-
2
-
-
84855172814
-
The pathogenesis of rheumatoid arthritis
-
McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. New Engl J Med 2011;365:2205-19
-
(2011)
New Engl J Med
, vol.365
, pp. 2205-2219
-
-
McInnes, I.B.1
Schett, G.2
-
3
-
-
84857737880
-
Inflammatory bone loss: Pathogenesis and therapeutic intervention
-
Redlich K, Smolen JS. Inflammatory bone loss: Pathogenesis and therapeutic intervention. Nat Rev Drug Discov 2012;11:234-50
-
(2012)
Nat Rev Drug Discov
, vol.11
, pp. 234-250
-
-
Redlich, K.1
Smolen, J.S.2
-
4
-
-
84863403514
-
Intensive treatment and treatment holiday of TNF-inhibitors in rheumatoid arthritis
-
Tanaka Y. Intensive treatment and treatment holiday of TNF-inhibitors in rheumatoid arthritis. Curr Opin Rheumatol 2012;24:319-26
-
(2012)
Curr Opin Rheumatol
, vol.24
, pp. 319-326
-
-
Tanaka, Y.1
-
5
-
-
84876257564
-
Next stage of ra treatment: Is tnf inhibitor-free remission a possible treatment goal?
-
Tanaka Y. Next stage of RA treatment: Is TNF inhibitor-free remission a possible treatment goal? Ann Rheum Dis 2013;72(Suppl 2):ii124-7
-
(2013)
Ann Rheum Dis
, vol.72
, Issue.SUPPL. 2
, pp. 124-127
-
-
Tanaka, Y.1
-
6
-
-
77950307115
-
Treating rheumatoid arthritis to target: Recommendations of an international task force
-
Smolen JS, Aletaha D, Bijlsma JW, et al. Treating rheumatoid arthritis to target: Recommendations of an international task force. Ann Rheum Dis 2010;69:631-7
-
(2010)
Ann Rheum Dis
, vol.69
, pp. 631-637
-
-
Smolen, J.S.1
Aletaha, D.2
Bijlsma, J.W.3
-
7
-
-
67449124635
-
Radiographic changes in rheumatoid arthritis patients attaining different disease activity states with methotrexate monotherapy and infliximab plus methotrexate: The impacts of remission and tumour necrosis factor blockade
-
Smolen JS, Han C, van der Heijde DM, et al. Radiographic changes in rheumatoid arthritis patients attaining different disease activity states with methotrexate monotherapy and infliximab plus methotrexate: The impacts of remission and tumour necrosis factor blockade. Ann Rheum Dis 2009;68:823-7
-
(2009)
Ann Rheum Dis
, vol.68
, pp. 823-827
-
-
Smolen, J.S.1
Han, C.2
Van Der Heijde, D.M.3
-
8
-
-
0028339282
-
Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2
-
Johnston JA, Kawamura M, Kirken RA, et al. Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2. Nature 1994;370:151-3
-
(1994)
Nature
, vol.370
, pp. 151-153
-
-
Johnston, J.A.1
Kawamura, M.2
Kirken, R.A.3
-
9
-
-
0028857954
-
Mutation of Jak3 in a patient with SCID: Essential role of Jak3 in lymphoid development
-
Russell SM, Tayebi N, Nakajima H, et al. Mutation of Jak3 in a patient with SCID: Essential role of Jak3 in lymphoid development. Science 1995;270:797-800
-
(1995)
Science
, vol.270
, pp. 797-800
-
-
Russell, S.M.1
Tayebi, N.2
Nakajima, H.3
-
10
-
-
0028840706
-
Defective lymphoid development in mice lacking jak3
-
Nosaka T, van Deursen JM, Tripp RA, et al. Defective lymphoid development in mice lacking Jak3. Science 1995;270:800-2
-
(1995)
Science
, vol.270
, pp. 800-802
-
-
Nosaka, T.1
Van Deursen, J.M.2
Tripp, R.A.3
-
11
-
-
0028171065
-
Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: Implications for XSCID and XCID
-
Russell SM, Johnston JA, Noguchi M, et al. Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: Implications for XSCID and XCID. Science 1994;266:1042-5
-
(1994)
Science
, vol.266
, pp. 1042-1045
-
-
Russell, S.M.1
Johnston, J.A.2
Noguchi, M.3
-
12
-
-
0034804745
-
Mutations in severe combined immune deficiency (SCID) due to JAK3 deficiency
-
