HLA-Bâ27 subtype specificity determines targeting and viral evolution of a hepatitis C virus-specific CD8+ T cell epitope

Journal of Hepatology

Volumn 60, Issue 1, 2014, Pages 22-29

  Nitschke, Katja ^a   Barriga, Alejandro ^b   Schmidt, Julia ^a   Timm, Jörg ^c   Viazov, Sergei ^c   Kuntzen, Thomas ^d   Kim, Arthur Y ^e   Lauer, Georg M ^e   Allen, Todd M ^d   Gaudieri, Silvana ^f,g   Rauch, Andri ^h   Lange, Christian M ⁱ   Sarrazin, Christoph ⁱ   Eiermann, Thomas ^j   Sidney, John ^k   Sette, Alessandro ^k   Thimme, Robert ^a   López, Daniel ^b   Neumann Haefelin, Christoph ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c UNIVERSITY OF DUISBURG ESSEN   (Germany)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^g MURDOCH UNIVERSITY   (Australia)

^h UNIVERSITY OF BERN   (Switzerland)

ⁱ UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^j UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^k LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

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Author keywords

CD8+ T cell response; Hepatitis C virus; HLA subtypes; HLA B 27; HLA B27; Vaccine design

Indexed keywords

EPITOPE; HLA ANTIGEN; HLA ANTIGEN CLASS 1; HLA B27 ANTIGEN; HOST FACTOR; GAMMA INTERFERON; HUMAN LEUKOCYTE ANTIGEN; NS 5 PROTEIN, HEPATITIS C VIRUS; NS-5 PROTEIN, HEPATITIS C VIRUS; VIRUS PROTEIN;

ANTIGEN SPECIFICITY; ARTICLE; CD8+ T LYMPHOCYTE; FLOW CYTOMETRY; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HLA TYPING; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MEDITERRANEAN SEA; MOLECULAR EVOLUTION; MULTICENTER STUDY; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; SEQUENCE ANALYSIS; VIRUS LOAD; VIRUS STRAIN; VIRUS TRANSMISSION; ACUTE HEPATITIS; ANTIGEN BINDING; CONTROLLED STUDY; FEMALE; GENE MUTATION; GERMAN (CITIZEN); HEPATITIS C VIRUS GENOTYPE 1; IRISH (CITIZEN); B-LCL; B-LYMPHOBLASTOID CELL LINES; CD8+ T CELL RESPONSE; CLASSIFICATION; EPSTEIN BARR VIRUS; HCV; HLA SUBTYPES; HLA SYSTEM; HLA-B(*)27; HLA-B27; IFN-Γ; IMMUNOLOGY; NON-STRUCTURAL PROTEIN 5B; NS5B; VACCINE DESIGN;

B-LCL; B-LYMPHOBLASTOID CELL LINES; CD8+ T CELL RESPONSE; EBV; EPSTEIN BARR VIRUS; HCV; HEPATITIS C VIRUS; HLA; HLA SUBTYPES; HLA-B(*)27; HLA-B27; HUMAN LEUKOCYTE ANTIGEN; IFN-Γ; INTERFERON-GAMMA; NON-STRUCTURAL PROTEIN 5B; NS5B; PBMC; PERIPHERAL BLOOD MONONUCLEAR CELL; VACCINE DESIGN;

CD8-POSITIVE T-LYMPHOCYTES; EPITOPES, T-LYMPHOCYTE; HEPACIVIRUS; HLA-B27 ANTIGEN; HUMANS; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84890561540     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2013.08.009     Document Type: Article

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