메뉴 건너뛰기




Volumn 15, Issue 1, 2014, Pages 103-113

Targeting the Janus kinases in rheumatoid arthritis: Focus on tofacitinib

Author keywords

Janus kinase; Rheumatoid arthritis treatment; Tofacitinib

Indexed keywords

JANUS KINASE; TOFACITINIB;

EID: 84890654789     PISSN: 14656566     EISSN: 17447666     Source Type: Journal    
DOI: 10.1517/14656566.2014.854771     Document Type: Article
Times cited : (18)

References (46)
  • 2
    • 84855172814 scopus 로고    scopus 로고
    • The pathogenesis of rheumatoid arthritis
    • McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. New Engl J Med 2011;365:2205-19
    • (2011) New Engl J Med , vol.365 , pp. 2205-2219
    • McInnes, I.B.1    Schett, G.2
  • 3
    • 84857737880 scopus 로고    scopus 로고
    • Inflammatory bone loss: Pathogenesis and therapeutic intervention
    • Redlich K, Smolen JS. Inflammatory bone loss: Pathogenesis and therapeutic intervention. Nat Rev Drug Discov 2012;11:234-50
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 234-250
    • Redlich, K.1    Smolen, J.S.2
  • 4
    • 84863403514 scopus 로고    scopus 로고
    • Intensive treatment and treatment holiday of TNF-inhibitors in rheumatoid arthritis
    • Tanaka Y. Intensive treatment and treatment holiday of TNF-inhibitors in rheumatoid arthritis. Curr Opin Rheumatol 2012;24:319-26
    • (2012) Curr Opin Rheumatol , vol.24 , pp. 319-326
    • Tanaka, Y.1
  • 5
    • 84876257564 scopus 로고    scopus 로고
    • Next stage of ra treatment: Is tnf inhibitor-free remission a possible treatment goal?
    • Tanaka Y. Next stage of RA treatment: Is TNF inhibitor-free remission a possible treatment goal? Ann Rheum Dis 2013;72(Suppl 2):ii124-7
    • (2013) Ann Rheum Dis , vol.72 , Issue.SUPPL. 2 , pp. 124-127
    • Tanaka, Y.1
  • 6
    • 77950307115 scopus 로고    scopus 로고
    • Treating rheumatoid arthritis to target: Recommendations of an international task force
    • Smolen JS, Aletaha D, Bijlsma JW, et al. Treating rheumatoid arthritis to target: Recommendations of an international task force. Ann Rheum Dis 2010;69:631-7
    • (2010) Ann Rheum Dis , vol.69 , pp. 631-637
    • Smolen, J.S.1    Aletaha, D.2    Bijlsma, J.W.3
  • 7
    • 67449124635 scopus 로고    scopus 로고
    • Radiographic changes in rheumatoid arthritis patients attaining different disease activity states with methotrexate monotherapy and infliximab plus methotrexate: The impacts of remission and tumour necrosis factor blockade
    • Smolen JS, Han C, van der Heijde DM, et al. Radiographic changes in rheumatoid arthritis patients attaining different disease activity states with methotrexate monotherapy and infliximab plus methotrexate: The impacts of remission and tumour necrosis factor blockade. Ann Rheum Dis 2009;68:823-7
    • (2009) Ann Rheum Dis , vol.68 , pp. 823-827
    • Smolen, J.S.1    Han, C.2    Van Der Heijde, D.M.3
  • 8
    • 0028339282 scopus 로고
    • Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2
    • Johnston JA, Kawamura M, Kirken RA, et al. Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2. Nature 1994;370:151-3
    • (1994) Nature , vol.370 , pp. 151-153
    • Johnston, J.A.1    Kawamura, M.2    Kirken, R.A.3
  • 9
    • 0028857954 scopus 로고
    • Mutation of Jak3 in a patient with SCID: Essential role of Jak3 in lymphoid development
    • Russell SM, Tayebi N, Nakajima H, et al. Mutation of Jak3 in a patient with SCID: Essential role of Jak3 in lymphoid development. Science 1995;270:797-800
    • (1995) Science , vol.270 , pp. 797-800
    • Russell, S.M.1    Tayebi, N.2    Nakajima, H.3
  • 10
    • 0028840706 scopus 로고
    • Defective lymphoid development in mice lacking jak3
    • Nosaka T, van Deursen JM, Tripp RA, et al. Defective lymphoid development in mice lacking Jak3. Science 1995;270:800-2
    • (1995) Science , vol.270 , pp. 800-802
    • Nosaka, T.1    Van Deursen, J.M.2    Tripp, R.A.3
  • 11
    • 0028171065 scopus 로고
    • Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: Implications for XSCID and XCID
    • Russell SM, Johnston JA, Noguchi M, et al. Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: Implications for XSCID and XCID. Science 1994;266:1042-5