Notarangelo LD, Mella P, Jones A, et al. Mutations in severe combined immune deficiency (SCID) due to JAK3 deficiency. Hum Mutat 2001;18:255-63
-
(2001)
Hum Mutat
, vol.18
, pp. 255-263
-
-
Notarangelo, L.D.1
Mella, P.2
Jones, A.3
-
13
-
-
33751300575
-
Changes in synovial tissue Jak-STAT expression in rheumatoid arthritis in response to successful DMARD treatment
-
Walker JG, Ahern MJ, Coleman M, et al. Changes in synovial tissue Jak-STAT expression in rheumatoid arthritis in response to successful DMARD treatment. Ann Rheum Dis 2006;65:1558-64
-
(2006)
Ann Rheum Dis
, vol.65
, pp. 1558-1564
-
-
Walker, J.G.1
Ahern, M.J.2
Coleman, M.3
-
14
-
-
31144460322
-
Expression of jak3, stat1, stat4, and stat6 in inflammatory arthritis: Unique jak3 and stat4 expression in dendritic cells in seropositive rheumatoid arthritis
-
Walker JG, Ahern MJ, Coleman M, et al. Expression of Jak3, STAT1, STAT4, and STAT6 in inflammatory arthritis: Unique Jak3 and STAT4 expression in dendritic cells in seropositive rheumatoid arthritis. Ann Rheum Dis 2006;65:149-56
-
(2006)
Ann Rheum Dis
, vol.65
, pp. 149-156
-
-
Walker, J.G.1
Ahern, M.J.2
Coleman, M.3
-
15
-
-
0035895505
-
The sequence of the human genome
-
Venter JC, Adams MD, Myers EW, et al. The sequence of the human genome. Science 2001;291:1304-51
-
(2001)
Science
, vol.291
, pp. 1304-1351
-
-
Venter, J.C.1
Adams, M.D.2
Myers, E.W.3
-
17
-
-
0242332186
-
Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor
-
Changelian PS, Flanagan ME, Ball DJ, et al. Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor. Science 2003;302:875-8
-
(2003)
Science
, vol.302
, pp. 875-878
-
-
Changelian, P.S.1
Flanagan, M.E.2
Ball, D.J.3
-
18
-
-
84866096861
-
Multiplexed mass cytometry profiling of cellular states perturbed by small-molecule regulators
-
Bodenmiller B, Zunder ER, Finck R, et al. Multiplexed mass cytometry profiling of cellular states perturbed by small-molecule regulators. Nat Biotechnol 2012;30:858-67
-
(2012)
Nat Biotechnol
, vol.30
, pp. 858-867
-
-
Bodenmiller, B.1
Zunder, E.R.2
Finck, R.3
-
19
-
-
84861827087
-
The JAK inhibitor tofacitinib regulates synovitis through inhibition of interferon-gamma and interleukin-17 production by human CD4+ T cells
-
Maeshima K, Yamaoka K, Kubo S, et al. The JAK inhibitor tofacitinib regulates synovitis through inhibition of interferon-gamma and interleukin-17 production by human CD4+ T cells. Arthritis Rheum 2012;64:1790-8
-
(2012)
Arthritis Rheum
, vol.64
, pp. 1790-1798
-
-
Maeshima, K.1
Yamaoka, K.2
Kubo, S.3
-
20
-
-
79955027327
-
Modulation of innate and adaptive immune responses by tofacitinib (CP- 690,550
-
Ghoreschi K, Jesson MI, Li X, et al. Modulation of innate and adaptive immune responses by tofacitinib (CP- 690,550). J Immunol 2011;186:4234-43
-
(2011)
J Immunol
, vol.186
, pp. 4234-4243
-
-
Ghoreschi, K.1
Jesson, M.I.2
Li, X.3
-
21
-
-
38049018155
-
A quantitative analysis of kinase inhibitor selectivity
-
Karaman MW, Herrgard S, Treiber DK, et al. A quantitative analysis of kinase inhibitor selectivity. Nat Biotechnol 2008;26:127-32
-
(2008)
Nat Biotechnol
, vol.26
, pp. 127-132
-
-
Karaman, M.W.1
Herrgard, S.2
Treiber, D.K.3
-
22
-
-
28544446226
-
Effects of JAK3 inhibition with CP-690,550 on immune cell populations and their functions in nonhuman primate recipients of kidney allografts
-
Paniagua R, Si MS, Flores MG, et al. Effects of JAK3 inhibition with CP-690,550 on immune cell populations and their functions in nonhuman primate recipients of kidney allografts. Transplantation 2005;80:1283-92
-
(2005)
Transplantation
, vol.80
, pp. 1283-1292
-
-
