Cationic amino acid based lipids as effective nonviral gene delivery vectors for primary cultured neurons

ACS Chemical Neuroscience

Volumn 4, Issue 12, 2013, Pages 1514-1519

  Aoshima, Yumiko ^a   Hokama, Ryosuke ^a   Sou, Keitaro ^a   Sarker, Satya Ranjan ^a   Iida, Kabuto ^a   Nakamura, Hideki ^a   Inoue, Takafumi ^a   Takeoka, Shinji ^a  

^a WASEDA UNIVERSITY   (Japan)

Author keywords

Cationic amino acid based lipids; gene delivery; green fluorescent protein; liposomes; primary cultured neurons; transfection

Indexed keywords

AMINO ACID TRANSPORTER; ARGININE; CHLORIDE ION; COUNTERION; LYSINE; PLASMID DNA; TRIFLUOROACETIC ACID;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL STRUCTURE; CYTOTOXICITY ASSAY; GENETIC TRANSFECTION; MOUSE; NERVE CELL CULTURE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL;

AMINO ACIDS, ACIDIC; ANIMALS; CELLS, CULTURED; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; LIPIDS; LIPOSOMES; MICE; NEURONS; PLASMIDS; TRANSFECTION;

EID: 84890643542     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn400036j     Document Type: Article

References (30)

