Photodistribution of blue-gray hyperpigmentation after amiodarone treatment: Molecular characterization of amiodarone in the skin

Archives of Dermatology

Volumn 144, Issue 1, 2008, Pages 92-96

  Ammoury, Alfred ^a,d   Michaud, Sandra ^b   Paul, Carle ^a   Prost Squarcioni, Catherine ^c   Alvarez, Florence ^a   Lamant, Laurence ^a   Launay, François ^a   Bazex, Jacques ^a   Chouini Lalanne, Nadia ^b   Marguery, Marie Claude ^a  

^a UNIVERSITÉ PAUL SABATIER   (France)

^b UNIVERSITÉ DE TOULOUSE   (France)

^c Research Unit   (France)

^d CHU PURPAN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACEBUTOLOL; AMIODARONE; LIPOFUSCIN; LISINOPRIL; LYSINE ACETYLSALICYLATE; SIMVASTATIN;

ADULT; ARTICLE; CASE REPORT; ELECTRON MICROSCOPY; ENDOTHELIUM CELL; FIBROBLAST; HEART FAILURE; HEART INFARCTION; HEART VENTRICLE ARRHYTHMIA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYPERPIGMENTATION; LIGHT DAMAGE; MACROPHAGE; MALE; PERICYTE; PHYSICAL EXAMINATION; PRIORITY JOURNAL; SCHWANN CELL; SKIN CELL; SUN EXPOSURE;

AMIODARONE; ANTI-ARRHYTHMIA AGENTS; BIOPSY, NEEDLE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FACIAL DERMATOSES; FOLLOW-UP STUDIES; HUMANS; HYPERPIGMENTATION; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY, ELECTRON; MIDDLE AGED; PHOTOSENSITIVITY DISORDERS; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX;

EID: 38549154613     PISSN: 0003987X     EISSN: 0003987X     Source Type: Journal    
DOI: 10.1001/archdermatol.2007.25     Document Type: Article

References (15)

1. Paillous N, Verrier M. Photolysis of amiodarone, an antiarrhythmic drug. Photochem Photobiol. 1988;47(3):337-343.
2. Miller RA, McDonald AT. Dermal lipofuscinosis associated with amiodarone therapy: report of a case. Arch Dermatol. 1984;120(5):646-649.
3. Alinovi A, Reverberi C, Melissari M, Gabrielli M. Cutaneous hyperpigmentation induced by amiodarone hydrochloride. J Am Acad Dermatol. 1985;12(3):563-566.
4. Zachary CB, Slater DN, Holt DW, Storey GC, MacDonald DM. The pathogenesis of amiodarone-induced pigmentation and photosensitivity. Br J Dermatol. 1984;110(4):451-456.
5. Blackshear JL, Randle HW. Reversibility of blue-gray cutaneous discoloration from amiodarone. Mayo Clin Proc. 1991;66(7):721-726.
6. Ferguson J, Addo HA, Jones S, Johnson BE, Frain-Bell W. A study of cutaneous photosensitivity induced by amiodarone. Br J Dermatol. 1985;113(5):537-549.
7. Rappersberger K, Honigsmann H, Ortel B, Tanew A, Konrad K, Wolff K. Photosensitivity and hyperpigmentation in amiodarone-treated patients: incidence, time course, and recovery. J Invest Dermatol. 1989;93(2):201-209.
8. Walter JF, Bradner H, Curtis GP. Amiodarone photosensitivity. Arch Dermatol. 1984;120(12):1591-1594.
9. Waitzer S, Butany J, From L, Hanna W, Ramsay C, Downar E. Cutaneous ultrastructural changes and photosensitivity associated with amiodarone therapy. J Am Acad Dermatol. 1987;16(4):779-787.
10. Yones SS, O'Donoghue NB, Palmer RA, Menage Hdu P, Hawk JL. Persistent severe amiodarone-induced photosensitivity. Clin Exp Dermatol. 2005;30(5):500-502.
11. Karrer S, Hohenleutner U, Szeimies RM, Landthaler M. Amiodarone-induced pigmentation resolves after treatment with the Q-switched ruby laser. Arch Dermatol. 1999;135(3):251-253.
12. Brazzelli V, Borroni G, Dal Tio R, Riva R, Bollati A, Rabbiosi G. Amiodarone-induced pigmentation: a histological, ultrastructural study and review of the literature [in Italian]. G Ital Dermatol Venereol. 1990;125(11):521-526.
13. Ha HR, Bigler L, Wendt B, Maggiorini M, Follath F. Identification and quantitation of novel metabolites of amiodarone in plasma of treated patients. Eur J Pharm Sci. 2005;24(4):271-279.
14. Eldred GE, Miller GV, Stark WS, Feeney-Burns L. Lipofuscin: resolution of discrepant fluorescence data. Science. 1982;216(4547):757-759.
15. Seehafer SS, Pearce DA. You say lipofuscin, we say ceroid: defining autofluorescent storage material. Neurobiol Aging. 2006;27(4):576-588.