scopus 로고    scopus 로고
    • Delivery of cytokines by recombinant virus in early life alters the immune response to adult lung infection
    • Harker JA, et al. (2010) Delivery of cytokines by recombinant virus in early life alters the immune response to adult lung infection. J Virol 84(10):5294-5302.
    • (2010) J Virol , vol.84 , Issue.10 , pp. 5294-5302
    • Harker, J.A.1
  • 32
    • 84855272559 scopus 로고    scopus 로고
    • Neonatal CD8 T-cell hierarchy is distinct from adults and is influenced by intrinsic T cell properties in respiratory syncytial virus infected mice
    • Ruckwardt TJ, et al. (2011) Neonatal CD8 T-cell hierarchy is distinct from adults and is influenced by intrinsic T cell properties in respiratory syncytial virus infected mice. PLoS Pathog 7(12):e1002377.
    • (2011) PLoS Pathog , vol.7 , Issue.12
    • Ruckwardt, T.J.1
  • 33
    • 0033514943 scopus 로고    scopus 로고
    • Interferon gamma expressed by a recombinant respiratory syncytial virus attenuates virus replication in mice without compromising immunogenicity
    • Bukreyev A, Whitehead SS, Bukreyeva N, Murphy BR, Collins PL (1999) Interferon gamma expressed by a recombinant respiratory syncytial virus attenuates virus replication in mice without compromising immunogenicity. Proc Natl Acad Sci USA 96(5): 2367-2372.
    • (1999) Proc Natl Acad Sci USA , vol.96 , Issue.5 , pp. 2367-2372
    • Bukreyev, A.1    Whitehead, S.S.2    Bukreyeva, N.3    Murphy, B.R.4    Collins, P.L.5
  • 34
    • 84871157894 scopus 로고    scopus 로고
    • Environmental and T cell-intrinsic factors limit the expansion of neonatal follicular T helper cells but may be circumvented by specific adjuvants
    • Mastelic B, et al. (2012) Environmental and T cell-intrinsic factors limit the expansion of neonatal follicular T helper cells but may be circumvented by specific adjuvants. J Immunol 189(12):5764-5772.
    • (2012) J Immunol , vol.189 , Issue.12 , pp. 5764-5772
    • Mastelic, B.1
  • 35
    • 35548967182 scopus 로고    scopus 로고
    • Decreased expression of tumor necrosis factor family receptors involved in humoral immune responses in preterm neonates
    • Kaur K, Chowdhury S, Greenspan NS, Schreiber JR (2007) Decreased expression of tumor necrosis factor family receptors involved in humoral immune responses in preterm neonates. Blood 110(8):2948-2954.
    • (2007) Blood , vol.110 , Issue.8 , pp. 2948-2954
    • Kaur, K.1    Chowdhury, S.2    Greenspan, N.S.3    Schreiber, J.R.4
  • 36
    • 49049099682 scopus 로고    scopus 로고
    • Deficient TACI expression on B lymphocytes of newborn mice leads to defective Ig secretion in response to BAFF or APRIL
    • Kanswal S, Katsenelson N, Selvapandiyan A, Bram RJ, Akkoyunlu M (2008) Deficient TACI expression on B lymphocytes of newborn mice leads to defective Ig secretion in response to BAFF or APRIL. J Immunol 181(2):976-990.
    • (2008) J Immunol , vol.181 , Issue.2 , pp. 976-990
    • Kanswal, S.1    Katsenelson, N.2    Selvapandiyan, A.3    Bram, R.J.4    Akkoyunlu, M.5
  • 37
    • 84864128728 scopus 로고    scopus 로고
    • The adjuvant LT-K63 can restore delayed maturation of follicular dendritic cells and poor persistence of both protein- and polysaccharide- specific antibody-secreting cells in neonatal mice
    • Bjarnarson SP, Adarna BC, Benonisson H, Del Giudice G, Jonsdottir I (2012) The adjuvant LT-K63 can restore delayed maturation of follicular dendritic cells and poor persistence of both protein- and polysaccharide- specific antibody-secreting cells in neonatal mice. J Immunol 189(3):1265-1273.
    • (2012) J Immunol , vol.189 , Issue.3 , pp. 1265-1273
    • Bjarnarson, S.P.1    Adarna, B.C.2    Benonisson, H.3    Del Giudice, G.4    Jonsdottir, I.5
  • 38
    • 0030817842 scopus 로고    scopus 로고
    • Atypical disease after Bordetella pertussis respiratory infection of mice with targeted disruptions of interferon-receptor or immunoglobulin μ chain genes
    • Mahon BP, Sheahan BJ, Griffin F, Murphy G, Mills KH (1997) Atypical disease after Bordetella pertussis respiratory infection of mice with targeted disruptions of interferon- receptor or immunoglobulin μ chain genes. J Exp Med 186(11):1843-1851.