    • (1994) Science , vol.266 , pp. 1042-1045
    • Russell, S.M.1    Johnston, J.A.2    Noguchi, M.3
  • 12
    • 0034804745 scopus 로고    scopus 로고
    • Mutations in severe combined immune deficiency (SCID) due to JAK3 deficiency
    • Notarangelo LD, Mella P, Jones A, et al. Mutations in severe combined immune deficiency (SCID) due to JAK3 deficiency. Hum Mutat 2001;18:255-63
    • (2001) Hum Mutat , vol.18 , pp. 255-263
    • Notarangelo, L.D.1    Mella, P.2    Jones, A.3
  • 13
    • 33751300575 scopus 로고    scopus 로고
    • Changes in synovial tissue Jak-STAT expression in rheumatoid arthritis in response to successful DMARD treatment
    • Walker JG, Ahern MJ, Coleman M, et al. Changes in synovial tissue Jak-STAT expression in rheumatoid arthritis in response to successful DMARD treatment. Ann Rheum Dis 2006;65:1558-64
    • (2006) Ann Rheum Dis , vol.65 , pp. 1558-1564
    • Walker, J.G.1    Ahern, M.J.2    Coleman, M.3
  • 14
    • 31144460322 scopus 로고    scopus 로고
    • Expression of jak3, stat1, stat4, and stat6 in inflammatory arthritis: Unique jak3 and stat4 expression in dendritic cells in seropositive rheumatoid arthritis
    • Walker JG, Ahern MJ, Coleman M, et al. Expression of Jak3, STAT1, STAT4, and STAT6 in inflammatory arthritis: Unique Jak3 and STAT4 expression in dendritic cells in seropositive rheumatoid arthritis. Ann Rheum Dis 2006;65:149-56
    • (2006) Ann Rheum Dis , vol.65 , pp. 149-156
    • Walker, J.G.1    Ahern, M.J.2    Coleman, M.3
  • 15
    • 0035895505 scopus 로고    scopus 로고
    • The sequence of the human genome
    • Venter JC, Adams MD, Myers EW, et al. The sequence of the human genome. Science 2001;291:1304-51
    • (2001) Science , vol.291 , pp. 1304-1351
    • Venter, J.C.1    Adams, M.D.2    Myers, E.W.3
  • 17
    • 0242332186 scopus 로고    scopus 로고
    • Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor
    • Changelian PS, Flanagan ME, Ball DJ, et al. Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor. Science 2003;302:875-8
    • (2003) Science , vol.302 , pp. 875-878
    • Changelian, P.S.1    Flanagan, M.E.2    Ball, D.J.3
  • 18
    • 84866096861 scopus 로고    scopus 로고
    • Multiplexed mass cytometry profiling of cellular states perturbed by small-molecule regulators
    • Bodenmiller B, Zunder ER, Finck R, et al. Multiplexed mass cytometry profiling of cellular states perturbed by small-molecule regulators. Nat Biotechnol 2012;30:858-67
    • (2012) Nat Biotechnol , vol.30 , pp. 858-867
    • Bodenmiller, B.1    Zunder, E.R.2    Finck, R.3
  • 19
    • 84861827087 scopus 로고    scopus 로고
    • The JAK inhibitor tofacitinib regulates synovitis through inhibition of interferon-gamma and interleukin-17 production by human CD4+ T cells
    • Maeshima K, Yamaoka K, Kubo S, et al. The JAK inhibitor tofacitinib regulates synovitis through inhibition of interferon-gamma and interleukin-17 production by human CD4+ T cells. Arthritis Rheum 2012;64:1790-8
    • (2012) Arthritis Rheum , vol.64 , pp. 1790-1798
    • Maeshima, K.1    Yamaoka, K.2    Kubo, S.3
  • 20
    • 79955027327 scopus 로고    scopus 로고
    • Modulation of innate and adaptive immune responses by tofacitinib (CP- 690,550
    • Ghoreschi K, Jesson MI, Li X, et al. Modulation of innate and adaptive immune responses by tofacitinib (CP- 690,550). J Immunol 2011;186:4234-43
    • (2011) J Immunol , vol.186 , pp. 4234-4243
    • Ghoreschi, K.1    Jesson, M.I.2    Li, X.3
  • 21
    • 38049018155 scopus 로고    scopus 로고
    • A quantitative analysis of kinase inhibitor selectivity
    • Karaman MW, Herrgard S, Treiber DK, et al. A quantitative analysis of kinase inhibitor selectivity. Nat Biotechnol 2008;26:127-32
    • (2008) Nat Biotechnol , vol.26 , pp. 127-132
    • Karaman, M.W.1    Herrgard, S.2    Treiber, D.K.3
  • 22
    • 28544446226 scopus 로고    scopus 로고
    • Effects of JAK3 inhibition with CP-690,550 on immune cell populations and their functions in nonhuman primate recipients of kidney allografts
    • Paniagua R, Si MS, Flores MG, et al. Effects of JAK3 inhibition with CP-690,550 on immune cell populations and their functions in nonhuman primate recipients of kidney allografts. Transplantation 2005;80:1283-92
