NK cell-depleting anti-asialo GM1 antibody exhibits a lethal off-target effect on basophils in vivo

Journal of Immunology

Volumn 186, Issue 10, 2011, Pages 5766-5771

  Nishikado, Hideto ^a   Mukai, Kaori ^a,b   Kawano, Yohei ^a   Minegishi, Yoshiyuki ^a   Karasuyama, Hajime ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2 INTEGRIN; GANGLIOSIDE GM1 ANTIBODY; IMMUNOGLOBULIN E;

ALLOTYPE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BASOPHIL; CHRONIC DISEASE; CONTROLLED STUDY; HAPLOTYPE; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MOUSE STRAIN; NATURAL KILLER CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN ALLERGY;

ANIMALS; ANTIBODIES; ANTIGENS, SURFACE; BASOPHILS; CYTOTOXICITY, IMMUNOLOGIC; FLOW CYTOMETRY; G(M1) GANGLIOSIDE; HYPERSENSITIVITY, IMMEDIATE; INTEGRIN ALPHA2; KILLER CELLS, NATURAL; LYMPHOCYTE DEPLETION; MICE; MICE, INBRED A; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, INBRED C57BL; RECEPTORS, IGE;

EID: 79956222931     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1100370     Document Type: Article

References (50)

1. Cooper, M. A., M. Colonna, and W. M. Yokoyama. 2009. Hidden talents of natural killers: NK cells in innate and adaptive immunity. EMBO Rep. 10: 1103-1110.
2. Orr, M. T., and L. L. Lanier. 2010. Natural killer cell education and tolerance. Cell 142: 847-856.
3. Vivier, E., D. H. Raulet, A. Moretta, M. A. Caligiuri, L. Zitvogel, L. L. Lanier, W. M. Yokoyama, and S. Ugolini. 2011. Innate or adaptive immunity? The example of natural killer cells. Science 331: 44-49.
4. Kasai, M., M. Iwamori, Y. Nagai, K. Okumura, and T. Tada. 1980. A glycolipid on the surface of mouse natural killer cells. Eur. J. Immunol. 10: 175-180.
5. Young, W. W., Jr., S. I. Hakomori, J. M. Durdik, and C. S. Henney. 1980. Identification of ganglio-N-tetraosylceramide as a new cell surface marker for murine natural killer (NK) cells. J. Immunol. 124: 199-201.
6. Kasai, M., T. Yoneda, S. Habu, Y. Maruyama, K. Okumura, and T. Tokunaga. 1981. In vivo effect of anti-asialo GM1 antibody on natural killer activity. Nature 291: 334-335.
7. Peace, D. J., and M. A. Cheever. 1989. Toxicity and therapeutic efficacy of highdose interleukin 2. In vivo infusion of antibody to NK-1.1 attenuates toxicity without compromising efficacy against murine leukemia. J. Exp. Med. 169: 161-173.
8. Carlyle, J. R., A. Mesci, B. Ljutic, S. Belanger, L. H. Tai, E. Rousselle, A. D. Troke, M. F. Proteau, and A. P. Makrigiannis. 2006. Molecular and genetic basis for strain-dependent NK1.1 alloreactivity of mouse NK cells. J. Immunol. 176: 7511-7524.
9. Lee, U., K. Santa, S. Habu, and T. Nishimura. 1996. Murine asialo GM1+CD8+ T cells as novel interleukin-12-responsive killer T cell precursors. Jpn. J. Cancer Res. 87: 429-432.
10. Trambley, J., A. W. Bingaman, A. Lin, E. T. Elwood, S. Y. Waitze, J. Ha, M. M. Durham, M. Corbascio, S. R. Cowan, T. C. Pearson, and C. P. Larsen. 1999. Asialo GM1(+) CD8(+) T cells play a critical role in costimulation blockade-resistant allograft rejection. J. Clin. Invest. 104: 1715-1722.
11. Wiltrout, R. H., A. Santoni, E. S. Peterson, D. C. Knott, W. R. Overton, R. B. Herberman, and H. T. Holden. 1985. Reactivity of anti-asialo GM1 serum with tumoricidal and non-tumoricidal mouse macrophages. J. Leukoc. Biol. 37: 597-614.
12. Slifka, M. K., R. R. Pagarigan, and J. L. Whitton. 2000. NK markers are expressed on a high percentage of virus-specific CD8+ and CD4+ T cells. J. Immunol. 164: 2009-2015.
13. Kataoka, S., Y. Konishi, Y. Nishio, K. Fujikawa-Adachi, and A. Tominaga. 2004. Antitumor activity of eosinophils activated by IL-5 and eotaxin against hepatocellular carcinoma. DNA Cell Biol. 23: 549-560. (Pubitemid 39244333)