Paniagua, R.1
Si, M.S.2
Flores, M.G.3
-
23
-
-
33750600290
-
Janus kinase 3 inhibition with CP-690,550 prevents allograft vasculopathy
-
Rousvoal G, Si MS, Lau M, et al. Janus kinase 3 inhibition with CP-690,550 prevents allograft vasculopathy. Transpl Int 2006;19:1014-21
-
(2006)
Transpl Int
, vol.19
, pp. 1014-1021
-
-
Rousvoal, G.1
Si, M.S.2
Lau, M.3
-
24
-
-
20244368823
-
Immunosuppression by the JAK3 inhibitor CP-690,550 delays rejection and significantly prolongs kidney allograft survival in nonhuman primates
-
Borie DC, Changelian PS, Larson MJ, et al. Immunosuppression by the JAK3 inhibitor CP-690,550 delays rejection and significantly prolongs kidney allograft survival in nonhuman primates. Transplantation 2005;79:791-801
-
(2005)
Transplantation
, vol.79
, pp. 791-801
-
-
Borie, D.C.1
Changelian, P.S.2
Larson, M.J.3
-
25
-
-
61349149899
-
Dissecting specificity in the Janus kinases: The structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase domains
-
Williams NK, Bamert RS, Patel O, et al. Dissecting specificity in the Janus kinases: The structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase domains. J Mol Biol 2009;387:219-32
-
(2009)
J Mol Biol
, vol.387
, pp. 219-2232
-
-
Williams, N.K.1
Bamert, R.S.2
Patel, O.3
-
26
-
-
0033118675
-
From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins
-
Korganow AS, Ji H, Mangialaio S, et al. From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins. Immunity 1999;10:451-61
-
(1999)
Immunity
, vol.10
, pp. 451-461
-
-
Korganow, A.S.1
Ji, H.2
Mangialaio, S.3
-
27
-
-
39749164515
-
Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis
-
Milici AJ, Kudlacz EM, Audoly L, et al. Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis. Arthritis Res Ther 2008;10:R14
-
(2008)
Arthritis Res Ther
, vol.10
-
-
Milici, A.J.1
Kudlacz, E.M.2
Audoly, L.3
-
28
-
-
84870325487
-
Regulation of inflammatory responses in tumor necrosis factor-activated and rheumatoid arthritis synovial macrophages by JAK inhibitors
-
Yarilina A, Xu K, Chan C, et al. Regulation of inflammatory responses in tumor necrosis factor-activated and rheumatoid arthritis synovial macrophages by JAK inhibitors. Arthritis Rheum 2012;64:3856-66
-
(2012)
Arthritis Rheum
, vol.64
, pp. 3856-3866
-
-
Yarilina, A.1
Xu, K.2
Chan, C.3
-
29
-
-
84867077631
-
Jak inhibition with tofacitinib suppresses arthritic joint structural damage through decreased rankl production
-
Labranche TP, Jesson MI, Radi ZA, et al. JAK inhibition with tofacitinib suppresses arthritic joint structural damage through decreased RANKL production. Arthritis Rheum 2012;3531-42
-
(2012)
Arthritis Rheum
, pp. 3531-3542
-
-
Labranche, T.P.1
Jesson, M.I.2
Radi, Z.A.3
-
30
-
-
0033134608
-
IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis
-
Kotake S, Udagawa N, Takahashi N, et al. IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest 1999;103:1345-52
-
(1999)
J Clin Invest
, vol.103
, pp. 1345-1352
-
-
Kotake, S.1
Udagawa, N.2
Takahashi, N.3
-
31
-
-
84857239335
-
The JAK inhibitor CP-690,550 (tofacitinib) inhibits TNF-induced chemokine expression in fibroblast-like synoviocytes: Autocrine role of type I interferon
-
Rosengren S, Corr M, Firestein GS, et al. The JAK inhibitor CP-690,550 (tofacitinib) inhibits TNF-induced chemokine expression in fibroblast-like synoviocytes: Autocrine role of type I interferon. Ann Rheum Dis 2011;71:440-7
-
(2011)
Ann Rheum Dis
, vol.71
, pp. 440-447
-
-
Rosengren, S.1
Corr, M.2
Firestein, G.S.3
-
32
-
-
62849094732
-
Selectivity and therapeutic inhibition of kinases: To be or not to be?