    • (2005) Transplantation , vol.80 , pp. 1283-1292
    • Paniagua, R.1    Si, M.S.2    Flores, M.G.3
  • 23
    • 33750600290 scopus 로고    scopus 로고
    • Janus kinase 3 inhibition with CP-690,550 prevents allograft vasculopathy
    • Rousvoal G, Si MS, Lau M, et al. Janus kinase 3 inhibition with CP-690,550 prevents allograft vasculopathy. Transpl Int 2006;19:1014-21
    • (2006) Transpl Int , vol.19 , pp. 1014-1021
    • Rousvoal, G.1    Si, M.S.2    Lau, M.3
  • 24
    • 20244368823 scopus 로고    scopus 로고
    • Immunosuppression by the JAK3 inhibitor CP-690,550 delays rejection and significantly prolongs kidney allograft survival in nonhuman primates
    • Borie DC, Changelian PS, Larson MJ, et al. Immunosuppression by the JAK3 inhibitor CP-690,550 delays rejection and significantly prolongs kidney allograft survival in nonhuman primates. Transplantation 2005;79:791-801
    • (2005) Transplantation , vol.79 , pp. 791-801
    • Borie, D.C.1    Changelian, P.S.2    Larson, M.J.3
  • 25
    • 61349149899 scopus 로고    scopus 로고
    • Dissecting specificity in the Janus kinases: The structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase domains
    • Williams NK, Bamert RS, Patel O, et al. Dissecting specificity in the Janus kinases: The structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase domains. J Mol Biol 2009;387:219-32
    • (2009) J Mol Biol , vol.387 , pp. 219-2232
    • Williams, N.K.1    Bamert, R.S.2    Patel, O.3
  • 26
    • 0033118675 scopus 로고    scopus 로고
    • From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins
    • Korganow AS, Ji H, Mangialaio S, et al. From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins. Immunity 1999;10:451-61
    • (1999) Immunity , vol.10 , pp. 451-461
    • Korganow, A.S.1    Ji, H.2    Mangialaio, S.3
  • 27
    • 39749164515 scopus 로고    scopus 로고
    • Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis
    • Milici AJ, Kudlacz EM, Audoly L, et al. Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis. Arthritis Res Ther 2008;10:R14
    • (2008) Arthritis Res Ther , vol.10
    • Milici, A.J.1    Kudlacz, E.M.2    Audoly, L.3
  • 28
    • 84870325487 scopus 로고    scopus 로고
    • Regulation of inflammatory responses in tumor necrosis factor-activated and rheumatoid arthritis synovial macrophages by JAK inhibitors
    • Yarilina A, Xu K, Chan C, et al. Regulation of inflammatory responses in tumor necrosis factor-activated and rheumatoid arthritis synovial macrophages by JAK inhibitors. Arthritis Rheum 2012;64:3856-66
    • (2012) Arthritis Rheum , vol.64 , pp. 3856-3866
    • Yarilina, A.1    Xu, K.2    Chan, C.3
  • 29
    • 84867077631 scopus 로고    scopus 로고
    • Jak inhibition with tofacitinib suppresses arthritic joint structural damage through decreased rankl production
    • Labranche TP, Jesson MI, Radi ZA, et al. JAK inhibition with tofacitinib suppresses arthritic joint structural damage through decreased RANKL production. Arthritis Rheum 2012;3531-42
    • (2012) Arthritis Rheum , pp. 3531-3542
    • Labranche, T.P.1    Jesson, M.I.2    Radi, Z.A.3
  • 30
    • 0033134608 scopus 로고    scopus 로고
    • IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis
    • Kotake S, Udagawa N, Takahashi N, et al. IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest 1999;103:1345-52
    • (1999) J Clin Invest , vol.103 , pp. 1345-1352
    • Kotake, S.1    Udagawa, N.2    Takahashi, N.3
  • 31
    • 84857239335 scopus 로고    scopus 로고
    • The JAK inhibitor CP-690,550 (tofacitinib) inhibits TNF-induced chemokine expression in fibroblast-like synoviocytes: Autocrine role of type I interferon
    • Rosengren S, Corr M, Firestein GS, et al. The JAK inhibitor CP-690,550 (tofacitinib) inhibits TNF-induced chemokine expression in fibroblast-like synoviocytes: Autocrine role of type I interferon. Ann Rheum Dis 2011;71:440-7
    • (2011) Ann Rheum Dis , vol.71 , pp. 440-447
    • Rosengren, S.1    Corr, M.2    Firestein, G.S.3
  • 32
    • 62849094732 scopus 로고    scopus 로고
    • Selectivity and therapeutic inhibition of kinases: To be or not to be?
