Humic acid in drinking well water induces inflammation through reactive oxygen species generation and activation of nuclear factor-κB/activator protein-1 signaling pathways: A possible role in atherosclerosis

Toxicology and Applied Pharmacology

Volumn 274, Issue 2, 2014, Pages 249-262

  Hseu, You Cheng ^a,b   Senthil Kumar, K J ^a   Chen, Chih Sheng ^a   Cho, Hsin Ju ^a   Lin, Shu Wei ^a   Shen, Pei Chun ^a   Lin, Cheng Wen ^a   Lu, Fung Jou ^c   Yang, Hsin Ling ^a,b  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

Author keywords

AP 1; Blackfoot disease; Humic acid; NF B; ROS

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; 3 NITROTYROSINE; ACYLTRANSFERASE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CYCLOOXYGENASE 2; HEME OXYGENASE 1; HUMIC ACID; I KAPPA B; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; NITRIC OXIDE; PROSTAGLANDIN E2; PROTEIN KINASE B; PYRROLIDINE DITHIOCARBAMATE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOTAGMIN I; TANSHINONE; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; WELL WATER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; BLACKFOOT DISEASE; CELL VIABILITY; CELLULAR DISTRIBUTION; CIRCULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOPLASM; DOWN REGULATION; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVATION; FEMALE; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION;

EID: 84890866098     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2013.11.002     Document Type: Article

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