14. Galli, S. J. 2000. Mast cells and basophils. Curr. Opin. Hematol. 7: 32-39.
15. Min, B., M. Prout, J. Hu-Li, J. Zhu, D. Jankovic, E. S. Morgan, J. F. Urban, Jr., A. M. Dvorak, F. D. Finkelman, G. LeGros, and W. E. Paul. 2004. Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite. J. Exp. Med. 200: 507-517.
16. Voehringer, D., K. Shinkai, and R. M. Locksley. 2004. Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production. Immunity 20: 267-277.
17. Mukai, K., K. Matsuoka, C. Taya, H. Suzuki, H. Yokozeki, K. Nishioka, K. Hirokawa, M. Etori, M. Yamashita, T. Kubota, et al. 2005. Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells. Immunity 23: 191-202. (Pubitemid 41169288)
18. Poorafshar, M., H. Helmby, M. Troye-Blomberg, and L. Hellman. 2000. MMCP-8, the first lineage-specific differentiation marker for mouse basophils. Elevated numbers of potent IL-4-producing and MMCP-8-positive cells in spleens of malaria-infected mice. Eur. J. Immunol. 30: 2660-2668.
19. Ugajin, T., T. Kojima, K. Mukai, K. Obata, Y. Kawano, Y. Minegishi, Y. Eishi, H. Yokozeki, and H. Karasuyama. 2009. Basophils preferentially express mouse Mast Cell Protease 11 among the mast cell tryptase family in contrast to mast cells. J. Leukoc. Biol. 86: 1417-1425.
20. Falcone, F. H., H. Haas, and B. F. Gibbs. 2000. The human basophil: a new appreciation of its role in immune responses. Blood 96: 4028-4038.
21. Obata, K., K. Mukai, Y. Tsujimura, K. Ishiwata, Y. Kawano, Y. Minegishi, N. Watanabe, and H. Karasuyama. 2007. Basophils are essential initiators of a novel type of chronic allergic inflammation. Blood 110: 913-920. (Pubitemid 47267429)
22. Sokol, C. L., G. M. Barton, A. G. Farr, and R. Medzhitov. 2008. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat. Immunol. 9: 310-318.
23. Denzel, A., U. A. Maus, M. Rodriguez Gomez, C. Moll, M. Niedermeier, C.Winter, R.Maus, S. Hollingshead, D. E. Briles, L. A. Kunz-Schughart, et al. 2008. Basophils enhance immunological memory responses. Nat. Immunol. 9: 733-742.
24. Wada, T., K. Ishiwata, H. Koseki, T. Ishikura, T. Ugajin, N. Ohnuma, K. Obata, R. Ishikawa, S. Yoshikawa, K. Mukai, et al. 2010. Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks. J. Clin. Invest. 120: 2867-2875.
25. Ohnmacht, C., C. Schwartz, M. Panzer, I. Schiedewitz, R. Naumann, and D. Voehringer. 2010. Basophils orchestrate chronic allergic dermatitis and protective immunity against helminths. Immunity 33: 364-374.
26. Min, B. 2008. Basophils: what they 'can do' versus what they 'actually do'. Nat. Immunol. 9: 1333-1339.
27. Karasuyama, H., K. Mukai, Y. Tsujimura, and K. Obata. 2009. Newly discovered roles for basophils: a neglected minority gains new respect. Nat. Rev. Immunol. 9: 9-13.
28. Sullivan, B. M., and R. M. Locksley. 2009. Basophils: a nonredundant contributor to host immunity. Immunity 30: 12-20.
29. Schroeder, J. T. 2009. Basophils beyond effector cells of allergic inflammation. Adv. Immunol. 101: 123-161.
30. Gibbs, B. F., C. Streatfield, and F. H. Falcone. 2009. Basophils as critical orchestrators of Th2-type immune responses. Expert Rev. Clin. Immunol. 5: 725-734.
31. Sokol, C. L., and R. Medzhitov. 2010. Emerging functions of basophils in protective and allergic immune responses. Mucosal Immunol. 3: 129-137.
32. Siracusa, M. C., J. G. Perrigoue, M. R. Comeau, and D. Artis. 2010. New paradigms in basophil development, regulation and function. Immunol. Cell Biol. 88: 275-284.