    • Ghoreschi K, Laurence A, O'Shea JJ. Selectivity and therapeutic inhibition of kinases: To be or not to be? Nat Immunol 2009;10:356-60
    • (2009) Nat Immunol , vol.10 , pp. 356-360
    • Ghoreschi, K.1    Laurence, A.2    O'Shea, J.J.3
  • 33
    • 84890639334 scopus 로고    scopus 로고
    • JAK inhibitor, tofacitinib, reduces the T cell stimulatory capacity of human monocyte-derived dendritic cells
    • Kubo S, Yamaoka K, Kondo M, et al. The JAK inhibitor, tofacitinib, reduces the T cell stimulatory capacity of human monocyte-derived dendritic cells. Ann Rheum Dis 2013; 34
    • (2013) Ann Rheum Dis , vol.34
    • Kubo, S.1    Yamaoka, K.2    Kondo, M.3
  • 34
    • 84864716411 scopus 로고    scopus 로고
    • Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis
    • Fleischmann R, Kremer J, Cush J, et al. Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis. New Engl J Med 2012;367:495-507
    • (2012) New Engl J Med , vol.367 , pp. 495-507
    • Fleischmann, R.1    Kremer, J.2    Cush, J.3
  • 35
    • 84874402383 scopus 로고    scopus 로고
    • Tofacitinib (CP- 690,550) in patients with rheumatoid arthritis receiving methotrexate: Twelve-month data from a twenty-four-month phase III randomized radiographic study
    • van der Heijde D, Tanaka Y, Fleischmann R, et al. Tofacitinib (CP- 690,550) in patients with rheumatoid arthritis receiving methotrexate: Twelve-month data from a twenty-four-month phase III randomized radiographic study. Arthritis Rheum 2013;65:559-70
    • (2013) Arthritis Rheum , vol.65 , pp. 559-570
    • Van Der Heijde, D.1    Tanaka, Y.2    Fleischmann, R.3
  • 36
    • 84864703156 scopus 로고    scopus 로고
    • Tofacitinib or adalimumab versus placebo in rheumatoid arthritis
    • van Vollenhoven RF, Fleischmann R, Cohen S, et al. Tofacitinib or adalimumab versus placebo in rheumatoid arthritis. New Engl J Med 2012;367:508-19
    • (2012) New Engl J Med , vol.367 , pp. 508-519
    • Van Vollenhoven, R.F.1    Fleischmann, R.2    Cohen, S.3
  • 37
    • 84873707288 scopus 로고    scopus 로고
    • Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: A randomised phase 3 trial
    • Burmester GR, Blanco R, Charles-Schoeman C, et al. Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: A randomised phase 3 trial. Lancet 2013;381:451-60
    • (2013) Lancet , vol.381 , pp. 451-460
    • Burmester, G.R.1    Blanco, R.2    Charles-Schoeman, C.3
  • 38
    • 84862122620 scopus 로고    scopus 로고
    • Lack of effect of tofacitinib (CP-690,550) on the pharmacokinetics of the CYP3A4 substrate midazolam in healthy volunteers: Confirmation of in vitro data
    • Gupta P, Alvey C, Wang R, et al. Lack of effect of tofacitinib (CP-690,550) on the pharmacokinetics of the CYP3A4 substrate midazolam in healthy volunteers: Confirmation of in vitro data. Br J Clin Pharmacol 2012;74:109-15
    • (2012) Br J Clin Pharmacol , vol.74 , pp. 109-115
    • Gupta, P.1    Alvey, C.2    Wang, R.3
  • 39
    • 67650093218 scopus 로고    scopus 로고
    • The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: Results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo
    • Kremer JM, Bloom BJ, Breedveld FC, et al. The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: Results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo. Arthritis Rheum 2009;60:1895-905
    • (2009) Arthritis Rheum , vol.60 , pp. 1895-1905
    • Kremer, J.M.1    Bloom, B.J.2    Breedveld, F.C.3
  • 40
    • 84860388892 scopus 로고    scopus 로고