-
Ghoreschi K, Laurence A, O'Shea JJ. Selectivity and therapeutic inhibition of kinases: To be or not to be? Nat Immunol 2009;10:356-60
-
(2009)
Nat Immunol
, vol.10
, pp. 356-360
-
-
Ghoreschi, K.1
Laurence, A.2
O'Shea, J.J.3
-
33
-
-
84890639334
-
JAK inhibitor, tofacitinib, reduces the T cell stimulatory capacity of human monocyte-derived dendritic cells
-
Kubo S, Yamaoka K, Kondo M, et al. The JAK inhibitor, tofacitinib, reduces the T cell stimulatory capacity of human monocyte-derived dendritic cells. Ann Rheum Dis 2013; 34
-
(2013)
Ann Rheum Dis
, vol.34
-
-
Kubo, S.1
Yamaoka, K.2
Kondo, M.3
-
34
-
-
84864716411
-
Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis
-
Fleischmann R, Kremer J, Cush J, et al. Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis. New Engl J Med 2012;367:495-507
-
(2012)
New Engl J Med
, vol.367
, pp. 495-507
-
-
Fleischmann, R.1
Kremer, J.2
Cush, J.3
-
35
-
-
84874402383
-
Tofacitinib (CP- 690,550) in patients with rheumatoid arthritis receiving methotrexate: Twelve-month data from a twenty-four-month phase III randomized radiographic study
-
van der Heijde D, Tanaka Y, Fleischmann R, et al. Tofacitinib (CP- 690,550) in patients with rheumatoid arthritis receiving methotrexate: Twelve-month data from a twenty-four-month phase III randomized radiographic study. Arthritis Rheum 2013;65:559-70
-
(2013)
Arthritis Rheum
, vol.65
, pp. 559-570
-
-
Van Der Heijde, D.1
Tanaka, Y.2
Fleischmann, R.3
-
36
-
-
84864703156
-
Tofacitinib or adalimumab versus placebo in rheumatoid arthritis
-
van Vollenhoven RF, Fleischmann R, Cohen S, et al. Tofacitinib or adalimumab versus placebo in rheumatoid arthritis. New Engl J Med 2012;367:508-19
-
(2012)
New Engl J Med
, vol.367
, pp. 508-519
-
-
Van Vollenhoven, R.F.1
Fleischmann, R.2
Cohen, S.3
-
37
-
-
84873707288
-
Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: A randomised phase 3 trial
-
Burmester GR, Blanco R, Charles-Schoeman C, et al. Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: A randomised phase 3 trial. Lancet 2013;381:451-60
-
(2013)
Lancet
, vol.381
, pp. 451-460
-
-
Burmester, G.R.1
Blanco, R.2
Charles-Schoeman, C.3
-
38
-
-
84862122620
-
Lack of effect of tofacitinib (CP-690,550) on the pharmacokinetics of the CYP3A4 substrate midazolam in healthy volunteers: Confirmation of in vitro data
-
Gupta P, Alvey C, Wang R, et al. Lack of effect of tofacitinib (CP-690,550) on the pharmacokinetics of the CYP3A4 substrate midazolam in healthy volunteers: Confirmation of in vitro data. Br J Clin Pharmacol 2012;74:109-15
-
(2012)
Br J Clin Pharmacol
, vol.74
, pp. 109-115
-
-
Gupta, P.1
Alvey, C.2
Wang, R.3
-
39
-
-
67650093218
-
The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: Results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo
-
Kremer JM, Bloom BJ, Breedveld FC, et al. The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: Results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo. Arthritis Rheum 2009;60:1895-905
-
(2009)
Arthritis Rheum
, vol.60
, pp. 1895-1905
-
-
Kremer, J.M.1
Bloom, B.J.2
Breedveld, F.C.3
-
40
-
-
84860388892
-