33. Schneider, E., N. Thieblemont, M. L. De Moraes, and M. Dy. 2010. Basophils: new players in the cytokine network. Eur. Cytokine Netw. 21: 142-153.
34. Nakanishi, K. 2010. Basophils as APC in Th2 response in allergic inflammation and parasite infection. Curr. Opin. Immunol. 22: 814-820.
35. Karasuyama, H., K. Mukai, K. Obata, Y. Tsujimura, and T. Wada. 2010. Nonredundant Roles of Basophils in Immunity. Annu. Rev. Immunol. 29: 45-69.
36. Karasuyama, H., T. Wada, S. Yoshikawa, and K. Obata. 2011. Emerging roles of basophils in protective immunity against parasites. Trends Immunol. 32: 125-130.
37. Ohnmacht, C., and D. Voehringer. 2009. Basophil effector function and homeostasis during helminth infection. Blood 113: 2816-2825.
38. Jamieson, A. M., P. Isnard, J. R. Dorfman, M. C. Coles, and D. H. Raulet. 2004. Turnover and proliferation of NK cells in steady state and lymphopenic conditions. J. Immunol. 172: 864-870.
39. Sokol, C. L., N. Q. Chu, S. Yu, S. A. Nish, T. M. Laufer, and R. Medzhitov. 2009. Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response. Nat. Immunol. 10: 713-720.
40. Perrigoue, J. G., S. A. Saenz, M. C. Siracusa, E. J. Allenspach, B. C. Taylor, P. R. Giacomin, M. G. Nair, Y. Du, C. Zaph, N. van Rooijen, et al. 2009. MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity. Nat. Immunol. 10: 697-705.
41. Yoshimoto, T., K. Yasuda, H. Tanaka, M. Nakahira, Y. Imai, Y. Fujimori, and K. Nakanishi. 2009. Basophils contribute to T(H)2-IgE responses in vivo via IL-4 production and presentation of peptide-MHC class II complexes to CD4+ T cells. Nat. Immunol. 10: 706-712.
42. Chen, K., W. Xu, M. Wilson, B. He, N. W. Miller, E. Bengtén, E. S. Edholm, P. A. Santini, P. Rath, A. Chiu, et al. 2009. Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell-stimulating programs in basophils. Nat. Immunol. 10: 889-898.
43. Tsujimura, Y., K. Obata, K. Mukai, H. Shindou, M. Yoshida, H. Nishikado, Y. Kawano, Y. Minegishi, T. Shimizu, and H. Karasuyama. 2008. Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis. Immunity 28: 581-589.
44. Charles, N., D. Hardwick, E. Daugas, G. G. Illei, and J. Rivera. 2010. Basophils and the T helper 2 environment can promote the development of lupus nephritis. Nat. Med. 16: 701-707.
45. Bodhankar, S., M. D. Woolard, X. Sun, and J. W. Simecka. 2009. NK cells interfere with the generation of resistance against mycoplasma respiratory infection following nasal-pulmonary immunization. J. Immunol. 183: 2622-2631.
46. Bodhankar, S., X. Sun, M. D. Woolard, and J. W. Simecka. 2010. Interferon gamma and interleukin 4 have contrasting effects on immunopathology and the development of protective adaptive immunity against mycoplasma respiratory disease. J. Infect. Dis. 202: 39-51.
47. Sandel, P. C., and J. G. Monroe. 1999. Negative selection of immature B cells by receptor editing or deletion is determined by site of antigen encounter. Immunity 10: 289-299.
48. Sandel, P. C., M. Gendelman, G. Kelsoe, and J. G. Monroe. 2001. Definition of a novel cellular constituent of the bone marrow that regulates the response of immature B cells to B cell antigen receptor engagement. J. Immunol. 166: 5935-5944.
49. Walzer, T., M. Bléry, J. Chaix, N. Fuseri, L. Chasson, S. H. Robbins, S. Jaeger, P. André, L. Gauthier, L. Daniel, et al. 2007. Identification, activation, and selective in vivo ablation of mouse NK cells via NKp46. Proc. Natl. Acad. Sci. USA 104: 3384-3389.
50. Gascoyne, D. M., E. Long, H. Veiga-Fernandes, J. de Boer, O. Williams, B. Seddon, M. Coles, D. Kioussis, and H. J. Brady. 2009. The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development. Nat. Immunol. 10: 1118-1124.