    • Phase II study of tofacitinib (CP-690, 550) combined with methotrexate in patients with rheumatoid arthritis and an inadequate response to methotrexate
    • Tanaka Y, Suzuki M, Nakamura H, et al. Phase II study of tofacitinib (CP- 690,550) combined with methotrexate in patients with rheumatoid arthritis and an inadequate response to methotrexate. Arthritis Care Res (Hoboken (2011;63:1150-8
    • (2011) Arthritis Care Res (Hoboken , vol.63 , pp. 1150-1158
    • Tanaka, Y.1    Suzuki, M.2    Nakamura, H.3
  • 41
    • 84866156845 scopus 로고    scopus 로고
    • A phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP- 690,550) versus placebo in combination with background methotrexate in patients with active rheumatoid arthritis and an inadequate response to methotrexate alone
    • Kremer JM, Cohen S, Wilkinson BE, et al. A phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP- 690,550) versus placebo in combination with background methotrexate in patients with active rheumatoid arthritis and an inadequate response to methotrexate alone. Arthritis Rheum 2012;64:970-81
    • (2012) Arthritis Rheum , vol.64 , pp. 970-981
    • Kremer, J.M.1    Cohen, S.2    Wilkinson, B.E.3
  • 42
    • 84857761516 scopus 로고    scopus 로고
    • Phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690,550) or adalimumab monotherapy versus placebo in patients with active rheumatoid arthritis with an inadequate response to disease-modifying antirheumatic drugs
    • Fleischmann R, Cutolo M, Genovese MC, et al. Phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690,550) or adalimumab monotherapy versus placebo in patients with active rheumatoid arthritis with an inadequate response to disease-modifying antirheumatic drugs. Arthritis Rheum 2012;64:617-29
    • (2012) Arthritis Rheum , vol.64 , pp. 617-629
    • Fleischmann, R.1    Cutolo, M.2    Genovese, M.C.3
  • 43
    • 84882266430 scopus 로고    scopus 로고
    • Tofacitinib in combination with nonbiologic disease-modifying antirheumatic drugs in patients with active rheumatoid arthritis: A randomized trial
    • Kremer J, Li ZG, Hall S, et al. Tofacitinib in combination with nonbiologic disease-modifying antirheumatic drugs in patients with active rheumatoid arthritis: A randomized trial. Ann Intern Med 2013;159:253-61
    • (2013) Ann Intern Med , vol.159 , pp. 253-261
    • Kremer, J.1    Li, Z.G.2    Hall, S.3
  • 44
    • 84890623916 scopus 로고    scopus 로고
    • The jak inhibitor tofacitinib suppresses synovial jak1-stat1 signalling in rheumatoid arthritis
    • Boyle DL, Wei N, Singhal AK, et al. The jak inhibitor tofacitinib suppresses synovial jak1-stat1 signalling in rheumatoid arthritis. Ann Rheum Dis 2013;72:138
    • (2013) Ann Rheum Dis , vol.72 , pp. 138
    • Boyle, D.L.1    Wei, N.2    Singhal, A.K.3
  • 45
    • 84877861892 scopus 로고    scopus 로고
    • Herpes zoster and tofacitinib therapy in patients with rheumatoid arthritis
    • Winthrop KL, Valdez H, Mortensen E, et al. Herpes zoster and tofacitinib therapy in patients with rheumatoid arthritis. Arthritis Rheum 2012;64:S1051
    • (2012) Arthritis Rheum , vol.64
    • Winthrop, K.L.1    Valdez, H.2    Mortensen, E.3
  • 46
    • 77953696525 scopus 로고    scopus 로고
    • EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs
    • Smolen JS, Landewe R, Breedveld FC, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs. Ann Rheum Dis 2010;69:964-75
    • (2010) Ann Rheum Dis , vol.69 , pp. 964-975
    • Smolen, J.S.1    Landewe, R.2    Breedveld, F.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.