    • (1997) J Exp Med , vol.186 , Issue.11 , pp. 1843-1851
    • Mahon, B.P.1    Sheahan, B.J.2    Griffin, F.3    Murphy, G.4    Mills, K.H.5
  • 39
    • 0037087256 scopus 로고    scopus 로고
    • The role of IFN in respiratory syncytial virus pathogenesis
    • Durbin JE, et al. (2002) The role of IFN in respiratory syncytial virus pathogenesis. J Immunol 168(6):2944-2952.
    • (2002) J Immunol , vol.168 , Issue.6 , pp. 2944-2952
    • Durbin, J.E.1
  • 40
    • 0035012068 scopus 로고    scopus 로고
    • Neonatal bacillus Calmette-Guérin vaccination induces adult-like IFN-gamma production by CD4+ T lymphocytes
    • Vekemans J, et al. (2001) Neonatal bacillus Calmette-Guérin vaccination induces adult-like IFN-gamma production by CD4+ T lymphocytes. Eur J Immunol 31(5): 1531-1535.
    • (2001) Eur J Immunol , vol.31 , Issue.5 , pp. 1531-1535
    • Vekemans, J.1
  • 41
    • 84869008952 scopus 로고    scopus 로고
    • Preexposure to CpG protects against the delayed effects of neonatal respiratory syncytial virus infection
    • Yamaguchi Y, et al. (2012) Preexposure to CpG protects against the delayed effects of neonatal respiratory syncytial virus infection. J Virol 86(19):10456-10461.
    • (2012) J Virol , vol.86 , Issue.19 , pp. 10456-10461
    • Yamaguchi, Y.1
  • 42
    • 36349032361 scopus 로고    scopus 로고
    • Virally delivered cytokines alter the immune response to future lung infections
    • Harker J, et al. (2007) Virally delivered cytokines alter the immune response to future lung infections. J Virol 81(23):13105-13111.
    • (2007) J Virol , vol.81 , Issue.23 , pp. 13105-13111
    • Harker, J.1
  • 43
    • 0036786453 scopus 로고    scopus 로고
    • Gamma interferon-dependent protection of the mouse upper respiratory tract following parenteral immunization with a respiratory syncytial virus G protein fragment
    • Plotnicky-Gilquin H, et al. (2002) Gamma interferon-dependent protection of the mouse upper respiratory tract following parenteral immunization with a respiratory syncytial virus G protein fragment. J Virol 76(20):10203-10210.
    • (2002) J Virol , vol.76 , Issue.20 , pp. 10203-10210
    • Plotnicky-Gilquin, H.1
  • 44
    • 0033816254 scopus 로고    scopus 로고
    • Role of interferon gamma in the pathogenesis of primary respiratory syncytial virus infection in BALB/c mice
    • van Schaik SM, et al. (2000) Role of interferon gamma in the pathogenesis of primary respiratory syncytial virus infection in BALB/c mice. J Med Virol 62(2):257-266.
    • (2000) J Med Virol , vol.62 , Issue.2 , pp. 257-266
    • Van Schaik, S.M.1
  • 45
    • 0023220673 scopus 로고
    • Inhibition of B lymphocyte activation by interferon-gamma
    • Reynolds DS, Boom WH, Abbas AK (1987) Inhibition of B lymphocyte activation by interferon-gamma. J Immunol 139(3):767-773.
    • (1987) J Immunol , vol.139 , Issue.3 , pp. 767-773
    • Reynolds, D.S.1    Boom, W.H.2    Abbas, A.K.3
  • 46
    • 43249118968 scopus 로고    scopus 로고
    • Inhibition of pulmonary antibacterial defense by interferon- gamma during recovery from influenza infection
    • Sun K, Metzger DW (2008) Inhibition of pulmonary antibacterial defense by interferon- gamma during recovery from influenza infection. Nat Med 14(5):558-564.
    • (2008) Nat Med , vol.14 , Issue.5 , pp. 558-564
    • Sun, K.1    Metzger, D.W.2
  • 47
    • 0037333391 scopus 로고    scopus 로고
    • Loss of the perforin cytotoxic pathway predisposes mice to experimental cytomegalovirus retinitis
    • Dix RD, Podack ER, Cousins SW (2003) Loss of the perforin cytotoxic pathway predisposes mice to experimental cytomegalovirus retinitis. J Virol 77(6):3402-3408.
    • (2003) J Virol , vol.77 , Issue.6 , pp. 3402-3408
    • Dix, R.D.1    Podack, E.R.2    Cousins, S.W.3
  • 48
    • 84857225568 scopus 로고    scopus 로고
    • Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection
    • Loebbermann J, et al. (2012) Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection. Mucosal Immunol 5(2):161-172.
