SCOPUS 정보 검색 플랫폼

ChemMedChem

Volumn 8, Issue 11, 2013, Pages 1846-1854

X-ray structural analysis of tau-tubulin kinase 1 and its interactions with small molecular inhibitors

(7) Xue, Yafeng a Wan, Paul T a Hillertz, Per a Schweikart, Fritz a Zhao, Yanlong b Wissler, Lisa a Dekker, Niek a

a ASTRAZENECA (United Kingdom)

b Viva Biotech (China)

Author keywords

Binding kinetics; Drug design; Kinase inhibitors; Structure activity relationships; Surface plasmon resonance

Indexed keywords

BACTERIAL ENZYME; PROTEIN TYROSINE KINASE; TAU TUBULIN KINASE 1; UNCLASSIFIED DRUG; ENZYME INHIBITOR; LIGAND; MOLECULAR LIBRARY; PROTEIN BINDING; PROTEIN SERINE THREONINE KINASE; TAU-TUBULIN KINASE;

ANIMAL CELL; ARTICLE; BETA SHEET; BINDING KINETICS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISSOCIATION; ELECTROSPRAY MASS SPECTROMETRY; ENZYME CONFORMATION; ENZYME PHOSPHORYLATION; ENZYME PURIFICATION; ENZYME STRUCTURE; ESCHERICHIA COLI; GENE OVEREXPRESSION; HUMAN; HYDROGEN BOND; INSECT CELL; MASS SPECTROMETRY; MOLECULAR LIBRARY; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; STRUCTURE ANALYSIS; SURFACE PLASMON RESONANCE; X RAY ANALYSIS; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; KINETICS; METABOLISM; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; HYDROGEN BONDING; KINETICS; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; SMALL MOLECULE LIBRARIES;

EID: 84890866966 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201300274 Document Type: Article

Times cited : (29)

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