Design, synthesis and biological evaluation of multivalent glucosides with high affinity as ligands for brain targeting liposomes

European Journal of Medicinal Chemistry

Volumn 72, Issue , 2014, Pages 110-118

  Qu, Boyi ^a   Li, Xiaocen ^a   Guan, Mei ^b   Li, Xun ^a   Hai, Li ^a   Wu, Yong ^a  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

Brain targeting; Cholesterylated glucosides; GLUT1 transporter; Liposome; Synthesis

Indexed keywords

DIAZEPAM; DOCETAXEL; GLUCOSE TRANSPORTER 1; GLUCOSIDE; LIPOSOME; LIGAND; TAXOID;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DESIGN; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG SCREENING; DRUG SYNTHESIS; DRUG TRANSPORT; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; TIME TO MAXIMUM PLASMA CONCENTRATION; ANIMAL; BLOOD; BRAIN; CONFORMATION; DRUG EFFECTS; INBRED MOUSE STRAIN; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; SYNTHESIS;

ADMINISTRATION, INTRAVENOUS; ANIMALS; BRAIN; DRUG DESIGN; GLUCOSIDES; LIGANDS; LIPOSOMES; MICE; MICE, INBRED STRAINS; MOLECULAR CONFORMATION; TAXOIDS;

EID: 84890852697     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.10.007     Document Type: Article

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