1. During, M. J., Naegele, J. R., O'Malley, K. L., and Geller, A. I. (1994) Long-term behavioral recovery in parkinsonian rats by an HSV vector expressing tyrosine hydroxylase Science 266, 1399-403
2. Kumar, P., Wu, H., McBride, J. L., Jung, K. E., Kim, M. H., Davidson, B. L., Lee, S. K., Shankar, P., and Manjunath, N. (2007) Transvascular delivery of small interfering RNA to the central nervous system Nature 448, 39-43
3. Bergen, J. M., Park, I. K., Horner, P. J., and Pun, S. H. (2008) Nonviral approaches for neuronal delivery of nucleic acids Pharm. Res. 25, 983-98
4. Chang, D. T., Honick, A. S., and Reynolds, I. J. (2006) Mitochondrial trafficking to synapses in cultured primary cortical neurons J. Neurosci. 26, 7035-7045
5. Halterman, M. W., Giuliano, R., Dejesus, C., and Schor, N. F. (2009) In-tube transfection improves the efficiency of gene transfer in primary neuronal cultures J. Neurosci. Methods. 177, 348-354
6. Davidson, B. L. and Breakfield, X. O. (2003) Viral vectors for gene delivery to the nervous system Nat. Rev. Neurosci. 4, 353-364
7. 2+-phosphate transfection efficiency in low-density neuronal cultures Nat. Protoc. 1, 695-700
8. Washbourne, P. and McAllister, A. K. (2002) Techniques for gene transfer into neurons Curr. Opin. Neurobiol. 12, 566-573
9. Thomas, C. E., Ehrhardt, A., and Kay, M. A. (2003) Progress and problems with the use of viral vectors for gene therapy Nat. Rev. Genet. 4, 346-358
10. Pérez-Martínez, F. C., Guerra, J., Posadas, I., and Ceña, V. (2011) Barriers to non-viral vector-mediated gene delivery in the nervous system Pharm. Res. 28, 1843-1858
11. Felgner, P. L., Gadek, T. R., Holm, M., Roman, R., Chan, H. W., Wenz, M., Northrop, J. P., Ringold, G. M., and Danielsen, M. (1987) Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure Proc. Natl. Acad. Sci. U.S.A. 84, 7413-7417
12. Gao, X. and Huang, L. (1991) A novel cationic liposome reagent for efficient transfection of mammalian cells Biochem. Biophys. Res. Commun. 179, 280-285
13. Dalby, B., Cates, S., Harris, A., Ohki, E. C., Tilkins, M. L., Price, P. J., and Ciccarone, V. C. (2004) Advanced transfection with Lipofectamine 2000 reagent: primary neurons, siRNA, and high-throughput applications Methods 33, 95-103
14. Zou, S., Scarfo, K., Nantz, M. H., and Hecker, J. G. (2010) Lipid-mediated delivery of RNA is more efficient than delivery of DNA in non-dividing cells Int. J. Pharm. 389, 232-243
15. Zhou, X. and Huang, L. (1994) DNA transfection mediated by cationic liposomes containing lipopolylysine: characterization and mechanism of action Biochim. Biophys. Acta 1189, 195-203
16. Zelphati, O. and Szoka, F. C., Jr. (1996) Intracellular distribution and mechanism of delivery of oligonucleotides mediated by cationic lipids Pharm. Res. 13, 1367-1372
17. Felgner, J. H., Kumar, R., Sridhar, C. N., Wheeler, C. J., Tsai, Y. J., Border, R., Ramsey, P., Martin, M., and Felgner, P. L. (1994) Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations J. Biol. Chem. 269, 2550-2561
18. Mintzer, M. A. and Simanek, E. E. (2009) Nonviral vectors for gene delivery Chem. Rev. 109, 259-302
19. Obata, Y., Suzuki, D., and Takeoka, S. (2008) Evaluation of cationic assemblies constructed with amino acid based lipids for plasmid DNA delivery Bioconjugate Chem. 19, 1055-1063
20. Obata, Y., Saito, S., Takeda, N., and Takeoka, S. (2009) Plasmid DNA-encapsulating liposomes: Effect of a spacer between the cationic head group and and hydrophobic moieties of the lipids on gene expression efficiency Biochim. Biophys. Acta, Biomembr. 1788, 1148-1158
21. Sarker, S. R., Arai, S., Murate, M., Takahashi, H., Takata, M., Kobayashi, T., and Takeoka, S. (2012) Evaluation of the influence of ionization states and spacers in the thermotropic phase behaviour of amino acid based cationic lipids and the transfection efficiency of their assemblies Int. J. Pharm. 422, 364-373
22. Obata, Y., Ciofani, G., Raffa, V., Cuschieri, A., Menciassi, A., Dario, P., and Takeoka, S. (2010) Evaluation of cationic liposomes composed of an amino acid based lipid for neuronal transfection Nanomedicine 6, 70-77
23. Sarker, S. R., Aoshima, Y., Hokama, R., Inoue, T., Sou, K., and Takeoka, S. (2013) Arginine-based cationic liposomes to deliver plasmid DNA to neuronal cells with low cytotoxity Int. J. Nanomed. 8, 1361-1375
24. Farhood, H., Serbina, N., and Huang, L. (1995) The role of dioleoyl phosphatidylethanolamine in cationic liposome mediated gene transfer Biochim. Biophys. Acta 1235, 289-295
25. Papa, M., Bundman, M. C., Greenberger, V., and Segal, M. (1995) Morphological analysis of dendritic spine development in primary cultures of hippocampal neurons J. Neurosci. 15, 1-11
26. Ziv, N. E. and Smith, S. J. (1996) Evidence for a role of dendritic filopodia in synaptogenesis and spine formation Neuron 17, 91-102
27. Sapoznik, S., Ivenshitz, M., and Segal, M. (2006) Age-dependent glutamate induction of synaptic plasticity in cultured hippocampal neurons Learn. Mem. 13, 719-727
28. Karra, D. and Dahm, R. (2010) Transfection techniques for neuronal cells J. Neurosci. 30, 6171-6177
29. Aberle, A. M., Bennett, M. J., Malone, R. W., and Nantz, M. H. (1996) The counterion influence on cationic lipid-mediated transfection of plasmid DNA Biochem. Biophys. Acta 1299, 281-283
30. Dass, C. R. (2002) Cytotoxicity issues pertinent to lipoplex-mediated gene therapy in-vivo J. Pharm. Pharmacol. 54, 593-601