Utilizing combinatorial chemistry and rational design: Peptidic tweezers with nanomolar affinity to DNA can be transformed into efficient vectors for gene delivery by addition of a lipophilic tail

Angewandte Chemie - International Edition

Volumn 52, Issue 52, 2013, Pages 14016-14020

  Kuchelmeister, Hannes Y ^a,b   Karczewski, Sarah ^a   Gutschmidt, Aljona ^a   Knauer, Shirley ^a   Schmuck, Carsten ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b STANFORD UNIVERSITY   (United States)

Author keywords

combinatorial chemistry; DNA binding; DNA transfection; DNA vectors; peptide tweezers

Indexed keywords

COMBINATORIAL CHEMISTRY; COVALENT ATTACHMENT; DNA BINDING; DNA TRANSFECTION; DNA VECTORS; LONG ALIPHATIC CHAIN; NANOMOLAR AFFINITY; TRANSFECTION EFFICIENCY;

AMINO ACIDS; BIOASSAY; BIOCHIPS; GENE TRANSFER; PEPTIDES;

DNA;

DNA;

ARTICLE; CHEMICAL STRUCTURE; COMBINATORIAL CHEMISTRY; DNA BINDING; DNA TRANSFECTION; DNA VECTORS; GENE TRANSFER; GENE VECTOR; GENETIC TRANSFECTION; GENETICS; PEPTIDE TWEEZERS;

COMBINATORIAL CHEMISTRY; DNA BINDING; DNA TRANSFECTION; DNA VECTORS; PEPTIDE TWEEZERS;

COMBINATORIAL CHEMISTRY TECHNIQUES; DNA; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; MOLECULAR STRUCTURE; TRANSFECTION;

EID: 84890731554     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201306929     Document Type: Article

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