    • (2012) Mucosal Immunol , vol.5 , Issue.2 , pp. 161-172
    • Loebbermann, J.1
  • 49
    • 0029829073 scopus 로고    scopus 로고
    • Specific cytotoxic T cells eliminate B cells producing virus-neutralizing antibodies [corrected]
    • Planz O, Seiler P, Hengartner H, Zinkernagel RM (1996) Specific cytotoxic T cells eliminate B cells producing virus-neutralizing antibodies [corrected]. Nature 382(6593):726-729.
    • (1996) Nature , vol.382 , Issue.6593 , pp. 726-729
    • Planz, O.1    Seiler, P.2    Hengartner, H.3    Zinkernagel, R.M.4
  • 50
    • 0030795092 scopus 로고    scopus 로고
    • Virus-specific CD8+ T lymphocytes downregulate T helper cell type 2 cytokine secretion and pulmonary eosinophilia during experimental murine respiratory syncytial virus infection
    • Srikiatkhachorn A, Braciale TJ (1997) Virus-specific CD8+ T lymphocytes downregulate T helper cell type 2 cytokine secretion and pulmonary eosinophilia during experimental murine respiratory syncytial virus infection. J Exp Med 186(3):421-432.
    • (1997) J Exp Med , vol.186 , Issue.3 , pp. 421-432
    • Srikiatkhachorn, A.1    Braciale, T.J.2
  • 51
    • 0026780401 scopus 로고
    • CD4+ T cells clear virus but augment disease in mice infected with respiratory syncytial virus. Comparison with the effects of CD8+ T cells
    • Alwan WH, Record FM, Openshaw PJM (1992) CD4+ T cells clear virus but augment disease in mice infected with respiratory syncytial virus. Comparison with the effects of CD8+ T cells. Clin Exp Immunol 88(3):527-536.
    • (1992) Clin Exp Immunol , vol.88 , Issue.3 , pp. 527-536
    • Alwan, W.H.1    Record, F.M.2    Openshaw, P.J.M.3
  • 52
    • 33746864480 scopus 로고    scopus 로고
    • Low expression of the interleukin (IL)-4 receptor alpha chain and reduced signalling via the IL-4 receptor complex in human neonatal B cells
    • Tian C, Kron GK, Dischert KM, Higginbotham JN, Crowe JE, Jr. (2006) Low expression of the interleukin (IL)-4 receptor alpha chain and reduced signalling via the IL-4 receptor complex in human neonatal B cells. Immunology 119(1):54-62.
    • (2006) Immunology , vol.119 , Issue.1 , pp. 54-62
    • Tian, C.1    Kron, G.K.2    Dischert, K.M.3    Higginbotham, J.N.4    Crowe Jr., J.E.5
  • 53
    • 84874920507 scopus 로고    scopus 로고
    • Endogenous IL-21 regulates pathogenic mucosal CD4 T-cell responses during enhanced RSV disease in mice
    • 10.1038/mi.2012.108
    • Dodd JS, et al. (2012) Endogenous IL-21 regulates pathogenic mucosal CD4 T-cell responses during enhanced RSV disease in mice. Mucosal Immunol 10.1038/mi.2012.108.
    • (2012) Mucosal Immunol
    • Dodd, J.S.1
  • 54
    • 79958094978 scopus 로고    scopus 로고
    • Intravaginal immunization using the recombinant HIV-1 clade-C trimeric envelope glycoprotein CN54gp140 formulated within lyophilized solid dosage forms
    • Donnelly L, et al. (2011) Intravaginal immunization using the recombinant HIV-1 clade-C trimeric envelope glycoprotein CN54gp140 formulated within lyophilized solid dosage forms. Vaccine 29(27):4512-4520.
    • (2011) Vaccine , vol.29 , Issue.27 , pp. 4512-4520
    • Donnelly, L.1
  • 55
    • 33746858063 scopus 로고    scopus 로고
    • A potential molecular mechanism for hypersensitivity caused by formalin-inactivated vaccines
    • Moghaddam A, et al. (2006) A potential molecular mechanism for hypersensitivity caused by formalin-inactivated vaccines. Nat Med 12(8):905-907.
    • (2006) Nat Med , vol.12 , Issue.8 , pp. 905-907
    • Moghaddam, A.1
  • 56
    • 77949769940 scopus 로고    scopus 로고
    • The chemokine MIP1a/CCL3 determines pathology in primary RSV infection by regulating the balance of T cell populations in the murine lung
    • Tregoning JS, et al. (2010) The chemokine MIP1a/CCL3 determines pathology in primary RSV infection by regulating the balance of T cell populations in the murine lung. PLoS ONE 5(2):e9381.
    • (2010) PLoS ONE , vol.5 , Issue.2
    • Tregoning, J.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.