Phase II study of tofacitinib (CP-690, 550) combined with methotrexate in patients with rheumatoid arthritis and an inadequate response to methotrexate
-
Tanaka Y, Suzuki M, Nakamura H, et al. Phase II study of tofacitinib (CP- 690,550) combined with methotrexate in patients with rheumatoid arthritis and an inadequate response to methotrexate. Arthritis Care Res (Hoboken (2011;63:1150-8
-
(2011)
Arthritis Care Res (Hoboken
, vol.63
, pp. 1150-1158
-
-
Tanaka, Y.1
Suzuki, M.2
Nakamura, H.3
-
41
-
-
84866156845
-
A phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP- 690,550) versus placebo in combination with background methotrexate in patients with active rheumatoid arthritis and an inadequate response to methotrexate alone
-
Kremer JM, Cohen S, Wilkinson BE, et al. A phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP- 690,550) versus placebo in combination with background methotrexate in patients with active rheumatoid arthritis and an inadequate response to methotrexate alone. Arthritis Rheum 2012;64:970-81
-
(2012)
Arthritis Rheum
, vol.64
, pp. 970-981
-
-
Kremer, J.M.1
Cohen, S.2
Wilkinson, B.E.3
-
42
-
-
84857761516
-
Phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690,550) or adalimumab monotherapy versus placebo in patients with active rheumatoid arthritis with an inadequate response to disease-modifying antirheumatic drugs
-
Fleischmann R, Cutolo M, Genovese MC, et al. Phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690,550) or adalimumab monotherapy versus placebo in patients with active rheumatoid arthritis with an inadequate response to disease-modifying antirheumatic drugs. Arthritis Rheum 2012;64:617-29
-
(2012)
Arthritis Rheum
, vol.64
, pp. 617-629
-
-
Fleischmann, R.1
Cutolo, M.2
Genovese, M.C.3
-
43
-
-
84882266430
-
Tofacitinib in combination with nonbiologic disease-modifying antirheumatic drugs in patients with active rheumatoid arthritis: A randomized trial
-
Kremer J, Li ZG, Hall S, et al. Tofacitinib in combination with nonbiologic disease-modifying antirheumatic drugs in patients with active rheumatoid arthritis: A randomized trial. Ann Intern Med 2013;159:253-61
-
(2013)
Ann Intern Med
, vol.159
, pp. 253-261
-
-
Kremer, J.1
Li, Z.G.2
Hall, S.3
-
44
-
-
84890623916
-
The jak inhibitor tofacitinib suppresses synovial jak1-stat1 signalling in rheumatoid arthritis
-
Boyle DL, Wei N, Singhal AK, et al. The jak inhibitor tofacitinib suppresses synovial jak1-stat1 signalling in rheumatoid arthritis. Ann Rheum Dis 2013;72:138
-
(2013)
Ann Rheum Dis
, vol.72
, pp. 138
-
-
Boyle, D.L.1
Wei, N.2
Singhal, A.K.3
-
45
-
-
84877861892
-
Herpes zoster and tofacitinib therapy in patients with rheumatoid arthritis
-
Winthrop KL, Valdez H, Mortensen E, et al. Herpes zoster and tofacitinib therapy in patients with rheumatoid arthritis. Arthritis Rheum 2012;64:S1051
-
(2012)
Arthritis Rheum
, vol.64
-
-
Winthrop, K.L.1
Valdez, H.2
Mortensen, E.3
-
46
-
-
77953696525
-
EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs
-
Smolen JS, Landewe R, Breedveld FC, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs. Ann Rheum Dis 2010;69:964-75
-
(2010)
Ann Rheum Dis
, vol.69
, pp. 964-975
-
-
Smolen, J.S.1
Landewe, R.2
Breedveld, F.C.3
|