HLA class i allele associations with HCV genetic variants in patients with chronic HCV genotypes 1a or 1b infection

Journal of Hepatology

Volumn 53, Issue 6, 2010, Pages 1022-1028

  Lange, Christian Markus ^a   Roomp, Kirsten ^b   Dragan, Anette ^a   Nattermann, Jacob ^c   Michalk, Monika ^c   Spengler, Ulrich ^c   Weich, Viola ^a   Lengauer, Thomas ^b   Zeuzem, Stefan ^a   Berg, Thomas ^d   Sarrazin, Christoph ^a  

^a GOETHE UNIVERSITY   (Germany)

^b MAX PLANCK INSTITUTE FOR INFORMATICS   (Germany)

^c UNIVERSITY HOSPITAL BONN   (Germany)

^d UNIVERSITY HOSPITAL LEIPZIG   (Germany)

Author keywords

Epitopes; Genetic variants; Hepatitis C; HLA restricted epitopes; Immune pressure

Indexed keywords

AMINO ACID; EPITOPE; HLA ANTIGEN CLASS 1; NONSTRUCTURAL PROTEIN 3; NONSTRUCTURAL PROTEIN 5B; PEGINTERFERON ALPHA2B; RIBAVIRIN; VIRUS PROTEIN;

ADAPTIVE IMMUNITY; ADULT; AGED; ALGORITHM; ALLELE; AMINO ACID SEQUENCE; ARTICLE; CD8+ T LYMPHOCYTE; CLINICAL TRIAL; COHORT ANALYSIS; DISEASE ASSOCIATION; FEMALE; GENE SEQUENCE; GENETIC VARIABILITY; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HLA SYSTEM; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN BINDING; SEQUENCE ANALYSIS;

ADOLESCENT; ADULT; AGED; ALLELES; BASE SEQUENCE; CD8-POSITIVE T-LYMPHOCYTES; COHORT STUDIES; DNA PRIMERS; FEMALE; GENES, MHC CLASS I; GENETIC ASSOCIATION STUDIES; GENETIC VARIATION; GENOTYPE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HOST-PATHOGEN INTERACTIONS; HUMANS; MALE; MIDDLE AGED; PHYLOGENY; PROSPECTIVE STUDIES; RNA, VIRAL; VIRAL ENVELOPE PROTEINS; VIRAL NONSTRUCTURAL PROTEINS; YOUNG ADULT;

EID: 78049465173     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2010.06.011     Document Type: Article

References (22)

1. J.G. McHutchison Understanding hepatitis C Am J Manag Care 10 2004 S21 S29
2. R. Thimme, C. Neumann-Haefelin, T. Boettler, and H.E. Blum Adaptive immune responses to hepatitis C virus: from viral immunobiology to a vaccine Biol Chem 389 2008 457 467
3. G.M. Lauer, E. Barnes, M. Lucas, J. Timm, K. Ouchi, and A.Y. Kim High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection Gastroenterology 127 2004 924 936
4. W.J. Schulze zur, G.M. Lauer, C.L. Day, A.Y. Kim, K. Ouchi, and J.E. Duncan Broad repertoire of the CD4+ Th cell response in spontaneously controlled hepatitis C virus infection includes dominant and highly promiscuous epitopes J Immunol 175 2005 3603 3613
5. J. Timm, G.M. Lauer, D.G. Kavanagh, I. Sheridan, A.Y. Kim, and M. Lucas CD8 epitope escape and reversion in acute HCV infection J Exp Med 200 2004 1593 1604
6. I. Tester, S. Smyk-Pearson, P. Wang, A. Wertheimer, E. Yao, and D.M. Lewinsohn Immune evasion versus recovery after acute hepatitis C virus infection from a shared source J Exp Med 201 2005 1725 1731
7. H. Wedemeyer, X.S. He, M. Nascimbeni, A.R. Davis, H.B. Greenberg, and J.H. Hoofnagle Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection J Immunol 169 2002 3447 3458
8. M. Lucas, A. Ulsenheimer, K. Pfafferot, M.H. Heeg, S. Gaudieri, and N. Gruner PLoS One 2 2007 e649
9. R. Thimme, J. Bukh, H.C. Spangenberg, S. Wieland, J. Pemberton, and C. Steiger Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease Proc Natl Acad Sci USA 99 2002 15661 15668
10. C. Neumann-Haefelin, D.N. Frick, J.J. Wang, O.G. Pybus, S. Salloum, and G.S. Narula Analysis of the evolutionary forces in an immunodominant CD8 epitope in hepatitis C virus at a population level J Virol 82 2008 3438 3451
11. A. Rauch, I. James, K. Pfafferott, D. Nolan, P. Klenerman, and W. Cheng Divergent adaptation of hepatitis C virus genotypes 1 and 3 to human leukocyte antigen-restricted immune pressure Hepatology 50 2009 1017 1029
12. T. Berg, V. Weich, G. Teuber, H. Klinker, B. Moller, and J. Rasenack Individualized treatment strategy according to early viral kinetics in hepatitis C virus type 1-infected patients Hepatology 50 2009 369 377
13. C. Kuiken, K. Yusim, L. Boykin, and R. Richardson The Los Alamos hepatitis C sequence database Bioinformatics 21 2005 379 384 (Pubitemid 40246609)
14. G. Ahlenstiel, K. Roomp, M. Daumer, J. Nattermann, M. Vogel, and J.K. Rockstroh Selective pressures of HLA genotypes and antiviral therapy on human immunodeficiency virus type 1 sequence mutation at a population level Clin Vaccine Immunol 14 2007 1266 1273
15. C. Sarrazin, T.L. Kieffer, D. Bartels, B. Hanzelka, U. Muh, and M. Welker Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir Gastroenterology 132 2007 1767 1777
16. C. Kuiken, C. Combet, J. Bukh, I. Shin, G. Deleage, and M. Mizokami A comprehensive system for consistent numbering of HCV sequences, proteins and epitopes Hepatology 44 2006 1355 1361
17. K. Yusim, R. Richardson, N. Tao, A. Dalwani, A. Agrawal, and J. Szinger Los Alamos hepatitis C immunology database Appl Bioinformatics 4 2005 217 225 (Pubitemid 41737124)
18. A.M. Wertheimer, C. Miner, D.M. Lewinsohn, A.W. Sasaki, E. Kaufman, and H.R. Rosen Novel CD4+ and CD8+ T-cell determinants within the NS3 protein in subjects with spontaneously resolved HCV infection Hepatology 37 2003 577 589
19. H. Rammensee, J. Bachmann, N.P. Emmerich, O.A. Bachor, and S. Stevanovic SYFPEITHI: database for MHC ligands and peptide motifs Immunogenetics 50 1999 213 219
20. T. Bhattacharya, M. Daniels, D. Heckerman, B. Foley, N. Frahm, and C. Kadie Founder effects in the assessment of HIV polymorphisms and HLA allele associations Science 315 2007 1583 1586
21. C. Neumann-Haefelin, J. Timm, H.C. Spangenberg, N. Wischniowski, N. Nazarova, and N. Kersting Virological and immunological determinants of intrahepatic virus-specific CD8+ T-cell failure in chronic hepatitis C virus infection Hepatology 47 2008 1824 1836
22. J. Timm, B. Li, M.G. Daniels, T. Bhattacharya, L.L. Reyor, and R. Allgaier Human leukocyte antigen-associated sequence polymorphisms in hepatitis C virus reveal reproducible immune responses and constraints on viral evolution Hepatology 46 2007 339 349